Effects of Lactobacillus salivarius Ren on cancer prevention and intestinal microbiota in 1, 2-dimethylhydrazine-induced rat model

Ming Zhang,Xing Fan,Bing Fang,Chengzhen Zhu,Jun Zhu,Fazheng Ren 한국미생물학회 2015 The journal of microbiology Vol.53 No.6

Probiotics have been suggested as a prophylactic measure in colon cancer. The aim of this study was to investigate the impact of Lactobacillus salivarius Ren (Ren) in modulating colonic microbiota structure and colon cancer incidence in a rat model after injection with 1,2-dimethyl hydrazine (DMH). The results indicated that oral administration of Ren could effectively suppress DMH-induced colonic carcinogenesis. A significant decrease in cancer incidence (87.5% to 25%) was detected in rats fed with a dose of 5 × 1010 CFU/kg bodyweight per day. Using denaturing gradient gel electrophoresis and Real-time PCR combined with multivariate statistical methods, we demonstrated that injection with DMH significantly altered the rat gut microbiota, while Ren counteracted these DMH-induced adverse effects and promoted reversion of the gut microbiota close to the healthy state. Tvalue biplots followed by band sequencing identified 21 bacterial strains as critical variables affected by DMH and Ren. Injection of DMH significantly increased the amount of Ruminococcus species (sp.) and Clostridiales bacteria, as well as decreasing the Prevotella sp. Administration of Ren reduced the amount of Ruminococcus sp., Clostridiales bacteria, and Bacteroides dorei, and increased the amount of Prevotella. Real-time PCR results were consistent with the results derived by t-value biplots. These findings suggested that Ren is a potential agent for colon cancer prevention. In conclusion, the results in the present study suggest a potential therapeutic approach based on the modulation of intestinal microflora by probiotics may be beneficial in the prevention of colorectal carcinogenesis.

기초신학

Latourelle, René,Fisichella, Rino,김석태 역 대전가톨릭대학교 2004 복음과 문화 Vol.- No.8

Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects

René,e Kosonen,Sumit Barua,Jong Youl Kim,Jong Eun Lee 대한해부학회 2021 Anatomy & Cell Biology Vol.54 No.2

Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an increasing number of agmatine-mediated effects have been discovered, demonstrating the benefits of agmatine on ischemic strokes, traumatic brain injury and numerous psychological disorders such as depression, anxiety, and stress. Agmatine also has cellular protective effects and contributes to cell proliferation and differentiation in the central nervous system (CNS). Neural progenitor cells are an important component in the recovery and repair of many neurological disorders due to their ability to differentiate into functional adult neurons. Recent data has revealed that agmatine can regulate and increase proliferation and the fate of progenitor cells in the adult hippocampus. This review aims to summarise and discuss the role of agmatine in the CNS; specifically, the effects and relationship between agmatine and neural progenitor cells and how these ideas can be applied to potential therapeutic application.

Positioning of Long-Acting Muscarinic Antagonists in the Management of Asthma

René Aalbers,박해심 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.5

Despite a range of efficacious therapies for asthma, including inhaled corticosteroids (ICS) and long-acting β2-agonists (LABA), a significant proportion of patients have poor asthma control and retain a risk of future worsening of their symptoms. Long-acting muscarinic antagonist (LAMA) bronchodilators offer a well-tolerated, efficacious, and cost-effective add-on to a patient’s treatment. Of the LAMAs currently under investigation or available for the treatment of asthma, evidence from a comprehensive clinical trial program in adults and children shows that once-daily treatment with tiotropium provides benefits for patients with uncontrolled asthma despite the use of ICS and LABAs. Tiotropium is included in the Global Initiative for Asthma (GINA) strategy document as an add-on therapy option for patients at Step 4 or 5 with a history of asthma exacerbations. Tiotropium Respimat® has demonstrated safety and efficacy in patients with a range of disease severities, ages, and phenotypes. This review describes the evidence for the use of LAMA as add-on therapy for patients with asthma who remain uncontrolled despite the use of ICS and LABA treatments.

A community-based aquatic exercise program to improve endurance and mobility in adults with mild to moderate intellectual disability

Renée M. Hakim,Michael D. Ross,Wendy Runco3,Michael T. Kane 한국운동재활학회 2017 JER Vol.13 No.1

Energy equivalent lumped damage model for reinforced concrete structures

Renério Pereira Neto,Daniel V.C. Teles,Camila S. Vieira,David L.N.F. Amorim 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.84 No.2

Lumped damage mechanics (LDM) is a recent nonlinear theory with several applications to civil engineering structures, such as reinforced concrete and steel buildings. LDM apply key concepts of classic fracture and damage mechanics on plastic hinges. Therefore, the lumped damage models are quite successful in reproduce actual structural behaviour using concepts well-known by engineers in practice, such as ultimate moment and first cracking moment of reinforced concrete elements. So far, lumped damage models are based in the strain energy equivalence hypothesis, which is one of the fictitious states where the intact material behaviour depends on a damage variable. However, there are other possibilities, such as the energy equivalence hypothesis. Such possibilities should be explored, in order to pursue unique advantages as well as extend the LDM framework. Therewith, a lumped damage model based on the energy equivalence hypothesis is proposed in this paper. The proposed model was idealised for reinforced concrete structures, where a damage variable accounts for concrete cracking and the plastic rotation represents reinforcement yielding. The obtained results show that the proposed model is quite accurate compared to experimental responses.

The liberal arts college and humanist learning

René V. Arcilla 서울대학교 교육연구소 2014 Asia Pacific Education Review Vol.15 No.1

What is liberal education? How do its aims differ from those of either grammar or vocational education? Does it truly deserve its own supporting institution? In response to these questions, Arcilla develops a defense of the liberal arts college. He observes that all projects of formal learning presuppose that the learner possesses answers to three fundamental, existential questions: What is one’s nature? What is the good for beings of this nature? What facilitates this good? We develop better responses to these questions by engaging in liberal learning. The mission of the liberal arts college, then, is first and foremost to support this learning. With this idea of liberal learning and its college in mind, we may nonetheless wonder whether the existential knowledge it seeks is really something that can be learned. Arcilla articulates a version of humanism that illuminates the conditions of possibility for liberal learning and affirms this learning’s intrinsic value. At the same time, this philosophical theory requires for its verification that we engage in liberal learning. Arcilla calls the symbiotic partnership formed by liberal learning and humanism “humanist learning,” and he points out that it is this learning, which is crucial to our other kinds of education, that would be lost if society ceased to support genuine colleges of the liberal arts.

ME, MYSELF, AND I: THE IMPACT OF SELF-CONSTRUAL AND IMAGECONGRUENCE ON CONSUMER PURCHASE INTENTION TOWARDS SUSTAINABLE GOODS

René Versteegh,James E Richard,Michelle Renton 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07

Introduction With environmental concern becoming a growing area for both the marketing academy and society, there is an increasing trend for consumers, governments, and society to deem environmental behaviours as both necessary, and desirable (Olsen, Slotegraaf, & Chandukala, 2014). There is a growing awareness around the negative impacts of human consumption developing amongst consumers and gaining greater focus in the media (Prothero, McDonagh, & Dobscha, 2010). However, despite the positive intentions surrounding the consumption of “green goods”, hitherto referred to as sustainable goods, a well-established gap exists between intention and behaviour (e.g., Carrington, Neville, & Whitwell, 2010; Hassan, Shiu, & Shaw, 2016). For example the United Nations Environment Program (2005) established that despite 40% of survey respondents indicating a willingness to purchase sustainable goods, only 4% did so. One lens through which the intention-behaviour gap can be viewed is the idea of the self. Individual identity has long been suggested as a driver of purchasing decisions (Grubb & Grathwohl, 1967). A consumer‟s aim to act both in accordance with their own identity, as well as how they see themselves in the context of society has been suggested to enhance purchasing (e.g., Graeff, 1996; Markus & Kitayama, 1991; Onkvisit & Shaw, 1987). This research seeks to use this idea of self, in the form of Self-Construal (SC), and Image- Congruence (IC), to enhance Purchase Intention (PI) towards sustainable goods. A contribution is sought by using consumers‟ sense of self to better understand the intention-behaviour gap. The proposed contribution benefits the marketing academy (furthering the understanding of consumer purchase intentions and behaviour), marketing practitioners (seeking to encourage behaviour change), and government policy makers (by furthering an understanding of possible nudges to influence behaviour). This research defines „sustainable goods‟, as characterising products with lower environmental impacts, including biodegradable, recycled, low energy, or reduced packaging (Costa Pinto, Herter, Rossi, & Borges, 2014). Sustainable goods have been suggested to present a perceived trade off to consumers, both in literature and the popular press (e.g., Consumer, n.d.-a, n.d.-b; Kaufman, 2014). Kaufman (2014) suggests that sustainable alternatives often carry a price premium, as well as a stigma of lower quality. An example of the trade off as presented in the popular press is through product testing by Consumer New Zealand, suggesting that household items such as eco-friendly (sustainable) laundry detergent come with a price premium, a reduction in efficacy, or both (Consumer, n.d.-a, n.d.-b). Therefore, this research hypothesises that sustainable goods may be perceived as an inferior (either by price or efficacy) product and thus consumers will perceive a trade off in their purchasing decision. This trade off can be summarised as; higher priced or less effective goods, in order to make an environmental contribution (e.g., reduced landfill, cleaner water). As such, it is argued consumers will be more willing to make this trade off where they are able to portray aspects of the self through the decision making process. Conceptual Model The aim of this study is: To investigate the impact of self-construal, and imagecongruence on consumers‟ purchase intention towards sustainable goods. In order to achieve the aim of this research, the following hypotheses are presented: H1a: The more interdependent an individual‟s self-construal, the higher their purchase intention towards sustainable goods. H1b: The more independent an individual‟s self-construal, the lower their purchase intention towards sustainable goods. H2: The greater the image-congruence towards sustainable goods, the higher the purchase intention towards sustainable goods. To illustrate the hypotheses the following conceptual model has been proposed: Studies of self-construal (SC) have demonstrated that individuals fall into two categories, independent and interdependent SC (Markus & Kitayama, 1991). Individuals with independent SC emphasise being unique and expressing their self and promoting their individual goals (Arnocky, Stroink, & DeCicco, 2007); conversely those with interdependent SC define their sense of self largely on relationships and a sense of harmony with others (Markus & Kitayama, 1991). Therefore, interdependent selfconstrual may drive purchasing activity of socially desirable goods. The alignment of products to a consumer‟s self-concept has long been considered a predictor of purchasing behaviour (Grubb & Grathwohl, 1967). The alignment between a product and the self-concept of a consumer is known as image-congruence and leads to an increased likelihood of purchase (Graeff, 1996; Onkvisit & Shaw, 1987). Conversely, where a product is not congruent with an individual‟s image the likelihood of purchase is reduced (Graeff, 1996; Onkvisit & Shaw, 1987). Purchase intention (PI) as used in this research is defined as a consumers‟ plan to purchase sustainable goods, meeting the criteria outlined previously, in the near future. The Brand Loyalty Intentions scale has been adapted for use in measuring PI (Algesheimer, Dholakia, & Herrmann, 2005), with the addition of a time definite item, „I will purchase sustainable products within the next six months”. SC is expected to impact PI as interdependent and independent people behave differently. Those with an interdependent SC behave in line with the expectations of society (Ybarra & Trafimow, 1998). Protection of the environment is seen as desirable behaviour by society (Olsen et al., 2014), thus leading to those with an interdependent SC consuming in line with this expectation. Conversely, individuals with independent SC are more likely to prioritise their individual benefits and are thus more likely to prioritise the lower price, or increased efficacy of non-sustainable products. IC is expected to impact PI as those whose self-concept is connected to the environment and sustainable goods, are expected to have an intent to purchase in line with their selfimage (Graeff, 1996; Onkvisit & Shaw, 1987). As such, individuals with image congruence to sustainable goods will be more willing to accept a trade off in order to consume in line with their own self-concept. Method Two phases of data collection were conducted to test the proposed model. An initial pretest, followed by a larger sample. A pre-test consisting of 258 participants was recruited through a Qualtrics research panel. Of the 258 participants, 15 were denied entry to the survey for being under 18 and 39 participants were deleted for non-completion of the survey. A final sample size of 204 participants (103 Male, 101 Female, mean age range 30-34) was collected. Reliability analysis was used to determine the internal reliability of the scales used to measure the model. Reliability analysis was performed to ensure the adequacy and reliability of scales; a regression analysis was further performed to determine model fit as well as the strength and direction of variable relationships (Field, 2013). The second phase of data collection consisted of 554 participants, recruited through a Qualtrics research panel. Of the 554 participants, 24 were denied entry to the survey for being under 18 and 98 participants were deleted for non-completion of the survey. A final sample size of 432 participants (226 Male, 206 Female, mean age range 35-39) was collected. Reliability analysis was again performed to ensure the adequacy and reliability of scales; further regression analysis was performed to determine model fit as well as the strength and direction of variable relationships (Field, 2013), discussion and conclusions were drawn from this second phase of data collection. Results Phase 1: Pre-Test The three variables in the model were measured using three established scales, one of these scales consists of two sub-scales, for a total of four analysed scales. All reported acceptable reliability (Cronbach's α > .70). Self-construal – interdependent (α = .854), self-construal – independent (α = .837), image-congruence (α = .913), and purchase intention (α = .899) A regression analysis was used to determine the strength and direction of the variable relationships. The overall model fit was R2 = .434. H1a was supported (β = .284, p = .004), as was H2 (β = .449, p < .001). H1b demonstrated a significant relationship (β = .231, p = .025), however, contrary to H1b, the relationship was positive, albeit to a lesser extent than in H1a. Phase 2: Final Data Collection As in phase 1, all scales used reported acceptable reliability (Cronbach's α > .70); selfconstrual – interdependent (α = .871), self-construal – independent (α = .867), imagecongruence (α = .920), and purchase intention (α = .900). As in the pre-test a regression analysis was used to test the stated hypotheses. The overall model fit was R2 = .478. H1a was supported (β = .284, p < .001), as was H2 (β = .546, p < .001). H1b demonstrated a significant relationship (β = .206, p = .05), again however, contrary to H1b, the relationship was positive, albeit to a lesser extent than in H1a. Discussion and Conclusion Two phases of data collection both yielded similar results in support of H1a, H1b and H2. H1a and H2 were supported, H1b in both phases of data collection and analysis yielded significant results, but not in line with the predicted direction of the relationship. H2 was fully supported with image-congruence found to be the strongest predictor of purchase intention (p < .001, β = .546). H1a was similarly fully supported with self-construal – interdependent found to be the second strongest predictor of purchase intention (β = .284, p < .001). The strength and direction of the H1a relationship suggests that individuals who see themselves as part of a broader society may be more inclined to purchase in a manner beneficial to this society. H1b yielded a significant relationship (β = .206, p = .05), however, as a positive predictor of purchase intention, the relationship was the opposite of that hypothesised. As the third strongest predictor, the relationship between self-construal – independent and purchase intention, suggests that strong focus on the self, independently of others, does not necessarily lead to a less „pro-social‟ purchasing pattern. By positing the strength of image-congruence as a driving factor in consumer‟s purchasing decisions towards green products, this research enhances the academy‟s understanding of „pro-social‟ purchasing. The understanding of the impact of selfconstrual on „pro-social behaviour is also enhanced. Hypotheses derived in line with extant literature suggest that those with an independent self-construal would be less likely to purchase „pro-social‟ goods where there is a perceived detriment to the individual (e.g. in the case of a trade-off). However, this research suggests that those with an independent self-construal may still desire „pro-social‟ products, just to a lesser degree than those with an interdependent self-construal. Thus, findings from this research suggest that independence and interdependence may act as moderators or mediators to other variables. For practitioners it is important to understand the types of psychological appeals that can be made in marketing materials. Future Research Future research around image-congruence, self-construal and purchase intention should examine the relationship between these and the possibility of mediation or moderation in the model. Despite strong support in the literature an independent SC also acted as a strong predictor of sustainable goods purchase intention therefore, further analysis to explore the possibility of independent self-construal acting as a mediator or moderator should be conducted.

Arterial Steal to the Penumbra Area in Patients with Acute MCA Occlusion: A Quantitative Angiographic Analysis

René van den Berg,Jenna J. Wildeman,Olvert A. Berkhemer,Rogier V. Immink,Henk A. Marquering,Charles B.L.M. Majoie,Dagmar Verbaan,Ed T. van Bavel 대한신경중재치료의학회 2020 Neurointervention Vol.15 No.3

Purpose: In acute middle cerebral artery (MCA) occlusion, collateral vessels provide retrograde supply to the occluded territory. We hypothesized that such collateral flow reduces perfusion of the non-occluded donor region (steal effect).Materials and Methods: Patients with an MCA occlusion with opacification of both ipsi- and contralateral anterior cerebral arteries (ACA) on angiography prior to endovascular treatment were selected. Arteriovenous transit time (AVTT) for both ACA territories was compared for different grades of collateral supply to the MCA territory. In addition, the influence of diabetes and hypertension was analyzed. After successful revascularization, AVTT was re-assessed to determine reversibility.Results: Forty-one patients were analyzed. An AVTT of 8.6 seconds (standard deviation [SD] 2.4 seconds) was seen in the ACA territory of the affected hemisphere in comparison to 6.6 seconds (SD 2.1 seconds) for the contralateral side (P<0.001). A more prolonged (but not significant) AVTT was seen in cases with a higher collateral grade. No difference in AVTT was seen in patients with diabetes or hypertension. After successful MCA revascularization, AVTT delay was 7.4 seconds (SD 2.1 seconds).Conclusion: A cerebral steal effect occurs in patients with an acute MCA occlusion, probably related to augmented flow to the penumbra area.

계시

Latourelle, René,김석태 역 대전가톨릭대학교 2006 복음과 문화 Vol.- No.10