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- 저자 : Olga Gruzdeva (검색결과 2 건)
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Olga Barbarash,Olga Gruzdeva,Evgenya Uchasova,Yulia Dyleva,Ekaterina Belik,Olga Akbasheva,Victoria Karetnikova,Aleksandr Shilov 대한진단검사의학회 2016 Annals of Laboratory Medicine Vol.36 No.4
Background: Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications. Methods: We included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups: the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA. Results: On day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004). Conclusions: The level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP.
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Vladimir B. Dorokhov,Anton I. Taranov1,Anna M. Narbut,Dmitry S. Sakharov,Svetlana S. Gruzdeva,Olga N. Tkachenko,Gleb N. Arsen’ev,Ilya S. Blochin,Arcady A. Putilov 대한수면학회 2019 sleep medicine research Vol.10 No.2
Background and Objective Human brain appears to be able to absorb, detect, and respond to low-level extremely low-frequency electromagnetic fields (ELF EMF). Controlled laboratory studies on human sleep under exposure to such fields are scarce. Only sleep-disturbing effects on nighttime sleep were reported for frequencies of 50/60 Hz, while lower frequencies (i.e., below 20 Hz) have not been tested. These frequencies overlap with the frequency range of the electroencephalographic (EEG) signal, and sleep researchers utilized the specific frequency patterns (1–15 Hz) for subdivision of the sleep-wake state continuum into wake and sleep stages. In particular, the deepest sleep stage (N3) is characterized by slow-wave EEG activity (1–4 Hz) and serves as an electrophysiological indicator of sleep restorative function. We examined the effects of exposure to a low-level ELF EMF on sleep architecture in afternoon naps. Methods Ten polysomnographic sleep characteristics obtained during two naps of 23 healthy volunteers, either with or without exposure to a 1 Hz/0.004 μT electromagnetic field, were compared. Results The effect of the 1 Hz/0.004 μT electromagnetic field exposure on amount of stage N3 was not significant despite the overlap of this intervention frequency with the frequency of slow waves. However, the total duration of sleep was significantly increased due to a significant increase of amount of stage N2. Thus, the exposure to an extremely slow (1 Hz) electromagnetic field did not reveal any sleep-disturbing effects. Instead, total duration of sleep increased due to increase of N2 amount. Conclusions A sleep-promoting action of exposure to the low-level 1 Hz electromagnetic field cannot be excluded.
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