정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Cis-Diaminocyclohexane을 배위자로 하는 백금(Ⅱ)착체의 선택적 세포독성

노영수,정세영,정지창 한국환경독성학회 1998 환경독성보건학회지 Vol.13 No.2

The use of cisplatin is limited by severe side effects such as renal toxicity. Our platinum-base drug discovery is aimed at developing drugs capable of diminishing toxicity and improving antitumor activity. We synthesized new Pt (II) complex analogue [Pt (cis-DACH)(DPPP)]ㆍ2NO₂,(PC) containing cis- l,2-diaminocyclohexane as a carrier ligand and 1, 3-bis(diphenylphosphino) propane as a leaving group. Furthermore, nitrate was added to improved the solubility. In this study, its structure was determined and its antitumor activity against SKOV-3 and NIH-OVCAR-3 human ovarian adenocarcinoma, and in nitro cytotoxicity was determined against primary cultured rabbit kidney proximal tubular and renal cortical cells of human kidney using colorimetric MTT assay. PC demonstrated acceptable antitumor activity against SKOV-3 and NIH-0VCAR-3 human ovarian adenocarcinoma and significant activity as compared with that of cisplatin. The toxicity of PC was found quite less than that of cisplatin using MTT and ³H-thymidine uptake tests in rabbit proximal tubular cells and human kidney cortical cells. PC was used for human cortical tissue in 7 weeks hitoculture by the glucose-consumption tests. We determined that the new platinum drug has lower nephrotoxicity than cisplatin. Based on these results, this novel platinum (Ⅱ) complex compound (PC) represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.

신경인성방광에서 요역동학적 고찰

노준,전상준,정치영,이기봉,이길용,소영석,김철성,장대수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and objectives : A disparity between clinical and urodynamic findings is commonly found and its application to the clinical management of neurogenic bladder is pratically as well embrassing as it reading. We investigated urodynamic study for the diagnosis and management of neurogenic bladder. Materials and methods : From July 1997 to June 2001, total of 83 patients of neurogenic bladder were evaluated by urodynamic study. Results : urodynamically, there were 20 cases(24%) showing detrusor hyperreflexia with detrusor external sphincter dyssynergia(DESD), 12 cases(15%) detrusor areflexia with low compliance. A disparity between the clinical and urodynamic assessment was noted in 26 cases(31%), clinically severe symptom with complication was particularily common in detrusor hyperreflexia with DESD, detrusor areflexia with low compliance and catheter indwelling patients. Conclusion : In neurogenic bladder, clinically symptom with complication was particularly common in detrusor hyperreflexia with DESD, detrusor areflexia with low compliance and catheter indwelling patients.

韓方藥劑의 品質評價와 藥效에 關한 硏究 (第5報) : 竹柴胡의 品質評價 Study on Quality Control of Bupleurum longiradiotum

盧榮洙,金申圭,陸昌洙 慶熙大學校 1988 論文集 Vol.17 No.-

A quantitative quality control method of traditional oriental drug Bupleurum falcatum and B. longiradiotum was attempted with the high performance liquid chromatograph. Sapons(saikoside D) could be assayed on an Ultrasil^TM-NH₂column(10μm, 4.5㎜×25㎝ length stainless steel column) by using a variable wavelength UV detector, The moble phase containing chloroform : Methanol : water : 2% Sodium hydroxide(10 : 1: 0.1) was utilized The proposed method is considered to be useful for the quality control of the above mentioned traditional oriental drug.

Al₂O₃-에폭시 복합재료의 크랙성장에 의한 파괴

노영창,김상욱,박철수 서울市立大學校 1987 論文集 Vol.21 No.2

Al₂O₃-filled epoxy resin composites system was studied with the linear elastic fracture mechanics and its mechanical properties. The effect of the Al₂O₃partical volume fraction(Vp)were also studied. The Young's modulus increased significantly with Vp, it shows empirical equation, Ec=Em(1-Vp_-2 56. The yield stress also increased with Vp, however, plastic flow appeared before fracture for low value of Vp and un-filled epoxy resin matrix. Between crack velocity of 10-5 and 10-1m/sec, the crack propagation occured in continuous and stable manner, so the stress intensity factor and crack opening displacement reached maximum values for Vp of 0.14/0.21.

제조업 근로자의 수면실태에 관한 조사

노정균,류기하,이영수,조영채 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

산업체 근로자의 수면실태를 조사하고자 1993년 3월에 한 고무제품 제조업 근로자 479명을 대상으로 수면양상에 대한 설문조사를 실시한 결과는 다음과 같다. 1. 전체 조사대상자의 수면장애 유병율은 32.8%였으며, 수면장애의 유형별로는 취면곤란 11.9%, 수면유지곤란6.1%, 조조각성이 6.9%였다. 2. 연령군별 수면유지곤란은 20대가 가장 낮았고 30대가 가장 높았으며, 취침전 진정제 또는 알코올을 이용한 군의 수면장애가 비사용군에 비해 현저히 높게 나타났다. 3. 직업이나 가정에 대해 만족하는 군일수록 수면장애가 불만족군에 비해 낮았으며, 낮잠을 자는 군, 신체적 통증이 없는 군일수록 적게 나타났다. 4. 수면장애에 대한 회귀분석결과 통계적 유의성을 보인 변수는 낮잠여부, 신체적 통증여부 및 근무기간이었다. This study was conducted to investigate sleep qualitys of manufacturing workers. The data were collected from the 479 manufacturing factory workers who were most 3 shift workers. The results obtained were as follows. The prevalence rate of sleep disorder was 32.8%, rate of difficulty in intiating sleep was 11.9%, that of difficulty in maintaining sleep was 6.1%, and that of early morning awakening was 6.9%. Disorders of difficulty in maintaining sleep was low in the age group of twenties and high in thirties. The group of sedative or alcohol use before sleep induction showed high prevalence rate of sleep disorder. The group of satisfying for job or family had the lower rate of sleep disorder than the unsatisfying group. The rate of sleep disorder were low in the group of day sleeping, no physical pain. The variables such as day sleep, physical pain and job tenure showed statistical significance in the logistic regression of sleep disorder.

漢方藥의 成分 및 藥效에 關한 硏究(第2報) : Berberine 骨格變換에 對한 硏究 Studies on the Variation of Skeletons of Berberine

盧榮洙,金申圭 慶熙大學校 1985 論文集 Vol.14 No.-

Previously we reported the simple photochemical valance automerization of berberinephenolbetaine derived from berbine in to the 8-methyl-8,14-cycloberbine. Treatmetn of the 8-methyl-8,14-cycloberbine with 10% acetone and Borontrifluorideethylether at room temperature for 3hr. afforded 8-hydro-8-methylspirobenzylisoquinoline(Ⅰ) Reduction of the substance (Ⅰ) with sodiumborohydride was converted easily to the 8,13-dihydroxy-8-menthyl-spirobenzylisoquinoline (Ⅱ) in good yields. On acidic treatment the 8-methyl-8,14-cycloberberne with thiophenol was afforded also 8-methyl-8-thiophenylspirobenzylisoquinoline (Ⅲ). The substance (Ⅲ) was strirred in methanol with sodiumborohydride at room temperature for 4hr. to give the 13-hydroxy-8-methyl-8-thiophenylspirobenzylisoquineoline (Ⅳ).

신경베체트병에 의한 신경인성방광 : 증례보고

이길용,임건한,소영석,노준,김철성,장대수 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

The co-existence of mouth and genital ulceration with iritis was first defined as a syndrome by Behcet. It is now known to be a chronic and relapsing systemic disease, which involves many other systems. Neurogenic bladder dysfunction due to Behcet's disease, however, is extremely rare, and only a limited number of cases have been reported in the international literature. Voiding disfunction in Behcet's disease can be due to neurological or direct bladder involvement and can be related to bladder and sphmctehc components in both phases of micturition. We report on a 35-year old patient with a neuropathic bladder secondary to Behcet's disease.

넙치(Paralichthys olivaceus)의 성현상

이영돈,노섬,고환봉,김동수 제주대학교 해양연구소 1994 해양자원연구소연구보고 Vol.18 No.-

Newcastle병 면역에 대한 연구

박경수,김종세,노영복 조선대학교 기초과학연구소 1987 自然科學硏究 Vol.10 No.1

A study was conducted to determine whether the vaccination programs for the control of Newcastle Disease (ND) would affect the immune status of hens against the disease as a purpose of suggesting the distinguished vaccination programs. Fifteen poultry flocks were surveyed to investigate the level of serum antibody against ND virus and the programs used for the vaccination of hens. Alternatively, vaccination was carried out by the programs designed against ND virus in hens called Manina and investigated the level of HI titer every week, and surveyed the alternation of hematological occurrence following the vaccination programs. The obtained results were summarized as follows: 1. Vaccination history of the investigated 15 poultry flocks were not according by standard vaccination programs and immunization was carried out for random at every poultry farms. Killed and Live vaccin was used together in 7 groups and only Live vaccin was used in 6 groups, and only killed vaccin was used in groups. 2. HI titer of these was 140 in average by killed and live vaccin, and live vaccin was 126 in average. The former was shown higher HI titer. 3. The number of leucocytes was shown much increased hy the designed vaccination program, and 9525/㎣ was shown by 2nd vaccination (9weeks), and 1067O/㎣ was shown highest by 6th vaccination (25weeks). 4. HI titer was 240 by 2nd vaccination and it was continuous to increase. HI titer was 320 by 6th vaccination. The effects of the repeated vaccination were distinguished. 5. Serum globulin value was increased according to the vaccination program. The highest value ware 3.54㎎/㎗ and 3.54㎎/㎗ in 22 weeks and 23 weeks, each γ globulin value of these were 0.95㎎/㎗ and 0.99㎎/㎗.