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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
노홍길,방익찬,김상현,현경훈,김준택,양영진,홍창수 제주대학교 해양연구소 1997 해양자원연구소연구보고 Vol.21 No.-
Currents are measured in the Straits of Cheju by detecting surface buoy tracks and mooring current meters in 1996-1997. As a result, north-eastward currents are decteted in the Straits of Cheju all the year round, which is weak in spring and strong in summer and fall. Average speeds of 20 cm/s to the east. 7 cm/s to the north and 22 cm/s to the north-east appeared in the surface. Currents are fast in the middle of the strait and slow near Cheju Island. East-west components of the currents are about 3 times faster than the north-south ones. Also. it is shown that surface buoys released within the distance of 6 miles away from Cheju do not drift out of the Straits of Cheju because of tongue-like warm waters appeared in the eastern entrance of the strait. Volume transports calculated by geostrophic calculation are shown to be 0.05-0.2 Sv in winter and 0.4-0.5 Sv in summer.
하나로에서의 NTD조사를 위한 중성자속 평탄화 장치의 최적화를 위한 예비분석
송영동,이헌주,이병철,전병진,김학노 제주대학교 산업기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.1
NTD(Neutron Transmutation Doping) method has several advantages of high resistivity and uniform doping in comparison with other method. To satisfy those conditions, the flux variations of radial and axial directions should be within ±5% and ±1.7%. respectively. The NTD facility in HANARO is purposed to irradiate the silicon ingot of 60cm in height. Hence, the flux flattener will be designed for 60cm. In this paper, preliminary study for optimal design is showed and the flux distribution of axial direction is calculated using MCNP4B code. The results show that the flattener model can flatten the flux to 83% of total length.
전상준,소영석,노준,김철성,장대수 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1
Spontaneous renal rupture is relatively rare. It is usually associated with benign and malignant renal tumors, vascular diseases and inflammatory disorders. however, a few patients in whom there is no apparent underlying disease are described. Recently we experienced a case of spontaneous renal rupture secondary to HFRS (Hemorrhagic Fever with Renal Syndrom) and report with a brief literature review.
하나로에서의 NTD 조사를 위한 중성자속 평탄화 장치의 최적화를 위한 예비분석
송영동,이헌주,이병택,전병진,김학노 濟州大學校 産業技術硏究所 2001 산업기술연구소논문집 Vol.12 No.1
NTD (Pieutron Transmutation Doping) method has several advantages of high resistivity and uniform doping in comparison with other method. To satisfy those conditions. the flux variations of radial and axial directions should be within ±5 % and ±1.7%. respectively. The NTD facility in HANARO is purposed to irradiate the silicon ingot of 60cm in height. Hence. the flux flattener will be designed for 60cm. In this paper. preliminary study for optimal design is showed and the flux distribution of axial direction is calculated using MCNP4B code. The results show that the flattener model can flatten the flux to 83% of total length.
1세대 Northgate SD-3와 3세대 Donier Compact Delta를 이용한 체외충격파쇄석술의 비교 : 상부 및 중부요관석 243례
고영록,노준,소영석 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2
Objectives: To compare the efficacy of the Dornier Compact Delta lithotriptor with the Northgate SD-3 lithotriptor in the treatment of upper and mid-ureteral stones. Materials and Methods: A total of 243 patients without any previous experience of ESWL were treated for upper and mid-ureteral stones. 121 patients were managed with the Northgate SD-3 lithotriptor which had ultrasonography targeting system and electro hydraulic shock wave source. The other 122 patients were treated with the Dornier Compact Delta equipped with a fluoroscopic focusing system and electromagnetic shock wave source. The locations and sizes of stones, sessions, stone-free rates, auxiliary procedures, and complications of ESWL were reviewed retrospectively. In each group stone-free results were determined by KUB 1 month after the last ESWL and then efficacy quotients (EQ) were obtained. Results: Baseline characteristics were equivalent, including patient ages, sex ratio, stone numbers and locations. Using the Northgate SD-3 lithotriptor, the average sessions and stone-free rates were 1.53 and 86.8%, respectively. Using the Dornier Compact Delta lithotriptor, average sessions and stone-free rate were 1.38 and 92.6 %, respectively. Effectiveness quotient(EQ) in the Northgate SD-3 and the Dornier Compact Delta was 61 and 65, the rates of the auxiliary procedure were 9.1% and 18%. Conclusions: The Dornier Compact Delta lithotripsy resulted in a higher stone-free rate and EQ, although it was associated with a higher rate of pre-ESWL auxiliary procedures than the Northgate SD-3 Lithotripsy.
Case Reports : A Case of Spontaneous Pneumomediastinum and Pneumopericardium in a Young Adult
Young Jung Lee,Seung Won Jin,Sung Hee Jang,Yi Sun Jang,Eun Kyoung Lee,Yong Joo Kim,Man Young Lee,Jun Chul Park,Tai Ho Rho,Jae Hyung Kim,Soon Jo Hong,Kyu Bo Choi 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3
Spontaneous medialstinal emphysema (pneumomediastinum) and pneumo-pericardium may be defined as the presence of free air or gas in the mediastinal structures and in the pericardial sac without an apparent precipitating cause. It most frequently occurs in y