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- 저자 : S. Ima Nirwana (검색결과 3 건)
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S. Ima-Nirwana,S. Suhaniza 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.1
Long-term glucocorticoid treatment is associated with severe side effects, such as obesity and osteoporosis. Apalm oil-derived vitamin E mixture had been shown previously to be protective against osteoporosis in rats given 120 mg/kgdexamethasone daily for 12 weeks. In this study we determined the effects of two isomers of vitamin E (i.e.,palm oil-derivedg-tocotrienol and the commercially available a-tocopherol, 60 mg/kg of body weight/day) on body composition and bone cal-cium content in adrenalectomized rats replaced with two doses of dexamethasone, 120 mg/kg and 240 mg/kg daily. Treatmentperiod was 8 weeks. g-Tocotrienol (60 mg/kg of body weight/day) was found to reduce body fat mass and increase the fourthlumbar vertebra bone calcium content in these rats, while a-tocopherol (60 mg/kg of body weight/day) was ineffective. There-fore, in conclusion, palm oil-derived g-tocotrienol has the potential to be utilized as a prophylactic agent in prevention of theside effects of long-term glucocorticoid use.
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Palm Vitamin E Prevents Osteoporosis in Orchidectomized Growing Male Rats
S. Ima Nirwana,A. Kiftiah,A. G. Zainal,M. Norazlina,M. T. Gapor,B. A. K. Khalid 한국생약학회 2000 Natural Product Sciences Vol.6 No.4
Testosterone deficiency increased bone resorption, giving rise to osteoporosis. Testosterone deficiency also increased lipid peroxidation and free radical formation. Free radicals have been shown to be toxic to osteoblasts as well as to activate osteoclasts. In this study, the effects of giving an antioxidant, i.e. vitamin E-rich extract from palm oil on bone mineral density and calcium content was studied. Palm vitamin E prevented the loss in bone mineral density due to orchidectomy, seen in the whole femur, proximal amd midshaft regions, as well as L4 vertebra. Similar observations were seen in bone calcium content of the L5 vertebra. Giving palm olein also prevented the loss in bone mineral density in the femoral midshaft and L4 vertebra; and bone calcium content in the L5 vertebra. In conclusion, vitamin E-rich extract from palm oil was effective in preventing the toss in bone mineral density and calcium content of orchidectomized male rats. This action is probably due to its role as an antioxidant.
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Combined Effects of Sex Hormones and Dietary Oils on Lipid Peroxidation
Z. Merican,M. Jamaludin,B. A. K Khalid.,S. Ima Nirwana 한국생약학회 1995 Natural Product Sciences Vol.1 No.1
The effects of orchildectomy with/without testosterone replacement in male rats, and ovarectomy with estrogen replacement in female rats on lipid peroxidation were studied in male and female rats fed with diets fortified with 20% w/w soybean oil or palm oil for 4 months. Serum, liver and heart homogenates were assayed for malonaldehyde and conjugated dime levels. Orchidectomy was found to reduce levels of lipid peroxidation products in the serum, liver and heart. Testosterone replacement did not increase the Lipid peroxidation products to levels in the nonorchildectomised rats, while estrogen did not influence lipid peroxidation significantly. Palm oil decreased, but soybean oil increased lipid peroxidation in the liver and heart of both the castrated and sex hormone-replaced male and female rats.
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