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      • 《左传》扬晋文抑齐桓析

        翁其斌(Weng Qi-Bin) 한림대학교 아시아문화연구소 2007 아시아문화 Vol.- No.24

        Qi Huangong and Jin Wengong, two of the hegemonic monarchs during Spring and Autumn Period, are always called Qi Huan Jin Wen by the posterity. Despite the fact that both Confucius and Mencius gave higher evaluation to Qi Huan, <Zuo Zhuan> tended to speak well of Jin Wen while depreciating Qi Huan. This tendency is manifested by the facts that the description of Jin Wen is much more detailed and the recognition of him is usually higher. This inclination can be attributed to the following two reasons. In the first place, the author is from Lu Guo, a weak nation that is often bullied by Qi Luo, while at the same time, the long distance between Lu Guo and Jin Guo functioned as the instrument preventing too many conflicts of interests, which therefore explains his repulsion toward Qi Luo. Secondly, the author of <Zuo Zhuan> attached great importance to Li. However, In his opinion, much of Qi Huan Gong's behavior did not conform to Li.

      • Sensitization of Cervical Carcinoma Cells to Paclitaxel by an IPP5 Active Mutant

        Zeng,,Qi-Yan,Huang,,Yu,Zeng,,Lin-Jie,Huang,,Min,Huang,,Yong-Qi,Zhu,,Qi-Fang Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

        Paclitaxel is one of the best anticancer agents that has been isolated from plants, but its major disadvantage is its dose-limiting toxicity. In this study, we obtained evidence that the active mutant IPP5 ($8-60hIPP5^m$), the latest member of the inhibitory molecules for protein phosphatase 1, sensitizes human cervix carcinoma cells HeLa more efficiently to the therapeutic effects of paclitaxel. The combination of $8-60hIPP5^m$ with paclitaxel augmented anticancer effects as compared to paclitaxel alone as evidenced by reduced DNA synthesis and increased cytotoxicity in HeLa cells. Furthermore, our results revealed that $8-60hIPP5^m$ enhances paclitaxel-induced G2/M arrest and apoptosis, and augments paclitaxel-induced activation of caspases and release of cytochrome C. Evaluation of signaling pathways indicated that this synergism was in part related to downregulation of NF-${\kappa}B$ activation and serine/threonine kinase Akt pathways. We noted that $8-60hIPP5^m$ downregulated the paclitaxel-induced NF-${\kappa}B$ activation, $I{\kappa}B{\alpha}$ degradation, PI3-K activity and phosphorylation of the serine/threonine kinase Akt, a survival signal which in many instances is regulated by NF-${\kappa}B$. Together, our observations indicate that paclitaxel in combination with $8-60hIPP5^m$ may provide a therapeutic advantage for the treatment of human cervical carcinoma.

      • SCOPUS

        Acoustic Evaluation of Noise Reduction in a Hearing Aid

        Yingyong Qi, 최철희(Chul-Hee Choi) 한국언어청각임상학회 2000 Communication Sciences and Disorders Vol.5 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        본 연구의 목적은 특정 보청기 (Phonak, Phonet2 AudioZoom)의 잡음축소기능을 음향학적으로 평가하는 것이다. KEMAR안의 즈위스라키카플러(Zwislocki coupler )에 장치한 마이크로폰을 사용하여 녹음을 하였다. 녹음된 신호의 신호대 잡음비가 다양한 녹음환경에서 얻어졌다. 이 녹음환경은 다음 세 가지를 포함한다. (1) 두 가지 다른 잡음 수준(0과 15 dB SNR) (2) 세 가지 다른 잡음 수준(white, cafeteria and multitaker) (3) 세 가지 다른 보청기 프로그램(Peak Clipping, Wide Dynamic Range Compres sion, and Super Compres sion with Adaptive Recovery Time) 신호대 잡음비는 Qi et al.에 의해 개발된 신호잡음비 추정 알고리즘에 의해 계산되었다. 이 알고리즘에서 신호는 말과 상관된 구성요소의 에너지로 계산되었으나 잡음은 남아 있는 말과 상관되지 않는 구성요소의 에너지로 계산되었다. 그 상관되지 않은 구성요소는 원래의 신호에 의해 나타난 장단기 상관관계를 체계적으로 배제하면서 얻어졌다. 보청기의 AudioZoom 기능 이 사용된 경우와 그렇지 않은 경우의 신호대 잡음비의 차이가 그 보청기의 잡음축소기능을 평가하기 위해 계산되었다. 연구결과 신호대 잡음비는 높은 잡음 수준에서 AudioZoom이 사용되었을 때가 사용되지 않았을 때보다 1- 2 dB 높았다. 이 크기는 녹음 환경에서 제시된 잡음의 유형에 의존하였다. 결과에서 신호대 잡음비는 다른 잡음들보다 white 잡음에 더욱 높았다. 낮은 잡음 수준에서는 의미있는 차이가 발견되지 않았다. 역시, 보청기 프로그램의 의미있는 효과도 발견되지 않았다. 요약하면, 본 연구는 높은 수준의 whit e 잡음이 제시되었을 때 AudioZoom의 기능이 극대화된다는 것을 분명히 제시하였다. The purpose of this study is to acoustically evaluate the noise reduction function of one specific type of hearing aid (Phonak, Piconet2 AZ). Recording were made using a microphone that was mounted on the Zwislocki coupler inside KEMAR. The signal- to- noise ratio (SNR) of the recorded signals were obtained for a variety of recording environments . These include: (1) high (0 dB SNR) and low (15 dB SNR) noise level, (2) three different types of noise (white, cafeteria, and multitalker ), and (3) three different hearing aid programs (Peak Clipping, Wide Dynamic Range Compression, and Super Compression with adaptive recovery Time). The SNRs were calculated using the signal- to- noise ratio estimation algorithm proposed by Qi et al. (in press ). In this algorithm, the signal was computed as the energy of correlated components of speech. Noise was computed as the energy of the remaining uncorrelated or random components of speech. The uncorrelated component was obtained by systematically removing any short- and long- term correlation exhibited by the original signal. The differences in SNR when the AudioZoom function was turned on or off was computed to evaluate the noise reduction function of the hearing aid. Results indicated that the SNR was about 1- 2 dB higher when AudioZoom was turned on than when it was turned off at the high noise level. This magnitude of the SNR increase depended on the type of noise presented in the environment. The SNR increase was significantly higher for white noise than for cafeteria noise or multitalker noise. No increase of SNR was observed when the AudioZoom function was turned on at the low noise level. The effect of hearing aid program is also not significant. It appears that the AudioZoom function is most effective when high- level white noise is present . It is not as useful when low- level, speech- like noise is present , no matter what hearing aid program is used.

      • 8-60hIPP5<sup>m</sup>-Induced G2/M Cell Cycle Arrest Involves Activation of ATM/p53/p21<sup>cip1/waf1</sup> Pathways and Delayed Cyclin B1 Nuclear Translocation

        Zeng,,Qi-Yan,Zeng,,Lin-Jie,Huang,,Yu,Huang,,Yong-Qi,Zhu,,Qi-Fang,Liao,,Zhi-Hong Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

        Protein phosphatase 1 (PP1) is a major serine/threonine phosphatase that controls gene expression and cell cycle progression. The active mutant IPP5 ($8-60hIPP5^m$), the latest member of the inhibitory molecules for PP1, has been shown to inhibit the growth of human cervix carcinoma cells (HeLa). In order to elucidate the underlying mechanisms, the present study assessed overexpression of $8-60hIPP5^m$ in HeLa cells. Flow cytometric and biochemical analyses showed that overexpression of $8-60hIPP5^m$ induced G2/M-phase arrest, which was accompanied by the upregulation of cyclin B1 and phosphorylation of G2/M-phase proteins ATM, p53, $p21^{cip1/waf1}$ and Cdc2, suggesting that $8-60hIPP5^m$ induces G2/M arrest through activation of the ATM/p53/$p21^{cip1/waf1}$/Cdc2/cyclin B1 pathways. We further showed that overexpression of $8-60hIPP5^m$ led to delayed nuclear translocation of cyclin B1. $8-60hIPP5^m$ also could translocate to the nucleus in G2/M phase and interact with $pp1{\alpha}$ and Cdc2 as demonstrated by co-precipitation assay. Taken together, our data demonstrate a novel role for $8-60hIPP5^m$ in regulation of cell cycle in HeLa cells, possibly contributing to the development of new therapeutic strategies for cervix carcinoma.

      • KCI등재

        Identification of differentially expressed miRNAs after Lactobacillus reuteri treatment in the ileum mucosa of piglets

        Qi,Wang,Qian,Sun,Jing,Wang,Xiaoyu,Qiu,Renli,Qi,Jinxiu,Huang 한국유전학회 2020 Genes & Genomics Vol.42 No.11

        Background Lactobacillus reuteri I5007 possesses many excellent probiotic characteristics in piglets. miRNA plays importantrole in host-microbiota interactions, but the mechanism by which L. reuteri I5007 regulates intestinal function throughits influence on miRNA expression is unknown. Objective This study analyzed the miRNA expression patterns in the ileum mucosa tissue of piglets by L. reuteri I5007treatment, aim to clarify its molecular mechanism for regulating intestinal function through miRNA. Methods Neonatal piglets were orally administered L. reuteri I5007 or a placebo daily starting on day 1, and differentialexpression of ileal miRNAs was analyzed at 10 and 20 days of age by small RNA sequencing. Results 361 known porcine miRNAs were identified, and ten miRNAs were highly expressed in the ileum mucosa in bothtreatments. Nineteen differentially expressed (DE) miRNAs were identified in response to L. reuteri treatment, and four DEmiRNAs (ssc-miR-196a, -196b-5p, -1285 and -10386) were differentially expressed at both time points. The KEGG pathwayanalyses showed the targets of 19 DE miRNAs were involved in 63 significantly enriched pathways, including the PI3KAktand MAPK pathways, which were confirmed to play important roles in probiotic-host communication. L. reuteri I5007exerted anti-inflammatory effects by influencing the levels of inflammatory cytokines. Suppressor of cytokine signalling 4gene was the target gene of ssc-miR-196a/-196b-5p, overexpression of ssc-miR-196a/-196b-5p downregulated the mRNAexpression of IL-1β and TNFα in IPEC-J2 cells. Conclusion Our study provides new insight into the role of miRNAs in the intestinal function of piglets after L. reuteriI5007 treatment.

      • Isotope Programming Model for Context aware Application

        Qi,Saiyu,Xi,Min,Qi,Yong 보안공학연구지원센터 2007 International Journal of Software Engineering and Vol.1 No.1

        The context-aware application's main feature is that the program can adjust its behavior according to the context environment. In the traditional object-oriented model, behaviors related to the context may be separated through branching statement, thus greatly reducing the degree of adaptation to environmental changes. This paper, after analyzing the issue of programming context-aware applications through the object-oriented model, puts forward Isotope Programming Model(IPM), which enlarges the concept of object and converts the object from the aggregation of attribute and behavior into the aggregation of attribute and a series of behavior code documents directed to different context. The analysis of IPM performances reveals that IPM model provides better adaptability for application development than the object-oriented model, and reduces environmental changes' impact. This paper also proposes the reason of isotope element's conflict and gives the resolve method for the conflicts, which can make the IPM model more effective.

      • KCI등재SCOPUS

        certainty and Dependence Analysis of Performance Limit State for Structural Multidimensional Fragility Evaluation

        Qi'ang,Wang,Ziyan,Wu,Lu,Liu 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.4

        Considering uncertainty and dependence of performance limit states (PLSs), the study addresses a methodology to evaluate multidimensional fragility. The purpose is to identify the PLS uncertainty quantitatively. The dependence between each PLS parameters is also investigated. The limit state band is firstly proposed to describe the bi-dimensional case. Through interval estimation, the band area with a certain confidence level is determined. A reinforcement concrete bridge is used as example to illustrate the proposed approach for developing fragility curves. PLS threshold samples are obtained to formulate limit state function using incremental dynamic analysis. The study investigates the sensitivity of the method for fragility assessment when different confidence levels are considered. In addition, influence of correlation coefficient between PLSs is evaluated. Results show that a fragility interval is obtained with the introduction of limit state band. The interval length decreases as with the reduction of the confidence level. The probability of failure becomes smaller when the dependence between PLSs is ignored, which will result in overestimation of the structural seismic performance

      • KCI등재

        Utilization of electron beam to modulate electron injection over Schottky barrier

        Qi,Zhang,Junjie,Qi,Yunhua,Huang,Huifeng,Li,Xin,Li,Ruoshui,Wang,Yue,Zhang 한국물리학회 2011 Current Applied Physics Vol.11 No.3

        Modulation of electron injection over Schottky barrier was realized by employing electron beam irradiation on the metal/ZnO-nanowire contact. The structure revealed a good response to the illumination at a scanning frequency of 0.1 Hz, which can be enhanced by increasing bias and decreased with the increase of electron beam energy. These phenomena can be attributed to the Schottky barrier formed at the metal/ZnO-nanowire interface which limits the electron transport across the contact. The electron beam irradiation gives rise to high efficiency of electron injection over the barrier, while the interplay between charge discreteness, coherent scattering, and Coulomb interaction may reduce the conductivity.

      • KCI등재

        A Colorimetric and Fluorescent pH Probe for Extremely Acidic Conditions and its Application in pH Test Paper

        Qi-Hua,You,Jinhai,Shen,Ganping,Shen,Liyun,Peng,Yuanqin,Lu,Qi,Fu,Yuqing,Xu,Lei,Zhang 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.3

        Here, we report a highly water-soluble colorimetric and fluorescent pH probe that works in the pH range 0.2–3.0. The probe showed a rapid response, high stability, and excellent reversibility to acidity. Moreover, the fluorescence of probe was not influenced by the existence of high concentration of cations. The pKa of probe was calculated to be 2.25 ± 0.06. Furthermore, the pH test papers coated with the probe exhibited a distinct color change in acidic conditions.

      • KCI등재SCOPUS

        Structural System Reliability Analysis Based on Improved Explicit Connectivity BNs

        Qi'ang,Wang,Ziyan,Wu 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.3

        The study proposes an improved Explicit Connectivity Bayesian Networks (ECBNs) for system reliability assessment. The framework combines Analytic Hierarchy Process (AHP) with the traditional ECBNs. AHP is adopted to consider probabilistic dependencies between system components. Judgment matrix is constructed and weight vector, which meets the requirement of a random consistency check, is extracted to describe a conditional probability information of BNs intermediate nodes. The framework is especially suitable for the system with rare damage filed data. In addition, considering the multiple failure modes for the system component, the multi-dimensional Performance Limit State (PLS) function is proposed to estimate the marginal probability for the BNs root nodes. PLSs are properly modeled as interdependent random variables instead of deterministic quantities. Failing to properly account for the dependencies between PLSs, the non-conservative failure probability results will be obtained. Finally, the system reliability can be calculated through the BNs Junction Tree forward inference algorithm, and the most vulnerable components in the system can be identified through backward diagnose inference. The improved ECBNs theory is first applied to the system reliability evaluation for a reinforced concrete bridge to verify its validity.

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