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Poster Session:PS 0572 ; Oncology : Lung Cancer with Revealing Skin Metastasis
( Miguel Arderius ),( Nayive Gomez ),( David Fortes ),( Alda Jordao ),( Gloria Silva ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Skin metastization is an uncommon manifestation of carcinomas (3-4% incidence in some series). Lung origin is more common in men (24 versus 4% in women, in recent meta-analysis), being the fi rst manifestation in 0.8% of cases. It appears in advanced stage and has poor prognosis. Case Presentation: 78 year old man, smoker, went to the ER because of the appearance, in the last 3 months, of 2 cutaneous nodules in the thorax, with progressive enlargement and infi ammatory signs. Concomitantly, he showed asthenia, adynamia, anorexia, exertional dyspnea and weight loss (10kg), symptoms the patient didn`t quite value, showing a very good Performance Status (Karnofsky scoring 70%). In observation, 2 solid subcutaneous nodules (3cm), parasternal, violaceous, ulcerated, non adherent, painful; and 2 similar nodules, smaller and non ulcerated, palpable in the inguinal regions. In the thorax radiography, peribronchial mass on the right, with irregular contour. Thoraco-abdomino-pelvic CT showed a perihilar mass (8cm) in the right lung, obliterating the anterior segment of the superior lobe; pulmonary artery compression; mediastinal pleura invasion; multiple adenomegalies; adrenal gland metastization; and subcutaneous masses in the anterior thoracic wall, abdominal wall and gluteal region. Analytically, elevated NSE (142μg/L). Bronchofi broscopy revealed complete bronchial obstruction, with the biopsy confi rming a Small Cell Carcinoma. The biopsies from the skin lesions had a mixed pattern (Combined Small Cell and Large Cell Neuroendocrine Carcinoma). He was discharged to Pneumological Oncology, where he started chemotherapy. Conclusion: Despite the fact that skin metastasis are rare, it`s timely recognition may be critical to the prognosis. The Internist should therefore be aware of its existence. In this case, the patient kept a good performance status despite the advanced disease.
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Plants cultivated in Choco, Colombia, as source of repellents against Tribolium castaneum (Herbst)
Karina Caballero-Gallardo,Nayive Pino-Benitez,Nerlis Pajaro-Castro,Elena Stashenko,Jesus Olivero-Verbel 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.4
Essential oils (EOs) of eight plants collected in Choco, Colombia, including Piper divaricatum, P. pseudolanceifolium,P. confertinodum, P. diazanum, Ocimum campechianum, Siparuna conica, Mikania micrantha and Hedychiumcoronarium, were analyzed by gas chromatography–mass spectrometry and tested as repellents against Triboliumcastaneum, using the area preference method, after 2 and 4 h exposure. The main components found in EOswere methyl eugenol, trans-β-cariophyllene, methyl eugenol, α-pinene, δ-cadinene, γ-elemene, α-pinene and1,8-cineol, for O. campechianum, P. pseudolanceifolium, P. divaricatum, P. confertinodum, P. diazanum, S. conica,M. micrantha, and H. coronarium, respectively. Best repellent activities were observed for oils fromO. campechianum and P. pseudolanceifolium with mean repellent concentration (RC50) values of 0.00006 and0.0001 μL/cm2 after 2 h, and 0.00003 and 0.0001 μL/cm2 after 4 h, respectively; whereas the least potent wasthat from M. micrantha, with RC50 values of 0.074 and 0.040 μL/cm2 at 2 and 4 h exposure times, respectively. Based on average percentage repellence, oils from P. pseudolanceifolium and O. campechianum were classifiedas Class IV repellents and were better than the commercial repellent IR3535, classified as Class II. These data evidencethe Choco region as an important source of natural repellents with promising commercial opportunities.
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