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내진성능에 대한 채널 형강으로 보강된 비좌굴 Knee Bracing System의 실험적 평가
이진(Lee Jin),이기학(Lee Ki-Hak),정미루(Jung Mi-Roo) 대한건축학회 2008 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.28 No.1(구조계)
In this study, the seismic performance of the Buckling Restrained Knee Bracing (BRKB) system is evaluated through the experiment. The BRKB were composed of a steel plate as a load-resisting core member and two channel sections to restrain local and global buckling of the core plate. A total of five models to execute the experiment are considered. The models are differently manufactured to take into account variables for core, stiffener and end plate. The force-deflection graph, obtained by the experiment, shows that performance of the models is relatively stable with hysteretic behavior between tension and compression and satisfactory for effects of the ductility and energy dissipation capacity, which are proposed in AISC 2005 Seismic Provision.
미래문제해결프로그램(FPSP)을 기반으로 한 기후변화 교육이 초등학생의 기후변화에 대한 인식·지식·태도와 창의적 문제해결력에 미치는 영향
이루리(Lee, Roo-Li),배진호(Bae, Jin-Ho) 에너지기후변화교육학회 2020 에너지기후변화교육 Vol.10 No.3
본 연구에서는 미래문제해결프로그램(FPSP : Future Problem Solving Program)을 기반으로 한 기후변화 교육이 초등학교 6학년 학생들의 기후변화에 대한 인식·지식·태도, 창의적 문제해결력에 미치는 영향에 대해 알아보고자 하였다. 연구 대상은 G도 D초등학교 6학년 1개 학급을 선정하였으며 이중에서 홀수 번호 학생 13명을 실험집단으로, 짝수 번호인 학생 12명을 비교집단으로 선정하여 실험집단은 미래문제해결프로그램(FPSP) 기반의 기후변화 교육 수업을 15차시 실시하였고, 비교집단은 교육과정에 의거한 일반적인 설명식 수업을 15차시 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 미래문제해결프로그램(FPSP)을 기반으로 한 기후변화 교육은 초등학생들의 기후변화에 대한 인식·지식·태도에 긍정적인 영향을 미쳤다. 특히 인식과 지식 하위 영역의 유의한 향상이 있었다. 둘째, 미래문제해결프로그램(FPSP)을 기반으로 한 기후변화 교육은 학생들의 창의적 문제해결력에 긍정적인 영향을 미쳤다. 즉 4개의 하위 영역인 자기확신 및 독립성, 확산적 사고, 비판적·논리적 사고, 동기적 사고에서 모두 유의한 향상이 있었다. 위와 같이 미래문제해결프로그램(FPSP)을 기반으로 한 기후변화 교육은 초등학생의 기후변화에 대한 인식·지식·태도, 창의적 문제해결력에 긍정적인 영향을 미쳤으며, 기후변화 및 미래 문제를 창의적으로 해결하고자 하는데 효과적인 학습 프로그램이라고 판단된다. The purpose of this study was to investigate the effect of climate change education based on the Future Problem Solving Program (FPSP) on 6th grade elementary school students’ perception, knowledge, attitude about climate change and creative problem solving skills. The subjects of this study consisted of 13 students in one class as a experimental group and 12 the other students of the same class as comparison group in D elementary school in G province area. The experimental group had climate change education lessons based on the Future Problem Solving Program (FPSP), and on the other hand the comparison group had climate change education lessons with teacher’s explanation and materials related to curriculum. The results of this study are as follows; First, the effect of climate change education based on the Future Problem Solving Program (FPSP) had a positive impact on elementary school students’ perception, knowledge, and attitude about climate change, especially knowledge and perception. Second, the effect of climate change education based on the Future Problem Solving Program (FPSP) had a positive impact on students’ creative problem solving skills. In other words, there was significant improvement in all of the four sub-areas of self-confidence and independence, extended thinking, critical and logical thinking, and motivational thinking. As above results, the climate change education based on the Future Problem Solving Program (FPSP) has had a positive impact on elementary school students’ perception, knowledge, attitude and creative problem solving skills of climate change, and is considered an effective learning program to solve climate change and future problems creatively.
비궤양성 소화불량환자에서 99mTc - Tincolloid를 이용한 Gastric Emptying Time의 측정
최진학(Jin Hak Choi),김영채(Young Chai Kim),이옥재(Ok Jae Lee),김건용(Kun Yong Kim),김한모(Han Mo Kim),류경렬(Kyoung Ryeol Roo),김성욱(Seong Ook Kim),정순일(Sun Il Chung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A Gastric motor dysfunction and concomitent gastric stasis have been implicated in the pathogenesis of non-ulcer dyspepia (NUD), but the cause-and-effect relationship is not established. In order to identify the relationship between nonspecific upper gastrointestinal symptoms and gastric emptying time in the patients with NUD, gastric emptying scan using 99mTc-tincolloid labelled chicken liver as solid test meal was performed on 20 healthy volunteers and 20 patients with NUD. The patients with NUD were subgrouped according to symptoms and the gastric emptying time of subgroups were compared. The results were as follows: The mean percentage of remnant radioisotope content in stomach is significantly high at 60 through 180 minutes after test meal in the patients with NUD, as compared with normal volunteers (p<0.01), The GET (T 1/2) was significantly delayed in patients with NUD (107.9+-17.5min), as compared with normal volunteer (90.15+-6.03min)(p<0.01). The GET was significantly delayed in the subgroup of NUD as compared with normal volunteers (p<0.01) and significantly delayed in the subgroup of dysmoltility-like dyspepsia (117.6+-22.25 min) as compared with the subgroups of ulcer-like dyspepsia (99.6+-10.25min) or reflux-like dyspepsia (103.0+-9.97 min)(p<0.01). ln conclusion, the scintigraphic measurement of gastric emptying time using radioisotope labelled solid meal is safe and convenient method to evaluate NUD. and above results suggest that delayed gastric emptying has important pathogenetic role in NUD.
Human microRNA prediction through a probabilistic co-learning model of sequence and structure
Nam, Jin-Wu,Shin, Ki-Roo,Han, Jinju,Lee, Yoontae,Kim, V. Narry,Zhang, Byoung-Tak Oxford University Press 2005 Nucleic acids research Vol.33 No.11
<P>MicroRNAs (miRNAs) are small regulatory RNAs of ∼22 nt. Although hundreds of miRNAs have been identified through experimental complementary DNA cloning methods and computational efforts, previous approaches could detect only abundantly expressed miRNAs or close homologs of previously identified miRNAs. Here, we introduce a probabilistic co-learning model for miRNA gene finding, ProMiR, which simultaneously considers the structure and sequence of miRNA precursors (pre-miRNAs). On 5-fold cross-validation with 136 referenced human datasets, the efficiency of the classification shows 73% sensitivity and 96% specificity. When applied to genome screening for novel miRNAs on human chromosomes 16, 17, 18 and 19, ProMiR effectively searches distantly homologous patterns over diverse pre-miRNAs, detecting at least 23 novel miRNA gene candidates. Importantly, the miRNA gene candidates do not demonstrate clear sequence similarity to the known miRNA genes. By quantitative PCR followed by RNA interference against Drosha, we experimentally confirmed that 9 of the 23 representative candidate genes express transcripts that are processed by the miRNA biogenesis enzyme Drosha in HeLa cells, indicating that ProMiR may successfully predict miRNA genes with at least 40% accuracy. Our study suggests that the miRNA gene family may be more abundant than previously anticipated, and confer highly extensive regulatory networks on eukaryotic cells.</P>
두 가지 스펙트럼영역 빛간섭단층촬영기, 펜타캠, 초음파각막측정계로 측정한 중심각막두께 비교
정유진(Yu Jin Cheong),이보람(Bo Ram Lee),한경은(Kyung Eun Han),전루민(Roo Min Jun) 대한안과학회 2016 대한안과학회지 Vol.57 No.10
목적: 정상안에서 두 가지 스펙트럼영역 빛간섭단층촬영기(optical coherence tomography, OCT), Pentacam??, 초음파각막측정계로 측정한 중심각막두께(central corneal thickness, CCT)를 비교하고자 하였다. 대상과 방법: 전안부 질환이 없는 건강인 32명을 대상으로 Cirrus OCT??, Spectralis OCT??, Pentacam??, 초음파각막측정계를 통하여 중심각막두께를 측정하고 각 장비 간 측정값을 비교하였다. 결과: Cirrus OCT??, Spectralis OCT??, Pentacam??, 초음파각막측정계(ultrasound pachymetry, USP)로 측정한 평균 중심각막두께는 각각 549.2 ± 28.7 μm, 545.2 ± 25.4 μm, 554.0 ± 27.8 μm, 548.4 ± 27.9 μm였다. 모든 측정치는 서로 통계적으로 유의하게 높은 상관관계를 보였으나(Pearson correlation coefficient r>0.9, all p-value<0.001) 각 측정치 사이에는 통계적으로 유의한 차이가 있었다(p<0.001). 네 가지 검사 방법 간 일치도 분석 결과 Cirrus OCT?玲? Spectralis OCT?? 간의 95% 일치도 범위는 27.70 μm, Cirrus OCT?玲? Pentacam?瑛? 26.1 μm, Cirrus OCT?玲? 초음파각막측정계는 26.97 μm, Spectralis OCT?玲? Pentacam?瑛? 22.91 μm, Spectralis OCT?玲? 초음파각막측정계는 35.59 μm, Pentacam?怜? 초음파각막측정계는 32.15 μm였다. 결론: 네 가지 기기를 이용한 중심각막두께의 측정값들은 서로 강한 상관관계를 보였으나 초음파각막측정계에 비하여 Pentacam?瑛? 경우 유의하게 두껍게 측정되었고, 두 가지 빛간섭단층촬영기(OCT)로 측정한 측정값은 초음파각막측정계로 측정한 값에 좀 더 유사한 값을 나타내어 중심각막두께 측정 결과 적용 시 이에 대한 고려가 필요하며 각 기기들의 측정값 사이에는 차이가 있어 호환하여 사용하기 어려울 것으로 보인다. <대한안과학회지 2016;57(10):1527-1534> Purpose: To compare the measurements of central corneal thickness (CCT) obtained using two kinds of spectral domain optical coherence tomography (OCT), Pentacam??, and ultrasound pachymetry (USP). Methods: CCT was measured by Cirrus OCT??, Spectralis OCT??, Pentacam??, and USP in 32 eyes from 32 subjects without ocular disease of the anterior segment. Results: The average CCT measurements using Cirrus OCT??, Spectralis OCT??, Pentacam??, and USP were 549.2 ± 28.7 μm, 545.2 ± 25.4 μm, 554.0 ± 27.8 μm, and 548.4 ± 27.9 μm respectively. The measurements were significantly highly correlated with each other (Pearson’s correlation coefficient r > 0.9, all p-values < 0.001), but were significantly different (p < 0.001). The CCT 95% limits of agreement between Cirrus OCT?? and Spectralis OCT??, Cirrus OCT?? and Pentacam??, Cirrus OCT?? and USP, Spectralis OCT?? and Pentacam??, and Spectralis OCT?? and USP were 27.70 μm, 26.1 μm, 26.97 μm, 22.91 μm, 35.59 μm, and 32.15 μm, respectively. Conclusions: The CCT values measured using the four devices were highly correlated with each other, but the measurement using Pentacam?? was significantly thicker than that using USP. The measurements of the two kinds of spectral domain OCT were similar to those using USP. Therefore, these differences should be considered in clinical use, and measurements cannot be considered interchangeable. J Korean Ophthalmol Soc 2016;57(10):1527-1534