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실행 요약: 당뇨병의 진단과 관리에서 검사실적 분석에 대한 지침과 권고안
David B. Sacks,Mark Arnold,George L. Bakris,David E. Bruns,Andrea Rita Horvath,M. Sue Kirkman,Ake Lernmark,Boyd E. Metzger,David M. Nathan 대한진단검사의학회 2011 Laboratory Medicine Online Vol.1 No.4
Background: Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. Approach: An expert committee compiled evidencebased recommendations for the use of laboratory analysis in patients with diabetes. A new system was developed to grade the overall quality of the evidence and the strength of the recommendations. A draft of the guidelines was posted on the Internet, and the document was modified in response to comments. The guidelines were reviewed by the joint Evidence-Based Laboratory Medicine Committee of the AACC and the National Academy of Clinical Biochemistry and were accepted after revisions by the Professional Practice Committee and subsequent approval by the Executive Committee of the American Diabetes Association. Content: In addition to the long-standing criteria based on measurement of venous plasma glucose, diabetes can be diagnosed by demonstrating increased hemoglobin A1c (HbA1c) concentrations in the blood. Monitoring of glycemic control is performed by the patients measuring their own plasma or blood glucose with meters and by laboratory analysis of Hb A1c. The potential roles of noninvasive glucose monitoring, genetic testing,and measurement of autoantibodies, urine albumin, insulin, proinsulin, C-peptide, and other analytes are addressed. Summary: The guidelines provide specific recommendations based on published data or derived from expert consensus. Several analytes are found to have minimal clinical value at the present time, and measurement of them is not recommended.
경민호,Elisha Sacks (사)한국컴퓨터그래픽스학회 2010 컴퓨터그래픽스학회논문지 Vol.16 No.2
기하학에서 민코스키합은 두 집합에 들어 있는 모든 점들간의 합으로 이루어지는 집합을 구하는 연산으로 정의되는데, 로보틱스, NC 가공, 솔리드 모델링 등의 다양한 분야의 기하학적 문제를 다루는 매우 유용한 이론적 도구로 사용되고 있다. 하지만, 단순한 정의에도 불구하고 수치연산의 반올림 오차로 인하여 다면체간의 민코스키합을 정밀하고 강건하게 계산하는 것은 매우 어렵다. 본 논문에서는 컨볼루션 계산방법을 이용하여 다면체간의 민코스키합 경계를 계산하는 알고리즘을 제안한다. 알고리즘의 강건성을 보장하기 위한 방법으로 CLP(controlled linear perturbation) 기법을 처음으로 적용하였다. CLP는 인위적 교란방법의 하나로 알고리즘의 강건성을 해치는 반올림 오차에 의한 논리적 오류발생을 막는다. 본 논문의 알고리즘은 실험 예제들에서 민코스키합의 경계면을 구성하는 완전한 2차원 다양체 구조메시를 10⁻¹⁴의 정밀도로 출력하고, 이때 입력 다면체의 꼭지점 좌표는 10⁻¹⁰까지 교란되는 결과를 얻었다 Minkowski sum of two polyedra is an operation to compute the sum of all pairs of points contained in the polyhedra. It has been a very useful tool to solve many geometric problems arising in the areas of robotics, NC machining, solid modeling, and so on. However, very few algorithms have been proposed to compute Minkowski sum of polyhedra, because computing Minkowski sum boundaries is susceptible to roundoff errors. We propose an algorithm to robustly compute the Minkowski sum boundaries by employing the controlled linear perturbation scheme to prevent numerically ambiguous and degenerate cases from occurring. According to our experiments, our algorithm computes the Minkowski sum boundaries with the precision of 10⁻¹⁴ by perturbing the vertices of the input polyhedra up to 10⁻¹⁰.
Tinsley, Kevin W.,Hong, Changwan,Luckey, Megan A.,Park, Joo-Young,Kim, Grace Y.,Yoon, Hee-won,Keller, Hilary R.,Sacks, Andrew J.,Feigenbaum, Lionel,Park, Jung-Hyun American Society of Hematology 2013 Blood Vol.122 No.14
<P>The zinc-finger protein Ikaros is a key player in T-cell development and a potent tumor suppressor in thymocytes. To understand the molecular basis of its function, we disabled Ikaros activity in vivo using a dominant negative Ikaros transgene (DN-IkTg). In DN-IkTg mice, T-cell development was severely suppressed, and positively selected thymocytes clonally expanded, resulting in a small thymus with a heavily skewed T-cell receptor (TCR) repertoire. Notably, DN-IkTg induced vigorous proliferation concomitant to downregulation of antiapoptotic factor expression such as Bcl2. Ikaros activity was required during positive selection, and specifically at the CD4<SUP>+</SUP>CD8<SUP>lo</SUP> intermediate stage of thymocyte differentiation, where it prevented persistent TCR signals from inducing aberrant proliferation and expansion. In particular, DN-IkTg induced the accumulation of CD4 single-positive (SP) thymocytes with a developmentally transitional phenotype, and it imposed a developmental arrest accompanied by massive apoptosis. Thus, we identified an in vivo requirement for Ikaros function, which is to suppress the proliferative potential of persistent TCR signals and to promote the survival and differentiation of positively selected thymocytes.</P>