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백선(Dyctamnus dasycarpus)복용 후 발생한 간 손상 2예
이화영,김재준,백승운,이종균,이준혁,고광철,이풍렬,이종철,오영륜,지영준 대한소화기학회 1998 대한소화기학회지 Vol.31 No.2
Although drug induced liver injury caused by herbal medicine is considered to be a frequent problem in Korea, there are only a few reports concerning the hepatotoxicity of herbal medicine. We recently experienced two cases of drug induced liver injury caused by ingestion of Dyctamnus dasycarpus, and one of herbal drug used for antipyretic and analgesic purposes. The first patient, a 48 year old man, was admitted due to jaundice after ingestion of the liquor containing Dyctamnus dasycarpus and some other herbal medications for 4 months. All viral markers were negative on admission, and the elevated bilirubin and transamiase levels normalized 5 months later after cessation of all herbal medications. Ten months after the first admission, he ingested only the liquor containing Dyctamnus dasycarpus, with lesser duration and amount, and was readmitted due to general weakness and fatigue and elevated transaminase ($gt;1,000 IU/L). The elevated transaminase level nearly returned to normal after discontinuing the causative agent. The second patient, a 62 year old man, was admitted due to jaundice after ingestion of Dyctamnus dasycarpus. The elevated bilirubin and transamiase levels normalized 4 months later after cessation of the causative agent. Dyctamnus dasycarpus induced liver injury presents with prolonged course lasting more than several weeks to months. Herbal drug induced liver disease should be considered in differential diagnosis of acute liver injury of unknown cause in Korea and we are also suggesting the necessity of a systematic approach for the study of the herbal drugs.
유승화 ( Seung Hwa Yoo ),강태한 ( Tae Han Kang ),백인환 ( In Hwan Paik ),김호준 ( Ho Joon Kim ),이한수 ( Han Soo Lee ),김인규 ( In Kyu Kim ) 한국환경생태학회 2009 한국환경생태학회지 Vol.23 No.4
시화호 초지대의 소각에 의한 조류의 서식 영향에 대한 연구는 2007년 3월에서 10월까지 경기도 화성시 마도면송정리 인근 시화호간척지의 초지에서 실시하였다. 계획소각은 2007년 2월 28일에서 3월 1일까지 시화호 간척지의 초지 중 육상부에 인접한 지역에 대해 실시하였다. 소각지역에서는 총 30종 최대개체수 합계 181개체의 조류가 관찰되었으며, 존치지역에서는 24종 최대개체수 합계 154개체가 관찰되어 소각지역의 관찰조류 종수와 개체수가 높았다. 하지만 우점종은 소각지와 존치지간에 차이가 없었다. 수조류와 산림성조류를 제외한 소각지와 존치지의 평균 종수, 평균개체수, 종 다양도, 종 풍부도는 차이가 없었다. 초기의 군집특성은 계획소각에 의하여 변화하였지만, 후기에는 차이가 감소하였다. 계획소각에 의한 서식지 교란은 일시적으로 새로운 서식지 및 취식장소를 제공하였다. 계획소각이 목본식물의 유입을 차단하여 초지생태계를 유지하는 효과적인 방법이며, 주기적인 계획소각이 초지생태계를 유지 및 관리하는 효율적인 방안임을 제안하고자 한다. This study was presented to effect of prescribed burning to the avian fauna and was conducted from March to October 2007 in Sihwa grassland, Gyeonggi-do, Korea. Prescribed burning was conducted at Sihwa grassland of Songjeong-ri Mado-myeon, Hwaseong city from 28th February to 1st March 2007. Thirty birds species were observed and sum of the maximum count was 181 individuals at the prescribed burning area for all survey time. Observed species was 24 species and sum of the maximum count was 154 individuals on the unburned area. Number of species and sum of the maximum count at the prescribed burning area was greater than unburned area. There is no differences in the dominant species between prescribed and unburned area. Average number of species, number of individuals, species diversity and species richness of the prescribed burning area were greater than unburned area in early stage (from March to June) after prescribed burning. Community indices in burned area during early season were different with unburned area by prediscribed burning. However, the indices had became similar between burned and unburned area as time goes by. Disturbance by prescribed burning created new habitat and feeding site temporarily for the avian species in grassland. We would suggest that prescribed burning is most effective method to maintain grassland ecosystem from the invading bush or tree and periodical prescribed burning is a good method to preserve and manage the grassland ecosystem.
이화영,김재준,백승운,이풍렬,이종철,고광철,고재향 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.2
Backgroud/Aims: Helicobacter pylori is found in more than 90% of patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Regression of lymphoma after H. pylori eradication was reported. Therefore, early detection of gastric MALT lymphoma is important. On reported several endoscopic findings, nonspecific gastritis with erosion and ulceration were common and there is no typical endoscopic findings. Methods: Therefore we analyzed the endoscopic findings of 16 low-grade B-cell gastric MALT lymphoma confirmed by biopsy, PCR and immunostain and compared histologic change after eradicating H. pylori infection in patients who refused operation retrospectively from March 1995 to October 1996. Results: The male: female ratio was 7:9 and mean age was 43,7 years ald (23-71 yr), On endoscopic findings of gastric MALT lymphoma, irregular shaped geographic superficial ulcer was 7 cases (43.7%), diffuse mucosal nodularity was 4 cases (25.0%) and erosion was 3 cases (18.7%). The most common site of MALT lymphoma was antrum and angle. H. pylori was positive in 87.5% (14/16 cases) and eradication of H. pylori was done in patients who refused operation and histologic improvement after H. pylori eradication was found in 62.5% (5/8 cases). Conclusion: The most common endoscopic findings of gastric MALT lymphoma was irregular geographic superficial ulcer but diffuse mucosal nodularity and erosions were also common. Therefore, biopsy must be taken, especially on the antrum and angle although nonspecific lesion may be suspected.
건강 검진자에서 역류성 식도염의 유병률 및 위험 인자에 대한 환자 -대조군 연구
이화영,김재준,최규완,백승운,고광철,이풍렬,이종철,손정일,신명희,전성국,현재근 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6
Background/Aims: There were few epidemiological data on reflux esophagitis in Korea. The aim o this study was to estimate the prevalence and risk factors of reflux esophagitis in Korea. Methods We examined 8314 subjects (male 4,876, female 3,438, age: 18-83 year) visiting health promotion center for routine check-up including EGD. All of them were given a questionnaire about smoking alcohol consumption, exercise, diet habits, use of drugs and medical history. We estimated the prevalence of reflux esophagitis and performed a case-control study to evaluate the risk factors of reflux esophagitis. We recruited 200 cases with reflux esophagitis and 400 controls without reflux esophagitis on EGD. Results: The prevalence of reflux esophagitis was 3.73% in male and 0.81% in female. The age-adjusted prevalence was 3.19% in male and 1.66% in female. The prevalence in male was significantly higher than that in female (p$lt;0.01). On the monovariate analysis, smoking and body mass index were significantly related with reflux esophagitis (p$lt;0.05). On the multivariate analysis, smoking was a significant risk factor of reflux esophagitis (p$lt;0.05). Conclusions: The prevalence of reflux esophagitis in subjects who had routine check-up was 3.73% in male and 0.81% in female. Smoking is suggested to be a significant risk factor of reflux esophagitis.
설명되지 않는 비심인성 흉통 환자의 식도 내장 과민성과 팽창성에 관한 연구
이화영,김재준,강인구,백승운,고광철,이풍렬,이종철,전성국 대한소화기학회 1998 대한소화기학회지 Vol.31 No.3
Background/Aims: Reduced visceral pain threshold as a cause of noncardiac chest pain is a subject of controversy. Compliance and pain perception are different in the smooth and striated muscle segments of the esophagus. The aim of this study is to evaluate the difference in visceral pain threshold and compliance of the upper and lower esophagus between patients with unexplained noncardiac chest pain and healthy controls. Methods: We examined 8 healthy controls (3 male, mean age: 24.5 years) and 8 patients with chest pain (3 male, mean age: 51.5 years) who were normal in coronary angiography or exercise myocardium perfusion scan and show normal finding on EGD, esophageal manometry and 24-hr esophageal pH monitoring. Intraesophageal balloon was placed at 5 cm above LES. Symptoms and intraballoon volumes were recorded while intaballoon pressure was increased in 1 mmHg increments using Barostat system (Distender series II^(R)). The above measurernents were repeated after the balloon was positioned 5 cm below UES. Compliance was also measured. Results: 1) At initial perception, intraballoon pressure (mmHg) of the upper and lower esophagus was not significantly different between the patients group (3.9±2.0, 6.5±4.7 respectively) and the control group (3.8±1.3, 6.5±3.0). Intraballoon volumes (ml) were not significantly different between patients (14.5±6.5, 22.0±10.2) and controls (11.5±2.8, 18.8±11.7). 2) During chest pain, intraballoon pressure (mmHg) of the upper and lower esophagus was not significantly different between patients (9.0±3.9, 17.6±9.6 respectively) and the controls (8.5±3.2, 12.9±3.2). Intraballoon volume (ml) was not significantly different between the patients (30.8±17.0, 62.9±32.0) and the controls (27.6±10.6, 44.6±15.4). 3) Esophageal compliance (ml/mmHg) of the upper and lower esophagus was not significantly different between patients (3.6±1.3, 3.9±2.3) and controls (3.1±0.3, 3.2±0.9). Conclusions: There was no difference in the visceral sensitivity and compliance of the upper and lower esophagus between patients with unexplained noncardiac chest pain and healthy controls.