Pretreatment Thrombocytosis as a Prognostic Factor in Women with Gynecologic Malignancies: a Meta-analysis

Yu, Min,Liu, Lei,Zhang, Bing-Lan,Chen, Qi,Ma, Xue-Lei,Wu, Yu-Ke,Liang, Chun-Shui,Niu, Zhi-Min,Qin, Xin,Niu, Ting Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: This study was performed to analyze the prognostic implications of pretreatment or preoperative thrombocytosis in women with gynecologic malignancies. Material and Methods: We surveyed 2 medical databases, PubMed and EMBASE, to identified all relevant studies. A total of 14 (n=3,490) that evaluated the link between thrombocytosis and 5-year survival were included. REVMAN version 5.1 was used for our analysis and publication bias was evaluated using the Begg's funnel plot and tested by STATA 11.0. Risk ratios (RRs) with 95% confidence intervals (CIs) generated by the random effect model were used to assess the strength of any association. Results: 709(20.3%) of the 3,490 patients exhibited thrombocytosis (platelet counts > $400{\times}10^9/L$) at primary diagnosis, and their mortality was 1.62-fold higher compared with the others (RR=1.62, 95%CI=[1.28-2.05], p<0.0001). Thrombocytosis failed to have a stronger effect on the survival of advanced patients of stages III to IV in our study (n=478, RR=1.29, 95% CI=[1.13-1.48], p=0.0003), nor in women with cervical cancer in stage IB (n=1371, RR=1.73, 95% CI=[1.71-2.58], p=0.007). In addition, when adjusted for different carcinoma, it was associated with worse prognosis for all except the ones with vulvar cancer (n=201, RR=0.43, 95% CI=[0.14-1.29], p=0.13). Conclusions: This meta-analysis indicated that thrombocytosis might be associated with a worse prognosis for patients with gynecologic malignancies but without specificity or sensitivity for the ones in advanced stage. When adjusted for different gynecologic malignancies, it showed a significant effect on survival of all except vulvar cancers.

Covalent Immobilization of Penicillin G Acylase onto Fe₃O₄@Chitosan Magnetic Nanoparticles

( Xiao Min Ling ),( Xiang Yu Wang ),( Ping Ma ),( Yi Yang ),( Jie Mei Qin ),( Xue Jun Zhang ),( Ye Wang Zhang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.5

Penicillin G acylase (PGA) was immobilized on magnetic Fe₃O₄@chitosan nanoparticles through the Schiff base reaction. The immobilization conditions were optimized as follows: enzyme/support 8.8 mg/g, pH 6.0, time 40 min, and temperature 25℃. Under these conditions, a high immobilization efficiency of 75% and a protein loading of 6.2 mg/g-support were obtained. Broader working pH and higher thermostability were achieved by the immobilization. In addition, the immobilized PGA retained 75% initial activity after ten cycles. Kinetic parameters Vmax and Km of the free and immobilized PGAs were determined as 0.113 mmol/min/mg-protein and 0.059 mmol/min/mg-protein, and 0.68 mM and 1.19 mM, respectively. Synthesis of amoxicillin with the immobilized PGA was carried out in 40% ethylene glycol at 25℃ and a conversion of 72% was obtained. These results showed that the immobilization of PGA onto magnetic chitosan nanoparticles is an efficient and simple way for preparation of stable PGA.

The effect of detraining on the body composition, physical fitness, quality of life and immune response of PLWHA

Xin-Min Qin,Chang-Hwa Joo 한국운동재활학회 2023 한국운동재활학회 학술대회 Vol.2023 No.6

The preservation effect of Metschnikowia pulcherrima yeast on anthracnose of postharvest mango fruits and the possible mechanism

Ya-qin Tian,Wen Li,Zi-tao Jiang,Min-min Jing,Yuan-zhi Shao 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1

This study aimed to determine the effects of Metschnikowia pulcherrima yeast on storage quality of ‘Tainong’ mango, and elucidate it’s possible anti–disease mechanism. The results showed that M. pulcherrima could inhibit the changes in peel colour, fruit firmness, the contents of total soluble solids, total acid and vitamin C, and maintain the storage quality of mango fruits. An investigation of the mechanism showed that M. pulcherrima competed not only for the primary carbon source, but also for living space with Colletotrichum gloeosporioides. In addition, M. pulcherrima promoted the activities of defence-related enzymes, including ß-1,3-glucanase(GLU) and chitinase (CHT), and secreted a small amount of antimicrobial substances composed of volatile and nonvolatile anti-fungal compounds. The results strongly demonstrated that antagonistic yeast M. pulcherrima could be applied as a biocontrol agent for deducing the spoilage and decay of mango fruit.

The preservation effect of Metschnikowia pulcherrima yeast on anthracnose of postharvest mango fruits and the possible mechanism

Tian, Ya-qin,Li, Wen,Jiang, Zi-tao,Jing, Min-min,Shao, Yuan-zhi 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1

This study aimed to determine the effects of Metschnikowia pulcherrima yeast on storage quality of 'Tainong' mango, and elucidate it's possible anti-disease mechanism. The results showed that M. pulcherrima could inhibit the changes in peel colour, fruit firmness, the contents of total soluble solids, total acid and vitamin C, and maintain the storage quality of mango fruits. An investigation of the mechanism showed that M. pulcherrima competed not only for the primary carbon source, but also for living space with Colletotrichum gloeosporioides. In addition, M. pulcherrima promoted the activities of defence-related enzymes, including ${\beta}$-1,3-glucanase(GLU) and chitinase (CHT), and secreted a small amount of antimicrobial substances composed of volatile and nonvolatile anti-fungal compounds. The results strongly demonstrated that antagonistic yeast M. pulcherrima could be applied as a biocontrol agent for deducing the spoilage and decay of mango fruit.

중국 자동차 산업의 경쟁전략과 성과에 대한 탐색적 연구

친즈민(Zhi-Min Qin),허문구(Moon-Goo Huh) 강원대학교 경영경제연구소 2021 Asia-Pacific Journal of Business Vol.12 No.2

Purpose - The purpose of this study was to analyze the impact of a company s competitive strategy on corporate performance in the highly competitive Chinese automotive industry. Design/methodology/approach - This study collected 14 survey data from automotive companies in China which be listed more than one year. We chosen the exploratory study with deriving research assignments, and the final research results are presented as propositions to proceed with the study. Findings - First, in the Chinese automobile industry, a company s competition strategy has a positive impact on corporate performance. and also the Differentiation strategy and the Low-cost strategy both have a positive impact on corporate performance. In addition, a company pursuing the Differentiation strategy that it would achieve better corporate performance than a company pursuing the Low-cost strategy. Second, it has been shown that the hybrid strategy rather than the pure strategy in the Chinese automobile industry can achieve higher corporate performance. Research implications or Originality - First, the type of competitive strategy in Chinese automotive industry were identified through the original strategies presented by Porter and Murray, and the impact of the Low-cost and the Differentiation strategies on corporate performance was analyzed. Second, contributing to the study of pure and hybrid strategies that are still under discussion now. Third, it also suggested practical implications that companies in China s automotive industry should pursue cost or differentiation advantages to secure competitive advantage.

STRONG CONVERGENCE THEOREM OF FIXED POINT FOR RELATIVELY ASYMPTOTICALLY NONEXPANSIVE MAPPINGS

Xiao long Qin,Shin Min Kang,Sun Young Cho 충청수학회 2008 충청수학회지 Vol.21 No.3

In this paper, we prove strong convergence theorems of Halpern iteration for relatively asymptotically nonexpansive map- pings in the framework of Banach spaces. Our results extend and improve the recent ones announced by [C. Martinez-Yanes, H. K. Xu, Strong convergence of the CQ method for ¯xed point iteration processes, Nonlinear Anal. 64 (2006), 2400{2411], [X. Qin, Y. Su, Strong convergence theorem for relatively nonexpansive mappings in a Banach space, Nonlinear Anal. 67 (2007), 1958{1965] and many others.

An Efficient Blind Detection Algorithm of Median Filtered Image

Yongzhen Ke,Fan Qin,Weidong Min,Qiang Zhang 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1

Due to the significant advances of digital photography and the availability of many powerful photo editing tools, it becomes easier to create forgery images by non-professional users. Median filtering that is usually applied to erase the forensically significant fingerprints has recently received increased attention. In this paper, we present an effective blind forensic algorithm to detect the median filtering manipulation. First, the median filtered residual (MFR) is generated by computing the difference between a testing image and a median filtered version of itself. Then, three feature sets including histogram, autocorrelation and gradient are extracted from the median filter residual. Last, those features are fetched into support vector machine (SVM) for training and classification. Our experimental results demonstrate that our proposed forensic method achieves not only better detection rate but also lower computational complexity compared with other existing median filtering detection methods. Our proposed forensic method also can locate local median filtering of image effectively.

Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes

Min Li,Lujun Song,Xiaodong Gao,Wenju Chang,Xinyu Qin 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.4

Type 1 diabetes mellitus is caused by the autoimmune destruction of β cells within the islets. In recent years,innate immunity has been proposed to play a key role in this process. High-mobility group box 1 (HMGB1), an inflammatory trigger in a number of autoimmune diseases,activates proinflammatory responses following its release from necrotic cells. Our aim was to determine the significance of HMGB1 in the natural history of diabetes in non-obese diabetic (NOD) mice. We observed that the rate of HMGB1 expression in the cytoplasm of islets was much greater in diabetic mice compared with non-diabetic mice. The majority of cells positively stained for toll-like receptor 4 (TLR4) were βcells; few α cells were stained for TLR4. Thus, we examined the effects of anti-TLR4 antibodies on HMGB1 cell surface binding, which confirmed that HMGB1 interacts with TLR4 in isolated islets. Expression changes in HMGB1 and TLR4 were detected throughout the course of diabetes. Our findings indicate that TLR4 is the main receptor on β cells and that HMGB1 may signal via TLR4 to selectively damage β cells rather than αcells during the development of type 1 diabetes mellitus.

백화점 뉴실버여성 의류매장 VMD에 대한 연구 : 중국의 베이징 신화백화점 의류매장에 대한 제안

Qin Li(이금),최정선(Choi Jung-Sun),김완민(Kim Wan-Min) 동북아시아문화학회 2009 동북아 문화연구 Vol.1 No.20

Visual merchandising (VMD hereafter) has become a more important issue because it plays a vital role in promoting a company's image and increasing sales. The purpose of this study is to investigate the effects of VMD image on new elderly female consumers' purchasing behavior. The sThjects of the study were 150 elderly customers aged from 50 to 65 in BeiJing, China who are called the 'new silver generation'. A survey was conducted to find out consumer attitudes towards the VMD of department stores and their purchasing behavior. The collected data was analyzed with frequency analysis. Through the results of the analysis, the following findings were discovered: First, the new elderly consumers showed a positive attitude toward the VMD of department stores so it seems important for retailers to make effective VMD methods for them as well as for younger consumers. Second, the new elderly consumers' preference for bright colors seems to reflect the fact that they always want to try to look younger, so the VMD display should use brighter colors. Third, as these elderly consumers grow older, their height tends to gradually shrink. Thus, the hanger height of department stores for them should be reduced accordingly, that is, 4-8 ㎝ lower than ordinary hanger heights. As these elderly customers have the habit of shopping with a frequent need for sitting, it is important to make the face out presentation around the store. Based on the results of the survey analysis of the VMD aspect of the Lotte Department Store in Korea and XinHua Department Store in China, efficient VMD methods have been proposed to promote clothing sales for the elderly in the region.