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Gene Therapy Options as New Treatment for Inherited Peripheral Neuropathy
Rajarathinam Thenmozhi,이지수,박나영,최병옥,홍영빈 한국뇌신경과학회 2020 Experimental Neurobiology Vol.29 No.3
Inherited peripheral neuropathy (IPN) is caused by heterogeneous genetic mutations in more than 100 genes. So far, several treatment options for IPN have been developed and clinically evaluated using small molecules. However, gene therapy-based therapeutic strategies have not been aggressively investigated, likely due to the complexities of inheritance in IPN. Indeed, because the majority of the causative mutations of IPN lead to gainof- function rather than loss-of-function, developing a therapeutic strategy is more difficult, especially considering gene therapy for genetic diseases began with the simple idea of replacing a defective gene with a functional copy. Recent advances in gene manipulation technology have brought novel approaches to gene therapy and its clinical application for IPN treatment. For example, in addition to the classically used gene replacement for mutant genes in recessively inherited IPN, other techniques including gene addition to modify the disease phenotype, modulations of target gene expression, and techniques to edit mutant genes have been developed and evaluated as potent therapeutic strategies for dominantly inherited IPN. In this review, the current status of gene therapy for IPN and future perspectives will be discussed.
Rajarathinam Ravikumar,Budhi Venkatesan Ranganathan,Kanchana Nandanan Chathoth,Sriramulu Gobikrishnan 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.5
Lignocellulosic biomass is an abundant, renewable resource, but the structural and chemical complexity of biomass acts as a hindrance in its effective utilization for cellulosic ethanol production. Hence, effective pretreatment is always necessary to remove the surrounding matrix of lignin prior to the enzymatic hydrolysis. Pretreatment of rice straw by Pleurotus florida was found to be effective and resulted in 49% lignin degradation, whereas fungus along with grape leaves resulted in 99% lignin degradation. This method not only explores a pathway for utilizing the solid agro waste but also results in a value-added product of edible mushrooms that has proved to be the best pretreatment technology for ethanol production. FTIR and SEM analysis confirmed the structural transformation taking place during the pretreatment. The components of grape leaves were also analyzed using GC-MS.
Comparative Histomorphology on Low and High Rubber Yielding Guayule Varieties of India
Jayabalan, Marimuthu,Rajarathinam, Kaniappanadar,Jayakumar, Muthukrishnan,Kil, Bong-Seop The Ecological Society of Korea 2001 Journal of Ecology and Environment Vol.24 No.6
A preliminary comparative histodimensional studies, such as wood to bark ratio, total area of parenchyma cells and bast fibers, height and diameter of vascular rays, pith diameter and phenological parameters, height of the plant, perimeter of the stem, dry weight of the stem and leaves have been investigated for the low and high rubber bearing Guayule plants growing in same and different climatic regions of India. A plausible correlation is found between the percentage of rubber content and anatomical characters in the investigated varieties.
Jayabalan, Marimuthu,Rajarathinam, Kaniappanadar,Jayakumar, Muthukrishnan,Kil, Bong-Seop 한국식물학회 2001 Journal of Plant Biology Vol.44 No.4
We investigated the leaf shape, venation pattern, trichomes, stomata, and branching of the inflorescence axes in 15 varieties of guayule (Parthenium argentatum Gray) growing in India. Working from our study objective, we were unable to identify any specific correlation between these macro -and micro- morphological characteristics and rubber content.
Magadum, Santoshkumar,Banerjee, Urbi,Ravikesavan, Rajasekaran,Thiyagu, Krishnasamy,Boopathi, Narayanan Manikanda,Rajarathinam, Sankaran 한국작물학회 2012 Journal of crop science and biotechnology Vol.15 No.3
Seed cotton yield and fibre quality are controlled by polygenes and highly influenced by the environment. Hence, selection merely based on yield is not effective. In order to enhance the yield potential of the cotton varieties, an understanding of the relationship among different characters is of more importance. Knowledge on the direct contribution of different characters to yield would be highly important for formulating a selection programme. Correlation and path coefficient analysis were carried out using 62 progenies of an interspecific backcross population (Gossypium hirsutum L. var. KC 3 ${\times}$ Gossypium barbadense L. var. Suvin) ${\times}$ KC 3. Genotypic correlation studies revealed that number of bolls per plant, boll weight, number of sympodia per plant, number of seeds per boll, seed index, lint index, days to first flowering, and plant height have a significant positive association with seed cotton yield per plant. Path coefficient analysis showed that number of bolls per plant contributed maximum direct effect to seed cotton yield per plant followed by boll weight and lint index. The highest positive indirect effect on seed cotton yield per plant was also observed through number of bolls per plant. This indicated that seed cotton yield per plant was highly influenced by number of bolls per plant directly and indirectly. Thus, a greater emphasis should be given to number of bolls per plant, boll weight, and lint index for increasing seed cotton yield per plant.
Santoshkumar Magadum,Urbi Banerjee,Rajasekaran Ravikesavan,Krishnasamy Thiyagu,Narayanan Manikanda Boopathi,Sankaran Rajarathinam 한국작물학회 2012 Journal of crop science and biotechnology Vol.15 No.3
Seed cotton yield and fibre quality are controlled by polygenes and highly influenced by the environment. Hence, selection merely based on yield is not effective. In order to enhance the yield potential of the cotton varieties, an understanding of the relationship among different characters is of more importance. Knowledge on the direct contribution of different characters to yield would be highly important for formulating a selection programme. Correlation and path coefficient analysis were carried out using 62 progenies of an interspecific backcross population (Gossypium hirsutum L. var. KC 3 x Gossypium barbadense L. var. Suvin) x KC 3. Genotypic correlation studies revealed that number of bolls per plant, boll weight, number of sympodia per plant, number of seeds per boll, seed index, lint index, days to first flowering, and plant height have a significant positive association with seed cotton yield per plant. Path coefficient analysis showed that number of bolls per plant contributed maximum direct effect to seed cotton yield per plant followed by boll weight and lint index. The highest positive indirect effect on seed cotton yield per plant was also observed through number of bolls per plant. This indicated that seed cotton yield per plant was highly influenced by number of bolls per plant directly and indirectly. Thus, a greater emphasis should be given to number of bolls per plant, boll weight, and lint index for increasing seed cotton yield per plant.