Should CAM and CAM Training Programs Be Included in the Curriculum of Schools That Provide Health Education?

Onal, Ozgur,Sahin, Deniz Say,Inanc, Betul Battaloglu KOREAN PHARMACOPUNCTURE INSTITUTE 2016 Journal of pharmacopuncture Vol.19 No.4

Objectives: This study aimed to determine the knowledge levels and attitudes of School of Health and Vocational School of Health students toward complementary and alternative medicine (CAM). Methods: Three hundred thirty-three (333) students studying at the Mehmet Akif Ersoy University School of Health and the Golhisar Vocational School of Health in Burdur, Turkey, were included in the study. Research data were collected by using a survey method based on the expressed opinions of the participants. Results: Of the participants, 69.7% were female and 97% were single (unmarried). Of cigarette users and those with chronic illnesses, 46.8% and 47.8%, respectively, used CAM. Those using CAM were statistically more likely to be female (P < 0.021), to have higher grades (P < 0.007), to be single (P < 0.005), to be vocational school of health graduates (P < 0.008), and to have fathers at work (P < 0.021). While 9.6% of the students thought CAM to be nonsense, 10.8% thought that the methods of CAM should be tried before consulting a doctor. Conclusion: A majority of the students in the study population were found to use complementary and alternative medicine, but that they lacked information about its methods. As a way to address this, CAM should be included in the curriculum of schools that provide health education, and CAM training programs should be given to healthcare professionals to improve their knowledge of CAM. In Turkey, many more studies should be performed to determine nurses' and doctors' knowledge of and attitudes about CAM methods so that they can give correct guidance to society and take more active responsibility in improving patient safety.

Relations between the Characteristics of Angora Rabbit Fibre

Onal, Levent,Korkmaz, Mahmut,Tutak, Mustafa The Korean Fiber Society 2007 Fibers and polymers Vol.8 No.2

Angora rabbit fibre is one of the finest specialty animal fibres with its well-known reputation for fineness, lightness and softness. This study evaluated the Angora fibre shape and morphology in comparison with Cashmere fibre and wool as well as the relation between characteristics of Angora fibre. Unlike other keratinous textile fibres, single Angora fibre composes of two sections named as body and head, each of which has individual surface characteristics. Differences between the scale shapes, scale length and scale frequency of Angora hair types were explained in details. Medullation in Angora fibre was explained for different types of Angora hairs defined as down, awn, and bristle. This classification was done according to the fibre fineness starting from the finer one. Relation between fibre shape and comfort factor was also analyzed. The relation between mean fibre diameter (MFD), fibre curvature (FC) and percentage of medullation by volume (MEDV) for Angora rabbit fibre was not as strong as wool and Cashmere fibre. Accordingly, when Angora hair types were analyzed individually, it was observed that relation between FC and MEDV for Angora fibre was stronger than wool and Cashmere fibre. Multiple regression analysis was also performed. Diameter distribution along the snippet length (about $200\;{\mu}m$) of Angora fibre is uneven compared to Cashmere fibre and wool.

Long-term outcomes of cervical cancer patients with complete metabolic response after definitive chemoradiotherapy

Cem Onal,Ozan Cem Guler,Mehmet Reyhan,Ali Fuat Yapar 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.5

Objective: We investigated the importance of metabolic parameters measured with18 F-fluorodeoxyglucose positron-emission tomography integrated with computed tomography (FDG-PET/CT) for predicting progression-free survival (PFS) and overall survival (OS) in cervical cancer with complete metabolic response (CMR) after chemoradiotherapy (ChRT). Methods: The clinical data and PET parameters including standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of 122 patients having CMR in post-treatment 18F-FDG-PET/CT delivered a median of 3.9 months after ChRT completion were analyzed. Results: With a median follow-up of 8.4 years, 55 patients (45%) presented with disease a median of 19.7 months after ChRT. For SUVp, MTVp, TLGp, SUVln, MTVln, and TLGp, the cut- off values for OS determined by receiver operating curve analysis were 15.8, 48.7 cm3, 552.3, 8.7, 7.0 cm3, respectively. All metabolic PET parameters were significant prognostic factors for OS and PFS in univariate analysis. International Federation of Gynecology and Obstetrics (FIGO) stage was predictive of both OS and PFS, while pelvic and/or para-aortic lymph node metastasis were predictive of OS only. In multivariate analysis, FIGO stage ≥IIB, MTVp ≥49.8 cm3, and TLGp ≥597.4 were predictive of worse OS. Advanced stage, presence of lymph node metastasis, higher TLGp, and larger MTVln were significant factors for poor PFS rates. Conclusion: We found that advanced stage and higher TLGp values were significant predictors for poor survival and higher progression rates. Volumetric PET parameters could be used to predict treatment outcomes in patients with CMR after definitive ChRT.

A multi-institutional analysis of sequential versus ‘sandwich’ adjuvant chemotherapy and radiotherapy for stage IIIC endometrial carcinoma

Cem Onal,Sezin Yuce Sari,Berna Akkus Yildirim,Guler Yavas,Melis Gultekin,Ozan Cem Guler,Serap Akyurek,Ferah Yildiz 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3

Objective: To analyze the outcomes of sequential or sandwich chemotherapy (ChT) and radiotherapy (RT) in patients with node-positive endometrial cancer (EC). Methods: Data from 4 centers were collected retrospectively for 179 patients with stage IIIC EC treated with postoperative RT and ChT (paclitaxel and carboplatin). Patients were either treated with 6 cycles of ChT followed by RT (sequential arm; 96 patients) or with 3 cycles of ChT, RT, and an additional 3 cycles of ChT (sandwich arm; 83 patients). Prognostic factors affecting overall survival (OS) and progression-free survival (PFS) were analyzed. Results: The 5-year OS and PFS rates were 64% and 59%, respectively, with a median followup of 41 months (range, 5–167 months). The 5-year OS rates were significantly higher in the sandwich than sequential arms (74% vs. 56%; p=0.03) and the difference for 5-year PFS rates was nearly significant (65% vs. 54%; p=0.05). In univariate analysis, treatment strategy, age, International Federation of Gynecology and Obstetrics (FIGO) stage, pathology, rate of myometrial invasion, and grade were prognostic factors for OS and PFS. In multivariate analysis, non-endometrioid histology, advanced FIGO stage, and adjuvant sequential ChT and RT were negative predictors for OS, whereas only non-endometrioid histology was a prognostic factor for PFS. Conclusion: Postoperative adjuvant ChT and RT for stage IIIC EC patients, either given sequentially or sandwiched, offers excellent clinical efficacy and acceptably low toxicity. Our data support the superiority of the sandwich regimen compared to the sequential strategy in stage IIIC EC patients for OS.

Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer

Cem Onal,Ezgi Oymak,Ayse Kotek,Esma Efe,Gungor Arslan 한국유방암학회 2012 Journal of breast cancer Vol.15 No.3

Purpose: The purpose of this study is to evaluate the correlation between the conventional plan parameters and dosimetric parameters obtained from conformal radiotherapy (RT) planning, and between these parameters and radiation pneumontitis (RP) incidence. Methods: Clinical and dosimetric data of 122 patients that were treated with mastectomy and adjuvant 3D conformal RT (39% received 2-field RT [2-FRT], and in addition, 61% received 4-field RT [4-FRT]) were retrospectively analyzed. Central lung depth (CLD), maximum lung depth (MLD), and lung length were measured by the conventional plan. Lung dose-volume histograms (DVH) were created with conformal planning, and the lung volumes receiving 5 to 50 Gy (V5Gy to V50Gy) were calculated. Minimum (Dmin), maximum (Dmax), and mean doses (Dmean) for the ipsilateral lung and bilateral lungs were measured by DVH. Correlations between 3D dosimetric data and 2D radiographic parameters were analyzed. Results: The conventional plan parameters did not significantly differ between 2-FRT and 4-FRT. The conformal plan Dmin, Dmax, and Dmean values were higher in 4-FRT versus 2-FRT. CLD and MLD were correlated with DVH parameter V5Gy to V45Gy values for ipsilateral, as well as bilateral lungs for 2-FRT. MLD and ipsilateral Dmean via 2-FRT planning had the strongest positive correlation (r=0.76, p<0.01). Moderate correlations existed between CLD and ipsilateral and bilateral lung V5Gy–45Gy, and between MLD and bilateral lung V5Gy–45Gy values in 2-FRT. Only four patients developed symptomatic RP, 4 with 4-FRT and one with 2-FRT. Conclusion: The conformal plan parameters were strongly correlated with dose-volume parameters for breast 2-FRT. With only 4 cases of Grade 3 RP observed, our study is limited in its ability to provide definitive guidance, however assuming that CLD is an indicator for RP, V20Gy could be used as a predictor for RP and for 2-FRT. A welldefined parameters are still required to predict RP in 4-FRT.

Factors associated with the weight change trend in the first year of the COVID-19 pandemic: the case of Turkey

Hulya Yilmaz Onal,Banu Bayram,Aysun Yuksel 대한지역사회영양학회 2021 Nutrition Research and Practice Vol.15 No.S

BACKGROUND/OBJECTIVES: To determine the weight change trend among the adult Turkish population after 1 yr of the coronavirus disease 2019 (COVID-19) pandemic and factors associated with weight change. MATERIALS/METHODS: This cross-sectional study was conducted between 26 February and 6 March 2021 using an online questionnaire that included questions for sociodemographic variables, eating habits, stress level, and the Three-Factor Eating Questionnaire-R18. Those who weighed themselves 1–2 weeks before the pandemic was declared in Turkey and remembered their weight were invited to participate in the study. Trends in weight and body mass index (BMI) change were calculated. The variables associated with a 1% change in BMI were assessed using hierarchical regression analysis. RESULTS: The study was conducted with 1,630 adults (70.25% female) with a mean age of 32.09 (11.62) yrs. The trend of weight change was found to increase by an average of 1.15 ± 6.10 kg (female +0.72 ± 5.51, male +2.16 ± 7.22 kg) for the first year of the COVID-19 pandemic. The rate of participants with a normal BMI (18.50–24.99 kg/㎡) decreased to 51.91% from 55.75%. Consuming an "Increased amount of food compared to before the pandemic" was found to be the independent variable that had the strongest association with a 1% increase in BMI (β = 0.23 P < 0.001). The average change in the BMI was higher in older individuals than in those who were younger. A high stress level was associated with a decrease in BMI (β = –0.04 P = 0.048). CONCLUSIONS: In this study, the factors associated with weight change after 1 yr of the pandemic in the Turkish population was reported for the first time. A high stress level and increased weight gain trend still occur in Turkey after 1 yr of the pandemic.

Autoimmunity and intestinal colonization by Candida albicans in patients with type 1 diabetes at the time of the diagnosis

Gursoy, Semra,Kockar, Tuba,Atik, Sezen Ugan,Onal, Zerrin,Onal, Hasan,Adal, Erdal The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.7

Purpose: Type 1 diabetes mellitus (T1DM) is a chronic and immune-mediated disease, which is characterized by the progressive destruction of pancreatic beta cells. T1DM precipitates in genetically susceptible individuals through environmental factors. In this study, we aimed to evaluate the impact of autoimmunity and intestinal colonization of Candida albicans on the development of T1DM. Methods: Forty-two patients newly diagnosed with T1DM and 42 healthy subjects were included in this monocentric study. The basic and clinical characteristics of the patients were recorded. T1DM-, thyroid-, and celiac-associated antibodies were evaluated. Stool cultures for C. albicans were performed to assess whether or not gut integrity was impaired in patients with T1DM. Results: The evaluation of T1DM- and thyroid-associated antibodies showed that the prevalences of islet cell antibodies and antithyroperoxidase positivity were higher in the study patients than in the patients in the control group. Furthermore, the direct examination and culture of fresh stool samples revealed that 50% of the patients with T1DM and 23.8% of the control subjects had fungi (C. albicans). Conclusion: Through this study, we suggest that the presence of intestinal C. albicans colonization at the time of the diagnosis of T1DM may indicate impairment of normal intestinal microbiota. We also suggest that there may be a tendency of T1DM in patients with a high prevalence of intestinal C. albicans.

4D-QSAR Study of p56^Ick Protein Tyrosine Kinase Inhibitory Activity of Flavonoid Derivatives Using MCET Method

Yilmaz, Hayriye,Guzel, Yahya,Onal, Zulbiye,Altiparmak, Gokce,Kocakaya, Safak Ozhan Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.12

A four dimensional quantitative structure activity relationship analysis was applied to a series of 50 flavonoid inhibitors of $p56^{lck}$ protein tyrosine kinase by the molecular comparative electron topological method. It was found that the -log (IC50) values of the compounds were highly dependent on the topology, size and electrostatic character of the substituents at seven positions of the flavonoid scaffold in this study. Depending on the negative or positive charge of the groups correctly embedded in these substituents, three-dimensional bio-structure to increase or decrease -log (IC50) values in the training set of 39 compounds was predicted. The test set of 11 compounds was used to evaluate the predictivity of the model. To generate 4D-QSAR model, the defined function groups and pharmacophore used as topological descriptors in the calculation of activity were of sufficient statistical quality ($R^2$ = 0.72 and $Q^2$ = 0.69). Ligand docking approach by using Dock 6.0. These compounds include many flavonoid analogs, They were docked onto human families of p56lck PTKs retrieved from the Protein Data Bank, 1lkl.pdb.

Radiation Exposure to Premature Infants in a Neonatal Intensive Care Unit in Turkey

Turan Olgar,Esra Onal,Dogan Bor,Nurullah Okumus,Yildiz Atalay,Canan Turkyilmaz,Ebru Ergenekon,Esin Koc 대한영상의학회 2008 Korean Journal of Radiology Vol.9 No.5

Objective: The aim of this work was to determine the radiation dose received by infants from radiographic exposure and the contribution from scatter radiation due to radiographic exposure of other infants in the same room. Materials and Methods: We retrospectively evaluated the entrance skin doses (ESDs) and effective doses of 23 infants with a gestational age as low as 28 weeks. ESDs were determined from tube output measurements (ESDTO) (n = 23) and from the use of thermoluminescent dosimetry (ESDTLD) (n = 16). Scattered radiation was evaluated using a 5 cm Perspex phantom. Effective doses were estimated from ESDTO by Monte Carlo computed software and radiation risks were estimated from the effective dose. ESDTO and ESDTLD were correlated using linear regression analysis. Results: The mean ESDTO for the chest and abdomen were 67 μGy and 65 μGy per procedure, respectively. The mean ESDTLD per radiograph was 70 μGy. The measured scattered radiation range at a 2 m distance from the neonatal intensive care unit (NICU) was (11-17 μGy) per radiograph. Mean effective doses were 16 and 27 μSv per procedure for the chest and abdomen, respectively. ESDTLD was well correlated with ESDTO obtained from the total chest and abdomen radiographs for each infant (R2 = 0.86). The radiation risks for childhood cancer estimated from the effective dose were 0.4 × 10-6 to 2 × 10-6 and 0.6 × 10-6 to 2.9 × 10-6 for chest and abdomen radiographs, respectively. Conclusion: The results of our study show that neonates received acceptable doses from common radiological examinations. Although the contribution of scatter radiation to the neonatal dose is low, considering the sensitivity of the neonates to radiation, further protective action was performed by increasing the distance of the infants from each other. Objective: The aim of this work was to determine the radiation dose received by infants from radiographic exposure and the contribution from scatter radiation due to radiographic exposure of other infants in the same room. Materials and Methods: We retrospectively evaluated the entrance skin doses (ESDs) and effective doses of 23 infants with a gestational age as low as 28 weeks. ESDs were determined from tube output measurements (ESDTO) (n = 23) and from the use of thermoluminescent dosimetry (ESDTLD) (n = 16). Scattered radiation was evaluated using a 5 cm Perspex phantom. Effective doses were estimated from ESDTO by Monte Carlo computed software and radiation risks were estimated from the effective dose. ESDTO and ESDTLD were correlated using linear regression analysis. Results: The mean ESDTO for the chest and abdomen were 67 μGy and 65 μGy per procedure, respectively. The mean ESDTLD per radiograph was 70 μGy. The measured scattered radiation range at a 2 m distance from the neonatal intensive care unit (NICU) was (11-17 μGy) per radiograph. Mean effective doses were 16 and 27 μSv per procedure for the chest and abdomen, respectively. ESDTLD was well correlated with ESDTO obtained from the total chest and abdomen radiographs for each infant (R2 = 0.86). The radiation risks for childhood cancer estimated from the effective dose were 0.4 × 10-6 to 2 × 10-6 and 0.6 × 10-6 to 2.9 × 10-6 for chest and abdomen radiographs, respectively. Conclusion: The results of our study show that neonates received acceptable doses from common radiological examinations. Although the contribution of scatter radiation to the neonatal dose is low, considering the sensitivity of the neonates to radiation, further protective action was performed by increasing the distance of the infants from each other.

Identification of Water/Cement Ratio of Cement Pastes, Basing on the Microstructure Image Analysis Data and using Artificial Neural Network

Ali Ugur Ozturk,Okan Onal 대한토목학회 2013 KSCE JOURNAL OF CIVIL ENGINEERING Vol.17 No.4

Artificial Neural Network (ANN) analysis has been established to forecast the Water/Cement (w/c) ratio values of cement pastes by using image analysis techniques in the scope of this study. W/c ratio values have reasonably great effects on the performance of cement based structural members. The service life or ultimate performances such as strength and durability characteristics are strongly affected by w/c ratios of cementitious materials. In this study, the relationship between microstructural phases such as unhydrated cement part, hydration products, capillary porosity, and w/c ratios predicted by ANN analysis, has been established. The predicted values are compared with estimated values obtained by proposed method in the literature. The study indicated that, using a contemporary data analysis technique, which is capable of searching nonlinear relationships more thoroughly, would result in more realistic prediction of the w/c ratios compared to the proposed method.