패혈증의 경과에 따른 혈중 스테로이드와 Nitric Oxide의 연관성

이규성 ( Keu Sung Lee ),김영선 ( Young Sun Kim ),이형노 ( Hyoung No Lee ),박주헌 ( Joo Hun Park ),오윤정 ( Yoon Jung Oh ),신승수 ( Seung Soo Sheen ),최영화 ( Young Hwa Choi ),박광주 ( Kwang Joo Park ),황성철 ( Sung Chul Hwang ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.4

연구배경: 패혈증에서 Nitric oxide 스테로이드 호르몬은 혈역학적 변화와 염증반응에 관여하는데 이 두 인자는 서로 상관성이 있는 것으로 알려지고 있다. 하지만 실제 환자에서 서로의 상관성이나 임상적 의의는 연구가 부족한 실정이다. 방법: 패혈증 환자 26예와 대조군 14예를 대상으로 혈중 총 NO와 혈중 코티졸 농도를 측정하였고 이어서 제 3, 5, 7병일에도 연속적으로 측정을 하였다. 결과: 패혈증 환자군에서 초기 혈중 코티졸 및 총 NO 농도는 대조군에 비하여 유의하게 증가하였고 경증 패혈증에 비하여 중증 패혈증 환자군에서 유의하게 높았다. 초기 혈중 총 NO의 농도는 APACHE II 점수, 정맥혈 lactate 농도와 상관성이 있었다. 패혈증의 시간의 경과에 따라 혈중 NO 농도는 제 1병일, 제 5병일, 제 7병일에 혈중 코티졸의 농도와 유의한 상관성이 있었다. 결론: 패혈증 환자들에서 혈중 NO와 코티졸 농도는 증가되어 있었으며, 경과에 따라 서로 유의한 상관성이 지속되었다. 상호작용기전에 대하여는 추가적인 연구가 필요할 것이다. Background: The nitric oxide (NO) released by inducible NO synthase (iNOS) plays an important role in the pathophysiology of sepsis. Corticosteroids also play a role in the hemodynamic and inflammatory reactions in sepsis. Both have been shown to have a relationship theoretically, but their correlation and clinical impacts have rarely been evaluated. Methods: 26 patients with sepsis and 14 healthy controls were enrolled in this study. The initial random plasma total NO and the serum cortisol levels were measured. The same measurements were serially carried out on the 3rd, 5th, and 7th days. Results: The initial total plasma levels of NO and cortisol were higher in the patients with sepsis than in the healthy controls. The total NO levels were higher in patients with severe sepsis than in the those with mild sepsis. There was a correlation between the total NO and cortisol level throughout the study. Conclusion: In patients with sepsis, the levels of plasma NO and cortisol were well correlated during the first week of sepsis, which suggests an interrelationship. However, the clinical and pathogenetic implications await further evaluation. (Tuberc Respir Dis 2007; 62: 308-313)

소아 Mycoplasma Pneumoniae에 의한 폐렴의 임상적 고찰

김상갑,노상현,정은경,윤중근,김용태,박영봉 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The author determined mycoplasma antibody titer in 127 cases of pneumonia who were admitted to the pediatric ward of Chosun University Hospital from December, 1989, to Novemver, 1990, and clinical investigation and statistical analysis were performed between mycoplasma antibody positive group and negative group. The following results were obtained: 1) In 127 cases of children with pneumonia, incidence of mycoplasma antibody positive cases was 22.8%(29/127). 2) Comparison of mean age between mycoplasma antibody positive group and negative group revealed significantly older in positive group than negative group (5.9±2.8 years, 2.7±3.5 years respectively), 3) The sex ratio was 1:1.23 in mycoplsma antibody positvie group and 1.6:1 in negative group. 4) There was no significant difference in the clinical symptoms and the physical signs betweem both groups. 5) There was no significant difference in total leukocyte count and ESR between both groups. 6) On radiological findings, the bronchopneumonia was significantly related to mycoplasma antibody positive group.

Sr(NO₃)₂ 용융염에서 이온교환이 K₂O-TiO₂-SiO₂ glass에 미치는 영향

박노형,유은성,이회관,허훈,Park, No-Hyung,Yoo, Eun-Sung,Lee, Hoi-Kwan,Huh, Hoon 한국결정성장학회 2011 한국결정성장학회지 Vol.21 No.5

Fresnoite 결정화 유리는 최근 비선형 광학특성으로 인하여 널리 연구되어 지고 있다. 그러나, 이전 연구 결과를 통하여 투명결정화 유리의 화학 조성으로는 정량적으로 Fresnoite 구조에 유사한 조성을 조절하는 것에 한계가 있음을 확인 할 수 있다. 본 연구에서는 $K_2O-TiO_2-SiO_2$ glass의 제조한 후, 제조된 유리를 $Sr(NO_3)_2$ 용융염에 담지하여 모유리의 표면에 Fresnoite 결정을 형성시키는 방법으로 투명결정화 유리를 제조하고, 이 때 Sr 이온이 비선형광학효과에 미치는 영향을 살펴보았다. XRD를 통하여 담지 시간에 따른 결정상 변화와 열처리를 통한 결정상 변화를 관찰하였으며, FE-SEM을 사용하여 생성된 결정의 미세구조와 Nd : YAG laser를 사용하여 2차비선형특성의 유무를 관찰하였다. A fresnoite glass-ceramics has been investigating considerably because of the second order nonlinearity as well as its permanent optical nonlinearity. However, the chemical compositions of transparent glass-ceramics examined in the previous studies have been limited to adjust the composition close to fresnoite stoichiometrically. In this study, to investigate the effect of strontium ions in glass-ceramics on second order nonlinearity, $K_2O-TiO_2-SiO_2$ (KTS) glasses soaked in molten $Sr(NO_3)_2$ were prepared. Crystalline phases of the soaked glasses were measured by X-ray diffraction (XRD) as soaking times and additional heat treatment. The exchange of strontium ions into the glass was verified by Field Emission Scanning Electron Microscope (FE-SEM). And the phenomena of second order harmonic generation (SHG) was observed using Nd-YAG laser.

중생 고품질 내병 다수성 벼 ‘영보(嶺寶)’

박노봉(No-Bong Park),김상열(Sang-Yeol Kim),여운상(Un-Sang Yeo),김정일(Jeong-Il Kim),이지윤(Ji-Yoon Lee),권오덕(Oh-Deog Kwon),박동수(Dong-Soo Park),이종희(Jong-Hee Lee),조준현(Jun-Hyun Cho),송유천(You-Cheon Song),오성환(Seong-Hwan Oh) 한국육종학회 2019 한국육종학회지 Vol.51 No.4

‘Yeongbo’ is a variety of japonica rice (Oryza sativa L.) with good eating quality, resistance to rice stripe virus, rice dwarf virus, and bacterial blight disease. It was developed by the rice breeding team of the Yeongdeok Branch, National Institute Crop Science, Rural Development Administration in 2014. This variety was derived from a cross between ‘Yeongdeog35’ with good eating quality and ‘Saekyehwa’ with good plant type in the 2002 summer season. A promising line selected through the pedigree breeding method, YR24269-1-2-1-2-3-3, was designated as ‘Yeongdeog57’ in 2011. After a local adaptability test at nine locations from 2012 to 2014, ‘Yeongdeog57’ was released under the name of ‘Yeongbo’ in 2014. ‘Yeongbo’ had a short culm length of 66 cm and medium growth duration. This variety was resistant to K1, K2, and K3 races of bacterial blight, rice stripe virus, and dwarf virus, and moderately resistant to leaf blast disease. ‘Yeongbo’ had translucent and clear milled rice kernel without white core and belly, and good eating quality according to a panel test. The yield potential of ‘Yeongbo’ in milled rice was approximately 5.75 MT/ha at an ordinary fertilizer level in the local adaptability test. This cultivar would be adaptable to middle plain area, south plain area, Yeongnam plain area, east costal area, and south mid-mountainous area. (Registration No.6804)

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

개에서 이중 결찰법을 통한 동맥관 개존증의 완치 예

윤헌영,정순욱,박희명,박철,정만복,김준영,한현정,황민,노병국,박상혁,장하영,박정윤 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1

A ten months old, female Yorkshire terrier weighing 2.88 kg referred to veterinary teaching hospital of college of veterinary medicine, Konkuk University because of syncope, cough and dyspnea. First hematological and serum chemical test revealed thrombocytopenia, mild anemia, and increase of concentration of ALP (195 U/L). On 57 days later, second hematological and serum chemical test revealed polycythemia, increase of concentration of ALP (211 U/L), and Tchol (387 mg/dl). Right atrium enlargement, main pulmonary artery bulge and cardiomegaly (VHS = 11.5) were observed in radiographic findings. Ultrasonographic images showed both right and left ventricular dilation and turbulent flow between the descending aorta and the main pulmonary artery in color Doppler imaging. ECG showed left ventricular enlargement, SA block, and electrical alternant. Thoracotomy was performed through left fourth intercostal incision under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. Cough and dyspnea disappeared on 5 days after operation. Turbulent flow was not found in color doppler imaging of ultrasonography on 10 days after operation. Ten months later after the operation, syncope could not exist any more.

119구급차로 이송된 환자의 병원 전 전문응급처치에 관한 조사

박진옥,이경희,노상균,최청숙 한국응급구조학회 2003 한국응급구조학회지 Vol.7 No.1

An analysis was performed to evaluate the prehospital advanced emergency care in Emergency Medical Service system(EMS) through the review of the 119 transport records of 190 patients who visited to Jecheon Seoul hospital emergency center at Chungpuk Jecheon via 119 system during the period from October 2002 to September 2003. The results were obtained as follows: 1. Among 190 patients, male were 127(66.8%) and female were 63(33.2%) and non-traumatic patients were 81(42.6%) and traumatic patients were 109(57.4%). 2. The analysis of prehospital care by Emergency Medical Technician(EMT) revealed that Airway maintenance and keeping oral airway(37.7%), oxygen supply(75.9%), Tourniquett or MAST(18.9%), Immobilization of neck or spine(94.7%), Immobilization of extremities(51.4%), wound bandage and dressing(25.0%), BCLS(12.1%) and Application of AED(2 patients). 3. The analysis of prehospital care by EMT revealed prehospital care was limited to keep of intubation or LMA, medication and IV insertion, insertion of gastric tube and ACLS. 4. There was no case of the notification to medical institute or consultation to doctor.

비용ㆍ편익 분석을 중심으로 한 중수도 시설의 처리방법별 적정규모선정

노상환,민동기,송영일,박태욱,박주양 한양대학교 환경공학연구소 2000 環境科學論文集 Vol.21 No.-

미래의 안정적인 수자원 확보를 위한 수요관리방안인 중수도 시설 설치 시 발생하는 비용과 편익의 현재가치를 이용하여 처리방식별로 중수도 시설의 경제성 분석을 하였다. 사회적 편익을 고려하였을 경우 중수도 시설규모가 300㎥이상의 1일 처리용량의 경우 경제성이 있는 것으로 나타났다. 그러나 사적편익을 고려하였을 경우에는 사회적 편익에서 고려된 환경비용절감등의 여러 외부 편익이 포함되지 않아 중수도 시설에 의한 편익이 작아지게 된다. 따라서 사적편익만을 고려할 경우에는 대체로 경제성이 있는 중수도 시설의 규모는 사회적 비용을 고려하였을 경우 보다 커진다. Water reuse is a control method of water demand to steadily assure water resources in the future. Economical efficiency of wastewater reuse plants with various treatment processes was studied using the present value of cost-benefit. When social benefits are considered, the capacity of 300㎥/ day was found to be economically effiecient. However, when private benefits are considered, the social benefit of wastewater treatment plant decreases because the private benefits do not include environmental expenses and other benefits which are included in social benefits. Therefore, when the private benefits are only considered, the economically efficient capacity of the wastewater reuse plant will be higher than that considering social expenses.

비강비호즈킨 림프종의 전산화단층촬영 소견 : CT Features

노태연,백호길,원종부,박성호,박오봉,백승국,신미정,김봉기,최한용 침례병원 1998 浸禮病院學術誌 Vol.14 No.-

소음 노출 남성 근로자에서의 청력저하와 혈청 마그네슘의 관련성

박완섭,이종영,정상재,유재영,최태성,홍성철,노성찬 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 소음에 노출된 남자 근로자를 대상으로 장기간 소음 폭로가 혈청 마그네슘의 농도와 관련이 있는지를 검정하고 이러한 혈청 마그네슘의 농도가 또한 청력저하와 관련이 있는지를 파악하기 위하여 수행되었다. 방법 : 소음에 노출되는 178명의 연구대상자를 청력저하의 정도에 따라 세 그룹으로 분류하고, 구조화된 설문, 신체계측, 혈액검사 등으로 청력저하에 대한 감수성 요인과 혈청 마그네슘 등을 수집하고 측정하였으며, 대상자들의 청력 역치를 측정하기 위하여 청력검사를 실시하였다. 결과 : 본 연구의 결과를 요약하면 다음과 같다. 첫재, 청력저하에 관련된 개인의 감수성 인자라고 알려진 변수인 흡연유무, 나이, 혈압, 헤마토크리트, 콜레스테롤, 혈당 중에서 나이, 이완기 혈압이 단순분석에서 세 그룹간에 차이가 있었고(p〈0.05), 혈청 마그네슘의 농도 또한 세 그룹간에 통계적으로 유의한 차이가 있었으며(p〈0.05) 청력저하가 심할수록 혈청 마그네슘 농도는 낮아지는 경향을 보였다. 둘째, 그룹간의 소음 노출력은 차이가 있었지만 (p〈0.05) 청력보호구 착용상태에는 유의한 차이가 없었다. 셋째, 혈청 마그네슘 농도에 영향을 줄 수 있는 변수인 소음 노출 기간, 마그네슘 함량이 많은 음식의 섭취정도, 스트레스 수준 중에서 소음 노출기간이 혈청 마그네슘 농도와 유의한 상관관계를 보였고(p〈0.05) 노출기간이 길수록 마그네슘의 혈청농도는 낮아지는 경향을 나타내었다. 넷째, 주파수별로 청력저하와 관련된 감수성 요인들에 대한 다중회귀분석 결과 주파수 1,000 Hz에서는 연령이 좌,우측 귀 모두에서 유의한 변수로 채택되었으며 (p〈0.05), 연령이 증가할수록 청력저하가 심해지는 경향을 보였고, 주파수 4,000 Hz에서는 확장기 혈압, 소음 노출 기간, 혈청 마그네슘 등이 청력저하에 대한 감수성 요인으로 채택되었으며(p(0.05), 이완기 혈압이 높을수록, 소음노출 기간이 길수록, 혈청 마그네슘의 농도가 낮을수록 청력저하가 심해지는 것으로 나타났다. Objectivea : This study was conducted to investigate that the chronic noise exposure is associated with decreased serum magnesium concentrations and evaluate whether decreased serum magnesium is associated with noise induced hearing loss. Methods : One hundred seventy-eight male workers exposed to noise were selected and classified three groups by the degree of hearing loss. Hearing threshold levels were less than 30 dB at 1,000 Hz or less than 40 dB at 4,000 Hz In group I, more than 30 dB at 1,000 Hz or more than 40 dB at 4,000 Hz and 15 dB and less of pure tone average[PTA : (500 Hz+l,000 Hz+2,000 Hz)/3] in group II, more than 30 dB at 1,000 Hz or more than 40 dB at 4,000 Hz and over 15 dB of PTA in group III. Results : Serum magnesium concentrations were 2.42±0.26 mg/dl in group 1, 2.35±0.23 mg/dl in group n , 2.26±0.24 mg/dl in group II, respectively and significantly differ-ent between group I and group III (p〈0.01). It was negatively correlated with duration of the noise exposure as correlation coefficient (r) of -0.194 (p(0.05) . Analysis of the multipleregression on hearing threshold levels showed that serum magnesium, diastolic blood pres-sure, duration of the noise exposure were statistically significant at 4,000 Hz (p(0.05) . While only age was statistically significant at 7,000 Hz (p(0.05) . Conclusions : These results suggest that chronic noise exposure may induces decreasein serum magnesium concentrations and that its decreased concentration is related with noise induced hearing loss.