Spinal Hydatid Cyst Disease : Challenging Surgery - an Institutional Experience

Caglar, Yusuf Sukru,Ozgural, Onur,Zaimoglu, Murat,Kilinc, Cemil,Eroglu, Umit,Dogan, Ihsan,Kahilogullari, Gokmen The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.2

Objective : Hydatid cyst disease is caused by the parasite Echinococcus granulosus. It is rarely seen in the vertebral system, occurring at a rate of 0.2-1%. The aim of this study is to present 12 spinal hydatid cyst cases, and propose a new type of drainage of the cyst. Methods : Twelve cases of spinal hydatid cysts, surgical operations, multiple operations, chronic recurrences, and spinal hydatic cyst excision methods are discussed in the context of the literature. Patients are operated between 2005 and 2016. All the patients are kept under routine follow up. Patient demographic data and clinicopathologic characteristics are examined. Results : Six male and six female patients with a median age of 38.6 at the time of surgery were included in the study. Spinal cyst hydatid infection sites were one odontoid, one cervical, five thoracic, two lumbar, and three sacral. In all cases, surgery was performed, with the aim of total excision of the cyst, decompression of the spinal cord, and if necessary, stabilization of the spinal column. Mean follow up was 61.3 months (10-156). All the patients were prescribed Albendazole. Three patients had secondary hydatid cyst infection (one lung and two hepatic). Conclusion : The two-way drainage catheter placed inside a cyst provides post-operative chlorhexidine washing inside the cavity. Although a spinal hydatid cyst is a benign pathology and seen rarely, it is extremely difficult to achieve a real cure for patients with this disease. Treatment modalities should be aggressive and include total excision of cyst without rupture, decompression of spinal cord, flushing of the area with scolicidal drugs, and ensuring spinal stabilization. After the operation the patients should be kept under routine follow up. Radiological and clinical examinations are useful in spotting a recurrence.

Comparative Analysis of Vertebroplasty and Kyphoplasty for Osteoporotic Vertebral Compression Fractures

Melih Bozkurt,Gokmen Kahilogullari,Mevci Ozdemir,Onur Ozgural,Ayhan Attar,Sukru Caglar,Can Ates 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.1

Study Design: A retrospective study. Purpose: The aim of this study is to compare the efficacy and outcome of vertebroplasty compared with unipedicular and bipedicular kyphoplasty for the treatment of osteoporotic vertebral compression fractures in terms of pain, functional capacity and height restoration rates. Overview of Literature: The vertebroplasty procedure was first performed in 1984 for the treatment of a hemangioma at the C2 vertebra. Kyphoplasty was first performed in 1998 and includes vertebral height restoration in addition to using inflation balloons and high-viscosity cement. Both are efficacious, safe and long-lasting procedures. However, controversy still exists about pain relief, improvement in functional capacity, quality of life and height restoration the superiority of these procedures and assessment of appropriate and specific indications of one over the other remains undefined. Methods: Between 2004 and 2011, 296 patients suffering from osteoporotic vertebral compression fracture underwent 433 vertebroplasty and kyphoplasty procedures. Visual analogue scale (VAS), the Oswestry Disability Index (ODI) and height restoration rates were used to evaluate the results. Results: Mean height restoration rate was 24.16%±1.27% in the vertebroplasty group, 24.25%±1.28% in the unipedicular kyphoplasty group and 37.05%±1.21% in the bipedicular kyphoplasty group. VAS and ODI scores improved all of the groups. Conclusions: Vertebroplasty and kyphoplasty are both effective in providing pain relief and improvement in functional capacity and quality of life after the procedure, but the bipedicular kyphoplasty procedure has a further advantage in terms of height restoration when compared to unipedicular kyphoplasty and vertebroplasty procedures.

Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

Ozgur Firat,Ozer Makay,Levent Yeniay,Goksel Gokce,Cigdem Yenisey,Ahmet Coker 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.93 No.1

Purpose: Lipid peroxidation and consequent reactive oxygen species in the setting of oxidative stress have crucial roles in liver regeneration, which may adversely affect the regeneration itself and lead to liver failure. The aim of the current study is to investigate whether omega-3 fatty acid supplementation inhibits oxidative stress in an experimental model of liver regeneration. Methods: Forty rats were allocated to four groups. Rats in group A received a sham operation. Rats in group B were subjected to right portal vein ligation (RPVL) and saline infusion. Rats in groups C and D were subjected to RPVL and total parenteral nutrition (TPN) with an all-in-one admixture containing a soybean oil based lipid emulsion. Rats in group D were additionally supplemented with omega-3 fatty acid infusion. Oxidative stresses in the blood and liver were measured by glutathione, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, and nitric oxide. Results: Omega-3 supplementation to the TPN solution significantly corrected alterations in the blood and tissue concentrations of oxidants and anti-oxidants during regeneration (P < 0.05). Conclusion: Omega-3 fatty acid supplementation to the TPN solution revealed promising results in removal of oxidative stress that emerges during liver regeneration.

A Flight Data Visualization Framework

Ozgur Aydin Yuksel,Jae Sug Ki 한국정보과학회 2003 한국정보과학회 학술발표논문집 Vol.2003 No.2

Chemical composition and anti-biofilm activity of Thymus sipyleus BOISS. subsp. sipyleus BOISS. var. davisianus RONNIGER essential oil

Ozgur Ceylan,Aysel Ugur 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6

In this study, antimicrobial and antibiofilmactivities and the chemical composition of Thymus sipyleusBOISS. subsp. sipyleus BOISS. var. davisianus RONNIGERessential oil was evaluated. The essential oil wasobtained by hydro-distillation and analyzed by gas chromatography-mass spectrometry. Fourteen compounds werecharacterized, having as major components thymol(38.31 %) and carvacrol (37.95 %). Minimum inhibitoryconcentrations (MICs) of oil and the major componentswere calculated by serial dilution method, and anti-biofilmeffects by microplate biofilm assay against five Grampositive (Staphylococcus aureus MU 38, MU 40, MU 46,MU 47, Stahylococcus epidermidis MU 30) and five Gramnegative (Pseudomonas aeruginosa MU 187, MU 188, MU189, Pseudomonas fluorescens MU 180, MU 181) bacteria. It was found that MICs for essential oil, thymol and carvacrolwere between 5 and 50 ll/ml, 0.125–0.5 lg/ml and0.125–05 ll/ml, respectively. The results showed thatdoses of MIC produced a greater anti-biofilm influencethan 0.5, 0.25 and 0.125 MIC. In the presence of essentialoil (MIC), the mean biofilm formation value was equal to67 ± 5.5 % for P. aeruginosa MU 188, and essential oil(MIC) inhibition exceeds 60 % for P. aeruginosa biofilms. The results also showed that carvacrol (MIC) was able toinduce an inhibition 72.9 ± 4.1 % for S.aureus (MU 40)biofilm. In addition, thymol (MIC) showed 68.6 ± 5.3 %reduction in biofilm formation of P. fluorescens MU 181. This study demonstrated the antimicrobial and antibiofilmactivity of T. sipyleus BOISS. subsp. sipyleus BOISS. var. davisianus RONNIGER essential oil and points out theexceptional efficiency of thymol and carvacrol, whichcould represent candidates in the treatment of Pseudomonasand Staphylococcus biofilms.

A Flight Data Visualization Framework

Ozgur Aydin Yuksel,Jae Sug Ki 한국HCI학회 2003 한국HCI학회 학술대회 Vol.2003 No.2

On Semiparallel and Weyl-semiparallel Hypersurfaces of Kaehler Manifolds

Ozgur, Cihan,Murathan, Cengizhan,Arslan, Kadri Department of Mathematics 2009 Kyungpook mathematical journal Vol.49 No.1

We study on semiparallel and Weyl semiparallel Sasakian hypersurfaces of Kaehler manifolds. We prove that a (2n + 1)-dimensional Sasakian hypersurface M of a (2n+2)-dimensional Kaehler manifold $\widetilde{M}^{2n+2}$ is semiparallel if and only if it is totally umbilical with unit mean curvature, if dimM = 3 and $\widetilde{M}^4$ is a Calabi-Yau manifold, then $\widetilde{M}$ is flat at each point of M. We also prove that such a hypersurface M is Weyl-semiparallel if and only if it is either an ${\eta}$-Einstein manifold or semiparallel. We also investigate the extended classes of semiparallel and Weyl semiparallel Sasakian hypersurfaces of Kaehler manifolds.

Harmony Search Algorithm for Continuous Network Design Problem with Link Capacity Expansions

Ozgur Baskan 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.1

The Continuous Network Design Problem (CNDP) deals with determining the set of link capacity expansions and the corresponding equilibrium link flows which minimizes the system performance index defined as the sum of total travel times and investment costs of link capacity expansions. In general, the CNDP is characterized by a bilevel programming model, in which the upper level problem is generally to minimize the total system cost under limited expenditure, while at the lower level problem, the User Equilibrium (UE)link flows are determined by Wardrop’s first principle. It is well known that bilevel model is nonconvex and algorithms for finding global or near global optimum solutions are preferable to be used in solving it. Furthermore, the computation time is tremendous for solving the CNDP because the algorithms implemented on real sized networks require solving traffic assignment model many times. Therefore, an efficient algorithm, which is capable of finding the global or near global optimum solution of the CNDP with less number of traffic assignments, is still needed. In this study, the Harmony Search (HS) algorithm is used to solve the upper level objective function and numerical calculations are performed on eighteen link and Sioux Falls networks. The lower level problem is formulated as user equilibrium traffic assignment model and Frank-Wolfe method is used to solve it. It has been observed that the HS algorithm is more effective than many other compared algorithms on both example networks to solve the CNDP in terms of the objective function value and UE traffic assignment number.

ON THE SEQUENCES RELATED TO FIBONACCI AND LUCAS NUMBERS

OZGUR NIHAL YILMAZ Korean Mathematical Society 2005 대한수학회지 Vol.42 No.1

In this paper, we obtain some properties of the sequences $U^{q}_n\;and\;V^{q}_n$ introduced in [6]. We find polynomial representations and formulas of them. For q = 5, $U^{5}_n$ is the Fibonacci sequence $F_n\;and\;V^{5}_n$ is the Lucas sequence $L_n$.

The Central Dislocation of Femoral Head in the Transverse and Both Column Acetabular Fractures: Is It Really Medialized?

( Ozgur Selek ),( Ahmet Y. Sarlak ) 대한고관절학회 2017 Hip and Pelvis Vol.29 No.3

Purpose: We hypothesized that the central dislocation of the femoral head does generally not occur in transverse acetabular fractures, although it does usually occur in both column fractures. Material and Methods: Fifty-two transverse and both column acetabular fracture cases were evaluated retrospectively. The distances between (a) the sciatic notch on the fracture side and the vertical axis of the pelvis (VA line) and (b) the contralateral intact sciatic notch and the VA line were measured. The a/b ratio corresponded to the superior iliac segment displacement or rotation. The ratio of the distance between the fracture side femoral head and the VA line (c) and the distance between the contralateral intact femoral head and the VA line (d) corresponded to the femoral head displacement. The width of ischium (e) on fractured side and (f) contralateral side were measured. The e/f ratio increment reflected ischiadic fragment mobility. Results: The median value of femoral head displacement (c/d) of the transverse fracture group (n=25) was 1.02 (1.000-1.07). Ischiadic fragment rotation (e/f ratio) of the transverse fracture group was 1.000. The median value of femoral head displacement (c/d) of the both column fractures (n=27) was 0.78 (0.64-0.85). Ischiadic fragment rotation (e/f ratio) of the both-column group was 1.15 (1.06-1.23). The differences between groups according to measurements were statistically significant. Conclusion: In contrary to Letournel description, our findings showed no medialization of femoral head in transverse acetabular fractures in general. This might be an illusion resulting from external rotation of the superior iliac segment.