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Toxicity Studies on Peristrophe paniculata (Forssk) Brummitt-an Ayurveda Drug.
R.V. Pradeep Chandran,A. Saraswathy,B. Murali Manohar,S. Vairamuthu 한국생약학회 2008 Natural Product Sciences Vol.14 No.2
Chronic oral toxicity studies (90 days) on aqueous and methanol extracts of the whole plant of Peristrophe paniculata (Forssk) Brummitt were carried out in Wistar rats. The dosage was 200 mg/kg/day, p.o. for both the extracts. All external morphological and biochemical changes, in addition to body weight and vital organ weights were recorded. During this investigation, no significant mortality was observed. The results showed that both the extracts were devoid of any toxicity at the dose level studied as compared to the control group.
Pradeep A. R.,Nair V. S. K. Korean Society of Sericultural Science 2005 International Journal of Industrial Entomology Vol.10 No.2
Though many insecticides are commercially available, development of resistance, pest resurgence and effects on non-target organisms led to the search for alternate insect pest management (IPM) strategy based on larval growth and reproductive fitness. Reproductive potential of insects depends on its acquiring of vitellogenic competence which is under hormonal control. Exogenous application of analogues of JR (JHAs) and ecdysterone could derail normal development and reproduction in insects by manipulating an array of physiological processes. In the rice pest, brown planthopper, Nilaparvata lugens, JHA, hydroprene induced metathetely from the fifth (final) instar nymphs in an age-dependent manner. Day 0 of the final instar showed highest sensitivity to induce this abnormal development. Adults emerged from treated day 3 nymphs looked normal. Both the morphotypes were reproductively incompetent and showed partial to complete sterility. Pre-adult exposure of the ovarian tissue to hydroprene suppressed mitotic division of germinal cells and induced abnormalities in the later s1ages of growth and differentiation of ovary in N. lugens. More over the nymphal exposure to hydroprene inhibited patency changes of follicular epithelium and affected competence of the follicles for yolk sequestration. In the absence of ovarian growth and oocyte differentiation, germarium found disintegrated, trophic core regressed and terminal oocytes resorbed. Hydroprene exposure to newly ecdysed brachypterous females did not affect ovarian development and egg production. Proper larval-adult transition appeared as a. prerequisite for vitellogenic competence in N. lugens for which the ovarian tissues must be exposed to ecdysterone in the internal milieu devoid of JH.
V. Vijayakumar,Pradeep Johnson,Ruban Whenish,A. John Rajan,Vincent H Wilson 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.4
The characteristics of Al 6061/SiCp Metal Matrix Composite (MMC) have been established for checking the suitability oflightweight spur gear using Powder Metallurgy (P/M) technique. Aluminium powder reinforced with SiCp particle withvarious weight.% (0, 5, 10 & 15) and particle sizes (35 μm and 65 μm). The smaller sized spur gears of 4 mm module, 48 mmpitch circle diameter and 22 mm face width were chosen. The complex gear profiled compaction die assembly was manufacturedfor making net shaped gear without any machining operation. The H frame hydraulic press was used to compact gear sampleswith compaction pressures of 132 MPa and 165 MPa. Then gear samples were sintered using muffle furnace at 570 ºC. Theprepared gear samples were used for density measurement, bending strength test, hardness measurement and microstructureanalysis. The research work leads to the observation of Al 6061 with 10 wt.% & 35 μm size of (SiCp) P/M gear exhibiting agreater enhancement of mechanical properties than the unreinforced Al alloy. Thus the effect of adding ceramic particles SiCpwith Al 6061 enhanced the mechanical properties and enabling Al 6061/SiCp composite spur gear suitable for lightweightapplications.
( A. R. Pradeep ),( V. S. K. Nair ) 한국잠사학회 2005 International Journal of Industrial Entomology Vol.10 No.2
Though many insecticides are commercially available, development of resistance, pest resurgence and effects on non-target organisms led to the search for alternate insect pest management (IPM) strategy based on larval growth and reproductive fitness. Reproductive potential of insects depends on its acquiring of vitellogenic competence which is under hormonal control. Exogenous application of analogues of JR (JHAs) and ecdysterone could derail normal development and reproduction in insects by manipulating an array of physiological processes. In the rice pest, brown plan-thopper, Nilaparvata lugens, JHA, hydroprene induced metathetely from the fifth (final) instar nymphs in an age-dependent manner. Day 0 of the final instar showed highest sensitivity to induce this abnormal development. Adults emerged from treated day 3 nymphs looked normal. Both the morphotypes were reproductively incompetent and showed partial to complete sterility. Pre-adult exposure of the ovarian tissue to hydroprene suppressed mitotic division of germinal cells and induced abnormalities in the later stages of growth and differentiation of ovary in N. lugens. More over the nymphal exposure to hydroprene inhibited patency changes of follicular epithelium and affected competence of the follicles for yolk sequestration. In the absence of ovarian growth and oocyte differentiation, germarium found disintegrated, trophic core regressed and terminal oocytes resorbed. Hydroprene exposure to newly ecdysed brachypterous females did not affect ovarian development and egg production. Proper larval-adult transition appeared as a. prerequisite for vitellogenic competence in N. lugens for which the ovarian tissues must be exposed to ecdysterone in the internal milieu devoid of JH.
Wound Healing Activity of the Chloroform Extract of Plumbago rosea Linn. and Plumbagin
A. Saraswathy,R.V. Pradeep Chandran,B. Murali Manohar,S.Vairamuthu 한국생약학회 2006 Natural Product Sciences Vol.12 No.1
wound healing activity of plumbagin and the chloroform extract of Plumbago rosea Linn. (Yoot),incorporated into ointments with yellow soft paraffin, have been investigated on rats. Wound healing activity wasstudied using excision and incision wound models in rats following topical application. Both plumbagin and thePlumbago rosea root extract produced a significant response in both of the wound models studied. The woundPlumbago rosea root extract (0.5%),as against in 22 days in the case of control animals. The results were also comparable to those of a standard drug,framycetin sulphate cream (1% w/w) in terms of wound contracting ability, wound closure time, tensile strengthof wound and regeneration of tissues at the wound site. Histological studies revealed evidences for the healingprocess by formation of fibrovascular tissue, epithelization and increased collagenization when compared tocontrol.Keywordswound healing activity, Plumbago rosea, plumbagin, Plumbaginaceae