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A novel radioactive particle tracking algorithm based on deep rectifier neural network
Dam, Roos Sophia de Freitas,dos Santos, Marcelo Carvalho,do Desterro, Filipe Santana Moreira,Salgado, William Luna,Schirru, Roberto,Salgado, Cesar Marques Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.7
Radioactive particle tracking (RPT) is a minimally invasive nuclear technique that tracks a radioactive particle inside a volume of interest by means of a mathematical location algorithm. During the past decades, many algorithms have been developed including ones based on artificial intelligence techniques. In this study, RPT technique is applied in a simulated test section that employs a simplified mixer filled with concrete, six scintillator detectors and a<sup>137</sup>Cs radioactive particle emitting gamma rays of 662 keV. The test section was developed using MCNPX code, which is a mathematical code based on Monte Carlo simulation, and 3516 different radioactive particle positions (x,y,z) were simulated. Novelty of this paper is the use of a location algorithm based on a deep learning model, more specifically a 6-layers deep rectifier neural network (DRNN), in which hyperparameters were defined using a Bayesian optimization method. DRNN is a type of deep feedforward neural network that substitutes the usual sigmoid based activation functions, traditionally used in vanilla Multilayer Perceptron Networks, for rectified activation functions. Results show the great accuracy of the DRNN in a RPT tracking system. Root mean squared error for x, y and coordinates of the radioactive particle is, respectively, 0.03064, 0.02523 and 0.07653.
Towards Green 3D-Microfabrication of Bio-MEMS Devices Using ADEX Dry Film Photoresists
Michael Markus Roos,Andreas Winkler,Madeleine Nilsen,Siegfried B. Menzel,Steff en Strehle 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.1
Current trends in miniaturized diagnostics indicate an increasing demand for large quantities of mobile devices for health monitoring and point-of-care diagnostics. This comes along with a need for rapid but preferably also green microfabrication. Dry film photoresists (DFPs) promise low-cost and greener microfabrication and can partly or fully replace conventional silicon- technologies being associated with high-energy demands and the intense use of toxic and climate-active chemicals. Due to their mechanical stability and superior film thickness homogeneity, DFPs outperform conventional spin-on photoresists, such as SU-8, especially when three-dimensional architectures are required for micro-analytical devices (e.g. microfluidics). In this study, we utilize the commercial epoxy-based DFP ADEX to demonstrate various application scenarios ranging from the direct modification of microcantilever beams via the assembly of microfluidic channels to lamination-free patterning of DFPs, which employs the DFP directly as a substrate material. Finally, kinked, bottom-up grown silicon nanowires were integrated in this manner as prospective ion-sensitive field-effect transistors in a bio-probe architecture directly on ADEX substrates. Hence, we have developed the required set of microfabrication protocols for such an assembly comprising metal thin film deposition, direct burn-in of lithography alignment markers, and polymer patterning on top of the DFP.
Thyrotropin Receptor Autoantibody Assessment in Thyroid Eye Disease: Does the Assay Type Matter?
Malik Moledina(Malik Moledina ),Jonathan Roos(Jonathan Roos ),Rachna Murthy(Rachna Murthy ) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.2
Purpose: Thyroid receptor antibodies can quantify thyroid eye disease activity, predict outcomes and aid timing of interventions. The type and generation of assay is frequently unspecified, complicating meta-analyses. To determine the clinical andbiochemical relationships between a second-generation thyrotropin receptor-binding inhibition antibody (TRAb) immunoassay,detecting stimulatory and blocking antibodies, with the thyroid stimulating immunoglobulin (TSI) bridging immunoassaydetecting the stimulatory component only. Methods: Retrospective review of 100 consecutive patients attending a regional specialist service. For each patient and visit,both a TRAb and TSI were performed, and a clinical activity score (CAS) recorded. Results: A significant positive correlation between TRAb and TSI (rho = 0.828, p < 0.01) but a weaker correlation betweenthe assays and CAS (TRAb: rho = 0.439, p < 0.01; TSI: r = 0.357, p < 0.01) were found. In 10% of the episodic data, patientshad a TRAb level that was disproportionately high (39.41 ± 52.84 IU/L), compared to their TSI levels (9.53 ± 12.10 IU/L) with ahigher-than-average CAS (2.47 ± 1.78; range, 0-5). Within 12 months of diagnosis, a significant positive correlation betweenCAS and TRAb (rho = 0.503, p < 0.01) as well as between CAS and TSI (rho = 0.329, p < 0.01) were found. In patients with adiagnosis over 12 months, the correlation with CAS for both TSI and TRAb were Spearman rank correlation coefficient of 0.347(p < 0.01) and 0.327 (p < 0.01), respectively. Conclusions: TRAb and TSI correlate strongly and to a lesser extent with the CAS. For most patients, TRAb can be replacedwith the more economical TSI. TRAb also correlates better with newly diagnosed, more active patients than TSI. In a subsetof patients, blocking antibodies may play a significant pathogenic role, requiring different treatment and monitoring. Furtherstudies are required to investigate this relationship.
Social Engagement Network and Corporate Social Entrepreneurship in Sido Muncul Company, Indonesia
Hani SIRINE,Roos Kities ANDADARI,Lieli SUHARTI 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11
The purpose of this study was to determine the social engagement network in Sido Muncul’s CSR, the partnership program with farmers, and how the implementation of corporate social entrepreneurship in the program is carried out. The research design uses qualitative methods with a grounded theory approach that tests the validity and reliability of the data using triangulation of data sources and methods, namely, data obtained through documentation and the results of surveys and interviews to more than one observation unit. Data was obtained from surveys and interviews with Sido Muncul’s Public Relations and CSR Division, as well as partner farmers. The results of this study indicate that the social engagement network in Sido Muncul’s partnership program is related to the role of farmer groups, farmer cooperatives, government, NGOs, universities, and private companies as facilitators and control functions, thus creating mutually beneficial relationships with one another. The process of implementing corporate social entrepreneurship in Sido Muncul’s CSR for the partnership program with farmers consists of nine stages: problem identification, coordination with related parties, allocation of resources and commitments, collaboration with NGOs, local entrepreneurs and government, social innovation and the creation of new businesses, documentation of activities, reporting, monitoring and evaluation, as well as publications.
Andreas Gutzeit,Justus E. Roos,Bettina Portocarrero-Fäh,Carolin Reischauer,Lulian Claas,Karin Gassmann,Klaus Hergan,Sebastian Kos,Biliana Rodic,Kerstin Winkler,Urs Karrer,Sabine Sartoretti-Schefer 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.3
Lemierre’s syndrome is characterized by anaerobic septicemia, internal jugular vein thrombosis, and septic emboli associated with infections of the head and neck. We describe an unusual and clinically confusing case of a young woman with an acute paresis of the abducens nerve and partial paresis of the right oculomotor nerve. After an extensive imaging diagnostic procedure, we also documented a peritonsillar abscess and various types of thromboses in intracranial and extracranial veins. Furthermore, we found brain and lung abscesses, which led us to establish the diagnosis of Lemierre's syndrome. Despite intensive anti-coagulation and antibiotic therapy,the patient developed a mycotic aneurysm in the right internal carotid artery directly adjacent to the previously thrombosed cavernous sinus. In summary, we were able to confirm that Lemierre's syndrome may occur in conjunction with uncharacteristic symptoms. Due to the sometimes confusing clinical symptoms as well as clinical and radiological specialties, we had to work on an interdisciplinary basis to minimize the delay prior to establishing the diagnosis and therapy.