Articulation Patterns of Children who Developed Articulation Disorders Associated with Ankyloglossia

박선영(Sun-Young Park),심선희(Sun-Hee Shim),장은실(Eun-Sil Jang),엄태훈(Tae-Hoon Eom),김영훈(Young-Hoon Kim),이순주(Soon-Ju Lee) 대한소아신경학회 2013 대한소아신경학회지 Vol.21 No.3

목 적 : 설소대와 조음장애의 관련성과 설소대 환아에서 조음장애 유무를 감별하는데 필요한 임상지침을 제시하기 위해 조음장애를 동반한 설소대 환아의 조음양상의 특징을 알아보고자 하였다. 방 법: 2002년 1월부터 2012년 12월까지 의정부성모병원 소아청소년과 외래를 방문한 124명의 환아 중 설소대를 제외한 다른 조음기관의 해부학적 이상, 신경학적 질환이나 발달/언어지연을 가진 46명의 환아를 제외한 총 78명을 설소대 유무에 따라 각각 환자군 23명과 대조군 55명으로 나누어 그림자음검사를 통해 조음양상을 비교분석하였다. 결 과 : 두 군에서 조음오류를 보인 자음유형에 따라 집계한 각 환자수는 연구개비음의 경우에만 차이를 보였다. 하지만 자음유형에 따른 조음오류의 환자별 관찰빈도수의 총합은 양순파열음, 연구개파열음과 연구개비음에서 유의한 차이를 보였다. 조음오류의 변화유형에 따라 집계한 환자수는 두 군에서 차이를 보이지 않았다. 하지만 조음변화 유형에 따른 환자별 관찰빈도수의 총합은 환자군에서 전설음화와 마찰음화가 낮게 관찰되었고, 경음화와 격음화과 높게 관찰되었다. 결 론 : 본 연구를 통해 설소대를 동반한 조음장애 환아의 일부에서 해부학적 이상을 동반하지 않은 기능적 조음장애 환아와 구별되는 특징을 보이는 결과를 관찰할 수 있었지만, 이를 설소대를 동반한 모든 조음장애 환아로 일반화할 수는 없었다. 따라서 설소대와 조음장애의 관련성은 여전히 논란의 여지가 있으며, 또한 수술적 치료를 포함한 설소대 치료를 결정하는데 주의를 기울여야 할 것으로 사료된다. Purpose : We investigated articulation patterns in children with ankyloglossia who developed articulation disorders in order to determine the relationship between ankyloglossia and articulation disorders, and to clinically detect children who have articulation disorders associated with ankyloglossia. Methods : The participants of this study were 23 children with articulation disorders that accompanied ankyloglossia and 55 controls with functional articulation disorders independent of anatomical problems, who were admitted to our hospital from January 1, 2002 to December 31, 2012. All children underwent speech-language pathologic evaluation using the Picture Consonant Articulation Test (PCAT; Young-Tae Kim, 1994). We retrospectively compared collected data between the subject and control groups using Fisher's exact test and odds ratio tests with a 95% confidential interval for categorical variables and the independent Mann-Whitney U-test for continuous variables. Results : The number of patients with articulation errors in the velar nasal was lower significantly only in the subject group (P =0.038). The total numbers of articulation errors in the bilabial plosive, velar plosive and velar nasal also were lower (P=0.007, P˂0.001, and P=0.034, respectively). There were no differences in the numbers of patients with articulation errors according to phonological changes between the two groups. However, the total numbers of fronting and frication were lower in the subject group (both P˂0.001), but the total numbers of plosivation and tensing were higher (P =0.002 and P =0.008, respectively). Conclusion : This study showed that the relationship between an articulation disorder and ankyloglossia is doubtful, although some results suggest that ankyloglossia may cause articulation errors only in certain individuals. Therefore, clinicians should be careful when determining the relationship between ankyloglossia and articulation disorders and use caution when making a treatment decision.

HMM에 의한 연속음성 인식 시스템의 구현

심장엽,김상범,김주성,김수훈,이영재,허강인 東亞大學校 附設 情報通信硏究所 1996 情報通信硏究所論文誌 Vol.4 No.1

This paper is a study on the composition of Real-Time Continuous Speech Recognition System for Man-Machine Interface and it examines the posibility that applies to automatic system. The Continous Speech Recognition System is composed of Contivuous Distribution HMM model and algorithm of One Pass DP method. The System is composed so that it may detect start point and end point of speech data which are converted into samples by 10 KHz, 8 bit A/D whthin real time, then so that it may recognie them by one Pass DP method, display the result of recognition on PC monitor and at same time sent control data to Interface. HMM models are creadted by training for continuous speech samples which are control words, area names and digital sounds. In the result of experiment by Continuous Speech Recognition System, there are some kind of errors which are insertion, replacement and deletion of one syllable, but it examined the posibility that can by applied to Man-Machine Interface on automatic system if post-process is performed for recognition.

노박덩굴(Celastrus orbiculatus)의 繁殖에 관한 硏究

沈慶久,安永熙,柳美先,劉鍾勳 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.2

Bittersweet(Celastrus orbiculatus) grown widely in the mountains of Korea is perennial, deciduous and climbing plant. They have strong vines, flower from May to June and mature in October. The red coloured fruits are beautiful, use as the cut-flower materials, and also as the food of birds. This is now considered worthwhile to exploit as an outstanding landscape plant. The objectives of this study were investigation of the suitable propagation methods, reaffirmation of the utility of mist room for softwood cuttings, influence of bed temperature for hardwood cuttings, and determination of the effectiveness of various rooting promotion treatments. The results obtained were summarized as follows. The germination rate was 70% when the period of stratification was 50 days. In softwood cuttings, the rooting percentage and rootlet number tended to be greater in closed moist chamber than those in mist rooms. The rooting percentage, rootlet number and length of root in the 25℃-bed temperature were higher than those in the bed of 20℃ or 30℃ in hardwood cuttings. Cuttings treated with IBA 1000ppm rooted better than those received other hormone treatments in hardwood and softwood cuttings.

알콜리즘에서 Buspirone에 대한 Cortisol과 Prolactin 반응

심주철,이정구,김정익,이유철,김영훈 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

연구목적: 본 연구는 buspirone에 대한 cortisol과 prolactin 반응을 통해 알콜리즘에서 5-HT1A 수용체기능을 조사하고자 하였다. 방법: 알콜리즘 환자군은 DSM-IV의 알콜리즘 진단기준에 부합되고 금주기간이 최소 3개월 이상이며 우울 및 불안증상이 없는, 한 정신병원 알콜 센터에 입원한 22명의 남자 환자였다. 대조군은 정상성인 남자 15명이었다. 이들에게 오전 9시에 5-HT□ 효현제인 buspirone 30mg을 경구 투여한 후 0, 30 , 60, 90, 120, 150분의 혈청 cortisol과 prolatine 농도를 측정한다. 결과: 환자군과 대조군간에 cortisol 기저치에는 유의한 차이가 없었다. Buspirone 투여 후 혈청 cortisol 농도는 정상대조군에서는 기저치에 비해 유의한 증가를 보였으나(p<0.01) 환자군에서는 유의환 증가가 없었다. 혈중 cortisol 농도는 buspiron 투여 60분 이후부터 환자군에서 정상 대조군에 비해 유의하게 저하되어 있었다(p<0.05). Buspirone에 대한 혈청 prolactin 반응은 환자군과 정상대조군간에 유의한 차이가 없었다. 결론: Buspirone 투여 후 둔마된 혈청 cortisol 반응을 통해 알콜리즘에 5-HT1A 수용체 반응성이 둔마되어 있음을 확인할 수 있었다. Objectives: The purpose of this study was to evaluate the prolactin and cortisol responses to 5-HT1A receptor activation by buspirone in alcoholics. Methods: The subjects were twenty two male alcoholic patients meeting the DSM-IV criteria for alcohol dependency and abstaining for more than 3 months. Patients were free from overt anxiety and depressive symptoms. Controls were fifteen male normal volunteers, with no psychiatric and medical illness. Blood samples for the measurement of serum cortisol and prolactin levels were drawn 0, 30, 60, 90, 120, 150 minutes after oral administration of 30mg buspirone hydrochloride at 9:00a.m. Results: The baseline cortisol levels were not significantly different between alcoholics and controls. Serum cortisol levels of controls after buspirone administration were significantly increased over time(p<0.01), but those of alcoholics did not increased. After 60 minutes following buspirone administration, cortisol levels were significantly lower in alcoholics than in contrlos(p<0.05). Prolactin responses to buspirone were not significantly different between the two groups. Conclusions: Our results suggested that 5-HT1A receptor function is decreased in alcoholic patients.

造景樹木의 VA內生菌根에 관한 硏究

沈慶久,李景俊,安永熙,劉鍾勳 成均館大學校 科學技術硏究所 1985 論文集 Vol.36 No.2

The beneficial role of Vesicular-Arbuscular Mycorrhizae (VAM) for growth of woody landscape plants has already been well demonstrated in many countries, but little has been studied about VAM in Korea. So far, researches concerning physiological aspects of VAM have been abundant compared to researches on the ecological sides in woody landscape plants. Especially, the study about VA mycorrhizal fungi indigenous to threeflower maple (Acer triflorum), Korean mountain-ash. (Sorbus alnifolia), and European bird cherry (Prunus padus) have been less studied. The studies described here were undertaken to identify the genera of VAM fungi living in the soil wherein threeflower maple, Korean mountain-ash, and European bird cherry rooted, to observe infected root of host plants, and to compare mycorrhizal colonization related to soil factors. The results obtained were as follows. Ornamental trees roots infected by VAM fungi were observed and identified genera of the fungi investigated in the rhizosphere soil were Glomus sp. The VAM fungi of threeflower maple and Korean mountain-ash showed a circular form, but spore of European bird cherry showed a ellipsoidal form. Vesicle diameter of landscape plants were found from 25.21㎛ to 50.43㎛. Mycorrhizal colonization of threeflower maple, Korean mountain-ash, and European bird cherry were respectively 46.7, 33.3, and 20.0%. Soil pH of landscape trees were slightly acid, and available soil phosphate in the rhizosphere soil showed lower than normal soils. Rhizosphere soil moisture content were 22.90-29.38%.

Cathode materials of Li ion battery

심영재,문성인,형유업,도칠훈,윤문수 국립경상대학교 공과대학 부설 첨단소재연구소 1994 尖端素材 Vol.4 No.-

Li ion 2차전지는 높은 전지전압, 낮은 자기방전율, High Energy Density High Power Density Non-Toxic, No Memory Effect등의 우수한 특성을 보유하고 있고, 환경적인 측면에서 Lead Acid 전지 및 Ni/Cd 전지 등과 같은 Pb, Cd 및 Hg 등으로 인한 환경오염문제가 없는 고성능 신형전지로써, 92년에 SONY사에서 최초의 시제품을 내놓은 이래 현재 소형녹음기, 캠코더 및 셀룰라폰용으로 시판되고 있으나 세계적으로 Li ion 전지를 생산할 수 있는 회사는 일본의 몇몇 기업으로 한정되어 있는 실정이다.

臺木 및 品種에 따른 矮性사과의 生育差異에 관한 硏究(第Ⅱ報)

沈慶久,安永熙,劉鍾勳 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.2

The introduction of dwarf apple growing in real terms in Korea has started from 1970. Nowadays, the cultivation area of dwarf apple trees has greately expanded, reaching 30% of total apple growing area in 1982 present. Many of the pomologists have interest in the growth habit of the dwarf apple trees but sy stematic studies on growth and flowering of them were not studied in detail. The present study was carried out to find out the effects of the most important dwarfing rootstocks; M.27, M.9, M.26, and MM.106 on their counter part scion cultivars; Fuji, Jonagold, Spur Earli Blaze, Starkrimson, Vista Bella, Oregon Spur, and Mutsu in their growth using 6-year-old apple trees. The results obtained were as follows. The tree height of Fuji on M.26 and on MM.106 were 288.60㎝, 291.20cm, respectively. The tree width of Fuji on M.26 and MM.106 were 328.20㎝, 292. 40cm, respectively. The tree height of Jonagold on M.26 were 256.20cm. The width of Jonaold on M.26 were 239.20cm. Therefore, a regardless of rootstocks, the tree height and width of Fuji cultivar were greater than those of Jonagold cultivar. The tree height, width, trunk circumference and number of shoots of Fuji on M.26 were greater than these of other scion cultivars on M.26. The Spur EarliBlaze on M.26 is superior to other cultivars in the number of flowers.

만성 정신분열병 환자에서 지연성 운동장애와 음성증상 및 인지기능 장애와의 연관성

심주철,반철식,성기수,이정구,정도운,정청,윤진상,김영훈 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

연구목적: 정신과 전문병원에 입원해 있는 만성정신분열병 환자들을 대상으로 첫째 지연성 운동장애의 유병율과 위험인자들을 조사하고, 둘째 지연성 운동장애와 정신분열병의 음성증상 및 인지기능 장애와의 상관성을 조사하고자 한다. 방법: 연구대상자는 마산동서병원에 입원 중인 환자 중 DSM-IV의 정신분열별 진단기준에 부합하며, 최근 3개월 이상 동일 용량의 항정신병약물 복용한 271명(남자 174명, 여자 97명)의 환자들이었다. 지연성 운동장애에 대한 평가는 Abnormal Involuntary Movement Scale(AIMS)을 이용하였고, DSM-IV와 Sc-hooler와 Kane(1982)의 진단기준 양자에 부합하는 환자들만을 지연성 운동장애군으로 분류하였다, 정신 분열병 정신병리에 대한 평가는 Brief Psychiatric Rating Scale(BPRS)와 Schedule for the Deficit Syndrome(SDS)을 이용하였고, 인지기능에 대한 평가는 Mini-Mental Status Examination(MMSE)을 이용하였다. 결과: 지연성 운동장애의 유병율은 50.9%이었고, 50세 이상, 남자에서 높았다. 그러나 입원기간과 항정신병 약물의 일일 사용량에 따른 차이는 없었다. 지연성 운동장애의 호발부위는 혀, 상지, 입술과 입 주위의 순이었다. BPRS 총점 및 소항목 척도점수와 SDS 척도점수는 지연성 운동장애의 유무에 따른 차이가 없었다. MMSE 총점 및 소항목 점수도 지연성 운동장애의 유무에 따른 차이가 없었다. 결론: 평균입원기간이 9년 이상인 만성정신분열병 환자들에게서의 지연성 운동장애의 유병율은 50.5%이었고, 연령이 가장 의미있는 위험인자임을 확인했다. 만성정신분열병 환자들이 주 대상인 본 연구에서는 지연성 운동장애와 정신분열병의 음성증상 및 인지기능 장애와의 상관성은 입증하지 못했다. Objectives: The purpose of present study was to determine the prevalence rate of tardive dyskinesia and to search for its risk factors in chronically institutionalized schizophrenic subjects. We also examined the relationship between tardive dyskinesia and both negative symptoms and cognitive impairments in the same subjects. Methods: Subjects were 271 in-patients(174 males, 97 females) at Masan Dongsuh Hospital. They met DSM-IV criteria for schizophrenia and had been taking fixed doses of antipsychotics for at least 3 months. Tardive dyskinesia was assessed by Abnormal Involuntary Movement Scale(AIMS). Cases of tardive dyskinesia were ascertained by the criteria of Schooler and Kane (1982) and DSM-IV. The rating of psychopathology was acquired using Brief Psychiatric Rating Scale(BPRS) and Schedule for the Deficit Syndrome(SDS) and the assessment of cognitive function using Mini-Mental State Examination(MMSE). Results: The prevalence of tardive dyskinesia is 50.9% and the frequency of tardive dyskinesia was high est in male above the age of fifty. But there was no statistically significant relationship between the frequency of tardive dyskinesia and both the length of hospitalization and the daily dose of antipsychotics. The frequency order of abnormal movement in the patients with tardive dyskinesia was as follows : tongue, upper extremities, lips and perioral area. We couldn't find any significant difference in the total and subscale scores of BPRS between the groups with and without tardive dyskinesia. There were no differences in MMSE scores between the groups with and without tardive dyskinesia. Conclusion: This study gave us that the prevalence of tardive dyskinesia was high in chronically institutionalized schizophrenic inpatients and that age was the most significant risk factor of tardive dyskinesia. The relationship between tardive dyskinesia and both negative symptoms and cognitive impairment, however, was not revealed.

복숭아나무(Prunus persica)의 VA內生菌根에 관한 硏究

沈慶久,李景俊,安永熙,劉鍾勳 成均館大學校 科學技術硏究所 1985 論文集 Vol.36 No.1

The beneficial role of Vesicular-Arbuscular Mycorrhizae (VAM) for the growth of fruit trees has already been well demonstrated in many countries, but little has been studied about VAM in Korea. So far, researches concerning physiological aspects of VAM have been abundant compared to researches on the ecological sides in fruit trees. Especially, the study about VA mycorrhizal fungi indigenous to peach orchard soil has been less studied. This study was conducted to identify the genera of VA mycorrhizal fungi living in the soil where in peach trees rooted and to observe infected roots of host plants in peach orchards in Suweon, Taegu, and Naju area. The results obtained were as follows. Peach roots infected by fungi were observed and spores of the fungi were noticed in the rhizosphere soil in Suweon, but only spores have been shown in Taegu, Naju. Identified genera of the fungi in peach orchards in Suweon were Glomus sp. The form of vescicular observed was oblong and irregular.

우울장애 환자에서 자살 시도와 트립토판 수산화 효소(Tryptophan Hydroxylase) A218C 유전자 다형성과의 관련성

심세훈,황보영,권영준,정희연,이분희,김용구 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2

Objectives : Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, Plays a vital role in serotonin metabolism. In a case-control study, we investigated whether the TPH gene was a susceptible factor for suicidal behavior in depressive patients. Methods : The subjects were 218 depressed patients who attempted suicide and visited emergency rooms in multi-medical centers. One hundred thirty hospitalized non-suicidal depressed patients and the 161 normal controls were matched with the suicidal group. Individuals in all 3 groups were evaluated independently by a Structured Clinical Interview for the purpose of establishing a DSM-IV criteria diagnosis (SCID). The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). Results : There was no significant difference in genotype distributions and allele frequencies of TPH intron 7 A218C polymorphisms among 3 groups. Furthermore, no significant difference in genotype counts and allele frequencies of the polymorphisms was found among lethal suicidal depressed patients, non-suicidal depressed patients and the normal controls. Conclusion : This study suggests that the A218C polymorphism of the TPH gene is unlikely to have a major effect on the susceptibility of suicidal behaviors in depressive patients.