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Two New C-Glucosyl Benzoic Acids and Flavonoids from Mallotus nanus and Their Antioxidant Activity
Phan Van Kiem,Nguyen Thi Mai,Chau Van Minh,Nguyen Huu Khoi,Nguyen Hai Dang,Nguyen Phuong Thao,Nguyen Xuan Cuong,Nguyen Hoai Nam,Nguyen Xuan Nhiem,Yvan Vander Heyden,Joëlle Quetin-Leclercq,김교남,장해동,김영호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.2
Two new 2-C-β-D-glucopyranosyl benzoic acid derivatives named mallonanosides A (1) and B (2) were isolated from the methanolic extract of the leaves of Mallotus nanus along with five known flavonoids, kaempferin (3), juglanin (4), quercitrin (5), myricitrin (6), and rhoifolin (7). Their structures were established on the basis of spectral and chemical evidence. Their antioxidant activities were shown to depend on the number of hydroxyl groups, and the location and species of sugar moiety.
Cytotoxic Oleane-type Triterpene Saponins from Glochidion eriocarpum
Nguyen Xuan Nhiem,김영호,Vu Kim Thu,Phan Van Kiem,Chau Van Minh,Bui Huu Tai,TRANHONG QUANG,Nguyen Xuan Cuong,Pham Hai Yen,Hye-Jin Boo,강정일,강희경 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.1
The anticancer activity of ten compounds from the aerial parts of Glochidion eriocarpum were evaluated on two human cancer cell lines, HL-60 and HCT-116. Compounds 1-4 displayed highly potent cytotoxic activity on the HCT-116 cancer cell line with IC50 values ranging of 0.41~1.16 μM. Compounds 1-4 significantly inhibited the HL-60 cell line with IC50 values ranging of 4.51~6.33 μM. These results suggested that the benzoyl group at the C-22 position in oleane-type triterpene saponins was essential for cytotoxicity towards tumor cells. Moreover, compounds 2 and 3 showed more potent cytotoxicity than compounds 1 and 4 against HL-60 and HCT-116 cells. With respect to the mechanism underlying cytotoxicity, compounds 1-4 increased chromatin condensation, a typical apoptotic characteristic in HL-60 and HCT-116 cells. In the mechanism of apoptosis induction, compounds 1-4 reduced Bcl-2expression, whereas the expression of Bax was increased compared to controls in HCT-116 cells. In addition, compounds 1-4 decreased the level of procaspase-3. The cleavage of poly (ADP-ribose) poly merase (PARP), a vital substrate of effector caspase, was observed in HCT-116 cells. Furthermore, the induction of apoptosis was also accompanied by an activation of extracellular signal-regulated kinase (ERK) and p38 kinase in HCT-116 cells. These findings provide evidence demonstrating that the pro-apoptotic effects of compounds 1-4 are mediated through the activation of ERK and p38 in HCT-116 cells.
Nguyen Xuan Nhiem,Pham Hai Yen,Nguyen Thi Thanh Ngan,TRANHONG QUANG,Phan Van Kiem,Chau Van Minh,Bui Huu Tai,Nguyen Xuan Cuong,Seok Bean Song,김영호 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4
Momordica charantia is used to treat various diseases, including inflammatory conditions. Previous reports indicated that the extract of this plant inhibits activation of nuclear transcription factor-jB (NF-jB) but activates peroxisome proliferator-activated receptor (PPAR). Additionally, cucurbitane-type triterpene glycosides are the main bioactive components of the fruit of M. charantia. Therefore, we investigated the anti-inflammatory activity of 17 cucurbitane-type triterpene glycosides (1–17) isolated from this plant. Their inhibition of NF-jB and activation of PPAR activities in HepG2 cells were measured using luciferase reporter and PPAR subtype transactivation assays. Compounds 6 and 8 were found to inhibit NF-jB activation stimulated by tumor necrosis factor-a (TNFa) in a dose-dependent manner. With 50% inhibition concentration (IC50) values of 0.4 lM, compounds 6 and 8 were more potent inhibitors than the positive control, sulfasalazine (IC50 = 0.9lM). Compounds 4, 6, and 8 also inhibited TNFa-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2mRNA. However, only compound 13 significantly increased PPARc transactivation.
Anatomic characteristics and novel transplantation model of the canine uterus
Xuan-Hai Do,Thanh-Hai Tong,Trung-Chuc Nguyen,Tuan-Anh Ngo,Minh-Trang Thi Tran 대한이식학회 2023 Korean Journal of Transplantation Vol.37 No.2
Background: In Vietnam, the rate of absolute uterine factor infertility is increasing, but no study has been published on uterine transplantation. The present study was designed to comprehensively observe the canine uterine anatomy and to examine the possibility of using a living canine donor for uterine transplantation training and further research. Methods: Ten female Vietnamese mixed-breed dogs were sacrificed for anatomical research, and 15 additional pairs were used to evaluate the novel uterine transplant model. Results: The anatomic features of the canine uterus differed considerably from those of the human uterus, with the uterine vessels originating from branches of the pudendal vessels (also known as the vaginal vessels). The uterine vascular pedicle had a small diameter (1 to 1.5 mm for arteries and 1.2 to 2.0 mm for veins) and required manipulation under a microscope. To perform uterine transplantation, the donor specimen’s artery and vein lengths were successfully reconstructed by anastomosis between both sides of the vasculature using autologous Y-shaped subcutaneous veins. The living-donor uterine transplantation model constructed in this study was feasible, with the transplanted uterus surviving in 86.7% of cases (13/15). Conclusions: Uterine transplantation was successfully performed in a Vietnamese canine living donor model. This model could be helpful in uterine transplantation training and improve the transplantation success rate in humans.
Hai Le Xuan,Quoc-Dong Hoang,Soon Geul Lee,Dat Pham Xuan,Hoang Tran Viet,Minh Pham Van,Hung Pham Van,Hung Pham Viet,PHAM DUC TUAN,Duc Anh Nguyen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.2
Ballbots, which have been studied for over ten years, are under-actuated mobile robots that operate using the inverted pendulum paradigm. Controlling a ballbot poses a number of challenges, including maintaining the stable upright posture from the ground in all directions and making sure it follows the desired trajectory. External factors such as a minor change in contact surface properties or fabrication errors can affect the system's stabilization and transfer capabilities. In this study, an adaptive hierarchical sliding mode control algorithm based on an artificial neural network is developed to make the ballbot robust to external factors. The use of the proposed controller ensures system stability despite uncertainties including friction, accidental centrifugal forces and gravity that occur when the ballbot follows the reference trajectory. The system stability is guaranteed on the basis of Lyapunov theory. Control efficiency and robot stability under system uncertainties are demonstrated by numerical simulation.
A New Dimeric Lignan from the Stems of Willughbeia edulis
Nguyen, Hai Xuan,Do, Truong Nhat Van,Le, Tho Huu,Dang, Phu Hoang,Nguyen, Mai Thanh Thi,Nguyen, Nhan Trung The Korean Society of Pharmacognosy 2022 Natural Product Sciences Vol.28 No.2
As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acid-catalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show 𝛼-glucosidase inhibitory activity with an IC<sub>50</sub> value > 250 𝜇M.
Yen, Nguyen Hai,Thanh, Pham Thi,Koledov, Victor V.,Kamantsev, Alexander P.,Mashirov, Alexey V.,Thanh, Tran Dang,Hau, Kieu Xuan,Yu, Seong Cho,Dan, Nguyen Huy IEEE 2018 IEEE transactions on magnetics Vol.54 No.6
<P>In this paper, we investigated the influence of annealing conditions on magnetic properties, magnetocaloric effect, and critical parameters of Ni<SUB>50</SUB>Mn<SUB>50−<I>x</I></SUB>Sn<SUB><I>x</I></SUB> ( <TEX>$x = 13$</TEX>, 13.5, and 14) alloy ribbons prepared by using the melt-spinning method. The ribbons were annealed at 1123 K for various times. A martensitic–austenitic (M–A) structural phase transformation was observed on both the as-quenched and annealed samples. Temperature of the M–A phase transition ( <TEX>$T_{M-A}$</TEX>) of the ribbons can be regulated in room temperature region by changing the annealing time. Maximum positive and negative magnetic entropy changes, <TEX>$\vert \Delta S_{m}\vert _{\mathrm {max}}$</TEX>, larger than 3 and 1 <TEX>$\text {J}\cdot \text {kg}^{-1}\cdot \text {K}^{-1}$</TEX>, respectively, were achieved on the Ni<SUB>50</SUB>Mn<SUB>37</SUB>Sn<SUB>13</SUB> sample after annealing for 0.5 h. Critical parameters were determined to elucidate magnetic orders in the alloy. The obtained parameters are very close to those of the mean field theory of long-range ferromagnetic orders.</P>
Truong Xuan NGUYEN,Toan Thanh NGUYEN,Hai Ngoc NGUYEN,Linh Thuy HOANG,Trung Vy CHAU 한국유통과학회 2018 KODISA ICBE (International Conference on Business Vol.2018 No.-
The study developed and tested the impact of occupation relevance, facility conditions, and social influence, skills on the actual use industry 4.0 on studying of students in universities in Ho Chi Minh City, Viet Nam. Both qualitative and quantitative methodologies were utilized in this study. Qualitative research first carried out with an in-depth interview, conducted to derive measurement items for the interested variables. Quantitative research used cross-sectional field design by pilot study and official study. The result of structural equation modeling showed that occupation relevance, skills, facility conditions, and social influence impacted the intermediates variables relevance advantage, perceived usefulness, behavioral intention to use, and actual to use. The occupation relevance, skills, facility conditions, and social influence are independent variables. They impact actual to use through mediating variables such as relevance advantage, perceived usefulness, and behavioral intention to use.
Pham Thi Thanh,Nguyen Van Duong,Nguyen Hai Yen,Nguyen Huy Ngoc,Nguyen Mau Lam,Kieu Xuan Hau,유성조,Nguyen Huy Dan 한국물리학회 2018 Current Applied Physics Vol.18 No.3
In this work, we investigated the influence of additional compounds of Nd-Cu-Al, Dy-Nb-Al, Dy-Zr-Al and Nb-Cu-Al on coercivity of sintered Nd-Fe-B magnets. The additional nanoparticles with size in the range of 40e80 nmwas mixed with the micrometer Nd-Fe-B powder before sintering process. The results show that the coercivity of the sintered Nd-Fe-B magnets can be improved by introducing additional nanoparticles to their grain boundaries. The improvement of the coercivity of the magnets is clearly dependent on composition and fraction of the additional compounds. While the Dy-Nb-Al, Dy-Zr-Al and Nb-Cu-Al compounds degrade the coercivity of the sintered Nd-Fe-B magnets, the Nd-Cu-Al nanoparticles considerably improve this quantity. The coercivity the sintered Nd16.5Fe77B6.5 magnets has been enhanced about 40% by adding 3 wt% of the Dy-free compound of Nd40Cu30Al30.