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토끼 귀의 출혈모델에서의 스트렙토키나제-덱스트란 포합체의 혈전용해효과 및 항원성 평가
명평근,최수라,박목순,박진규 충남대학교 약학대학 의약품개발연구소 2000 藥學論文集 Vol.16 No.-
The way in which a thrombolytic agent, streptokinase(SK, Dongkook) and streptokinase-Dextran conjugate(SK-DEX, Russia), cause the dissolution of haemostatic plugs of different ages was investigated in a novel rabbit bleeding model, and antigenicity of SK and SK-DEX was elvalutated by indirect ELISA using antisera collected after 7 days intravenous injection to a rabbit ear. Standardized incisions were made on rabbit ear and the wounds were left to heal for 0.5 h or 24 h, before the thrombolytic agent was infused. SK showed a pronounced fresh colt selectivity since it was significantly more effective in lysing flesh clots than old ones (96% vs 52%) respectively, percent lysis of haemostatic plus of different ages with SK-DEX conjugate (150,000 IU/㎏) was more effective in lysing fresh clots than old ones (20% vs 0%) respectively. The time onset of bleeding observed for SK(Dongkook) (19min) was the same as that of SK (Kabi) (19min), but the bleeding time observed for SK(Dongkook) (90 min) was twice longer than that formed SK(Kabi) (49min). However, the time to onset of bleeding of SK-DEX(Russia) (61min) was longer than that of the formed SK(Dongkook) (19 min). The bleeding time observed for SK-DEX(Russia, 150,000 IU/㎏) (1min) was shorter than that found for SK(Dongkook) (90min). The antigenicity of SK-DEX(Dongkook) was more effective than that of SK(Dongkook) in comparision with each control. These results suggest that the fresh clot selectivity demonstrated for SK and SK-DEX may be clinically beneficial and remains to be clarified by further invertigations.
LED배열을 이용한 광Vector-Matrix 곱셈에 관한 연구
최평석,박한규 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.2
인코히어런트광은 이용하여 vector-matrix 곱셈기를 LED 배열 및 lens계, mask 등으로 구성하였다. 입력 vector 는 LED 배열로 나타내었으며 matrix 는 mask 상에 면적변조방식으로 부호화 하였다. 곱셈의 결과는 lens계를 통하여 photodiode 배열로 검출하였으며 하나의 채널로 출력을 관찰하기 위해 analog multiplexer를 사용하였다. vector 및 matrix의 원소가 양의 실수 및 복소수일 경우에 대하여 출력파형을 관찰하였으며 특히 복소수 data일 경우 mask 상에 부호화 하는 방법을 제시하였다. The vector-matrix multiplier using incoherent optical illumination is constructed with a LED array, lens system and mask. The input vector is represented by a LED array and the matrix is encoded on a film by the mask modulation method. The result of multiplication is detected by a photodiode array through the lens system, and an analog multiplexer is used for looking at output signal on the channel. When the elements of a vector and matrix are positive number and complex number, the output signal is observed. Finally an encoding method in case of complex data is suggested.
정평림,이규재,양용석,안영겸 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1996 Journal of biomedical laboratory sciences Vol.2 No.2
최근 한국에 있어서 광절열두조충 감염예가 가끔 보고되고 있다. 저자등은 1994년 10월 강원도 춘천시 거주 남녀 부부가 함께 담수산 송어회를 먹고 감염된 2예에 대하여 보고하는 바이다. 구충은 하제(下濟)로서 Magnesium sulfate 15gm, 구충제 Praziquantel 15mg/kg를 투여 하였다. 제1예는 인OO, 43세 남자, 69kg의 건강체였으며, 구충하여 얻은 충체는 길이 6.65m, 폭 8-13mm였다. 제2예는 최OO, 39세 여자, 56kg으로 소화불량, 복부 불쾌감을 호소하였고, 구충하여 얻은 충체는 5.50m, 폭 8-13mm이었다. 2예 모두에서 두부는 검출 되지 않았다. 구충하여 얻은 충체의 외관상 형태, 자궁의 선회, 자궁분지(uterine loops)의 수, 생식공의 위치와 절단표본상 음경낭과 저정낭의 형태, 질의 위치, 자궁구의 위치등과 충란을 광학현미경으로 관찰 한 형태, 크기 및 SEM으로 관찰 한 표피의 작은 점각(pits)의 유무, 분포등 형태학적인 특징등으로 Diphyllobothrium latum으로 동정하였다. 이번의 인체 감염은 담수산 송어회가 원인이 된 것으로 믿어지는 예이다. A total of 31 human diphyllobothriasis cases have been reported in Korea. Authors experienced two more human cases of Diphyllobothrium latum infection, especially due to eating raw freshwater trout. Two cases were husband and wife in a famil residing in Chunchon city, Kangwon-do, who raw fish in October 1994. A 43-year old male(husband) was 69kg in body weight and healthy. A worm (6.65m in length; 8-l3mm in width) was expelled from him anthelmintic treatment. The second case(wife) was a 39-year old female who weighted She complained about gastrointestinal trouble and abdominal discomfort. A worm (5.50m in length; 9-l3mm in width) was Obtained her after anthelmintic treatment. No scolex was collected from the two worms. Two patients were administrated with praziquantel(l5mg/kg of body weight) and l5gm of magnesium sulfate as a purgative. Two worms identified as D. latum, based on the following biological characters: extermal morphologies, coiling of uterus, the number of uterine loops, position of genital opening, morphologies of cirrus and cirrus sac and seminal vesicle on the histological sections, positions of vagina and uterine pore, distribution patterns of vitellaria, and microscopical and SEM morphologies of the egg.
박한규,최평석,양혁재 연세대학교 산업기술연구소 1980 논문집 Vol.12 No.2
마이크로스트립 單一共振器를 直列로 연결한 周波數스캐닝 안테나의 製作 및 動作原理에 대하여 고찰하였다. 마이크로스프립 基板의 두께가 1/32inch(0.8mm)이고 比誘電率 εr=2.45를 사용하였을 경우 8.7㎓에서 9.25㎓까지 周波數를 변환시켰을 때 ±30°로 스캐닝 하였으며 이때 共振器 자체의 反射波에 의한 位相偏移가 30%까지 차지하였다. In this paper, the principles and fabrication of the frequency scanning antenna formed by the cascaded array of single resonators are described. As the microstrip substrate, the depth of 1/32 inch and ?? of 2.45 substrate is used and the resultant beam scan angle is 30° from 8.7 ㎓ to 9.25 ㎓ range. It is showed that this scanning is due to the phase shift in a resonator as well as the transmission line and the resonator phase shift responsible for 30% of the total phase shift. Experimental results shows a little discrepancy from the theoretical value and this considered to come from the mis-matching of each resonators.
시장지향성과 전략적 포지션의 관계와 병원성과에 미치는 영향
김평웅,류규수,이용기,김문주 대한보건협회 2002 대한보건연구 Vol.28 No.2
The purpose of this study is to prove that market orientation and strategic positioning are the main factors for obtaining a competitive advantage among hospitals, and to find out co-relationship between market orientation and strategic positioning (strategic differentiation, low-cost strategy/lowering price) among the selected hospitals. First, the analysis of co-relationship between market orientation and differentiation strategy(drawing a distinction from others providing specialized care), the market orientation is more effective on co-relationship compared to the differentiation strategy. Second, among market orientation, differentiation strategy and the low-cost strategy(lowering price), the differentiation strategy is the most effective on the hospital's performance while the market orientated efforts came in second, and the low-cost strategy was last. Third, in the relationship between market orientation and the effect on the hospital's performance, there was no co-relationship among the market orientation, differentiation strategy and the low-cost strategy, however, only the differentiation strategy proved to be playing an intermediary role.