Robust MR assessment of cerebral blood volume and mean vessel size using SPION-enhanced ultrashort echo acquisition

Han, S.H.,Cho, J.H.,Jung, H.S.,Suh, J.Y.,Kim, J.K.,Kim, Y.R.,Cho, G.,Cho, H. Elsevier 2015 NeuroImage Vol.112 No.-

<P><B>Abstract</B></P> <P>Intravascular superparamagnetic iron oxide nanoparticles (SPION)-enhanced MR transverse relaxation rates (∆<I>R<SUB>2</SUB> <SUP>⁎</SUP> </I> and ∆<I>R<SUB>2</SUB> </I>) are widely used to investigate <I>in vivo</I> vascular parameters, such as the cerebral blood volume (CBV), microvascular volume (MVV), and mean vessel size index (mVSI, ∆<I>R<SUB>2</SUB> <SUP>⁎</SUP>/∆R<SUB>2</SUB> </I>). Although highly efficient, regional comparison of vascular parameters acquired using gradient-echo based <I>∆R<SUB>2</SUB> <SUP>⁎</SUP> </I> is hampered by its high sensitivity to magnetic field perturbations arising from air–tissue interfaces and large vessels. To minimize such demerits, we took advantage of the dual contrast property of SPION and both theoretically and experimentally verified the direct benefit of replacing gradient-echo based <I>∆R<SUB>2</SUB> <SUP>⁎</SUP> </I> measurement with ultra-short echo time (UTE)-based <I>∆R<SUB>1</SUB> </I> contrast to generate the robust CBV and mVSI maps. The UTE acquisition minimized the local measurement errors from susceptibility perturbations and enabled dose-independent CBV measurement using the vessel/tissue <I>∆R<SUB>1</SUB> </I> ratio, while independent spin-echo acquisition enabled simultaneous <I>∆R<SUB>2</SUB> </I> measurement and mVSI calculation of the cortex, cerebellum, and olfactory bulb, which are animal brain regions typified by significant susceptibility-associated measurement errors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>ΔR<SUB>2</SUB> <SUP>⁎</SUP> </I>-CBV is vessel orientation dependent and vulnerable to susceptibility artifacts. </LI> <LI> UTE acquisition minimizes susceptibility artifacts and enables dose-independent CBV. </LI> <LI> UTE-based CBV can theoretically and experimentally replace <I>ΔR<SUB>2</SUB> <SUP>⁎</SUP> </I> for vessel size. </LI> <LI> UTE-based <I>ΔR<SUB>1</SUB> </I> contrasts enable consistent CBV and mVSI maps in mouse brain. </LI> <LI> <I>ΔR<SUB>1</SUB> </I> and <I>ΔR<SUB>2</SUB> <SUP>⁎</SUP> </I> contrasts can be synergistically combined to enhance SPION contrast. </LI> </UL> </P>

Lp-CONVERGENCE OF HIGHER ORDER HERMITE OR HERMITE-FEJÉR INTERPOLATION POLYNOMIALS WITH EXPONENTIAL-TYPE WEIGHTS

H. S. Jung,R. Sakai 장전수학회 2015 Advanced Studies in Contemporary Mathematics Vol.25 No.3

Let R = (-, ∞), and let Q ∈ C1(R) : R → R+ = [0, ∞) be an even function, which is an exponent. We consider the weight wρ(x) = |x|ρe-Q(x), ρ > 0, x ∈ R, and then we can construct the orthonormal polynomials pn(w2ρ; x) of degree n for w2ρ(x). In this paper we obtain Lp-convergence theorems of even order Hermite-Fejér interpolation polynomials at the zeros {xk,n,ρ}n k=1 of pn(w2 ρ; x). Let R = (-, ∞), and let Q ∈ C1(R) : R → R+ = [0, ∞) be an even function, which is an exponent. We consider the weight wρ(x) = |x|ρe-Q(x), ρ > 0, x ∈ R, and then we can construct the orthonormal polynomials pn(w2ρ; x) of degree n for w2ρ(x). In this paper we obtain Lp-convergence theorems of even order Hermite-Fejer interpolation polynomials at the zeros {xk,n,ρ}n k=1 of pn(w2 ρ; x).

Antibiotic susceptibility and resistance of Streptococcus iniae and Streptococcus parauberis isolated from olive flounder (Paralichthys olivaceus)

Park, Y.K.,Nho, S.W.,Shin, G.W.,Park, S.B.,Jang, H.B.,Cha, I.S.,Ha, M.A.,Kim, Y.R.,Dalvi, R.S.,Kang, B.J.,Jung, T.S. Elsevier Scientific Pub. Co 2009 Veterinary microbiology Vol.136 No.1

The rates of antibiotic susceptibility and resistance were investigated in Streptococcus iniae and Streptococcus parauberis isolates obtained from diseased olive flounders (Paralichthys olivaceus) collected from fish farms in Jeju Island, Korea. Isolates of S. iniae (n=65) were susceptible to cefotaxime, erythromycin, ofloxacin, penicillin, tetracycline and vancomycin, as demonstrated by the minimum inhibitory concentration (MIC) test. Isolates of S. parauberis (n=86) were highly resistant to erythromycin (58% of the 86 isolates tested) and tetracycline (63% of the 86 isolates tested). Fifty-four isolates of tetracycline-resistant S. parauberis contained the tet(M/O/S) genes, of which 39 and 12 isolates contained the tet(M) and tet(S) genes, respectively, whereas 3 isolates contained both the tet(M) and tet(S) genes. Among the erythromycin-resistant isolates of S. parauberis (n=50) only 14 contained the erm(B) gene. These results suggest that the tet(S) and erm(B) genes of S. parauberis are involved in the acquisition of high-level resistance to erythromycin and tetracycline. Our findings reveal a high rate of antibiotic resistance among strains of S. parauberis and emphasize the need to develop an appropriate vaccine to reduce the use of antibiotics.

유지혈액투석 환자에 있어 영양상태와 염증지표의 관계에 대한 연구

한상엽(S. Y. Han),조상경(S. K. Jo),윤종우(J. W. Yoon),신진호(J. H. Shin),이소영(S. Y. Lee),차대룡(D. R. Cha),권영주(Y. J. Kwon),조원용(W. Y. Cho),표희정(H. J. Pyo),정태시(T. S. Jung) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.2

N/A Malnutrition is known to be an independent risk factor of morbidity and mortality in hemodialysis patients. The causes of malnutrition were obsucure. Several catabolic cytokines such as interleukin-1β(IL-1β), interleukin-6(IL-6), and tumar necrosis fac-tor-α(TNF-α) were reported to be elevated in hemo-dialysis patients with malnutrition, To evaluate the nutritrional status and relationship among cytokines IL-1β, TNF-α, and various parameters, we performed a cross-sectional study in maintenance hemodialysis patients who have undergone for six months at least. Patients who were taking steroid. showed any sign of infection, or had residual renal function were excluded from the study. Nutritional status was classified into well nourished(A), mild to moderate malnutrition(B), and severe malnutrition(C) by using subjective global assessment(SGA). Patients were divided into two groups (I: A, II: B and C) based on SGA. The level of IL-10, TNF-a were estimated by ELISA. Total patients were 23(M/F:15/8 mean age 52.0±1.56yrs). There were significant differences in weight changes for 6 months, CRP, and SGA between two groups based on the level of serum albumin(using 4.0g/dL as a cutoff value). Moreover, based on SGA, there were significant differences in age, BMI, CRP, and albumin between the group I and IL Serum albumin levels was directly correlated with transferrin(r=0.302, p=0.04), and was inversly correlated with age(r=-0.329, p=0.007). TNF- u was inversly correlated with Kt/Vueea(r=-0.291, p= 0.047), and directly correlated with the duration of maintenance hemodialysis(r=0,346, p=0.036), BMI(r-0.453, p<0.05). These data support the fact that albumin and CRP can be a good marker of nutritional status in maintenance hemodialysis patient. However cytokines and transferrin might not be related to nutritional status.

융합기술 R&D를 위한 개방형 혁신시스템 도입방향

전효리,정성영,Jeon, H.R.,Jung, S.Y. 한국전자통신연구원 2010 전자통신동향분석 Vol.25 No.1

기술간 산업간 융합 현상은 R&D 범위의 복잡성을 가중시켰고, 국가나 지역 단위의 시장이 아닌 지구 단위의 시장경쟁을 첨예화시킴으로써 과거의 폐쇄적 R&D 시스템의 한계를 여실하게 드러내는 계기가 되었다. 즉, 시장 규모의 글로벌화, 제품개발 주기의 단축, 지식체화 인력의 유동성 증가를 극복하기 위해서는 기존의 폐쇄형 R&D 방법이 아닌, 다양한 지식자원을 활용함과 동시에 R&D 활동 전후방에 위치한 모든 주체들이 참여하는 개방화된 R&D 방법을 도입할 때 비로소 새로운 가치를 창출할 수 있게 될 것이다. 따라서, 본 연구에서는 R&D 변화의 추세, 개방형 R&D의 개념 및 필요성을 살펴본 후 '융합기술 R&D를 위한 개방형 혁신 시스템 도입 방향'을 제언하고자 한다.

Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression

Kim, E-S,Cha, Y,Ham, M,Jung, J,Kim, S G,Hwang, S,Kleemann, R,Moon, A Macmillan Publishers Limited 2014 Oncogene Vol.33 No.27

A crucial role of the inflammatory lipid sphingosine-1-phosphate (S1P) in breast cancer aggressiveness has been reported. Recent clinical studies have suggested that C-reactive protein (CRP) has a role in breast cancer development. However, limited information is available on the molecular basis for the expression of CRP and its functional significance in breast cell invasion. The present study aimed to elucidate the molecular link between S1P and CRP during the invasive process of breast epithelial cells. This is the first report showing that transcription of CRP was markedly activated by S1P in breast cells. Our data suggest that not only S1P treatment but also the endogenously produced S1P may upregulate CRP in breast carcinoma cells. Transcription factors CCAAT/enhancer-binding protein beta and c-fos were required for S1P-induced CRP expression. Coupling of S1P<SUB>3</SUB> to heterotrimeric G<SUB>αq</SUB> triggered the expression of CRP, utilizing signaling pathways involving reactive oxygen species (ROS), Ca<SUP>2+</SUP> and extracellular signal-related kinases (ERKs). S1P-induced CRP expression was crucial for the transcriptional activation of matrix metalloproteinase-9 through ERKs, ROS and c-fos, leading to breast cell invasion. Using a xenograft mice tumor model, we demonstrated that S1P induced CRP expression both in vitro and in vivo. Taken together, our findings have revealed a molecular basis for S1P-induced transcriptional activation of CRP and its functional significance in the acquisition of the invasive phenotype of human breast epithelial cells under inflammatory conditions. Our findings may provide useful information on the identification of useful therapeutic targets for inflammatory breast cancer.

Deoxygenative silylation of aromatic carbonyl compounds with HSiCl₃ in the presence of quaternary phosphonium chloride: A facile route to arylmethyltrichlorosilane

Han, J.S.,Kang, S.H.,Jung, I.N.,Yoo, B.R. Korean Society of Industrial and Engineering Chemi 2016 Journal of industrial and engineering chemistry Vol.42 No.-

Aromatic carbonyl compounds such as aromatic aldehydes and ketones [R<SUP>1</SUP>R<SUP>2</SUP>C?O: R<SUP>1</SUP>=H; R<SUP>2</SUP>=Ph (1a), 2,4-Cl<SUB>2</SUB>Ph (1b), 2,4-Me<SUB>2</SUB>Ph (1c): R<SUP>1</SUP>=Ph; R<SUP>2</SUP>=Ph (1d), 4-ClPh (1e), 4-MePh (2f), 2,4-Me<SUB>2</SUB>Ph (1g) undergo the deoxygenative silylation with HSiCl<SUB>3</SUB> in the presence of Bu<SUB>4</SUB>PCl at 150<SUP>o</SUP>C within 1.0-1.5h to give arylmethyltrichlorosilanes 2 (R<SUP>1</SUP>R<SUP>2</SUP>CH-SiCl<SUB>3</SUB>) in high yields (85-95%). The reactivity of aromatic carbonyl compounds decreases with increasing the electron withdrawing ability of substituent(s) on the benzene-ring. A highly efficient synthetic route to arylmethyltrichlorosilanes has been developed starting from aromatic aldehydes and ketones in this study.

혈청 Creatine Kinase측정 표준화에 관한 연구(Ⅵ)

이창규,이승관,조경진,정수경,박종성,박상숙,류정록,남현철,김상섭,김석수,장철수,최명재 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

In European countries or Japan they made an attempt for the standardization of assays in AST, ALT, ALP, CK, LD and GGT 10 years ago. For the actualization of the trial, they managed to succeeded in development of certified reference material and enzyme reference material. And they are now forecasting the unification of test results produced differently under the respective situatons. Then, through the highly developed communication system, someone can access any test results whenever or whereever only if they want to. It means that we can expect much greater improvements in medical services through the information exchanges. In this study the authors tried to ascertain the interchangeability comparing the obtained results of the CK tests between two general hospitals. Fortunately, the data got in the internal QC programs came to fall within the normal tolerances. The reference intervals for the CK test were different accarding to the chosen reagents and the results from the pooled serum were also shown differently each other. However, from the two hospitals, we could get glucose K factors, upon which the measurements were obtained and compared. Using K factors we measured the CKs, then we multiply the CK values by correction coefficients. We could found that the two results were showing good coincidence in the comparison. The main purpose of the standardization of enzyme assays is the creation of a new unified value which can be expressed differently otherwise. Using the standardized values we can exploit the data everywhere, reduce the medical costs from repeated or duplicated tests, save the foreign exchanges preventing the diversification of impart connections.

혈청 LDH 효소분석 검사의 효준화에 관한 연구(Ⅴ)

이창규,이승관,조경진,박종성,정수경,유병서,박상숙,류정록,남현철,김석수,김상섭,김재영,이국성 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

Since the Korean Association of Quality Assurance for Clinical Laboratory was established in 1976, the numbers of the participating hospitals nowadays were increased from 40 to 450 or more hospitals all over the country. In the early day the both internal and external quality control programs were started at the same time, however, the external QC programs prevailed over the internal ones putting the cart before the horse. The accuracy and the precision of the data are not satisfying in spite of the 20 years experiences of quality control programs. All the daily data should be reported after the validity is assured by the self-evaluation not by third party evaluation. It is regret that the CVs of enzymatic tests in external QC are exceeding 10% and there is no sign of diminishing CVs. One of the major reasons is that the types of anaytical instrurments and reagents are diverisified. Moreover, most of them are subject to the standards of the respective country of manufacturer. Accordingly, we can make a suggestion that the reagents and instruments should be imported or supplied meeting the established requirements for Korean standardization.

Progress in the development of heating systems towards long pulse operation for KSTAR

Kwak, J.G.,Bae, Y.D.,Chang, D.H.,Chang, D.S.,Hong, B.G.,Hwang, C.K.,In, S.R.,Jeong, S.H.,Jin, J.T.,Jung, K.S.,Kim, B.R.,Kim, J.,Kim, S.K.,Kim, T.S.,Lee, D.W.,Lee, K.W.,Oh, B.H.,Seo, C.S.,Seo, M.S.,Yoo International Atomic Energy Agency 2007 Nuclear fusion Vol.47 No.5

<P>Construction of the Korea superconducting tokamak advanced research (KSTAR) tokamak is in its final phase. For the long-pulse KSTAR discharges, the ion cyclotron range of frequencies (ICRF) and neutral beam injection (NBI) heating systems are expected to play important roles through a selective heating of ions and electrons, control of the plasma pressure and current profiles, a core fuelling and beam diagnostics for the KSTAR. In addition, the ICRF system is expected to be used for possible discharge cleaning and assisting in the tokamak startup. In this paper, the recent progress in the development of the ICRF and the NBI heating systems is described. The four-strap ICRF antenna has been successfully tested for a voltage up to 41 kV for a pulse length of 300 s (to 46 kV for 20 s) in a test chamber. A prototype KSTAR NBI system has been developed. At present, the system has successfully produced a 1 MW beam power for 200 s and a 3.5 MW output beam power for 4 s.</P>