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Recombinant Human Erythropoietin 및 N-acetylcysteine의 방사선 조영제에 의한 신독성 예방효과
정사라 ( Sa Rah Chung ),김의식 ( Eui Sik Kim ),정지윤 ( Ji Yoon Jung ),김난희 ( Nan Hee Kim ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),이강욱 ( Kang Wook Lee ),신영태 ( Young Tai Shin ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.6
Purpose : We investigated the effects of recombinant human erythropoietin (EPO) and N-acetylcysteine (NAC) in the prevention of radiocontrast-induced nephrotoxicity in patients with underlying renal ysfunction, who are regarded as a high risk group. Methods : This study included 77 individuals with renal insufficiency, defined by a serum creatinine concentration above 1.2 mg/dL or creatinine clearance of more than 15 mL/min/1.73m2 and less than 60 mL/min/1.73m2. These patients who needed radiologic interventions including the use of radiocontrast materials from August 2006 to May 2007 were randomly assigned to one of four groups, which were treated with EPO only, NAC only, EPO plus NAC and placebo respectively. The serum creatinine and cystatin-C were measured before, 24 hours and 48 hours after the intervention. The creatinine clearance was obtained using the Cockcroft-Gault equation. Results : The serum level of creatinine in EPO plus NAC group was not significantly elevated 24 and 48 hours after radiocontrast exposure compared to control group (p=0.012). Also, the creatinine clearance of EPO plus NAC group was not significantly decreased after radiocontrast exposure compared to control group (p=0.046). The serum level of creatinine in EPO and NAC group increased less than control group, but there were no significant differences between the groups. Also, the creatinine clearance in EPO and NAC group decreased less than control group, but there were no significant differences between the groups. Conclusion : EPO plus NAC showed a renoprotective effect on radiocontrast study in patients with underlying renal dysfunction.
정금희(Jung, Kum Hee),조사라(Cho, Sa Rah) 전남대학교 글로벌디아스포라연구소 2013 디아스포라 연구 Vol.7 No.1
1955년 도미한 화가 김보현은 한국 근현대미술사에 있어서 마지막 남은 추상표현주의 1세대로 미술사적으로 중요한 의미를 지니고 있는 인물이다. 그는 굴곡의 한국 근현대사 속에서 좌우 이념의 희생양이 되어 고국을 등진 후 60년 가까이 뉴욕에서 작업 활동을 하고 있다. 김보현은 한국에서 3차례나 정신적ㆍ신체적으로 고통을 겪게 되면서 한국 화단과 40년 간 단절하였다. 도미 후 그의 60여년 화업에 있어서 고국에서 받았던 트라우마는 예술의 근원으로 작용했다. 디아스포라의 전형적 삶을 살았던 김보현의 예술세계도 자연 그로부터 자유롭지 못했다. 본 연구는 이러한 디아스포라적인 김보현의 예술을 이해하기 위해 먼저 재미 한인사와 미술사를 알아본다. 미국으로 이주한 한인들은 초기에는 하와이와 로스앤젤레스를 중심으로 살았으나 1950년대 이후 미국 전역으로 확산된다. 김보현이 도미했던 당시 뉴욕은 현대미술의 메카로 떠오르면서, 전 세계 수많은 미술가들을 비롯해 한국 작가들도 서서히 모여들었고, 현대미술의 흐름을 주도하고 있었다. 본 논문은 김보현의 작품 속에 드러나는 디아스포라적 이미지와 특성이 무엇이며, 그의 예술이 지닌 의미와 가치에 대해 문제를 제기시켜 본다. 이러한 연구를 위해 오늘날 디아스포라 미술의 의미와 디아스포라의 정의 및 형성을 알아보고 김보현 예술을 이러한 디아스포라 관점에서 분석하고자 한다. 연구 범주는 김보현이 미국으로 이주한 1950년대 말부터 1960년대 초창기 작품을 중심으로 한다. 김보현 예술에 대한 디아스포라적 관점의 분석은 현대미술에 드러난 디아스포라적 이미지와 특징을 도출해낼 수 있는 근거가 될 것이다. 또한 글로벌 시대 디아스포라적 관점에서 한국의 정체성과 특질을 연구한 사례로 의미를 가지며, 한국근현대미술사의 한 영역으로서 재미 작가 재조명 측면에서도 일정 부분 역할을 할 것으로 기대된다. Bo-hyun Kim, Korean-American artist, went to America in 1955. He is the last one of the first generation of Korean abstract expressionists, having significant implications for the art history. Kim was scapegoated in the long and winding modern history of Korea, and forced to leave his native country. He has been in New York for six decades. After he suffered both mental and physical pain three times in Korea, Kim had to cut himself from the Korean artist community for over four decades. The trauma he has had to endure over the past six decades has always been the source of his artistic inspiration. Kim who had to flee his native country is a classic example of ‘diaspora’. This study examines the Korean-American history and the American art history first to understand his works inspired by diaspora. The Korean-American history traces back to 1903 when the Gaelic docked in Honolulu with around 100 Korean immigrants - who left their home country to pursue the American Dream - aboard. It has been 110 years since then, and around two million Koreans now live in the United States. Early generations of Korean Americans settled first in Hawaii and Los Angeles, and, in the 1950s, they started to spread across the country. Currently, the 40 percent of Korean Americans live in New York and Los Angeles, the two largest cities in the United States. When Bo-hyun Kim arrived at New York first, the city was rising as the mecca of contemporary American art, attracting many artists around the world including those from Korea and leading the contemporary art trend of the time. This study analyzes the images and characters of diaspora that is melted in his works, and raises questions on the implications and values of his works in art history. To do so, the implications of today’s diaspora art and the definition and development of diaspora are reviewed. This study mainly focuses on Kim’s early works from the late 1950s to the early 1960s. Analyzing Kim’s works from the aspect of diaspora will serve as a ground to extract general images and characters of diaspora that is expressed in modern art. It will also have implications for studying the identity and characters of Korea from the same perspective in this global era, as well as for contributing to the history of modern and contemporary Korean art by discovering and shedding new light on Korean-American artists.
홍성화,홍승희,Sa Rah Jung,Su Jin Park,Nam Kyung Lee,Soon Nam Kim,Sang Mo Kang,Hong Ki Min,Sue Nie Park,Si Hyung Yoo 한국미생물학회 2006 The journal of microbiology Vol.44 No.1
Plasma-derived products are produced from plasma via fractionation and chromatography techniques, but can also be produced by other methods. In the performance of nucleic acid amplification tests (NAT) with plasma-derived products, it is necessary to include an internal control for the monitoring of all procedures. In order to avoid false negative results, we confirmed the usefulness of the bovine viral diarrhoea virus (BVDV) for use as an internal control in the detection of hepatitis C virus (HCV) RNA in plasma-derived products. These products, which were spiked with BVDV, were extracted and then NAT was performed. Specificity and sensitivity were determined via the adjustment of primer concentrations and annealing temperatures. BVDV detection allows for validation in the extraction, reverse transcription, and amplification techniques used for HCV detection in plasma-derived products. Plasma-derived products are produced from plasma via fractionation and chromatography techniques, but can also be produced by other methods. In the performance of nucleic acid amplification tests (NAT) with plasma-derived products, it is necessary to include an internal control for the monitoring of all procedures. In order to avoid false negative results, we confirmed the usefulness of the bovine viral diarrhoea virus (BVDV) for use as an internal control in the detection of hepatitis C virus (HCV) RNA in plasma-derived products. These products, which were spiked with BVDV, were extracted and then NAT was performed. Specificity and sensitivity were determined via the adjustment of primer concentrations and annealing temperatures. BVDV detection allows for validation in the extraction, reverse transcription, and amplification techniques used for HCV detection in plasma-derived products.
타목시펜과 프레드니솔론으로 호전된 경화성 피막성 복막염 (sclerosing encapsulating peritonitis)
정지윤 ( Ji Yoon Jung ),장원익 ( Won Ik Jang ),윤지현 ( Ji Hyun Yoon ),김의식 ( Eui Sik Kim ),정사라 ( Sa Rah Chung ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),이강욱 ( Kang Wook Lee ),강대영 ( Dae Young Kang ),신영태 ( Young 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Sclerosing encapsulating peritonitis (SEP) is an uncommon but serious complication of long-term peritoneal dialysis (PD). Entrapment of the intestine in fibrous tissue, causing complete intestinal obstruction, is referred to as SEP. The usual clinical presentation is with partial or complete small bowel obstruction, ascites, abdominal mass, or impaired peritoneal ultrafiltration. Conservative treatment carries a poor outcome and surgery has offered variable results. Even though there is no established medical treatment, immunosuppressive drugs, steroid and tamoxifen are often used. Tamoxifen is a nonsteroidal anti-estrogenic drug commonly used in the management of breast cancer. To our knowledge, this is the first case of sclerosing encapsulating peritonitis successfully treated with tamoxifen and prednisolone in Korea. Recently, we have treated three SEP patients with tamoxifen and prednisolone. All three patients showed clinical improvement within a few months.