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Applicability of Nuclear Reaction Models Implemented in PHITS to Simulations on Single-event Effects
S. Abe,S. Hirayama,Y. Watanabe,N. Sano,Y. Tosaka,M. Tsutsui,H. Furuta,T. Imamura 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The nuclear reaction models implemented in the PHITS (Particle and Heavy Ion Transport code System), i.e., the INC model, the QMD model and "event generator mode (e-mode)" with the JENDL-3.3 are validated to apply it to simulations on single-event effects. The model calculations are compared with available experimental data of light-ion (proton and alpha particle) production from neutron-induced reactions on ^(nat)Si and ^(16)O for neutron energies below 100 MeV. Since there is no measurement of lightion production from Si for neutron energies more than 100 MeV, proton-induced reactions on ^(27)Al are also used in the model validation. Comparisons of calculated and measured data for lightion production show that the e-mode calculation with JENDL-3.3 provides better agreement with the experimental data below 20 MeV than the INC and QMD models, and the QMD model reproduces them well above 20 MeV.
Ashraf A. Sabe,Ahmed A. Sadek,Nassrene Y. Elmadhun,Rahul S. Dalal,Michael P. Robich,Cesario Bianchi,Frank W. Sellke 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.1
Resveratrol has been shown to improve cardiac perfusion and ventricular function after chronic ischemic injury. Using proteomic analysis, we sought to objectively investigate potential mechanisms, by which resveratrol exerts its cardioprotective effects in the setting of metabolic syndrome and chronic myocardial ischemia. Yorkshire swine were divided into two groups based on diet: high cholesterol (n = 7) or a high-cholesterol diet with supplemental resveratrol (n = 6). Four weeks later, all animals underwent surgical placement of an ameroid constrictor to their left circumflex artery. Diets were continued for another 7 weeks, and then the ischemic myocardium was harvested for proteomics analysis. Proteomic analysis identified 669 common proteins between the two groups. Of these proteins, 76 were statistically different, of which 41 were characterized (P < .05). Pathway analysis demonstrated that in animals supplemented with resveratrol, there was a downregulation in several proteins involved with mitochondrial dysfunction, cell death, and unfavorable cardiac remodeling. Furthermore, there was an upregulation in proteins involved in free radical elimination. We conclude that resveratrol supplementation significantly alters several critical protein markers in the chronically ischemic myocardium. Further investigation of these proteins may help elucidate the mechanisms by which resveratrol exerts its cardioprotective effects.
확장된 기술수용모델을 통한 스마트폰 관광어플리케이션 이용의도에 관한 연구
한사비나(S. Sabe Na Hahn),윤지환(Ji Hwan Yoon),김정만(Joung Man Kim) 한국호텔외식관광경영학회 2014 호텔경영학연구 Vol.23 No.3
The advent of tourism applications has changed tour patterns through making it easy to access information intourism industry. This study extends the tourism acceptance model (TAM) by introducing two determinants,perceived enjoyment and perceived cost savings, to better explain and predict users` behavioral intentions to usetourism applications specifically in regard to specific age groups who are active travelers and heavy smartphoneowners. In order to conduct empirical research, an online survey on smartphone was carried out by mobile researchservice, ‘OpenSurvey’, and data from 300 participants were analyzed by structural equation modeling (SEM). Theresults show that the impact of perceived usefulness and perceived cost savings on behaviour intention is greater thanperceived enjoyment and perceived ease of use. Perceived ease of use has little direct effect on intention to usetourism applications but indirectly influences through perceived usefulness. Perceived cost savings in time, effortsand monetary value have significant influences on the decision of using tourism applications, but the fun-aspect ofapplications does not greatly help to affect behavior intention. This study offers some practical implications fortourism marketing as a tourism travel tool.
Enterourachal Fistula as an Initial Presentation in Crohn Disease
Sankararaman, Senthilkumar,Sabe, Ramy,Sferra, Thomas J.,Khalili, Ali Salar The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.1
Crohn disease has a wide spectrum of clinical presentations and rarely can present with complications such as a bowel stricture or fistula. In this case report, we describe a 17-year-old male who presented with a history of recurrent anterior abdominal wall abscesses and dysuria. He was diagnosed with Crohn disease and also found to have a fistulous communication between the terminal ileum and a patent urachus. An ileocecectomy with primary anastomosis and complete resection of the abscess cavity was performed. He is on azathioprine for maintenance therapy and currently in remission. Clinicians should have a high index of suspicion for this complication in Crohn disease patients presenting with symptoms suggestive of urachal anomalies such as suprapubic abdominal pain, dysuria, umbilical discharge, and periumbilical mass.
Enterourachal Fistula as an Initial Presentation in Crohn Disease
Senthilkumar Sankararaman,Ramy Sabe,Thomas J. Sferra,Ali Salar Khalili 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.1
Crohn disease has a wide spectrum of clinical presentations and rarely can present with complications such as a bowel stricture or fistula. In this case report, we describe a 17-year-old male who presented with a history of recurrent anterior abdominal wall abscesses and dysuria. He was diagnosed with Crohn disease and also found to have a fistulous communication between the terminal ileum and a patent urachus. An ileocecectomy with primary anastomosis and complete resection of the abscess cavity was performed. He is on azathioprine for maintenance therapy and currently in remission. Clinicians should have a high index of suspicion for this complication in Crohn disease patients presenting with symptoms suggestive of urachal anomalies such as suprapubic abdominal pain, dysuria, umbilical discharge, and periumbilical mass.
Omar Alaber,Ramy Sabe,Virginia Baez-Socorro,Senthilkumar Sankararaman,Erica Roesch,Thomas J. Sferra 대한소아소화기영양학회 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.4
Purpose: The prevalence of eosinophilic esophagitis (EoE) has been on the rise since it was first described in the 1990s. Several diseases and exogenous factors have been associated with EoE. Our aim was to investigate the epidemiology of EoE in cystic fibrosis (CF) patients. Methods: We identified individuals with CF from September 2014 to September 2019 within a database (IBM Explorys Solutions, Inc.). The prevalence of EoE in patients with CF was compared to the general population. Results: The database included 36,111,860 patients during the 5-year study period: 12,950 with CF (0.036%) and 28,090 with EoE (0.078%). EoE prevalence was higher in CF patients than the general population (46 in 10,000 vs. 7.8 in 10,000, p<0.001). Patients with CF and EoE were more likely to be male (50% vs. 33.5%, p<0.008), children (33.3% vs. 16.5%, p<0.001), and non-Hispanic (100% vs. 88.7%, p<0.001) than CF patients without EoE. CF with EoE patients were more likely to be children than EoE only (33.3% vs. 10.5%, p<0.001). Allergic conditions were generally more prevalent in CF with EoE than CF only (83.3% vs. 68.3%, p=0.01) and EoE only (83.3% vs. 69.3%, p=0.014). Conclusion: EoE is nearly 6-times more prevalent in CF patients. Those patients had higher incidence of other atopic conditions. EoE must be considered in the differential diagnosis of patients with CF presenting with dysphagia, refractory gastroesophageal reflux, vomiting, and other esophagus-related symptoms.
( Jordi Carratala ),( Marta Bodro ),( Nuria Sabe ),( Fe Tubau ),( Francesc Gudiol ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: We sought to determine the risk factors, molecular epidemiology, antibiotic therapy and outcomes of bacteremia due to extensively drug-resistant (XDR) Pseudomonas aeruginosa in solid organ transplant (SOT) recipients. Methods: All episodes of bacteremia occurring in SOT recipients were prospectively documented from 2007 to 2013. Results: Of 318 episodes of bacteremia prospectively documented from 2007 to 2013, 49 were due to P. aeruginosa. Thirty-one strains (63%) were XDR, defi ned by non-susceptibility to =1 agent in all but =2 antipseudomonal antimicrobial categories. Time from transplantation to bacteremia was shorter in cases caused by XDR P. aeruginosa than in those due to other etiologies (median 66 days vs. 278; p=0.03). Factors independently associated with XDR P. aeruginosa bacteremia were prior transplantation, nosocomial acquisition, and septic shock at onset. XDR P. aeruginosa isolates belonged to a single clone (ST-175). Compared to patients with bacteremia due to other etiologies, those with bacteremia due to XDR P. aeruginosa more frequently received inadequate empirical antibiotic therapy. Persistence of bacteremia, shock, respiratory failure, ICU admission and need for mechanical ventilation were more frequent in patients with XDR P. aeruginosa. The overall case-fatality rate was higher among patients with XDR P. aeruginosa bacteremia than in the others (38% vs. 16%; p=0.009). Conclusions: Bacteremia due to XDR P. aeruginosa should be carefully considered when selecting empirical antibiotic therapy for hospitalized SOT recipients with prior transplantation presenting with septic shock.