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Immunological Roles of Pasteurella multocida Toxin (PMT) Using a PMT Mutant Strain
Kim, Tae-Jung,Toan, Nguyen Tat,Jang, Eun-Jin,Jung, Bock-Gie,Lee, Jae-Il,Lee, Bong-Joo The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.4
The immunological role of the Pasteurella multocida toxin (PMT) in mice was examined using a PMT mutant strain. After a nasal inoculation, the mutant strain failed to induce interstitial pneumonia. Moreover, PMT had no significant effect on the populations of CD4+, CD8+, CD3+, and CD19+ immunocytes in blood or on the populations of CD4+ and CD8+ splenocytes (P<0.01). However, there was a significant increase in the total number of cells in the BAL samples obtained from the wild-type P. multocida-inoculated mice. On the other hand, the level of IL-l expression decreased when the macrophages from the bronchio-alveolar lavage were stimulated with PMT. Overall, PMT appears to play some role (stimulating and/or inhibiting) in the immunological responses but further studies will be required to confirm this.
Immunological Roles of Pasteurella multocida Toxin (PMT) Using a PMT Mutant Strain
Tae Jung Kim,Nguyen Tat Toan,Eun Jin Jang,정복기,이재일,이봉주 한국미생물학회 2007 The journal of microbiology Vol.45 No.4
The immunological role of the Pasteurella multocida toxin (PMT) in mice was examined using a PMT mutant strain. After a nasal inoculation, the mutant strain failed to induce interstitial pneumonia. Moreover, PMT had no significant effect on the populations of CD4+, CD8+, CD3+, and CD19+ immunocytes in blood or on the populations of CD4+ and CD8+ splenocytes (P<0.01). However, there was a significant increase in the total number of cells in the BAL samples obtained from the wild-type P. multocida-inoculated mice. On the other hand, the level of IL-1 expression decreased when the macrophages from the bronchio-alveolar lavage were stimulated with PMT. Overall, PMT appears to play some role (stimulating and/or inhibiting) in the immunological responses but further studies will be required to confirm this.