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Rachel Ghasemi Goorbandi,Mohammad Reza Mohammadi,Kianoosh Malekzadeh 한국생체재료학회 2020 생체재료학회지 Vol.24 No.2
Background: Genistein (C15H10O5) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range. This property cause to impede its usage as chemotherapeutic agent. Therefore, this hypothesis raised that synthesizing biocompatible nanoparticle could assist to prevail this struggle. Methods: Genistein covalently attached on Fe3O4 nanoparticles decorated with carboxymethylated chitosan to fabricate Fe3O4-CMC-genistein in alkaline circumstance. This obtained nanoparticles were evaluated by TEM, DLS, FTIR, XRD and VSM and its anti-cancer effect by growth rate and MTT assays as well as flow cytometer on ALL cancer cell lines. Results: Different evaluations indicated that the drug delivery vehicle had a mean diameter size around 12ƞm with well bounded components. This system presented high degree of magnetization and superparamagnetic properties as well as good water solubility. In comparison with pure genistein, significant growth inhibition on hematopoietic cancer cells in lower dose of genistein nano-conjugated onto Fe3O4-CMC. It increased long lasting effect of genistein in cancer cells also. Conclusion: This delivery system for genistein could be remarkably promised and futuristic as biocompatible chemotherapeutic agent against hematopoietic malignant cells.
Rachel Esther Lim,Yoon Hi Sung,Eun Yeon Kang,Kacy Kim 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
This research intends to examine whether these types of data – behavioral versus social networking data – affect consumer response to personalized ads. With the advancement in technology, marketers have access to various types of personal data, including their online/offline behaviors and social networking activities, and use those data to retarget consumers. Moreover, this research examines the moderating role of SNS privacy concerns on consumer response to different types of retargeted ads. The findings of this research may offer theoretical and practical implications to understand consumers' responses to retargeted ads that use social networking information.
Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations
Rachel Williams,Muthu Periasamy 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.4
Obesity-associated metabolic illnesses are increasing at an alarming rate in Asian countries. A common feature observed in the Asianpopulation is a higher incidence of abdominal obesity—the “skinny-fat” Asian syndrome. In this review, we critically evaluate the relative roles of genetics and environmental factors on fat distribution in Asian populations. While there is an upward trend in obesityamong most Asian countries, it appears particularly conspicuous in Malaysia. We propose a novel theory, the Malaysian gene-environment multiplier hypothesis, which explains how ancestral variations in feast-and-famine cycles contribute to inherited genetic predispositions that, when acted on by modern-day stressors—most notably, urbanization, westernization, lifestyle changes, dietary transitions, cultural pressures, and stress—contribute to increased visceral adiposity in Asian populations. At present, the major determinants contributing to visceral adiposity in Asians are far from conclusive, but we seek to highlight critical areas for further research.
Rachel F. Madera,Lihua Wang,Wenjie Gong,Yulia Burakova,Sterling Buist,Jerome Nietfeld,Jamie Henningson,Ada G. Cino-Ozuna,Changchun Tu,Jishu Shi 대한수의학회 2018 JOURNAL OF VETERINARY SCIENCE Vol.19 No.3
Highly contagious classical swine fever (CSF) remains a major trade and health problem in the pig industry, resulting in large economic losses worldwide. In CSF-endemic countries, attenuated CSF virus (CSFV) vaccines have been routinely used to control the disease. However, eradication of CSFV in a geographical area would require permanent reduction to zero presence of the virus. It is therefore of paramount importance to develop a safe, potent, and non-infectious CSF vaccine. We have previously reported on a cost-effective CSF E2 subunit vaccine, KNB-E2, which can protect against CSF symptoms in a single dose containing 75 mg of recombinant CSFV glycoprotein E2. In this study, we report on a series of animal studies undertaken to elucidate further the efficacy of KNB-E2. We found that pigs vaccinated with a single KNB-E2 dose containing 25 mg of recombinant CSFV glycoprotein E2 were protected from clinical symptoms of CSF. In addition, KNB-E2-mediated reduction of CSF symptoms was observed at two weeks post-vaccination and the vaccinated pigs continued to exhibit reduced CSF clinical signs when virus challenged at two months and four months post-vaccination. These results suggest that KNB-E2 effectively reduces CSF clinical signs, indicating the potential of this vaccine for safely minimizing CSF-related losses.
Assessment of Post-Earthquake Fire Behavior of a Steel MRF Building in a Low Seismic Region
Rachel Chicchi,Amit Varma 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.4
Building-level response to post-earthquake fi re hazards in steel buildings has been assessed using primarily two-dimensional analyses of the lateral force resisting system. This approach may not adequately consider potential vulnerabilities in the gravity framing system. For this reason, three-dimensional (3D) fi nite element models of a 10-story case study building with perimeter moment resisting frames were developed to analyze post-earthquake fi re events and better understand building response. Earthquakes are simulated using ground motion time histories, while Eurocode parametric time–temperature curves are used to represent compartment fi res. Incremental dynamic analysis and incremental fi re analysis procedures capture a range of hazard intensities. Findings show that the structural response due to earthquake and fi re hazards are somewhat decoupled from one another. Regardless of the level of plastic hinging present in the moment framing system due to a seismic event, gravity column failure is the initiating failure mode in a fi re event.
Rachel Yi-Xin Ng,Yi-Sheng Wong,Joshua-Yi Yeo,Crystal Ling-Zhen Koh,Cynthia Wilson,Samuel Ken-En Gan 한국식품연구원 2018 Journal of Ethnic Foods Vol.5 No.3
Background: Dietary quality, biological health, culture, religiosity, and perceived stress are co-related. However, there is a dearth of research conducted on Asian populations in secularized and harmonious multicultural societies. Methods: This study addresses these gaps by conducting an investigation in the multicultural and multireligious Singapore to examine the parameters of culture and gender and the associations with (1) dietary quality, (2) biological health indicators, (3) religiosity, and (4) perceived stress. One hundred fifty participants (18e60 years old) were recruited, and their blood pressure (BP), body mass index (BMI), and body fat percentage (BF%) were also measured along with a 5-part questionnaire on demographics, dietary practice, food frequency, religiosity, and perceived stress. Results and conclusion: Results showed that cultural differences are associated with certain dietary practices, where the three ethnic groups of Chinese, Malays, and Indians significantly differed in their choices of meal locations such as Western fast food restaurants (H ¼ 12.369, p ¼ .002061*). Our analysis revealed that perceived stress significantly correlated with fat intake (rs ¼ .169, N ¼ 150, p ¼ .03865) and sugar intake (rs ¼ .172, N ¼ 150, p ¼ .03575). On the other hand, biological parameters such as diastolic BP (rs ¼ .0473, N ¼ 150, p ¼ .565), systolic BP (rs¼ .00972, N ¼ 150, p ¼ .906), BMI (rs ¼ .0403, N ¼ 150, p ¼ .6246), and BF% (rs ¼ .110, N ¼ 150, p ¼ .1811) did not have significant correlations with perceived stress. Similarly, religiosity did not significantly correlate with perceived stress (rs ¼ .025, N ¼ 150, p ¼ .7616). In conclusion, our findings provide insights into the changing intersection of food practices mitigated by ethnicity, religiosity, stress, and gender in the harmonious multiracial and multicultural Singapore.
Getting Early Childhood onto the Reform Agenda: An Australian Case Study
Rachel Flottman,Jane Page 육아정책연구소 2012 International Journal of Child Care and Education Vol.6 No.1
Many Governments around the world turned their attention to early childhood policy and service provision throughout the early 2000s, and the Victorian State Government within Australia was no different. Over the past six years, the Victorian Government has reformed the early childhood education and care system substantially. The factors leading to this emphasis on early childhood reform were not straight-forward. This article adapts Richmond’s and Kotelchuck’s (1983) model for examining the interacting forces shaping public policy to make sense of how early childhood so successfully found itself at the centre of the Victorian Government’s reform agenda. It concludes that far from being random, it was a combination of political will, a rich, expanding and interdisciplinary knowledge base and a well-developed social strategy for the application of the knowledge base that led to early childhood being at the centre of the reform agenda. It concludes that much of the evidence by which the reform agenda was informed came from studies conducted internationally and that more Australian research is needed to investigate early childhood program effectiveness in our own local context if the momentum is to continue.