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Inverse Electron-demand Diels-Alder 반응을 이용한 핵의학 영상 프로브의 합성 및 활용
( Sajid Mushtaq ),전종호 ( Jongho Jeon ) 한국공업화학회 2017 공업화학 Vol.28 No.2
1,2,4,5-테트라진 유도체를 이용한 inverse electron-demand Diels-Alder (IEDDA) 반응은 다양한 생체물질, 고분자, 나노물질 복합체의 효율적인 합성에 폭넓게 활용되고 있다. IEDDA는 유기용매에서뿐만 아니라 생리학적 조건 하에서도 우 특이적이며 빠른 반응속도를 가지고 있는 것으로 알려져 있다. 이러한 특성으로 인해 본 반응은 다양한 생물학적 활성을 가지는 물질의 방사성동위원소 표지와 분자영상 및 질병 치료를 위한 방사성의약품 개발에도 활발히 응용되고 있다. 본 리뷰 논문은 IEDDA 반응을 방사화학 및 핵의학 분야에서 이용한 최근 연구 동향 및 연구 결과 그리고 향후 전망에 대해 소개하고자 한다. Inverse electron-demand Diels-Alder reactions (IEDDA) between tetrazine derivatives and strained dienophiles have attracted a lot of attention for the efficient conjugation of biomolecules, polymers, and nanomaterials. Excellent specificity, exceptionally fast reaction rate, and biocompatibility are key features of IEDDA. Therefore, it has also been applied to the development of new labeling methods using several radioisotopes and development of radiotracers to carry out various nuclear imaging as well as therapeutic studies. The purpose of this review is to introduce the reader to the recent advances and applications of IEDDA in the fields of radiochemistry and nuclear medicine.
Recent development in hybrid conducting polymers: Synthesis, applications and future prospects
Sajid Iqbal,Sharif Ahmad 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-
The hybrid conducting polymers (HCPs) possesses unusual properties of both conducting polymers (CPs) and organic/inorganic nanoparticles, which drawn much attraction to the scientist and researchers. The processing of HCPs have helped in overcoming the drawbacks associated with CPs such as poor processability, solubility, stability and low yield. In view of this, the present review article highlights the important synthesis techniques of HCPs and their conduction mechanism. Additionally, much attention has been paid to their diverse applications in energy storage devices, EMI shielding, sensors, biomedicals, anti-corrosive coatings. Finally, the future prospects and current challenges of such polymers have also been overviewed.
( Sajid Mushtaq ),전종호 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
The purpose of this study was to synthesize (125)I-labeled 2-(4-iodophenethyl)-2-methylmalonic acid ([(125)I]IMA) and its biodistribution study for the development of new apoptosis imaging tracer. The optimized radiolabeling procedure provided [(125)I]IMA with high radiochemical yield (75.5 ± 5.2%) and excellent radiochemical purity (>99%) within 100 min. Specific radioactivity of [(125)I]IMA was observed to be 31.0 MBq/mol. Ex vivo biodistribution study of [(125)I]IMA was carried out using male ICR mouse and the result showed the uptake values in apoptotic cells of the testes of the male mice were more than 1.7 fold higher than those of leg muscle. Those results demonstrated that [(125)I]IMA will be a potentially useful radiotracer for in vivo imaging of apoptotic cell and tissue.
Highly visible light active Ag@ZnO nanocomposites synthesized by gel-combustion route
Sajid Ali Ansari,조무환,칸모하마드만숩,이진태 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
Highly visible light active 1% and 3% Ag@ZnO nanocomposites were synthesized via a gel combustion route using citric acid as a fuel. The formation of the nanocomposites with enhanced properties was confirmed using a range of characterization techniques, photocatalysis and photoelectrochemical studies. Compared to the pristine ZnO nanoparticles, the Ag@ZnO nanocomposites exhibited enhanced visible light photocatalytic activity for the degradation of methylene blue and photoelectrochemical response. A mechanism was proposed to account for the photocatalytic activities of the Ag@ZnO nanocomposite that showed the surface plasmon resonance (SPR) of Ag is an effective way of enhancing the visible light photocatalytic activities.
Sajid Mushtaq,Jung Eun Park,Ha Eun Shim,Chang Heon Lee,Hee Soon Shin,So-Young Lee,Jongho Jeon 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.5
A lot of people in Korea have suffered from severe toxicity of PHMG, a humidifier disinfectant. To assess the risk and in-depth mechanistic understanding of toxicity posed by a hazardous substance, it is essential to determine its biological uptake in organs. In this study, we investigate the biodistribution of PHMG using radioanalytical techniques. By labeling PHMG with radioactive indium (<SUP>111</SUP>In), the uptake values of PHMG in organs can be measured after intravenous injection in Sprague–Dawley rats for up to 168 h. The results indicate that PHMG is distributed in the liver (28.63% injected dose (%ID)) and lungs (12.44%ID) at 30 min post administration. In addition, the clearance rate of PHMG distributed in the internal organs is slow, with approximately 65% of injected PHMG remaining in the lungs after 1 week. Moreover, we quantified biodistribution of the radiolabeled PHMG exposed through intratracheal instillation and oral administration routes, and the observed data were compared to each other to understand in vivo behavior of PHMG. In addition, radiolabeled PHMG in an animal model can be visualized using SPECT/CT. The obtained results indicate that repetitive exposure to PHMG results in damage to lungs, as well as extrapulmonary organs.