Cardiovascular Disease Risk in Children and Adolescents with Attention Deficit/Hyperactivity Disorder

Necati Uzun(Necati Uzun ),Mehmet Akif Akıncı(Mehmet Akif Akıncı ),Hayrullah Alp(Hayrullah Alp ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Objective: The aim of this case-controlled study is to evaluate chronic inflammation, subclinical atherosclerosis and cardiovascular disease risk in children and adolescents with ADHD. Methods: A total of 51 medication-free children and adolescents with ADHD and 51 healthy controls were included in this study. K-SADS-PL was used to determine the diagnosis of ADHD and other psychiatric disorders. Conners’ Parent Rating Scale-Revised Short Form and the Conners’ Teacher Rating Scale-Revised Short Form severity of ADHD was used to evaluate severity of ADHD. In order to evaluate subclinical atherosclerosis, common carotid intima media thickness (IMT), epicardial adipose tissue thickness (EAT), and periaortic adipose tissue thickness (PAT) were assessed as well as clinical parameters. Results: The IMT (0.037 ± 0.005 cm vs. 0.026 ± 0.003 cm), EAT (0.472 ± 0.076 cm vs. 0.355 ± 0.051 cm), and PAT (0.135 ± 0.016 cm vs. 0.118 ± 0.009 cm) measurements were significantly higher in the ADHD group than in the control group. Additionally, partial correlation analyses revealed that a positive correlation was observed between IMT and EAT, and PAT measurements separately. Multivariate linear regression analysis revealed that, body mass index (BMI) positively predicted IMT. Also, age and BMI positively predicted the EAT levels of the subjects with ADHD. Conclusion: Our results suggest that children and adolescents with ADHD have a risk for cardiovascular disease. For this reason, subclinical atherosclerosis should be taken into consideration in the follow-up and treatment of ADHD for cardiovascular disease risk.

A study on the correlation between spleen volume estimated via cavalieri principle on computed tomography images with basic hemogram and biochemical blood parameters

Necati Emre Sahin,Zulal Oner,Serkan Oner,Muhammed Kamil Turan 대한해부학회 2022 Anatomy & Cell Biology Vol.55 No.1

Considering its hematological and immunological functions, spleen is a very important organ. A change occurs in its size as the spleen performs these functions. This study aims to examine the possible relationships between spleen volume and the basic hemogram and biochemical parameters in serum. Multidetector computed tomography images and basic hemogram and biochemical parameters of 74 adult individuals, 34 male and 40 female, who were found to be healthy, were used in the study. Spleen volume was estimated using the Cavalieri method on multidetector computed tomography images and the correlations between the volume value with basic hemogram and biochemistry parameters were researched. While negative significant correlations were found between the estimated spleen volume and lymphocyte percentage (r=-0.224) and platelet level (r=-0.271); positive significant correlations were found between hemoglobin level (r=0.228), hematocrit level (r=0.237), alanine aminotransferase (r=0.345), and erythrocyte level (r=0.375). As a result of this study, a relationship was found between spleen volume and lymphocyte percentage, hematocrit level, erythrocyte level, platelet level, and alanine aminotransferase level in serum. We believe that the results of the study will provide a larger perspective to clinicians in the diagnosis of diseases associated with spleen.

Pathological and Immunohistochemical Findings in Broilers Inoculated with a Low Virulent Strain of Infectious Laryngotracheitis Virus

Necati Timurkaan,Fethi Yilmaz,Hakan Bulut,Harun Ozer,Yusuf Bolat 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

and Immunohistochemical Findings in Broilers Inoculated with a Low Virulent Strain of Infectious Laryngotracheitis VirusNecati Timurkaan*, Fethi Yilmaz, Hakan Bulut1, Harun Ozer and Yusuf Bolat1

Oxytocin and Vasopressin Levels and Related Factors in Adolescents with Social Phobia and Other Anxiety Disorders

Necati Uzun,Ö,mer Faruk Akç,a,İ,brahim Kılınç,Tevfik Balcı 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.2

Objective: This study aimed to determine whether a difference exists in plasma oxytocin and vasopressin levels among social anxiety disorder, other anxiety disorders, and healthy control groups in adolescents. The relationship between several psychiatric variables (i.e., state and trait anxiety, social anxiety, childhood trauma, and behavioral inhibition) and oxytocin or vasopressin levels were also investigated in adolescents with anxiety disorders. Methods: The study included three groups of adolescents: social anxiety disorder (n = 29), those with other anxiety disorders (n = 27), and the control group (n = 28). The participants filled out self-report scales to determine various psychological variables. Oxytocin and vasopressin levels were determined from the blood samples of the participants. Results: The oxytocin levels did not show a significant difference between the social anxiety disorder group and the other anxiety disorders group. However, the oxytocin levels were significantly higher in the social anxiety disorder and other anxiety disorders groups than in the control group. The vasopressin levels did not show a significant difference among the groups. According to the hierarchical regression analysis, the state and trait anxiety levels predicted oxytocin in opposite directions. Oxytocin showed positive and negative relationship with trait and state anxiety respectively. No predictive factors were found for the vasopressin levels. Conclusion: We found that the oxytocin levels of adolescents with social anxiety disorder were not different from those of adolescents with other anxiety disorders. Further studies can improve our knowledge of the relationship among anxiety disorders and oxytocin or vasopressin.

Evaluation of marginal discrepancy in metal frameworks fabricated by sintering-based computer-aided manufacturing methods

Kaleli, Necati,Ural, Cagri,Us, Yesim Olcer The Korean Academy of Prosthodonitics 2020 The Journal of Advanced Prosthodontics Vol.12 No.3

PURPOSE. The aim of this in vitro study was to evaluate the effect of sintering procedures on marginal discrepancies of fixed partial metal frameworks fabricated using different sintering-based computer-aided design and computer/aided manufacturing (CAD/CAM) techniques. MATERIALS AND METHODS. Forty resin die models of prepared premolar and molar abutment teeth were fabricated using a three-dimensional (3D) printer and divided into four groups (n = 10) according to the fabrication method of metal frameworks used: HM (via hard milling), SM (via soft metal milling), L25 (via direct metal laser melting [DMLM] with a 25 ㎛ layer thickness), and L50 (via direct DMLM with a 50 ㎛ layer thickness). After the metal frameworks were fabricated and cemented, five vertical marginal discrepancy measurements were recorded in each site (i.e., buccal, facing the pontic, lingual, and facing away from the pontic) of both abutment teeth under a stereomicroscope (×40). Data were statistically analyzed at a significance level of 0.05. RESULTS. No statistically significant differences (P>.05) were found among the four axial sites of metal frameworks fabricated by sintering-based CAD/CAM techniques. The HM and L25 groups showed significantly (P<.001) lower marginal discrepancy values than the SM and L50 groups. CONCLUSION. Marginal discrepancy in the sites facing the pontic was not influenced by the type of sintering procedure. All fabrication methods exhibited clinically acceptable results in terms of marginal discrepancies.

A SOLVABLE SYSTEM OF DIFFERENCE EQUATIONS

Taskara, Necati,Tollu, Durhasan T.,Touafek, Nouressadat,Yazlik, Yasin Korean Mathematical Society 2020 대한수학회논문집 Vol.35 No.1

In this paper, we show that the system of difference equations $x_n={\frac{ay^p_{n-1}+b(x_{n-2}y_{n-1})^{p-1}}{cy_{n-1}+dx^{p-1}_{n-2}}}$, $y_n={\frac{{\alpha}x^p_{n-1}+{\beta}(y_{n-2}x_{n-1})^{p-1}}{{\gamma}x_{n-1}+{\delta}y^{p-1}_{n-2}}}$, n ∈ ℕ₀ where the parameters a, b, c, d, α, β, γ, δ, p and the initial values x-2, x-1, y-2, y-1 are real numbers, can be solved. Also, by using obtained formulas, we study the asymptotic behaviour of well-defined solutions of aforementioned system and describe the forbidden set of the initial values. Our obtained results significantly extend and develop some recent results in the literature.

An integrated approach for structural health monitoring using an in-house built fiber optic system and non-parametric data analysis

Masoud Malekzadeh,Necati Catbas,Mustafa Gul,권일범 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.14 No.5

Multivariate statistics based damage detection algorithms employed in conjunction with novel sensing technologies are attracting more attention for long term Structural Health Monitoring of civil infrastructure. In this study, two practical data driven methods are investigated utilizing strain data captured from a 4-span bridge model by Fiber Bragg Grating (FBG) sensors as part of a bridge health monitoring study. The most common and critical bridge damage scenarios were simulated on the representative bridge model equipped with FBG sensors. A high speed FBG interrogator system is developed by the authors to collect the strain responses under moving vehicle loads using FBG sensors. Two data driven methods, Moving Principal Component Analysis (MPCA) and Moving Cross Correlation Analysis (MCCA), are coded and implemented to handle and process the large amount of data. The efficiency of the SHM system with FBG sensors, MPCA and MCCA methods for detecting and localizing damage is explored with several experiments. Based on the findings presented in this paper, the MPCA and MCCA coupled with FBG sensors can be deemed to deliver promising results to detect both local and global damage implemented on the bridge structure.

Neutrophil-lymphocyte and Platelet-lymphocyte Ratios among Adolescents with Substance Use Disorder: A Preliminary Study

Serdar Karatoprak,Necati Uzun,Mehmet Akif Akıncı,Yunus Emre Dönmez 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.4

Objective: Substance use disorder (SUD) is a serious public health problem affecting both the individual and the society, and substance use-related deaths and disability have been shown to increase gradually. Recent etiologic studies have reported that there is a relation between inflammatory parameters and psychiatric disorders. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) used as an indicator of inflammation have been shown to be increased in various psychiatric disorders. In this study, we aimed to investigate the NLR and PLR in adolescents with SUD. Methods: This study was conducted by retrospectively examining the records of 55 male adolescents who were followed up with SUD in a child and adolescent psychiatry outpatient clinic between November 2019−June 2020. Patients who had comorbid psychiatric disorder were included, and those who received any psychotropic medication were excluded. A total of 61 healthy male adolescents in the same age range without any psychiatric disorders were recruited as a control group. Neutrophil-lymphocyte-platelet counts were noted retrospectively from complete blood tests, and NLR-PLR were calculated. Results: The NLR and PLR of adolescents with SUD were significantly higher than the healthy adolescents (p < 0.01, p < 0.01, respectively). In addition, conduct disorder, depression, and attention deficit/hyperactivity disorder, which were determined as the most common comorbid psychiatric disorders had no effects on NLR (p = 0.513, p = 0.584, p = 0.394, respectively) and PLR (p = 0.210, p = 0.346, p = 0.359, respectively). Conclusion: The results of current study indicate that inflammatory processes may have a key role in the pathophysiology of SUD.

Reliability and fatigue life evaluation of railway axles

Meral Bayraktar,Necati Tahrali,Rahmi Guclu 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.3

The axle is one of the most important components of a rail vehicle which transmits the weight of the vehicle to the wheels, meets the vertical and horizontal loads formed during static and dynamic moving, and carries the driving moment and braking moment. The prediction of fatigue failure of axles plays an important role in preventing fatigue fractures. Varying loads on components lead to cumulative failure in the mechanism. In this study, failures in axles of rail vehicles serving the Istanbul Transportation Co. have been investigated. Statistical evaluation of real life values has been performed by taking into account the kilometer and load cycle. Equivalent stresses have been used to derive life equations and diagrams by using one of the cumulative life theories known as the Palmgren-Miner method. Finally,theoretical and practical Wohler diagrams S-N (σ-N: stress-life) have been plotted to reveal error calculation.

Investigation of Shear Complex Modulus and Phase Angle Values of Short- and Long-term Aged Polymer Modified Bitumens at Different Frequencies

Taner Alatas,Mesude Yilmaz,Necati Kuloglu,Mehmet Cakiroglu,Tacettin Geckil 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.7

In this study, modified bitumens were prepared by mixing two types of Styrene-Butadiene-Styrene (SBS-D and SBS-M) and Ethylene-Vinyl-Acetate (EVA) with B 160/220 base bitumen 3% by weight. The short- and long-term aging processes were applied to base and modified binders with rolling thin film oven test and pressure aging vessel, respectively. Dynamic Shear Rheometer (DSR) test conducted at different temperatures and frequencies showed that while the shear complex modulus (G*) of unaged, short- and long-term aged binders reduced, the phase angle (δ) of those increased. The shear complex modulus values increased and the phase angle values decreased by the effect of aging and increase in frequency. The G*/sinδ values increased with the addition of modifiers to the base bitumen. Comparison of modifiers demonstrated that the effective modifier type shows variety according to frequency, temperature and aging conditions.