A Case Report of Prolonged Hemorrhage Following Traditional Phlebotomy (Fasd)

Sadeghi Sajjad,Sadeghi Sajjad 대한약침학회 2024 Journal of pharmacopuncture Vol.27 No.1

Phlebotomy, a therapeutic method of bloodletting typically performed using a needle, has a traditional technique known as “Fasd.” In this method, blood is extracted by creating a longitudinal incision on a vein (3-5 mm) with a surgical scalpel blade, usually blade No. 11. Due to the incision in the vessel wall, establishing hemostasis is more challenging compared to conventional methods. Hemostasis is usually achieved within minutes after Fasd. We present a case highlighting an uncommon yet significant complication of traditional phlebotomy. A 55-year-old man with no prior medical conditions underwent traditional phlebotomy at an academic traditional medicine clinic. Senior MD-PhD students in Iranian Traditional Medicine, under professor supervision, performed Fasd. A sterile scalpel blade No. 11 was used to create a longitudinal incision of approximately 4 mm on the patient’s median basilic vein in the right hand. After removing 400 cc of blood, a pressure dressing was applied to the incision site. Despite attempts such as hand elevation, ice pack application, prolonged direct pressure, and tight elastic bandaging, bleeding from the incision persisted. After an hour of supportive therapy, hemostasis was eventually achieved within a few minutes using burnt cotton dressing (a traditional method for blood hemostasis). Following intravenous hydration, the patient was discharged in stable condition and reported no issues during the one-month follow-up. The traditional phlebotomy (Fasd) carries the risk of serious complications, including uncontrolled and prolonged bleeding. Further research on the efficacy and safety of burnt cotton dressing for controlling hemostasis is recommended.

Incidence and Mortality of Testicular Cancer and Relationships with Development in Asia

Sadeghi, Mostafa,Ghoncheh, Mahshid,Mohammadian-Hafshejani, Abdollah,Gandomani, Hamidreza Sadeghi,Rafiemanesh, Hosein,Salehiniya, Hamid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: Testicular cancer is one of the most common cancers among young men between ages 20-34 in countries with high or very high levels of the Human Development Index (HDI). This study investigated the incidence and mortality of prostate cancer and the relationship with the HDI and its dimensions in Asia in 2012. Materials and Methods: The study was conducted based on data from the world data of cancer and the World Bank (including the HDI and its components). Standardized incidence and mortality rates of testicular cancer were calculated for Asian countries. Correlations between incidence and/ormortality rates, and the HDI and its components were assessed with the use of the correlation test, using SPSS software. Results: There was a total of 14902 incidences and 5832 death were recorded in Asian countries in 2012. Among the Asian countries, the five countries with the highest standardized incidence rates of testicular cancer were Israel, Georgia, Turkey, Lebanon and Kazakhstan and the five countries with the highest standardized mortality rates were Turkey, Georgia, Jordan, Cambodia and the Syrian Arab Republic. A positive correlation of 0.382 was observed between the standardized incidence rates of testicular cancer and the HDI (p=0.009). Also a negative correlation of 0.298 between the standardized mortality rate of testicular cancer and the Human Development Index was noted although this relation was statistically non-significant (p=0.052). Conclusions: There is a positive correlation between HDI and the standardized incidence rate of testicular cancer and negative correlation with standardized mortality rate.

Efficacy of plasmapheresis in neutropenic patients suffering from cytokine storm because of severe COVID-19 infection

Alireza Sadeghi,Somayeh Sadeghi,Mohammad Saleh Peikar,Maryam Yazdi,Mehran Sharifi,Safie Ghafel,Farzin Khorvash,Behrooz Ataei,Mohammad Reza Safavi,Elahe Nasri 대한혈액학회 2023 Blood Research Vol.58 No.2

Background With the emergence of the coronavirus disease 2019 (COVID-19) and inability of healthcare systems to control the disease, various therapeutic theories with controversial responses have been proposed. Plasmapheresis was administered as a medication. However, the knowledge of its efficacy and indications is inadequate. This study evaluated the use of plasmapheresis in critically ill patients with cancer. Methods This randomized clinical trial was conducted on 86 patients with malignancies, including a control group (N=41) and an intervention group (N=45) with severe COVID-19 during 2020-21. Both groups were treated with routine medications for COVID-19 management according to national guidelines, and plasmapheresis was applied to the intervention group. C-reactive protein (CRP), D-dimer, ferritin, lactate dehydrogenase, hemoglobin, and white blood cell, polymorphonuclear, lymphocyte, and platelet levels were measured at admission and at the end of plasmapheresis. Other variables included neutrophil recovery, intensive care unit admission, intubation requirements, length of hospital stay, and hospitalization outcomes. Results CRP (P <0.001), D-dimer (P <0.001), ferritin (P =0.039), and hemoglobin (P =0.006) levels were significantly different between the groups after the intervention. Neutrophil recovery was remarkably higher in the case than in the control group (P <0.001). However, plasmapheresis did not affect the length of hospital stay (P=0.076), which could have significantly increased survival rates (P <0.001). Conclusion Based on the study findings, plasmapheresis led to a significant improvement in laboratory markers and survival rate in patients with severe COVID-19. These findings reinforce the value of plasmapheresis in cancer patients as a critical population suffering from neutropenia and insufficient immune responses.

Development of non-destructive method of detecting steel bars corrosion in bridge decks

Sadeghi, Javad,Rezvani, Farshad Hashemi Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.46 No.5

One of the most common defects in reinforced concrete bridge decks is corrosion of steel reinforcing bars. This invisible defect reduces the deck stiffness and affects the bridge's serviceability. Regular monitoring of the bridge is required to detect and control this type of damage and in turn, minimize repair costs. Because the corrosion is hidden within the deck, this type of damage cannot be easily detected by visual inspection and therefore, an alternative damage detection technique is required. This research develops a non-destructive method for detecting reinforcing bar corrosion. Experimental modal analysis, as a non-destructive testing technique, and finite element (FE) model updating are used in this method. The location and size of corrosion in the reinforcing bars is predicted by creating a finite element model of bridge deck and updating the model characteristics to match the experimental results. The practicality and applicability of the proposed method were evaluated by applying the new technique to a two spans bridge for monitoring steel bar corrosion. It was shown that the proposed method can predict the location and size of reinforcing bars corrosion with reasonable accuracy.

Nonlinear numerical simulation of RC columns subjected to cyclic oriented lateral force and axial loading

Sadeghi, Kabir Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.53 No.4

A nonlinear Finite Element (FE) algorithm is proposed to analyze the Reinforced Concrete (RC) columns subjected to Cyclic Loading (CL), Cyclic Oriented Lateral Force and Axial Loading (COLFAL), Monotonic Loading (ML) or Oriented Pushover Force and Axial Loading (OPFAL) in any direction. In the proposed algorithm, the following parameters are considered: uniaxial behavior of concrete and steel elements, the pseudo-plastic hinge produced in the critical sections, and global behavior of RC columns. In the proposed numerical simulation, the column is discretized into two Macro-Elements (ME) located between the pseudo-plastic hinges at critical sections and the inflection point. The critical sections are discretized into Fixed Rectangular Finite Elements (FRFE) in general cases of CL, COLFAL or ML and are discretized into Variable Oblique Finite Elements (VOFE) in the particular cases of ML or OPFAL. For pushover particular case, a fairly fast converging and properly accurate nonlinear simulation method is proposed to assess the behavior of RC columns. The proposed algorithm has been validated by the results of tests carried out on full-scale RC columns.

Oyster Shell Disposal: Potential as a Novel Ecofriendly Antimicrobial Agent for Packaging: a Mini Review

Sadeghi, Kambiz,Park, Kitae,Seo, Jongchul Korea Society of Packaging Science and Technology 2019 한국포장학회지 Vol.25 No.2

The management of oyster shell disposal is an ongoing challenge in the southern coast of Korea because of continuously dumping the oyster shell in environment. Oyster shell wastes could be a biocidal alternative after calcination using a heat treatment. Calcined oyster shell is normally obtained through thermally conversion of $CaCO_3$ (main component in oyster shell (96%)) into CaO. This study provides a brief overview of oyster shell disposal and its potential as an antimicrobial agent with a focus on calcination process, antimicrobial mechanisms, and packaging applications.

Production of Recombinant Human Interleukin-11 (IL-11) in Transgenic Tobacco (Nicotiana tabacum) Plants

Sadeghi, Abdorrahim,Mahdieh, Majid,Salimi, Somayeh The Korean Society of Plant Biotechnology 2016 식물생명공학회지 Vol.43 No.4

Interleukin-11 (IL-11) is a cytokine that plays a key regulatory role in the immune system. Recombinant human IL-11 (rhIL-11) exerts a preventative effect against apoptotic cell death and inhibits preadipocyte differentiation. IL-11 also is used to stimulate the bone marrow to produce platelets in order to prevent low platelets that may be caused by chemotherapy. Unfortunately, the high production cost of IL-11 associated. In this study, we investigated the feasibility of transgenic plants for the cost-effective production of rhIL-11. Production of rhIL-11 proteins in whole-plant expression system will be more economical when compared to the current E. coli based expression system. The human rhIL-11 gene was codon optimized to maximize plant host system expression. IL-11 expression vector under the control of a constitutive cauliflower mosaic virus 35S (CaMV 35S) promoter was introduced into tobacco by Agrobacterium-mediated transformation. The 5'-leader sequence (called ${\Omega}$) of tobacco mosaic virus (TMV) as a translational enhancer was added to construct. Transgenic tobacco plants expressing various levels of rhIL-11 protein were generated. Western blotting of the stably transformed lines demonstrated accumulation of the appropriately sized rhIL-11 protein in leaves. This research demonstrated the efficacy of using tobacco as an expression system for the production of rhIL-11.

Dynamic response analysis of a foam-based nanoscale plate based on finite strip method

Sadeghi, Zahra Techno-Press 2021 Coupled systems mechanics Vol.10 No.4

The present article dealswith a dynamic response analysis of a foam-based nanoscale plate based on finite strip method (FSM). The nanoscale plate formulation has been adopted based upon a higher order plate theory and then, a higher orderfinite strip has been used to solve the problem.The considered finite strip is capable of considering the bending displacement and also shear deformation effects. The foam-based material has been treated as a porous material with some particular pore distribution. The non-uniformity ofstrain field as well asthe nonlocality ofstress field have been incorporatedwith the usage of nonlocalstrain gradient elasticity.It is clearly showen that the proposed solution based on finite strip method can accurately simulate the dynamic response of considered plate under external forces.The scale factors due to smallsize of the plate and foam-based material willshow a remarkable impact on the dynamic response.

AoI Analysis and Optimization in Systems with Computations-Intensive Updates

Sadeghi Vilni, Saeid,Moltafet, Mohammad,Leinonen, Markus,Codreanu, Marian 한국통신학회 2023 Journal of communications and networks Vol.25 No.5

We consider a status update system consisting of a sampler, a controller, a processing unit, a transmitter, and a sink. The sampler generates a sample upon receiving a request from the controller and the sample requires further processing before transmission, hence is computation-intensive. This is mathematically modeled by a server called process server. After processing the sample, the status update packet is generated and sent to the transmitter for delivery to the sink. This is mathematically modeled by a server called transmit server. The service time of each packet at the transmit and process servers follow geometric distributions. Moreover, we consider that the servers serve packets under the blocking policy, i.e., whenever a server is busy at the arrival time of a new packet, the new arriving packet is blocked and discarded. We analyze the average age of information (AoI) for two fixed policies, namely, 1) zero-wait-one policy and 2) zero-wait-blocking policy. According to the former policy, the controller requests sampling when there is no packet in the system. According to the zero-wait-blocking policy, the controller requests a sample whenever the process server is idle. Furthermore, we develop an optimal control policy to minimize the average AoI using the tools of Markov decision process (MDP). In numerical results, we evaluate the performance of the policies under different system parameters. Moreover, we analyze the structure of the optimal policy.

BUS Monitoring System using a GIS and Electronic Booklet

Sadeghi N. Abolghasem,Kim Kyehyun,Torfeh"nejad Hamid 대한공간정보학회 2006 한국지형공간정보학회 학술대회 Vol.2006 No.5

Since the high rate of road accident fatalities which is about 22,000 people each year is one of the most important problems affecting the Iran's road transportation, Road Maintenance and Transportation Organization as the main industrial authority of road transportation affairs is working on renewal of transportation fleet and structure of roads and speed controlling in order to reduce the rate of accidents occurring in roads network. The traditional method of speed control in Iran is based on the Tachograph which records vehicle's speed, time of leaving, and stoppage in conventional mechanical processing. In this method, the drivers must submit the Tachograph paper to each road police station and the police officer will give ticket to driver if he violated the authorized speed rate. However, since the speed rate and time of leaving is taken from the mechanical component of vehicle (speedometer)and recorded on the paper, in addition to the possible mechanical errors, it makes the manipulation of results possible. The Information Technology Department of Road Maintenance and Transportation Organization arranged an offline pilot study for the first time in Iran on 90 buses in the 431 kilometer Tehran-Esfahan route via new technologies like USB memory and GPS in order to develop a solution for above mentioned problem. In this method, additional information about the bus's route including real-time speed, average speed, unauthorized stopping points, speed violations, deviations from the predetermined route direction, bus and driver specifications, etc. can be collected, which was not possible using the traditional method such as Tachograph. After implementation and collection of existing information about the buses travel routes and other marginal information, this information were entered into the GIS(Geographic Information System) of the organization. The GIS was developed on the context of roads and technical constructions near the roads in the scale of 1:250,000. The various analyses were made to improve and control the fleet deployment situation under the GIS environment. Comparisons of drivers speed violations and accident occurred nearby and also relationship between accident happening and unauthorized stoppage of buses along the route, improvement and correction of authorized time limits of buses for traveling, are some examples. Finally, this research helped to monitor and control speed of bus driver to decrease the numbers of fatalities from traffic accidents.