하시모토 갑상선염과 동반된 갑상선 유두암에서 BRAFV600E의 발현과 임상적 특징

남성진,최영식,박요한,김정훈 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: An association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is still controversial. Studies to date established the coexistence of HT in 11% to 36% of PTC patients. BRAFV600E mutation was presented 90% with no HT, 64% with HT in PTC patients. Therefore, BRAFV600E mutation is associated with the pathogenesis of PTC arising in HT. The purpose of this study was to identify predictive factors for the coexistence of PTC and HT and to evaluate the association of the BRAFV600E mutation with the clinicopathological features of coexistence of PTC and HT. Methods: A total of 247 patients underwent surgery for thyroid disorders between January 2007 and April 2009. In all, 212 patients was diagnosed as thyroid papillary carcinoma only (PTC group), 33 had coexistence of PTC and HT (PTC+HT group), and 2 had been diagnosed with HT. DNA was extracted from paraffin embedded thyroid tumor specimens taken from 99 patients with PTC, 13 coexistence of PTC and HT, and 2 was HT. The presence of the BRAFV600E mutation was determined by polymerase chain reaction amplification of exon 15 followed by direct sequencing. Results: Among clinicopathological features sex, age, tumor size and capsule invasion was not significant between PTC group and PTC+HT group. Lymph node metastasis and stage was significantly lower in PTC+HT group than PTC group (p=0.044). BRAFV600E mutation was found in 34 of the 99 PTC group (34.3%), 1 of the 13 PTC+HT group and 2 HT show no BRAFV600E mutation. Conclusion: These data demonstrated that the coexistence of PTC and HT was less aggressive than PTC only.

전압비교기를 이용한 AB급 연산증폭기의 슬루율 개선에 관한 연구

김요섭,손상희 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.33 No.2

In this paper, we introduce a circuit which has improved power consumption and slew rate by adding a voltage comparator on the structure of the class AB rail to rail folded cascode OP amplifier. Using a voltage comparator, bias voltage near to VDD is applied in charging and discharging time and so high voltage is transferred to the output load. Therefore, proposed class AB rail to rail folded cascode OP amplifier circuit has high slew rate and low power consumption. From the simulation results of slew rate, we know that slew rate of proposed circuit is improved from 2.5V/us to 12V/us comparing to the conventional circuit. That is the reason why voltage comparator transmits voltage near to the value of VDD to the load stage. From the simulation results of power consumption, we know that power consumption of proposed circuit is improved from 1.2mW to 0.5mW comparing to the conventional circuit. Proposed class AB rail to rail folded cascode OP amplifier is designed and simulated by using the TSMC 0.18um 1-Poly & 6-Metal CMOS process.

인터넷 WEB SITE구축을 통한 의료정보교육의 효과에 관한 연구

남상요 高神大學校保健科學硏究所 1998 보건과학연구소보 Vol.8 No.-

Yet many students do nat have any education about internet, the importance of internet in medical fields is emphasizing nowadays. The purpose of this study aims are to build web based medical facility information providing system and to compare the situation of students before and after having internet lecture. The results are as follows; 1. Student's attitude about internet are positively changed after they have internet lecture. Especially the change of knowledge about internet is statistically significant. 2. web based medical facility information providing system is made to provide medical facility information to those who need to access a proper medical facility for their disease and to educate the students who will be provider of medical information in the near future. The database was made through assembling newspaper articles which contain hospital facility information and data that was collected by the students who have work experience at various hospitals. This system is composed of 5 parts: 1. Search of the hospital by region 2. Treatment of information by disease 3. Consultation regarding hospital affairs 4. Current issues of various hospitals 5. Bulletin board system. It is possible not only to give the medical facility information to people but also to motivate and develope the information processing technical skills for the students y constructing this system.

技術效率 및 配分效率의 평가를 통한 病院資源의 效率性 向上에 관한 硏究

南商堯 高神大學校保建科學硏究所 1994 보건과학연구소보 Vol.4 No.-

This study applied Data Envelopment Analysis (DEA) to a set of hospitals to evaluate their relative efficiency, DEA is constructed from observed inputs and outputs using programming techniques and efficiency is assessed relative to the frontier of the technology using measures similar to those suggested by Farrell. The efficiency measure of a hospital is defined by its position relative to the frontier of the best performance hospitals established mathematically by the ration of weighted sum of outputs to weighted sum of inputs. The output measure used in this study is based on health insurance point system which was used in both in-patient departments and out-patient departments. Inputs included working time of the doctors, nurses, thchnicians, and manegerial deparment staffs. Based on the data provided on the inputs and outputs, the analysis showed 7 of the 17 hospitals to be technicaly inefficient, And 15 of the 17 hospitals to be allocatively inefficient. In addition, managerial strategies based on dual variables were constructed to indicate the manner in which inefficient hospitals may be made efficient.

항응고제 치료와 연관된 자발성 근육내 혈종

김수성,조재훈,이학승,박현영,장혁,김요식,조광호 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1

항응고제 치료의 주된 합병증은 출혈로서 주로 뇌실질과 복강 내에 발생하며 사지 근육에 발생하는 근육내 혈종은 매우 드문 것으로 알려져 있다. 이러한 항응고제 치료 후 발생하는 자발성 근육내 혈종은 발생빈도가 드물 뿐 아니라, 심부정맥혈전증과 그 증상이 유사하여 감별하기가 쉽지 않다. 저자들은 항응고제 치료 후 운동 마비가 발생한 사지 근육에서 자발성 근육내 혈종이 발생한 증례를 경험하여 이를 보고한다. Spontaneous intramuscular hematoma(SIH) is an uncommon but serious bleeding complication of anticoagulation therapy that has received little attention. We present a patient of spontaneous muscular hematoma during anticoagulation therapy for acute stroke management. A-74-year old man was admitted with sudden onset of dysarthria and left hemiparesis. Brain MRI and MRA showed acute cerebral infarction along right middle cerebral artery territory and severe stenosis of right proximal cervical internal carotid artery. During intravenous heparin treatment, he complained acute pain and swelling on left leg. Muscular CT showed enhancing focal soft tissue mass on left gastrocnemius muscle and ultrasonography demonstrated multiple hematomas on left gastrocnemius muscle. Treatment of heparin was stopped immediately. After conservative management for hematomas, symptoms were subsided.

한국에서의 간질의 사회적 낙인

이상암,유희정,허경,박형국,신동진,송홍기,정원영,권오영,이성수,김요식,김성은,이병인 대한간질학회 2002 대한간질학회지 Vol.6 No.2

치열 공간 부조화와 두개안면골격 형태의 상관성

김요숙,정애진,강경화,김상철 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.4

치열 공간 부조화에 영향을 미치는 골격 및 치성요소를 알아보기 위하여 하악 치열궁내 총생을 보이는 성인 45명과 공극을 보이는 성인 39명의 Ⅰ급 부정 교합 환자와 정상적인 배열을 갖는 성인 40명을 선정하여 측모 두부방사선사진과 모형을 분석하여 다음과 같은 결론을 얻었다. 1.공극군보다 총생군의 ANB각이 컸다. 2.공극군보다 총생군이 하악골 및 상악골의 전하방 경사가 커서 안모의 수직적 양상이 심했다. 3. 총생군보다 공극군이 전두개저와 하악체 길이가 컸다. 4. ANB 각, 전안면 고경과 하악지 길이가 공간 부조화 양의 예측에 기여하며, 다음과 같은 회귀방정식이 산출되었다. space discrepancy = 46.51 - 2.51ANB - 0.58AFH + 0.65RH (R² = 0.40) The purpose of this study was to investigate the relationship between the space discrepancy of the mandibular dentition and craniofacial morphology in adults with good Angle class I occlusion. Dental casts of normal group, crowded group and spaced group were selected on the basis of dental crowding and spacing. Subjects with excessive space to accomodate the lower teeth were classified as spaced group(39). Subjects with a space discrepancy of more than 4mm were classified as crowded group(45). Normal subjects had little or no dental crowding and spacing(40). Various skeletodental measurements in lateral cephalograms were evaluated and compared by ANOVA, Pearson correlation analysis and multiple stepwise regression analysis. The results were as follows : 1. ANB angle was larger in crowded group than in spaced group. 2. Maxilla and mandible in crowded group were inclined more downward and forward than in spaced group, so crowded group was found to have vertical tendency. 3. Anterior cranial base length and mandibular body length were longer in spaced group than in crowded group. 4. According to the multiple stepwise regression analysis with space discrepancy as dependent variable, 40% of variance of space discrepancy could be explained by ANB angle, anterior facial height and ramus height. Multiple regression equation was as follows Space discrepancy=46.51-2.51ANB-0.58AFH+0.65RH

Thermafil 충전법의 근관폐쇄성에 관한 연구

임성삼,여인호,박찬제 大韓齒科保存學會 1996 Restorative Dentistry & Endodontics Vol.21 No.2

세립형 고강도 구조용 강재를 이용한 보-기둥재의 실험적 평가

김요숙,임성우,장인화 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

As the structure becomes higher and longer-spanned nowadays, the need for strong and reliable structural material becomes greater. In order to apply high strength steel to the building structure, adaptability of the current design codes to the design with high strength steel has to be reviewed. Beam-column tests subjected to the simple and the combined bending and axial compressive load were performed with variable slenderness ratio. The ultimate strengths were satisfied with both of ASD and LHFD codes regardless of whether characteristic of yield phenomenon is continuous yielding or not.

세립형 고강도 구조용 강재를 이용한 압축재의 실험적 평가

김요숙,임성우,장인화 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

As for the experimental check, stub and long column tests were carried out. Comparison tests for local and global buckling strength evaluation of box-type and H-shaped welded columns were performed with variable width-thickness ratio. Two kinds of steels were used for tests: High strength steel as a material with yield plateau and same grade steel as a material with continuous yielding. All of the specimens were satisfied with design codes regardless of exceeding the design limits. It means that the current width-thickness ratios may apply to both of the material with yield plateau and that with continuous yielding.