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Ersoy, Hakan,Ozpolat, Lutfiye,Civalek, Omer Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.32 No.5
A numerical method is developed to investigate the effects of some geometric parameters and density variation on frequency characteristics of the circular and annular membranes with varying density. The discrete singular convolution method based on regularized Shannon's delta kernel is applied to obtain the frequency parameter. The obtained results have been compared with the analytical and numerical results of other researchers, which showed well agreement.
Hakan Ersoy,Lutfiye Ozpolat,Omer Civalek 국제구조공학회 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.32 No.5
A numerical method is developed to investigate the effects of some geometric parameters and density variation on frequency characteristics of the circular and annular membranes with varying density. The discrete singular convolution method based on regularized Shannon’s delta kernel is applied to obtain the frequency parameter. The obtained results have been compared with the analytical and numerical results of other researchers, which showed well agreement.
Lycopene Protects Against Spontaneous Ovarian Cancer Formation in Laying Hens
Kazim Sahin,Engin Yenice,Mehmet Tuzcu,Cemal Orhan,Cengizhan Mizrak,Ibrahim H. Ozercan,Nurhan Sahin,Bahiddin Yilmaz,Birdal Bilir,Bulent Ozpolat,Omer Kucuk 대한암예방학회 2018 Journal of cancer prevention Vol.23 No.1
Background: Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene’s molecular mechanisms of action in ovarian cancer have not been fully understood. Therefore, in the present study, we investigated the effects of lycopene on the ovarian cancer formation using the laying hen model, a biologically relevant animal model of spontaneous ovarian carcinogenesis due to high incidence rates similar to humans. Methods: In this study, a total of 150 laying hens at age of 102 weeks were randomized into groups of 50: a control group (0 mg of lycopene per kg of diet) and two treatment groups (200 mg or 400 mg of lycopene per kg of diet, or ~26 and 52 mg/d/hen, respectively). At the end of 12 months, blood, ovarian tissues and tumors were collected. Results: We observed that lycopene supplementation significantly reduced the overall ovarian tumor incidence (P < 0.01) as well as the number and the size of the tumors (P < 0.004 and P < 0.005, respectively). Lycopene also significantly decreased the rate of adenocarcinoma, including serous and mucinous subtypes (P < 0.006). Moreover, we also found that the serum level of oxidative stress marker malondialdehyde was significantly lower in lycopene-fed hens compared to control birds (P < 0.001). Molecular analysis of the ovarian tumors revealed that lycopene reduced the expression of NF-B while increasing the expression of nuclear factor erythroid 2 and its major target protein, heme oxygenase 1. In addition, lycopene supplementation decreased the expression of STAT3 by inducing the protein inhibitor of activated STAT3 expression in the ovarian tissues. Conclusions: Taken together, our findings strongly support the potential of lycopene in the chemoprevention of ovarian cancer through antioxidant and anti-inflammatory mechanisms. (J Cancer Prev 2018;23:25-36)