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Biochar-supported nanomaterials for environmental applications
Oscar M. Rodriguez-Narvaez,Juan Manuel Peralta-Hernandez,Ashantha Goonetilleke,Erick R. Bandala 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.78 No.-
Immobilizing nanomaterials in highly porous, surface active, structurally stable biochar creates novelnanocomposites that combines the well-known advantages of both materials. The exceptionalcontaminant adsorption and/or catalytic degradation capabilities of these nanocomposites haveattracted the attention of the scientific community for possible use in environmental applications. Thispaper reviews the different methodologies for synthesizing biochar-supported nanomaterials, the keyphysical and chemical characteristics of these nanomaterials, and their performance in environmentalapplications, as well as identifies current knowledge gaps and potential directions for further researchand development.
Valorization of rice bran: Modified supercritical CO2 extraction of bioactive compounds
Oscar Benito-Román,Sandra Varona,María Teresa Sanz,Sagrario Beltrán 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
In this work, as afirst step in a comprehensive strategy for the valorization of rice bran, the extraction ofoil using supercritical CO2 and ethanol as cosolvent has been studied. The effect of extractiontemperature (40 and 60 C), pressure (30 and 40 MPa) and amount of ethanol used (0, 5 and 10%) has beenconsidered. The quality extracted oil has been evaluated in terms of antioxidant activity, fatty acid profileand bioactive compounds such as phenolics,flavonoids, g-oryzanols, and tocopherols content. Results revealed that, using neat CO2, the best oil in terms of antioxidant activity was obtained at 40 Cand 30 MPa. However, the addition of ethanol as modifier significantly increased the amount of bioactivemolecules extracted and hence the overall antioxidant activity of the oil, which was maximum at 40 MPaand 10% ethanol, regardless the temperature. The use of ethanol also affected the amount of fatty acidsand g-oryzanols extracted.
Upper Cervical Spine Trauma: WFNS Spine Committee Recommendations
Oscar L. Alves,Leopoldina Pereira,김세훈,Andrey Grin,Nobuyuki Shimokawa,Nikolay Konovalov,Mehmet Zileli 대한척추신경외과학회 2020 Neurospine Vol.17 No.4
Craniovertebral junction (CVJ) trauma is a challenging clinical condition. Being a highly mobile functional unit at the junction of the skull and the vertebral column, traumatic events in this area may produce devastating neurological complications and death. Additionally, many of the CVJ traumatic injuries can be left undiagnosed or even raise difficult treatment dilemmas. We present a literature review in the format of recommendations on the diagnosis and management of different scenarios for upper cervical trauma and produce recommendations, which can be applicable to various areas of the globe.
Oscar Antonio Ortega-Rivera,Pamela Gallegos-Alcalá,Mariela Jiménez,J. Luis Quintanar,Flor Torres-Juarez,Bruno Rivas-Santiago,Susana del Toro-Arreola,Eva Salinas 한국유방암학회 2023 Journal of breast cancer Vol.26 No.2
Purpose: Conventional therapies and surgery remain the standard treatment for breast cancer. However, combating the eventual development of metastasis is still a challenge. Newcastle disease virus (NDV) is one of the various species of viruses under clinical evaluation as a vector for oncolytic, gene-, and immune-stimulating therapies. The purpose of this study was to evaluate the antitumor activity of a recombinant NDV (rNDV-P05) in a breast cancer murine model. Methods: Tumors were induced by injecting the cellular suspension (4T1 cell line) subcutaneously. The virus strain P05 was applied three times at intervals of seven days, starting seven days after tumor induction, and was completed 21 days later. Determination of tumor weight, spleen index, and lung metastasis were done after sacrificing the mice. Serum levels of interferon (IFN)-α, IFN-γ, tumor necrosis factor (TNF)-α, and TNF-related apoptosis-inducing ligand (TRAIL) were quantified by enzyme-linked immunosorbent assay. CD8+ infiltrated cells were analyzed by immunofluorescence. Results: rNDV-P05 showed a route-of-administration-dependent effect, demonstrating that the systemic administration of the virus significantly reduces the tumor mass and volume, spleen index, and abundance of metastatic clonogenic colonies in lung tissue, and increases the inhibition rate of the tumor. The intratumoral administration of rNDV-P05 was ineffective for all the parameters evaluated. Antitumor and antimetastatic capability of rNDV-P05 is mediated, at least partially, through its immune-stimulatory effect on the upregulation of TNF-α, TRAIL, IFN-α, and IFN-γ, and its ability to recruit CD8+ T cells into tumor tissue. Conclusion: Systemic treatment with rNDV-P05 decreases the tumoral parameters in the breast cancer murine model.
Osseointegrated Finger Prostheses Using a Tripod Titanium Mini-Plate
Oscar J Manrique,Pedro Ciudad,Matthew Doscher,Federico Lo Torto,Ralph Liebling,Ricardo Galan 대한성형외과학회 2017 Archives of Plastic Surgery Vol.44 No.2
Background Digital amputation is a common upper extremity injury and can cause significant impairment in hand function, as well as psychosocial stigma. Currently, the gold standard for the reconstruction of such injuries involves autologous reconstruction. However, when this or other autologous options are not available, prosthetic reconstruction can provide a functionally and aesthetically viable alternative. This study describes a novel technique, known as a tripod titanium mini-plate, for osseointegrated digit prostheses, and reviews the outcomes in a set of consecutive patients. Methods A retrospective review of patients who underwent 2-stage prosthetic reconstruction of digit amputations was performed. Demographic information, occupation, mechanism of injury, number of amputated fingers, and level of amputation were reviewed. Functional and aesthetic outcomes were assessed using the quick disabilities of the arm, shoulder, and hand (Q-DASH) scale and a visual analog scale (VAS) score, respectively. In addition, complications during the postoperative period were recorded. Results Seven patients were included in this study. Their average age was 29 years. Five patients had single-digit amputations and 2 patients had multiple-digit amputations. Functional and aesthetic outcomes were assessed using the Q-DASH score (average, 10.4) and VAS score (average, 9.1), respectively. One episode of mild cellulitis was seen at 24 months of follow-up. However, it was treated successfully with oral antibiotics. No other complications were reported. Conclusions When autologous reconstruction is not suitable for digit reconstruction, prosthetic osseointegrated reconstruction can provide good aesthetic and functional results. However, larger series with longer-term follow-up are required in order to rule out the possibility of other complications.
Thallium poisoning: a case report
( Oscar Jimenez ),( Hector Cáceres ),( Luis Gimenez ),( Luciana Soto ),( Micaela Montenegro ),( Jhon Alexander Avila Rueda ) 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.3
Thallium poisoning is usually accidental. We present a case of a 51-year-old woman who was evaluated in June 2018 for myalgia, vertigo, asthenia, and abdominal pain. Physical examination revealed temporal-spatial disorientation, jaundice, and asterixis. The laboratory reported the following: bilirubin, 10.3 mg/dL; aspartate transaminase, 78 U/L; alanine transaminase, 194 U/L; albumin, 2.3 g/dL; prothrombin time, 40%; and platelet count, 60,000/㎣. Serology performed for hepatitis A, B, and C; Epstein-Barr virus; cytomegalovirus; and human immunodeficiency virus was negative, and a collagenogram was negative. Physical reevaluation revealed alopecia on the scalp, armpits, and eyebrows; macules on the face; plantar hyperkeratosis; and ulcers on the lower limbs. Tests for lead, arsenic, copper, and mercury were carried out, which were normal; however, elevated urinary thallium (540 μg/g; range, 0.4-10 μg/g) was observed. The patient was treated with D-penicillamine 1,000 mg/day and recovered her urinary thallium levels were within normal range at annual follow-up. Thallium poisoning is extremely rare and can be fatal in small doses. An adequate clinical approach can facilitate early diagnosis.