하시모토 갑상선염과 동반된 갑상선 유두암에서 BRAFV600E의 발현과 임상적 특징

남성진,최영식,박요한,김정훈 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: An association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is still controversial. Studies to date established the coexistence of HT in 11% to 36% of PTC patients. BRAFV600E mutation was presented 90% with no HT, 64% with HT in PTC patients. Therefore, BRAFV600E mutation is associated with the pathogenesis of PTC arising in HT. The purpose of this study was to identify predictive factors for the coexistence of PTC and HT and to evaluate the association of the BRAFV600E mutation with the clinicopathological features of coexistence of PTC and HT. Methods: A total of 247 patients underwent surgery for thyroid disorders between January 2007 and April 2009. In all, 212 patients was diagnosed as thyroid papillary carcinoma only (PTC group), 33 had coexistence of PTC and HT (PTC+HT group), and 2 had been diagnosed with HT. DNA was extracted from paraffin embedded thyroid tumor specimens taken from 99 patients with PTC, 13 coexistence of PTC and HT, and 2 was HT. The presence of the BRAFV600E mutation was determined by polymerase chain reaction amplification of exon 15 followed by direct sequencing. Results: Among clinicopathological features sex, age, tumor size and capsule invasion was not significant between PTC group and PTC+HT group. Lymph node metastasis and stage was significantly lower in PTC+HT group than PTC group (p=0.044). BRAFV600E mutation was found in 34 of the 99 PTC group (34.3%), 1 of the 13 PTC+HT group and 2 HT show no BRAFV600E mutation. Conclusion: These data demonstrated that the coexistence of PTC and HT was less aggressive than PTC only.

전압비교기를 이용한 AB급 연산증폭기의 슬루율 개선에 관한 연구

김요섭,손상희 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.33 No.2

In this paper, we introduce a circuit which has improved power consumption and slew rate by adding a voltage comparator on the structure of the class AB rail to rail folded cascode OP amplifier. Using a voltage comparator, bias voltage near to VDD is applied in charging and discharging time and so high voltage is transferred to the output load. Therefore, proposed class AB rail to rail folded cascode OP amplifier circuit has high slew rate and low power consumption. From the simulation results of slew rate, we know that slew rate of proposed circuit is improved from 2.5V/us to 12V/us comparing to the conventional circuit. That is the reason why voltage comparator transmits voltage near to the value of VDD to the load stage. From the simulation results of power consumption, we know that power consumption of proposed circuit is improved from 1.2mW to 0.5mW comparing to the conventional circuit. Proposed class AB rail to rail folded cascode OP amplifier is designed and simulated by using the TSMC 0.18um 1-Poly & 6-Metal CMOS process.

ZnGa₂O₄및 ZnGa₂O₄: Er^(3+) 형광체의 광학적 특성 연구

최성휴,서남희,김요완 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.2

ZnGa₂O₄ 및 ZnGa₂O₄:Er^(3+) 형광체의 결정구조와 광학적 특성을 측정하였다. 이 형광체는 공간군이 Fd3m에 속한 Cubic구조로 결정화 되었으며, 순수한 결정의 격자상수는 ZnGa₂O₄ 경우 a=8.3348Å이었고, 불순물 erbium 첨가한 결정의 격자상수는 a=8.3354Å이다. 기초흡수단 영역에서 측정한 ZnGa₂O₄의 직접전이 에너지 간격은 297K에서 3.057eV으로 주어졌고, erbium 불순물 첨가하였을 때 광학적 에너지 간격은 3.037eV이었다. 300K에서의 600~800nm영역에서 측정된 ZnGa₂O₄:Er^(3+) 형광체의 PL spectra는 660~712nm 영역에서 erbium 이온에 기인한 5개의 예리한 피크가 관찰되었다. Undoped ZnGa₂O₄phosphors crystallized in the cubic (space group Fd3m) with lattice constant a =8.3348Å. The lattice constant of ZnGa₂O₄:Er^(3+) was given as a=8.3354Å. The optical absorption measured near the fundamental band edge showed that the optical energy band structure of these compounds had a direct and indirect band gap, the direct energy gaps are found to be 3.057eV for ZnGa₂O₄, and 3.037eV for ZnGa₂O₄:Er^(3+) at 297K. The photoluminescence spectra of ZnGa₂O₄:Er^(3+) measured in the wavelength ranges of 600-800nm at 300K are observed in the regions 660~712nm and five sharp emission peak due to Er^(3+)ion.

Thermafil 충전법의 근관폐쇄성에 관한 연구

임성삼,여인호,박찬제 大韓齒科保存學會 1996 Restorative Dentistry & Endodontics Vol.21 No.2

치열 공간 부조화와 두개안면골격 형태의 상관성

김요숙,김상철 원광대학교 생체재료·매식연구소 1999 원광생체재료·매식 Vol.8 No.1

The purpose of this study was to investigate the relationship between the space discrepancy of the mandibular dentition and carniofacial morphology in adults with good Angle class I occlussion. Dental casts of normal group, crowded group and spaced group were selected on the basis of dental crowing and spacing. Subjects with excessive space to accomodate the lower teeth were classified as spaced group(39). Subjects with a space discrepancy of more than 4mm were classified as crowded group(45). Normal subjects had little or no dental crowding and spacing(40). Various skeletodental measurements in lateral cephalograms were evaluated and compared by ANOVA, Pearson correlation analysis and multiple stepwise regression analysis. The results were as follows: 1. ANB angle was larger in crowded group than in spaced group. 2. Maxilla and mandible in crowded group were inclined more downward and forward than in spaced group, so crowded group was found to have vertical tendency. 3. Anterior cranial base length and mandibular body length were longer in spaced group than in crowded group. 4. According to the multiple stepwise regression analysis with space discrepancy as dependent variable, 40% of variance of space discrepancy could be explained by ANB angle, anterior facial height and ramus height. Multiple regression equation was as follows space discrepancy = 46.51 - 2.51ANB - 0.58AFH + 0.65RH

란크릭 캅셀(플루옥세틴 20mg)에 대한 프로작 캅셀의 생물학적 동등성 시험

심상범,조요나,오한석,류재환,이경태,김남재,서성훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Bioequivalence of two flouxetine capsule, ProzacR (Lilly kora Ltd.) and LanclicR (Samsung Pharm. IND. Co.), was evalated according to the guideline of KFDA. Twenty four healthy male volunteers (21-26 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After 60mg of fluoxetine was orally administered, blood was taken at 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 32, 48 and 72 hours after administration and just before administration. Plasma was analyzed for fluoxetine and internal standard (clomipramine) by a sensitive and validated HPLC assay. The pharmaco kinetic parameters (AUCt, Cmax and Tmax) wre calculated and ANOVA test was used for the statistical analysis of parameters. Differences in (AUCt, Cmax and Tmax between two capsules were -0.90, 3.46 and -14.08% respectively. All powers (1-β) for AUGt, Cmax and Tmax were more than 0.9. Detectable differences (Δ) and confidence interval were all less than ±20%. All the parameters above met the criteria of KFDA for bioequivalence and indicated that LanclicR capsules are bioequivalent to ProzacR capsules.

齒根端肉芽腫과 齒根端襄腫의 電子顯微鏡的 硏究

林成森,呂寅浩 大韓齒科保存學會 1988 Restorative Dentistry & Endodontics Vol.13 No.2

The purpose of this study was to investigate the characteristic features of the cells and tissues of the chronic periapical lesions using light microscope and electron microscope. Fifteen dental periapical lesions were obtained from the patients undergoing periapical surgery. Each specimen was divided into two parts along the tooth axis. One part was routinely processed for histopathologic examinations. 12 periapical lesions were diagnosed as granuloma and 3 periapical specimens as periapical cyst. The other part was fixed in 2.5% glutaraldehyde in 0.1M sodium cacodylate buffer at pH 7.4 and 1% osmic acid in same buffer. They were embedded in Epon 812. The semithin sections were used for the orientation of the lesions and the ultrathin sections were stained conventionally and examined with AEI Corynth 500 electron microscope. The results were as follows. 1. PMN and macrophages, which were dominant cell type, were scattered in small or large numvers throughout the central destuctive area of granuloma. In the granulomatous area, plasma cells and lymphoytes sere found in significant number and a lot of new capillary formation were revealed. Clefts caused by cholesterol sere often seen in the connective tissue. Occasionally foam cell s became collected in groups and epithelial proliferation were present. 2. In both granuloma and cyst, some plasma cells contained narrow cisternae of granular endoplasmic reticulum of which was tightly packed with electron dense materials, and other cells exhibited dilated profiles of granular endoplasimic reticulum. 3. In the area where plasma cells and lymphocytes were collected in groups, lymphocytes with well developed nucleolus and profuse cytoplasm were found and differentiating plasma cells were also present. 4. In the epithelial strands of the granulomatous area, epithelial cells contained enlarged endoplasmic reticulum, tonofilaments and ribosoms. Toward the intercellular space epithelial cells protruded a few microvilli. In the intercellular space, exudate-like electron dense materials, most of which was attached to the plasma membrane, appeared. 5. Some foam cells filled with numerous lipid droplets and others had lipid droplets and crystal-like structures. 6. Cyst epithelium consisted of bright cells and dark cells. The former had bright cytoplasm and small amounts of ribosoms, and the latter dark cytoplasm, many ribosoms, mitochondria and elongated microvilli. 7. Epithelial cells near the cyst lumen protruded a lot of long microvilli toward intercelluar space and cyst lumen.

하이너 뮐러의 희곡『필록테트』의 교훈 : 신화의 지양 Aufhebung des Mythos

서요성 한국독어독문학회 2002 獨逸文學 Vol.84 No.1

In dieser Abhandlung sollen die Stellungen von Mu¨ller und dessen Kritikern zum Mythos und zum antiken Erbe herausgearbeitet werden. Mu¨ller ist entta¨uscht u¨ber die totalita¨re Herrschaft der DDR. Er sieht von der laufenden Wirklichkeit ab, um nicht wieder an ihr zu scheitern. Aber er nimmt keinen Abschied von ihr zur Herausarbeitung der Dausalita¨ten hinter der Wirklichkeitsfassade und fa¨ngt mit der Selbstpru¨fung des Sozialismus an. Dieser soll nach der marxistischen Logik ein endpunkt sein, das der menschliche Geist die ganze Bahn rationalistischer Erkenntnis durchla¨uft und endlich erreicht. Die sozialistischen Utopisten vertrauen blind dem unend- lichen Fortschritt nach dem Zusammenbruch des Kapitalismus durch den Klassenkampf. Die DDR muss das historisch Neue sine. Aber bei Mu¨ller herrscht die Vorstellung, dass die sittliche Beschaffen- heit der Menschen nicht einfach durch die Herstellung der neuen Ordnung des Eigentums vera¨ndert werden kann. Die vorsozialistischen Beziehungen halten sich in allem Wechsel unvera¨ndert und bilden den Kern der Mentali- ta¨t nach. Mu¨ller gelangt zur Erkenntnis, dass sich die Geschichte nicht auf der abgemessen gerechneten Zeit, sondern auf der zyklischen Wiederholung befindet. Die DDR-Gesellschaft ist nicht von der Auswirkung des Mythos befeit und ist ein Posten auf dem Weg von der Antike zur Utopie.

PTEN 유전자 돌연변이를 동반한 Cowden병 1예

남성진,최영식,박요한,김규종,박선자 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Cowden's disease, also known as various hamartomatous malformations of multiple organs, is a rare autosomal dominant disorder. The most important feature of Cowden's disease is an increased incidence of malignant neoplasm, particularly in the breast and thyroid gland. PTEN (phosphatase and tensin homologue deleted in chromosome 10) is a candidate tumor suppressor gene. Mutations of this gene are responsible for PTEN hamartoma tumor syndromes, including Cowden's disease, Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, and Proteus-like syndromes. After identification of PTEN as the gene for Cowden's disease, the incidence of Cowden's disease was estimated to be 1 in 200,000. However Cowden's disease with malignant neoplasm is quite rare in Korea so far. Recently we experienced a family with Cowden's disease who carry a frame shift germline mutation(C.606del T) at 10q23, exon 6 of PTEN gene. The authors report this case with literature review.

인터넷 WEB SITE구축을 통한 의료정보교육의 효과에 관한 연구

남상요 高神大學校保健科學硏究所 1998 보건과학연구소보 Vol.8 No.-

Yet many students do nat have any education about internet, the importance of internet in medical fields is emphasizing nowadays. The purpose of this study aims are to build web based medical facility information providing system and to compare the situation of students before and after having internet lecture. The results are as follows; 1. Student's attitude about internet are positively changed after they have internet lecture. Especially the change of knowledge about internet is statistically significant. 2. web based medical facility information providing system is made to provide medical facility information to those who need to access a proper medical facility for their disease and to educate the students who will be provider of medical information in the near future. The database was made through assembling newspaper articles which contain hospital facility information and data that was collected by the students who have work experience at various hospitals. This system is composed of 5 parts: 1. Search of the hospital by region 2. Treatment of information by disease 3. Consultation regarding hospital affairs 4. Current issues of various hospitals 5. Bulletin board system. It is possible not only to give the medical facility information to people but also to motivate and develope the information processing technical skills for the students y constructing this system.