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Patterning droplets with durotaxis
Style, Robert W.,Che, Yonglu,Park, Su Ji,Weon, Byung Mook,Je, Jung Ho,Hyland, Callen,German, Guy K.,Power, Michael P.,Wilen, Larry A.,Wettlaufer, John S.,Dufresne, Eric R. National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.31
<P>Numerous cell types have shown a remarkable ability to detect and move along gradients in stiffness of an underlying substrate—a process known as durotaxis. The mechanisms underlying durotaxis are still unresolved, but generally believed to involve active sensing and locomotion. Here, we show that simple liquid droplets also undergo durotaxis. By modulating substrate stiffness, we obtain fine control of droplet position on soft, flat substrates. Unlike other control mechanisms, droplet durotaxis works without imposing chemical, thermal, electrical, or topographical gradients. We show that droplet durotaxis can be used to create large-scale droplet patterns and is potentially useful for many applications, such as microfluidics, thermal control, and microfabrication.</P>
HPV vaccination among seropositive, DNA negative cohorts: a systematic review & meta-analysis
Colm Mac Eochagain,Robert Power,Imelda Parker,Donal Brennan 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.3
Objective: Vaccine efficacy among previously exposed, but currently uninfected women, i.e., those who have serological evidence of a prior human papillomavirus (HPV) infection without corresponding detectable HPV DNA, remains incompletely defined. This meta- analysis assessed the serotype-specific efficacy of prophylactic HPV vaccination against HPV16/18 persistent infection (PI) and cervical intraepithelial neoplasia (CIN) among seropositive, DNA negative (SPDN) women enrolled to randomized controlled trials (RCTs) of HPV L1-based vaccines. Methods: Searches were conducted on 08/16/20 on MEDLINE, Embase, Scopus and CENTRAL. RCTs of L1-based prophylactic bivalent or quadrivalent HPV vaccines, reporting serotype-specific clinical efficacy endpoints in the HPV16/18 seropositive, DNA-negative populations were included. Relative risks (RRs) of 6-month PI (6mPI), 12-month PI (12mPI), CIN1+ and CIN2+ were pooled using a random-effects model. Results: A total of 1,727 citations were reviewed. 8 studies, with a total of 9,569 SPDN participants, met all eligibility criteria. The RR of 6mPI (RR=0.22; 95% confidence interval [CI]=0.08–0.61; p=0.018), 12mPI (RR=0.20; 95% CI=0.05–0.80; p=0.035), CIN1+ (RR=0.13; 95% CI=0.05–0.30; p=0.003) and CIN2+ (RR=0.15; 95% CI=0.04–0.59; p=0.022) was significantly reduced in the vaccinated compared to the unvaccinated group. Conclusion: Our findings suggest high serotype-specific efficacy for HPV vaccination among cohorts of women with evidence of prior HPV16/18 infections, including 87% efficacy (95% CI=70%–95%; p=0.003) against HPV16/18 cervical dysplasia. HPV vaccination is highly effective among uninfected women, regardless of prior exposure history. Trial Registration: PROSPERO Identifier: CRD42020206888
Reduced Complexity Signal Detection for OFDM Systems with Transmit Diversity
Kim, Jae-Kwon,Heath Jr. Robert W.,Powers Edward J. The Korea Institute of Information and Commucation 2007 Journal of communications and networks Vol.9 No.1
Orthogonal frequency division multiplexing (OFDM) systems with multiple transmit antennas can exploit space-time block coding on each subchannel for reliable data transmission. Spacetime coded OFDM systems, however, are very sensitive to time variant channels because the channels need to be static over multiple OFDM symbol periods. In this paper, we propose to mitigate the channel variations in the frequency domain using a linear filter in the frequency domain that exploits the sparse structure of the system matrix in the frequency domain. Our approach has reduced complexity compared with alternative approaches based on time domain block-linear filters. Simulation results demonstrate that our proposed frequency domain block-linear filter reduces computational complexity by more than a factor of ten at the cost of small performance degradation, compared with a time domain block-linear filter.