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Ragini Gupta,Anshu Jain,Rahul Joshi,Meenakshi Jain 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.3
A series of 5-indolylpyrimido[4,5-d]pyrimidinones (4a-h) were obtained by multi-component reaction of 3-formylindole (1), thiobarbituric acid/barbituric acid (2) and thiourea/urea (3) under microwave irradiation in dry media. Secondly, grinding together neat reactants also gave the titled compounds in good yields. All the synthesized compounds have been characterized on the basis of elemental analyses and spectral data (IR, 1H NMR and Mass). Representative compounds were also evaluated for their antimicrobial activity against Rhizopus stolonifer, Fusarium oxysporum, Escherichia coli, and Pseudomonas aeruginosa at different concentrations. Some of the compounds showed promising activity.
Ragini Gupta,Anshu Jain,Meenakshi Jain,Rahul Joshi 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A simple facile ‘one pot’ synthesis of 2-amino-3-cyano-4,6-diarylpyridine derivatives via three component reaction of chalcone, malanonitrile and ammonium acetate under ultrasonic irradiation and grindstone technology. All the synthesized compounds have been characterized on the basis of their elemental analyses and spectral data (IR, 1H NMR, 13C NMR and Mass).
Gupta, Ragini,Jain, Anshu,Joshi, Rahul,Jain, Meenakshi Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.3
A series of 5-indolylpyrimido[4,5-d]pyrimidinones (4a-h) were obtained by multi-component reaction of 3-formylindole (1), thiobarbituric acid/barbituric acid (2) and thiourea/urea (3) under microwave irradiation in dry media. Secondly, grinding together neat reactants also gave the titled compounds in good yields. All the synthesized compounds have been characterized on the basis of elemental analyses and spectral data (IR, $^1H$ NMR and Mass). Representative compounds were also evaluated for their antimicrobial activity against Rhizopus stolonifer, Fusarium oxysporum, Escherichia coli, and Pseudomonas aeruginosa at different concentrations. Some of the compounds showed promising activity.
Smart nanomaterials for cancer diagnosis and treatment
Singh Ragini,Sharma Ayush,Saji Joel,Umapathi Akhela,Kumar Santosh,Daima Hemant Kumar 나노기술연구협의회 2022 Nano Convergence Vol.9 No.21
Innovations in nanomedicine has guided the improved outcomes for cancer diagnosis and therapy. However, frequent use of nanomaterials remains challenging due to specific limitations like non-targeted distribution causing low signal-to-noise ratio for diagnostics, complex fabrication, reduced-biocompatibility, decreased photostability, and systemic toxicity of nanomaterials within the body. Thus, better nanomaterial-systems with controlled physicochemical and biological properties, form the need of the hour. In this context, smart nanomaterials serve as promising solution, as they can be activated under specific exogenous or endogenous stimuli such as pH, temperature, enzymes, or a particular biological molecule. The properties of smart nanomaterials make them ideal candidates for various applications like biosensors, controlled drug release, and treatment of various diseases. Recently, smart nanomaterial-based cancer theranostic approaches have been developed, and they are displaying better selectivity and sensitivity with reduced side-effects in comparison to conventional methods. In cancer therapy, the smart nanomaterials-system only activates in response to tumor microenvironment (TME) and remains in deactivated state in normal cells, which further reduces the side-effects and systemic toxicities. Thus, the present review aims to describe the stimulus-based classification of smart nanomaterials, tumor microenvironment-responsive behaviour, and their up-to-date applications in cancer theranostics. Besides, present review addresses the development of various smart nanomaterials and their advantages for diagnosing and treating cancer. Here, we also discuss about the drug targeting and sustained drug release from nanocarriers, and different types of nanomaterials which have been engineered for this intent. Additionally, the present challenges and prospects of nanomaterials in effective cancer diagnosis and therapeutics have been discussed.
Gupta, Ragini,Jain, Anshu,Jain, Meenakshi,Joshi, Rahul Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A simple facile 'one pot' synthesis of 2-amino-3-cyano-4,6-diarylpyridine derivatives via three component reaction of chalcone, malanonitrile and ammonium acetate under ultrasonic irradiation and grindstone technology. All the synthesized compounds have been characterized on the basis of their elemental analyses and spectral data (IR, $^1H$ NMR, $^{13}C$ NMR and Mass).
Polymer based blue electrophosphorescent light emitting devices
이창렬,Rupasree Ragini Das,김장주 한국물리학회 2005 Current Applied Physics Vol.5 No.4
A series of bis-orthometalated monocyano Ir(III) complexes, [Ir(ppy)2PX3CN], (X¼ Oph, Ph and n-bu) were synthesized and theinuence of the steric and electronic eects of the phosphine ligand on the photophysical and electrochemical properties of com-plexes were studied. These cyano phosphine complexes emit light from an admixture of triplet metal-to-ligand charge-transfer(3MLCT) and ligand centered (LC) states in the region of 455498 nm with a vibronic progression. The trends of the photophysicaland electrochemical properties of metal complexes in the series were well understood by the electronic parameter of the phosphineligands. Polymer light emitting devices were fabricated by doping Ir(ppy)2P(n-bu)3CN in the PVK host and the device performanceswere investigated. The maximum external quantum eciencyðgexÞwas 1.45% for a 10wt% Ir(ppy)2P(n-bu)3CN doped PVK device.A power eciency of 0.99 lm/W at 230 cd/m2 and 6 mA/cm2 was obtained. The corresponding chloro complexes of the generalformula [Ir(ppy)2PX3Cl] were also synthesized and the optical and device properties were compared with the cyano complexes..
Polymer based blue electrophosphorescent light emitting devices
Lee, Chang-Lyoul,Ragini Das, Rupasree,Kim, Jang-Joo Elsevier 2005 CURRENT APPLIED PHYSICS Vol.5 No.4
<P><B>Abstract</B></P><P>A series of bis-orthometalated monocyano Ir(III) complexes, [Ir(ppy)<SUB>2</SUB>PX<SUB>3</SUB>CN], (X=Oph, Ph and <I>n</I>-bu) were synthesized and the influence of the steric and electronic effects of the phosphine ligand on the photophysical and electrochemical properties of complexes were studied. These cyano phosphine complexes emit light from an admixture of triplet metal-to-ligand charge-transfer (<SUP>3</SUP>MLCT) and ligand centered (LC) states in the region of 455–498 nm with a vibronic progression. The trends of the photophysical and electrochemical properties of metal complexes in the series were well understood by the electronic parameter of the phosphine ligands. Polymer light emitting devices were fabricated by doping Ir(ppy)<SUB>2</SUB>P(<I>n</I>-bu)<SUB>3</SUB>CN in the PVK host and the device performances were investigated. The maximum external quantum efficiency (<I>η</I><SUB>ex</SUB>) was 1.45% for a 10 wt% Ir(ppy)<SUB>2</SUB>P(<I>n</I>-bu)<SUB>3</SUB>CN doped PVK device. A power efficiency of 0.99 lm/W at 230 cd/m<SUP>2</SUP> and 6 mA/cm<SUP>2</SUP> was obtained. The corresponding chloro complexes of the general formula [Ir(ppy)<SUB>2</SUB>PX<SUB>3</SUB>Cl] were also synthesized and the optical and device properties were compared with the cyano complexes.</P>
Kumar, Mohit,Das, Rupasree Ragini,Samal, Monica,Yun, Kyusik Elsevier 2018 Materials chemistry and physics Vol.218 No.-
<P><B>Abstract</B></P> <P>We report the synthesis and characterization of Cu<SUB>2</SUB>O nanoparticles (NPs) in the presence of the coordinating ligands like <SMALL>L</SMALL>-glutamic acid (Glu-Cu<SUB>2</SUB>O) and <SMALL>D</SMALL>-glucosamine (GlcN-Cu<SUB>2</SUB>O). Even if –NH<SUB>2</SUB> group is common to both the ligands, <SMALL>L</SMALL>-glutamic acid is a straight chain compound containing additional two –COOH groups, whereas, glucosamine is a cyclic compound with additional four –OH groups and an ether (-O-) linkage. Thus the coordinating ligands are different in the nature of the functional groups as well as their molecular skeletons leading to cubic morphology (∼350 nm of average edge length) for <SMALL>L</SMALL>-glutamic acid coordinated Cu<SUB>2</SUB>O and spherical morphology (∼250 nm of average diameter) for glucosamine one as observed by Field Effective Scanning Electron Microscopy (FE-SEM) and Transmission Electron Microscopy (TEM) images. The observed band gap of Cu<SUB>2</SUB>O of 1.89 eV is decreased to 1.84 ev for both the ligated structures. Both the ligated cuprous oxide (Cu<SUB>2</SUB>O) nanoparticles (NPs) were used for the photocatalytic degradation of methylene Blue (MB). The spherical GlcN-Cu<SUB>2</SUB>O showed 98% degradation of MB in 105 min and after 3 cycles of operation, the photocatalytic activity was enough for the 93% degradation of the dye, whereas, the cubic Gu-Cu<SUB>2</SUB>O could degrade MB up to 97% in 135 min and after three cycles, only 86% of the dye was degraded. This indicates, the molecular skeleton and functional groups on the ligand control the shape and size of the Cu<SUB>2</SUB>O nanoparticles as well as the photocatalytic efficiency and stability. It is presumed, the cyclic glucosamine ligand can protect the Cu<SUB>2</SUB>O nanoparticles from erosion during the degradation process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Different structure of functionalized Cu<SUB>2</SUB>O was synthesized. </LI> <LI> NH<SUB>2</SUB> group is common to both the ligands. </LI> <LI> Photocatalytic dye degradation was done. </LI> <LI> Synthesized nanomaterials were highly stable up to third cycle. </LI> </UL> </P>