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Liwei Fan,Reti Hai,Zexiang Lu 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.5
A subsurface flow constructed wetland (SSFW) was simulated by using a commercial computational fluid dynamic (CFD) code (Fluent 6.22, Fluent Inc.). The liquid residence time distribution in the SSFW was obtained by the particle trajectory model. The simulation confirmed that the effect of the distribution and/or catchment area on the hydraulic efficiency is significant. An inappropriate horizontal distribution and/or catchment area can result in poor hydraulic efficiency. The hydraulic efficiency of the SSFW with the vertical distribution and/or catchment area can be kept at a high level (above 0.898). The design of the vertical distribution and/or catchment area in the SSFW is better than that of the horizontal. From the point of view of the engineering design, a small dimension distribution and/or catchment area in the SSFW is advisable, which maintains a considerable hydraulic efficiency of the SSFW (above 0.840), but also benefits the increase of the purge area.
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The Major Role of NF-κB in the Depth of Invasion on Acral Melanoma by Decreasing CD8+ T Cells
Hermin Aminah Usman,Bethy S. Hernowo,Maringan Diapari Lumban Tobing,Reti Hindritiani 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.3
Background: The tumor microenvironment including immune surveillance affects malignant melanoma (MM) behavior. Nuclear factor κB (NF-κB) stimulates the transcription of various genes in the nucleus and plays a role in the inflammatory process and in tumorigenesis. CD8+ T cells have cytotoxic properties important in the elimination of tumors. However, inhibitory receptors on the cell surface will bind to programmed death-ligand 1 (PD-L1), causing CD8+ T cells to lose their ability to initiate an immune response. This study analyzed the association of NF-κB and PD-L1 expression levels and CD8+ T-cell counts with depth of invasion of acral MM, which may be a predictor of aggressiveness related to an increased risk of metastasis. Methods: A retrospective cross-sectional study was conducted in the Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital using 96 cases of acral melanoma. Immunohistochemical staining was performed on paraffin blocks using anti–NF-κB, –PD-L1, and –CD8 antibodies and invasion depth was measured using dotSlide-imaging software. Results: The study showed significant associations between the individual expression of NF-κB and PD-L1 and CD8+ T-cell number, with MM invasion depth. NF-κB was found to be a confounding variable of CD8+ T-cell number (p < .05), but not for PD-L1 expression (p = .154). Through multivariate analysis it was found that NF-κB had the greatest association with the depth of invasion (p < .001), whereas PD-L1 was unrelated to the depth of invasion because it depends on the number of CD8+ T cells (p = .870). Conclusions: NF-κB plays a major role in acral MM invasion, by decreasing the number of CD8+ T cells in acral MM.
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