Classification of Multivariate Time-Series with Different Time Length on Grassmann Manifold using Neural Ordinary Differential Equations

Nuriye Bezawit Habtamu(베자윗),Beomseok Oh(오범석) 한국정보과학회 2022 한국정보과학회 학술발표논문집 Vol.2022 No.06

Randomized Minimal Gated Units for Multivariate Time Series Classification

Nuriye Bezawit Habtamu,Hyeon Seo(서현),Beomseok Oh(오범석) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6

Efficacy and Safety of First Line Vincristine with Doxorubicin, Bleomycin and Dacarbazine (ABOD) for Hodgkin's Lymphoma: a Single Institute Experience

Ozdemir, Nuriye,Dogan, Mutlu,Sendur, Mehmet Ali Nahit,Yazici, Ozan,Abali, Huseyin,Yazilitas, Dogan,Akinci, Muhammed Bulent,Aksoy, Sercan,Zengi, Nurullah Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Background: ABVD (doxorubicin, bleomycin, vinblastine (Vb) and dacarbazine) is the standard regimen in Hodgkin's lymphoma (HL).Vincristine (O) is a mitotic spindle agent like Vb. We aimed to evaluate the efficacy and safety of O as a part of ABOD in HL. Materials and Methods: Patients who had ABOD were enrolled. Stage I-II HL were evaluated for unfavorable risk factors according to NCCN. National Cancer Institute Common Toxicity Criteria was used for toxicity. Results: Seventy-nine HL patients in our center between 2003 and 2007 were evaluated retrospectively. Median follow-up was 54 months. Most of the patients were male in their third decade. Median ABOD cycles were 6 (2-8). Primary refractory disease rate was 17.7% whereas it was 5.1% for early relapse and 5.1% for late relapse disease. Response rates were as 82.3% for complete response, 11.4% for partial response, 5.1% for stable disease and 1.3% for progressive disease. Half of relapsed patients had autologous stem cell transplantation. Estimated 5-year failure-free survival was 71% and significantly longer in early stage patients without risk factors, bulky disease or radiotherapy (RT) (p=0.05, p<0.0001, p=0.02; respectively). Estimated 5-year overall survival was 74% and significantly longer in those who had no RT (p=0.001). Dose modification rate was 5.1% and chemotherapy delay rate was 19%. There were no toxicity-related deaths. Conclusions: ABOD seems to be effective with managable toxicity in HL, even in those with poor prognostic factors.

영화 〈오아시스〉의 등장인물과 공간적 특성 고찰

네빈(BASKAYA Nuriye Nevin) 한국비평문학회 2020 批評文學 Vol.- No.77

〈오아시스〉는 가족과 사회로부터 분리되어 타자화된 홍종두와 한공주가 그들만의 공간에서 주체성을 회복하는 과정을 그린 영화이다. 그들은 가족에게 인정받지 못하고 사회에서 독립된 인격체로 존중받지 못한다. 가족과 사회적 타자로서 경계인이 된 종두와 공주가 〈오아시스〉에서 어떻게 주체성을 회복하는지 분석하기 위해 행위소 모델을 원용하였다. 그리고 등장인물의 행동과 심리상태를 구체적으로 분석하기 위해 푸코의 헤테로토피아 개념을 활용하여 〈오아시스〉의 공간적 특성을 고찰하였다. 그 결과, 가족과 사회에 의해 자신의 의지와 상관없이 타자로서의 삶을 강요받았던 종두와 공주가 서로 소통하면서 사랑하는 주체적인 인물임을 확인할 수 있었다. 이는 곧 그들이 자신들을 타자로 규정한 현실에 대한 환상을 통해 물리적 공간의 경계를 넘어선 공간으로서의 오아시스를 구축함으로써, 가족과 사회의 억압적 시선에서 벗어난 삶을 살아가는 존재임을 의미한다. 따라서 〈오아시스〉는 사회적 편견에 의해 타자로 대상화된 존재들의 주체성에 대한 새로운 인식을 담보한 영화라 할 수 있다. 〈Oasis〉 is a film depicting the process of regain subjectivity in their own space by the characters Hong Jong-du and Gong-ju Han who are separated from both their families and society and become others. They are neither recognized by their families nor respected as individuals by society. Hence, the Actantial model is used to analyze how Jong-du and Gong-ju, who become marginal both in family and society as others, regain their subjectivity in 〈Oasis〉. In addition, space in 〈Oasis〉 is analyzed through Foucault’s concept of heterotopia in order to examine the behaviour and psychological state of the characters in detail. As a result, it was confirmed that Jong-du and Gong-ju, who were forced to live as others by their families and society against their will, communicated with each other and fell in love. Beyond the eyes of family and society, Jong-du and Gong-ju find an oasis in a realistic space beyond the boundaries of physical space by sharing a fantasy of reality that they are not defined as others. Therefore, we can say that 〈Oasis〉 shows a new perception of the subjectivity of beings who are objectified as others by social prejudice.

Phage Assembly Using APTES-Conjugation of Major Coat p8 Protein for Possible Scaffolds

Kim, Young Jun,Korkmaz, Nuriye,Nam, Chang Hoon Korean Society for Bioinformatics 2012 Interdisciplinary Bio Central (IBC) Vol.4 No.3

Filamentous phages have been in the limelight as a new type of nanomaterial. In this study, genetically and chemically modified fd phage was used to generate a biomimetic phage self-assembly product. Positively charged fd phage (p8-SSG) was engineered by conjugating 3-aminopropyltriethoxysilane (APTES) to hydroxyl groups of two serine amino acid residues introduced at the N-terminus of major coat protein, p8. In particular, formation of a phage network was controlled by changing mixed ratios between wild type fd phage and APTES conjugated fd-SSG phage. Assembled phages showed unique bundle and network like structures. The bacteriophage based self-assembly approach illustrated in this study might contribute to the design of three dimensional microporous structures. In this work, we demonstrated that the positively charged APTES conjugated fd-SSG phages can assemble into microstructures when they are exposed to negatively charged wild-type fd phages through electrostatic interaction. In summary, since we can control the phage self-assembly process in order to obtain bundle or network like structures and since they can be functionalized by means of chemical or genetic modifications, bacteriophages are good candidates for use as bio-compatible scaffolds. Such new type of phage-based artificial 3D architectures can be applied in tuning of cellular structures and functions for tissue engineering studies.

Lymphoproliferative Disorders in Multiple Primary Cancers

Demirci, Umut,Ozdemir, Nuriye,Benekli, Mustafa,Babacan, Nalan Akgul,Cetin, Bulent,Baykara, Meltem,Coskun, Ugur,Zengin, Nurullah,Buyukberber, Suleyman Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

Background: Cancer survivors are at increased risk of second cancers. Lymphoproliferative disorders (LPD) are common neoplasms that are primary or subsequent cancers in cases of multiple primary cancer. We here analyzed metachronous or synchronous LPD in multiple primary cancers. Methods: Between 2001 and 2010, LPD were assessed retrospectively in 242 multiple primary cancers patients. Results: Forty nine (20.2%) patients with LPD were detected. Six patients had two LPD where one patient had three LPD. The median age of patients was 60.5 years (range: 28-81). LPD were diagnosed in 29 patients as primary cancer, in 23 patients as second cancer, and in three patients as third cancer in multiple primary cancers. Primary tumor median age was 56 (range: 20-79). Diffuse large B cell lymphoma (n=16), breast cancer (n=9), and lung cancer (n=6) were detected as subsequent cancers. Alklylating agents were used in 19 patients (43.2%) and 20 patients (45.5%) had received radiotherapy for primary cancer treatment. The median follow-up was 70 months (range: 7-284). Second malignancies were detected after a median of 51 months (range: 7-278), and third malignancies with a median of 18 months (range: 6-72). Conclusions: In this study, although breast and lung cancer were the most frequent detected solid cancers in LPD survivors, diffuse large B cell lymphoma was the most frequent detected LPD in multiple primary cancers.

Tracking acute phase protein response during acute and chronic Toxoplasma gondii infection

Hasan Tarik Atmaca,Aycan Nuriye Gazyagci,Osman Safa Terzi,Gungor Cagdas Dincel,Tugce Sumer 한국실험동물학회 2019 Laboratory Animal Research Vol.35 No.2

Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii, which occurs worldwide in mammals and birds. Brain is the primary target organ because Toxoplasma gondii is a ubiquitous intracellular parasite that causes most frequently life-threatening encephalitis in immunocompromised patients. Relation of tissue cysts number, histopathology score and acute phase proteins were investigated. In this study, 36 mice are infected with Me49 strain of Toxoplasma gondii. The control group has 6 healthy mice. After inoculation of Toxoplasma gondii, at 10., 15., 20., 30., 45., 60. days, 6 each mice euthanized after collection of blood samples. Hemopexin, haptoglobulin, macroglobulin, serum amyloid A and clusterin levels are determined by ELISA. Then, brain tissues were investigated histopathologically and lesions were scored. The average cyst numbers were determined by counting three samples (25 μl each) of each brain homogenate under light microscopy. Inflammatory reaction was observed on day 10 days after inoculation (d.a.i.) The lesions were characterized by perivascular mononuclear cell infiltration, focal mononuclear cell infiltration in the meninges, and glial proliferation. Tissue cysts were observed in all Toxoplasma gondii-infected groups. The highest lesion score was observed at 60 d.a.i. And the most tissue cyst number were on day 30. d.a.i. Serum levels of hemopexin, haptoglobulin, macroglobulin, serum amyloid A and clusterin were significantly higher than the control group on day 10–20., 10., 10–30., 10.,10–45 d.a.i., respectively. High level of acute phase proteins in mice on certain days infected with Toxoplasma gondii was exhibited a relationship between brain lesions and tissue cysts.

Knowledge, Attitudes and Beliefs about Cervical Cancer and Human Papilloma Virus Vaccination with Related Factors in Turkish University Students

Yilmazel, Gulay,Duman, Nuriye Buyukkayaci Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: This study aimed to determine knowledge, attitudes and believes about cervical cancer and human papilloma virus (HPV) vaccination with related factors in Turkish university students. Materials and Methods: This descriptive and cross sectional study was conducted between June-July 2013 in Hitit University located in Corum, a rural area to the East of Ankara. The population consisted of 550 university students who were training in first and last year from Faculties of Economics, Theology and Health. We reached 463 volunteer students without selection. The study of data was collected with a 44 item questionaire covering socio-demographic features, knowledge, attitudes and beliefs about cervical cancer, HPV and vaccination. Also for this study ethic committee report was taken from Bozok University. Data were evaluated with the SPSS 17.0 programme using the Ki kare test with P<0.05 accepted as statistically significant. Results: It was seen that there was a statistically significant variation between classrooms and departments of students with knowledge about cervical cancer and human papilloma virus and vaccine (p<0.001; p<0.01; p<0.05). Also we found low attitudes to thinking about taking HPV vaccination of girls and their children in the future. Conclusions: In light of the study findings; it was concluded that knowledge levels, beliefs and attitudes of the university students about cervical cancer, HPV infection and HPV vaccination were low.

ABO and Rh Blood Groups and Risk of Colorectal Adenocarcinoma

Urun, Yuksel,Ozdemir, Nuriye Yildirim,Utkan, Gungor,Akbulut, Hakan,Savas, Berna,Oksuzoglu, Berna,Oztuna, Derya Gokmen,Dogan, Izzet,Yalcin, Bulent,Senler, Filiz Cay,Onur, Handan,Demirkazik, Ahmet,Zengi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: Previous studies have observed an association between ABO blood group and risk for certain gastrointestinal malignancies, including pancreatic and gastric cancer. However, it is unclear whether there is such an association with colorectal cancer (CRC). In this study, possible relationships between ABO blood groups and Rh factor and KRAS status in patients with CRC were investigated. Materials and Methods: In 1,620 patients with CRC, blood group and Rh factor were examined and compared with the control group of 3,022,883 healthy volunteer blood donors of the Turkish Red Crescent between 2004 and 2011. The relationship of blood groups with wild type K-ras status was also evaluated. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (45% A, 7.2% AB, 16.4% B, 31.4% O, and 87.2% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0.099). However, there were statistically significant difference between patients and controls with respect to O vs. non O blood group (p=0.033) and marginally significant difference for A vs. non-A blood group (p=0.052). Among patients, the median age was 62 (range 17-97), 58.1% were male. There were no statistically significant differences respect to sex and K-ras status. Conclusion: In present study, the ABO/Rh blood groups were statistically significantly associated with the risk of CRC. There were no relationship between K-ras status and ABO blood group and Rh factor. However further studies with larger numbers of patients are needed to establish the role of blood groups and to define t he mechanisms by which ABO blood type affect CRC.

Effects of Breast Cancer Fatalism on Breast Cancer Awareness among Nursing Students in Turkey

Kulakci, Hulya,Ayyildiz, Tulay Kuzlu,Yildirim, Nuriye,Ozturk, Ozlem,Topan, Aysel Kose,Tasdemir, Nurten Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: Breast cancer is the most common cancer among women and leading cause of death worldwide, including in Turkey. High perceptions of cancer fatalism are associated with lower rates of participation in screening for breast cancer. This study was conducted to evaluate the effect of breast cancer fatalism and other factors on breast cancer awareness among nursing students in Turkey. Materials and Methods: This cross-sectional descriptive study was conducted at three universities in the Western Black Sea region. The sample was composed of 838 nursing students. Data were collected by Personal Information Form, Powe Fatalism Inventory (PFI) and Champion's Health Belief Model Scale (CHBMS). Results: Breast cancer fatalism perception of the students was at a low level. It was determined that students; seriousness perception was moderate, health motivation, BSE benefits and BSE self-efficacy perceptions were high, and BSE barriers and sensitivity perceptions were low. In addition, it was determined that students awareness of breast cancer was affected by breast cancer fatalism, class level, family history of breast cancer, knowledge on BSE, source of information on BSE, frequency of BSE performing, having breast examination by a healthcare professional within the last year and their health beliefs. Conclusions: In promoting breast cancer early diagnosis behaviour, it is recommended to evaluate fatalism perceptions and health beliefs of the students and to arrange training programs for this purpose.