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다양한 신경학적 이상을 나타낸 glufosinate ammonium(바스타®) 급성 경구 중독 1례
백진휘 ( Jin Hui Paik ),김준식 ( Jun Sig Kim ),이현규 ( Hyeon Gyu Yi ),박현주 ( Hyun Joo Park ),하충건 ( Choong Kun Ha ),노형근 ( Hyung Keun Roh ) 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2
BASTA is an herbicide which contains glufosinate ammonium as a main component with an anionic surfactant, polyoxyethylene alkylether sulfate, and nonselectively inhibits glutamine synthetase. It became a wildly used herbicide in Korea and its intoxication is now increasing. A 42-year old woman ingested about 300ml of BASTA in a suicide attempt. She showed unconsciousness and respiratory distress in the beginning, and later developed multiple generalized convulsions, low blood pressure, fever and diabetes insipidus. Although she became alert 12 days after the ingestion, she showed retrograde amnesia for a period of about recent 10 years. A neuropsychological test on day 22 revealed frontal lobe dysfunction, visual memory disturbance and slight decrease in visuospatial function. All these neurological abnormalities that might occur due to glufosinate ammonium were almost improved in the followup test performed a month later.
A Study on the Community Characteristics and Habitat use of Birds in Goseong-gun, Gangwon-do, Korea
Jin, Seon-Deok,Yu, -Jae-Pyoung,Paik, In-Hwan,Kang, Jung-Hoon,Kim, In-Kyu,Han, Sung-Woo,Kang, Tae-Han,Kim, Wan-Byung,Park, Chi-Young,Kim, Seok-Yee,Kang, Sung-Jun,Jeon, Hui-Bae,Paek, Woon-Kee national science museum of korea 2010 Journal of Korean nature Vol.3 No.4
This study was conducted to clarify the community characteristics of birds in Goseong-gun, Gangwon-do, Korea at June and September of 2010. The result observed a total of 6,557 birds of 98 species. Dominant species included, in decreasing order, Larus crassirostris 3,319 counts (50.62%), Passer montanus 664 counts (10.13%), Sterna hirundo 208 counts (3.17%), Paradoxornis webbianus and Egretta alba modesta 178 counts (2.71%). In terms of the families, the herons showed a total of 7 species at 303 counts, the ducks showed 4 species of 185 counts, the raptors showed 6 species of 26 counts, the waders showed 13 species of 114 counts, the gulls showed 8 species of 3,585 counts, the passerine birds showed 56 species of 2,323 counts and others (Grebe, Cormorant, Pheasant, Moorhen) showed only 4 species of 26 counts. In terms of the number of species' habitat usage, the forest area showed the highest level of species at 52 species, and human inhabited areas showed the lowest level at 14 species.
강진아 ( Jin Ah Kang ),김강호 ( Kang Ho Kim ),백진휘 ( Jin Hui Paik ),홍대영 ( Dae Young Hong ),김지혜 ( Ji Hye Kim ),이경미 ( Kyoung Mi Lee ),김준식 ( Jun Sig Kim ),한승백 ( Seung Baik Han ) 대한외상학회 2006 大韓外傷學會誌 Vol.19 No.1
Penetrating facial wounds are uncommon and are usually life threatening because of the possibility of brain damage. There are three possible pathways for penetrating the cranium through the orbit: via the orbital roof, via the superior orbital fissure, or between the optic canal and lateral wall of the orbit. Brain injuries resulting from the penetrating wounds show extensive parenchymal damage, hemorrhage, and brain edema. Transorbital penetrating wounds can lead to diverse lesions of the optical apparatus, including the eye globe, the optical nerve, and the chiasm. Moreover, intracerebral structures may be hurt, and bleeding and infection may occur. Early diagnosis and prompt debridement are the fundamental factors affecting the outcome of a penetrating facial wound. An 87-year-old man was admitted to the emergency department with a grinder impacted into the medial aspect of the right eye. On presentation, the man was fully conscious with a Glasgow Coma Scale score of 15 and complained of a visual disturbance of the right eye. Computed tomography demonstrated a right orbital medial and inferior wall fracture, a frontal bone fracture, and a contusional hemorrhage in frontal lobe of the brain. A craniotomy with hematoma removal and repair of the orbital floor was done. He showed no neurological deficits except right visual loss. This appears to be the first report of a man with a penetrating facial wound caused by a grinder, who presented with a potentially disastrous craniocerebral injury that did not lead to any serious neurological seguelae. (K Korean Soc Traumatol 2006;19:89-92)
CXCR4 antagonist inhibits perineural invasion of adenoid cystic carcinoma
Jeong, Woo-Jin,Choi, Ik Joon,Park, Min-Woo,An, Soo-Youn,Jeon, Eun-Hui,Paik, Jin Ho,Sung, Myung-Whun,Ahn, Soon-Hyun BMJ Publishing Group Ltd 2014 Journal of clinical pathology Vol.67 No.11
<P><B>Aim</B></P><P>Perineural invasion and expression of CXCR4 is characteristic of adenoid cystic carcinoma (ACC). Herein, we aimed to demonstrate CXCR4 expression in ACC, identify its association with perineural invasion and investigate the impact of CXCR4 inhibitor in vitro and in a murine perineural invasion model.</P><P><B>Methods</B></P><P>Expression of CXCR4 was assessed in ACC cell lines and in human tissue. The effects of gene knockdown using siRNA and specific blocker of CXCR4 (AMD3100) were evaluated in vitro. A preclinical perineural invasion model was developed using BALB/c nude mouse. The effect of AMD3100 was evaluated in vivo.</P><P><B>Results</B></P><P>CXCR4 was highly expressed in aggressive strains of ACC in vitro, in the tumour in the animal model and in the tumour of human tissue. SDF-1 expression was also demonstrated in the nerve of murine and human tissue. Gene knockdown by siRNA and inhibition by a CXCR4-specific inhibitor AMD3100 effectively abrogated invasion but not proliferation of ACC in vitro. The rate of perineural invasion was significantly decreased with AMD3100 treatment in the animal model.</P><P><B>Conclusions</B></P><P>CXCR4 is associated with perineural invasion in ACC. AMD3100, which can effectively diminish perineural invasion of ACC, may have an adjuvant role in the management of ACC.</P>
김재진 ( Jae Jin Kim ),윤성현 ( Sung Hyun Yun ),정현민 ( Hyun Min Jung ),김지혜 ( Ji Hye Kim ),한승백 ( Seung Baik Han ),김준식 ( Jun Sig Kim ),백진휘 ( Jin Hui Paik ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.1
Ethylene glycol poisoning is treated mainly by alcohol dehydrogenase inhibition therapy and hemodialysis. Early recognition and initiation of treatment is important because toxic metabolites increase over time by hepatic metabolism; however, there is no confirmative diagnostic tool in our clinical setting. Therefore, diagnosis is dependent on history, high anion gap acidosis, high osmolal gap, etc.. Diagnosis and treatment are delayed in cases where history taking is not possible, such as a mental changed patient. Authors report on two cases of ethylene glycol poisoning by contrasting clinical outcomes, demonstrating the importance of early diagnosis and treatment for achievement of a good outcome.
Chang, Yongmin,Paik, Jong Soo,Lee, Hui Joong,Chang, Hyuk Won,Moon, Hye-Jin,Allen, Richard P,Earley, Christopher J,Cho, Yong Won Butterworths [etc.] 2014 Neurological research Vol.36 No.8
<P>A prior diffusion tensor imaging (DTI) of restless legs syndrome (RLS) subjects found alterations in brain white matter (WM). The aim of this study was to explore the possible mechanism of altered integrity of brain WM in RLS patients.</P>
Sung Ho Kyung,Paik Jin Hui,Lee Yu Jin,Kang Soo 대한의학회 2021 Journal of Korean medical science Vol.36 No.16
Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted various aspects of daily living and has influenced the life of every individual in a unique way. Acute myocardial infarction (AMI) is associated with high morbidity and mortality; thus, timely treatment is crucial to prevent poor prognosis. Therefore, an immediate emergency department (ED) visit is required; however, no domestic studies have reported the effect of COVID-19 on ED visits by patients with AMI. Therefore, this study aimed to assess the changes in the pattern of ED visits by patients with AMI by comparing visits during the COVID-19 outbreak period to those during two control periods. Methods: This nationwide, retrospective study used registry data of the National Emergency Department Information System. The ‘outbreak period’ was defined as the period between February 21, 2020 and April 1, 2020, while the ‘control period’ was defined as the same time period in the preceding two years (2018 and 2019). The primary outcome of our study was the number of patients admitted to the ED owing to AMI during the outbreak and control periods. Secondary outcomes were time from symptom onset to ED visit, length of ED stay, and 30-day mortality following admission. Results: During the outbreak period, 401,378 patients visited the ED; this number was lower than that during the control periods (2018: 577,548; 2019: 598,514). The number of patients with AMI visiting the ED was lower during the outbreak period (2,221) than during 2018 (2,437) and 2019 (2,591). Conclusion: The COVID-19 pandemic has caused a reduction in ED visits by patients with AMI. We assume that this could likely be caused by misinterpretation of AMI symptoms as symptoms of respiratory infection, fear of contracting severe acute respiratory syndrome coronavirus 2, and restrictions in accessing emergency medical care owing to overburdened healthcare facilities. This study sheds light on the fact that healthcare and emergency medical staff members must work towards eliminating hurdles due to this pandemic for patients to receive timely emergency care, which in turn will help curb the growing burden of mortality.
글리포세이트 중독 환자의 임상 양상 및 사망 관련 인자 분석
은희민 ( Hee Min Eun ),백진휘 ( Jin Hui Paik ),서주현 ( Joo Hyun Suh ),정진희 ( Jin Hee Jung ),어은경 ( Eun Kyung Eo ),노형근 ( Hyung Keun Roh ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.2
Purpose: Glyphosate is widely used and its toxic exposures are not rare. Occasionally, glyphosate intoxication can lead to death. The aim of this study is to analyze clinical findings and fatality in glyphosate intoxication. Methods: Clinical data on acute glyphosate intoxication were prospectively collected at 28 hospitals nationwide between August 2005 and July 2006. The patients’ clinical symptoms and characteristics of fatalities were investigated and statistical analysis was performed. Results: Among 105 patients who were finally included, gastrointestinal symptoms(59%) were the most common. A significant difference in the amount ingested was observed between patients with higher systolic blood pressure and those with systolic blood pressure less than or equal to 80 mmHg (p<0.001). The more the patients ingested, the more aggravated their mental status became (p=0.004). Seven patients(6.7%) died, and all of them had ingested greater than or equal to 200 ml. Patients who died had ingested greater amounts than the survivors (p<0.001), and their mental status was worse (p<0.001), and systolic blood pressure was lower (p<0.001). According to the result of logistic regression analysis, relative risk was 24.1-fold higher in the ‘poor’ mental status group compared with ‘good’. Conclusion: Patients who ingested large amounts of glyphosate showed poor mental status and lower blood pressure. Statistical difference in amount ingested, mental status, and systolic blood pressure was observed between survivors and patients who died. Ingested amounts and mental status were the most important factor of the prognosis of glyphosate intoxication.
다양한 신경학적 이상을 나타낸 glufosinate ammonium(바스타$^{(R)}$) 급성 경구 중독 1례
백진휘,김준식,이현규,박현주,하충건,노형근,Paik Jin Hui,Kim Jun Sig,Yi Hyeon Gyu,Park Hyun Joo,Ha Choong-Kun,Roh Hyung-Keun 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2
BASTA is an herbicide which contains glufosinate ammonium as a main component with an anionic surfactant, polyoxyethylene alkylether sulfate, and nonselectively inhibits glutamine synthetase. It became a wildly used herbicide in Korea and its intoxication is now increasing. A 42-year old woman ingested about 300ml of BASTA in a suicide attempt. She showed unconsciousness and respiratory distress in the beginning, and later developed multiple generalized convulsions, low blood pressure, fever and diabetes insipidus. Although she became alert 12 days after the ingestion, she showed retrograde amnesia for a period of about recent 10 years. A neuropsychological test on day 22 revealed frontal lobe dysfunction, visual memory disturbance and slight decrease in visuospatial function. All these neurological abnormalities that might occur due to glufosinate ammonium were almost improved in the follow-up test performed a month later.