중등도 및 중증고혈압에서 Nifedipine 설하투여의 강압효과에 관한 연구

김영훈,서순규,최인석,김열홍,안희권,심완주,노영무 대한내과학회 1986 대한내과학회지 Vol.31 No.5

In order to assess the efficacy of sublingual nifedipine in the acute treatment of moderate to severe hypertension, a single blind test was done in 30 patients, 10 males and 20 females, aged 40 to 76 years, with moderate to severe hypertension. The patients with mean sitting blood pressure(BP) of more than J40 mmHg received sublingual placebo, and BP and pulse rate(PR) were measured in sitting position 10,20 and 30 minutes after the sublingual placebo was given. The patients with post-placebo 30 minutes sitting mean BP of less than 13pmmHg were excluded from the study. The placebo treatment period was followed by the administration of 10mg of sublingual nifedipine, and BP and PR were measured 10,20,30 and 45 minutes after nifedipine was given. BP decreased with placebo treatment(p$lt;0. 01 by paired t-test, preplacebo vs. post-placebo 30 minutes). With sublingual nifedipine BP started to fall in 10 minutes and reached the lowest levels in 30 or 45 minu1es. The systolic BP decreased from 198.0±21.4mmHg to 159±20.4mmHg, diastolic BP from 122.5±13.0 mmHg to 103.2±14.4 mmHg and mean from 147.7±13.4 mmHg to 121.7±14.8 mmHg 45minutes after nifedipine(p$lt;0.01 by paired t-test). The average fall in systolic BP/diastolic BP/mean BP 45 minutes after nifedipine was 39/19/26 mmHg(p$lt;0. 001, by paired t-test). The maximal fall in systolic BP correlated better with pretreatment value(r=0.42) than the maximal fall in diastolic pressure(r=0.21), PR increased from 79±12 to 87±11/minute with nifedipine(p$lt;0.001, by paired t-test). Side effects were mild facial flushing(16.7%) and palpitation (3.3%). The findings suggest that a dose of 10mg of sublingual nifedipine is a simple, effective and safe method for the acute treatment of moderate to severe hypertension and can be used as a non-injecting alternative agent for the treatment of hypertensive emergency.

복사전열 가열로 튜브의 파손방지에 대한 연구

윤기봉,심상훈,유홍선,오현환 한국산업안전학회 1998 한국안전학회지 Vol.13 No.1

Radiant heater tubes with an inside burner are designed to transfer the heat generated from the burner to the outside of the tube by radiation. Hence, tube metal must suffer high temperature of approximately 900-1000℃. The radiant tube is usually manufactured by centrifugal casting with high Ni-Cr alloys. In this study, failure analysis results of the radiant tube arc reported. Failure mechanism of the tube was investigated by visual observation of the failed tube, metallographic study of the cracked region and chemical analysis of tube metal and oxide scales. It was argued that the main cause of the cracking is repeated oxidation of the tube metal located beneath the thick oxide scale. Oxidation was caused by abnormally high operating temperature which can be verified by aged microstructure and internal void formation.

Zone melting furnace 온도와 성장속도가 90 % Bi2Se3n 형 단결정의 열전특성에 미치는 영향

현도빈,황종승,심재동,오태성,하헌필 대한금속재료학회(대한금속학회) 2000 대한금속·재료학회지 Vol.38 No.1

The effects of the zone melting temperature and growth rate on the thermoelectric properties for 0.15 wt% CdI₂ and 0.05 wt% CdCl₂ doped 90% Bi₂Te₃-10% Bi₂Se₃ single crystals were investigated. The Seebeck coefficient and electrical resistivity of the 0.15 wt% CdI₂ doped single crystals were initially decreased along the ingots due to the condensation of iodine in the melts. The sharp increase of the Seebeck coefficient and electrical resistivity at the last-to-freeze region were considered as results of the evaporation of iodine from the molten zone and the compensation of electrons due to the formation of the antistructure defects. The figure-of-merit was enhanced with increasing the zone melting temperature and lowering the growth rate. The single crystels grown at the zone melting temperature of 800℃ and the growth rate of 0.1 ㎜/min exhibited the maximum figure-of-merit of 2.8×10^(-3)/K.

Sbi3 를 첨가한 25% Bi2Te3-75% Sb2Te3 와 15% Bi2Te3-85% Sb2Te3 단결정의 전기적특성과 열전특성

현도빈,황종승,심재동,오태성,하헌필 대한금속재료학회(대한금속학회) 1999 대한금속·재료학회지 Vol.37 No.8

The temperature dependences of the electrical and thermoelectric properties of the SbI₃-doped 25% Bi₂Te₃-75% Sb₂Te₃ and 15% Bi₂Te₃-85% Sb₂Te₃ single crystals, grown by the Bridgman method, were measured at temperatures ranging from 77 K to 600 K. For the Sb₂Te₃-rich single crystals, the temperature dependence of the Hall mobility was T^(-1.0) regardless the Sb₂Te₃ contents and added amount of SbI₃. The temperature dependences of (m*/m_o)^(3/2)·μ_c and effective mass m*/m_o were T^(-1.5) and T^(-1/3), respectively. The decrease of the saturated hole concentration and the change of the slope of the Seebeck coefficient with temperature were considered in the view point of the two sub-bands in the valence band. The maximum figure-of-merit at 300 K of 0.2 wt% SbI₃-doped 25% Bi₂Te₃-75% Sb₂Te₃ and 0.4 wt% SbI₃-doped 15% Bi₂Te₃-85% Sb₂Te₃ single crystals were 2.25×10^(-3)/K and 1.95×10^(-3)/K, respectively.

(100-x)%Bi2Te3-x%Sb2Te3(x≥66.7) 단결정의 전기적 특성과 열전특성

현도빈,심재동,오태성,하헌필,한동균 대한금속재료학회(대한금속학회) 1999 대한금속·재료학회지 Vol.37 No.11

Electrical and thermoelectric properties of the undoped (100-x)% Bi₂Te₃-x% Sb₂Te₃ (x≥66.7) pseudo-binary single crystals grown by the zone melting method were measured over the temperature range from 77 to 600K. For the (100-x)% Bi₂Te₃-x% Sb₂Te₃ (x≥66.7) alloys, the temperature dependence of the Hall mobility was T^(-1.0) regardless the Sb₂Te₃ contents. The temperature dependences of (m^*/m_o)^(3/2)·μ_c and the effective mass were proportional to T^(-1.5) and T^(-1/3), respectively. The saturated hole concentration decreased with increasing temperature and the slope of the Seebeck coefficient changed at about 350K, which implied the two sub-bands in the valence band. While the 33.3% Bi₂Te₃-66.7% Sb₂Te₃ alloy exhibited the highest figure-of-merit among the undoped Bi₂Te₃-Sb₂Te₃ alloys, the maximum figure-of-merit could be expected fur the 22.5% Bi₂Te₃-77.5% Sb₂Te₃ alloy with optimizing the carrier concentration.

배추흰나비 변태에 따른 중추신경계의 형태학적 변화

이봉희,심재원,윤혜련,권도우 고려대학교 한국곤충연구소 1992 昆蟲硏究誌 Vol.18 No.1

배추흰나비 변태에 따른 중추신경계의 형태학적 변화. 이봉희, 심재원, 윤혜현, 권도우 (순천향대학교 자연광학대학 생물학과), 昆蟲硏究誌. 18 : 55 ~ 62, 1992. 곤충 변태에 따른 중추신경계의 형태학적 변화가 배추흰나비(Pieris rapae)5령유충, 1일용, 2일용, 그리고 1일성충에서 조사되었다. 변태에 따라 중추신경계는 인접 신경절사이의 신경삭(nerve connective)이 짧아지거나 길어졌고 인접 신경절사이의 신경삭이 완전히 제거되어 신경절끼리 융합하기도 하였다. 또한 대부분의 신경절내에서도 큰 변화가 수반되었다. 이와같은 중추신경계의 형태학적 변화는 중추신경계의 길이가 상당히 짧아지는 것이 가장 큰 특징이었다. 중추신경계의 길이 감소는 전 변태기 동안 일어났지만 특히 5령유충 중추신경계는 변태기간 동안 계속 길이가 감소하여 1일성충에서는 48%가 감소되어 있었다. 신경절은 또한 서로 융합하여 특히 thoracic neuron center와 abdominal neuron center를 형성하였다. thoracic neuron center는 1일용과 2일용 사이의 변태기간 동안 제1과 제2 복부신경절이 먼저 융합하고 이어서 2일용 이후의 용기에서의 변태기간 동안 융합된 제 1, 2 복부신경절이 제 2와 제 3 흉부신경절과 융합되어있는 제 7과 제8복부신경절은 1일성체로 되는 용기의 변태기간동안 제6복부신경절과 융합하여 abdominal neuron center를 형성하였다. 중추 신경계를 구성하는 모두 13개의 신경절은 주로 용기의 변태기간 동안 구조적으로 분화하여 성충의 중추신경계를 형성하였다. The morphological changes occurring in the central nervous system of Pieris rapae have been investigated during metamorphosis from the fifth instar larva to the 1-day-old adult. These changes consist of (1) shortening or lengthening of the connectives between the neighbouring ganglia, (2) fusion of adjacent ganglia, and (3) sizable changes within the various ganglia. A considerable shortening of the central nervous system occurs through the metamorphic periods which were investigated in this experment; in particular when the fifth instar larva changes to the prepupa and the 1-day-old pupa to the 2-day-old pupa. The 48% of total length of the central nervous system of the fifth instar larva decreases in the 1-day-old adult. The 1st and 2nd dbdominal ganglia fuse completely during a metamorphic period between the 1-day-old pupa and 2-day-old pupa. The fused 1st and 2nd abdominal ganglia fuse again with the 2nd and 3rd thoracic ganglia between the 2-day-old pupa and the 1-day-old adult, forming the thoracic neuron center. The previously fused 7th and 8th abdominal ganglia in the fifth instar larva fuse completely with the 6th abdominal ganlion between the 2-day-old pupa and the 1-day-old adult, forming the abdominal neuron center. The extensive differentiaton of the various ganglia, especially cerebral ganglion, occurs mostly during the pupal stages.

SbI3 를 첨가한 33.3 % Bi2Te3-66.7 % Sb2Te3 열전반도체의 전기적특성과 열전특성

현도빈,황종승,심재동,오태성,황창원 대한금속재료학회(대한금속학회) 1999 대한금속·재료학회지 Vol.37 No.2

The temperature dependences of the electrical and thermoelectric properties of the SbI₃-doped 33.3% Bi₂Te₃66.7% Sb₂Te₃ single crystals have been measured at temperatures ranging from 77K to 600K. The scattering parameter of the 33.3 Bi₂Te₃-66.7% Sb₂Te₃ single crystals was determined as s = 0. With increasing the amount of SbI₃ dopant, the hole concentration of the 33.3% Bi₂Te₃-66,7% Sb₂Te₃ single crystal is decreased, resulting in the increment of the Seebeck coefficient and electrical resistivity, and the temperature for the maximum figure-of-merit shifted to lower temperature. A maximum figure-of-merit of 2.3×10^(-3)/K was obtained for 0.3 wt% SbI₃-doped specimen. It has been revealed that. the addition of SbI₃ as a donor dopant is useful in controlling the hole concentration of p-type 33.3% Bi₂Te₃ 66.7% Sb₂Te₃ alloy system.

0.2wt% SbI3 첨가 90% Bi2Te3-(10-x)% Sb2Te3-x% Sb2Se3 고용체 합금의 전기적특성 및 열전특성

현도빈,황종승,심재동,오태성,Barabash, V . A . 대한금속재료학회(대한금속학회) 1998 대한금속·재료학회지 Vol.36 No.8

Electrical and thermoelectric properties of the 0.2 wt% SbI₃- doped n-type 90% Bi₂Te₃-(10-x)% Sb₂Te₃-x% Sb₂Se₃ single crystals have been investigated at temperatures ranging from 77K to 600K. The carrier concentration and Seebeck coefficient were independent of the Sb₂Se₃ content. With increasing the Sb₂Se₃ content, the electrical resistivity increased and Hall mobility decreased, which was attributed to the lattice distortion. The thermal conductivity decreased with increasing Sb₂Se₃ content, which was mainly due to the decrease of the electronic thermal conductivity. With increasing the Sb₂Se₃ content, the maximum figure-of-merit decreased and was shifted to the lower temperature. The 0.2 wt% SbI₃-doped 90% Bi₂Te₃-5% Sb₂Te₃-5% Sb₂Se₃ single crystal showed the maximum figure-of-merit of 1.65×10^(-3)/K at 280K.

급성일산화탄소 중독증에 병발된 폐부종에 대한 임상적 고찰

정기석,김준우,심영수,한용철 대한내과학회 1986 대한내과학회지 Vol.30 No.5

409 patients with acute CO poisoning were reviewed, for clinical manifestations, incidence and possible mechanism of complicated pulmonary edema. The following results were observed; 1) The incidence of pulmonary edema complicating acute CO poisoning was 4.9% (20 out of 409) and no significant difference in age and sex distribution between pulmonary edema and control group was found. 2) The mean PaO₂ in pulmonary edema group was 52.2 mmHg which was markedly decreased comparing with 80.0 mmHg in control group, But there was no significant difference in PaCO₂ and pH between two groups. 3) Tbe increase of HbCO level had a close relationship with development of pulmonary edema and the incidence of pulmonary edema was markedly increased when HbCO was over 50%. 4) The prognoeis was worse in pulmonary edema group, but the severity of chest X-ray finding was not considered as a prognostic factor.

Pseudomonas sp . 접종에 의한 항산화물 다량함유 로즈마리(Rosmarinus officialis L .)계통 선발

박충헌,이봉호,심강보,Shetty, K . 한국국제농업개발학회 1999 韓國國際農業開發學會誌 Vol.11 No.3

Pseudomonas sp.의 접종에 내성을 가진 로즈마리 계통은 basal phenolics, RA 함량 및 lignin 합성 등 여러 가지 생리적인 요인에 의해 항산화물의 합성을 조장내지는 억제하는 것으로 나타났으며 본 시험에서 나타난 주요결과는 요약하면 다음과 같다. 1. 이형종자집단(heterogeneous bulk population)에서 항산화물 합성량이 높은 7계통을 선발하였으며 계통의 유지 및 대량증식에는 MS/BAP 배지가 적당하였다. 2. R-11, 19 계통은 온실에서 다른 선발계통에 비해 2배정도 증식이 빠르고 Pseudomonas sp. 의 접종에 따른 phenolics 합성량도 많아 유망시되었다. The object of this experiment is to systemize micropropagation as well as select high rosmarinic acid producing rosemary clonal lines which are from heterogeneous seed population. Clonal line R-11, 19 showed higher level of phenolic compounds and rosmarinic acid by inoculation of Pseudomonas sp. Elite clonal lines which produced higher phenolic compounds and promoted lignification metabolic processing are R-11. 19.