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RISS 인기검색어
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- 저자 : Nawab Ali (검색결과 8 건)
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Arshad Ali,Farman Ullah,Irum Sabir Ali,Ahmad Faraz,Mumtaz Khan,Syed Tahir Ali Shah,Nawab Ali,Muhammad Saeed 한국유방암학회 2016 Journal of breast cancer Vol.19 No.2
Purpose: The promoter methylation status of cell cycle regulatory genes plays a crucial role in the regulation of the eukaryotic cell cycle. CpG cytosines are actively subjected to methylation during tumorigenesis, resulting in gain/loss of function. E2F5 gene has growth repressive activities; various studies suggest its involvement in tumorigenesis. This study aims to investigate the epigenetic regulation of E2F5 in breast cancer to better understand tumor biology. Methods: The promoter methylation status of 50 breast tumor tissues and adjacent normal control tissues was analyzed. mRNA expression was determined using SYBR® green quantitative polymerase chain reaction (PCR), and methylation- specific PCR was performed for bisulfite-modified genomic DNA using E2F5-specific primers to assess promoter methylation. Data was statistically analyzed. Results: Significant (p<0.001) upregulation was observed in E2F5 expression among tumor tissues, relative to the control group. These samples were hypo-methylated at the E2F5 promoter region in the tumor tissues, compared to the control. Change in the methylation status (Δmeth) was significantly lower (p=0.022) in the tumor samples, indicating possible involvement in tumorigenesis. Patients at the postmenopausal stage showed higher methylation (75%) than those at the premenopausal stage (23.1%). Interestingly, methylation levels gradually increased from the early to the advanced stages of the disease (p<0.001), which suggests a putative role of E2F5 methylation in disease progression that can significantly modulate tumor biology at more advanced stage and at postmenopausal age (Pearson’s r=0.99 and 0.86, respectively). Among tissues with different histological status, methylation frequency was higher in invasive lobular carcinoma (80.0%), followed by invasive ductal carcinoma (46.7%) and ductal carcinoma in situ (20.0%). Conclusion: Methylation is an important epigenetic factor that might be involved in the upregulation of E2F5 gene in tumor tissues, which can be used as a prognostic marker for breast cancer.
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Mumtaz Ali,Muhammad Zeeshan,Muhammad Bilal Qadir,Rabia Riaz,Sheraz Ahmad,Yasir Nawab,Aima Sameen Anjum 한국섬유공학회 2018 Fibers and polymers Vol.19 No.11
Auxetic materials expand in at least one dimension, when stretched longitudinally i.e. they have negative Poisson’s ratio. Development of 2D woven auxetic fabrics (AF) is a new approach to develop mechanically stable auxetic textile structures. However, the mechanical response of such emerging structure is still not studied in detail yet, therefore different mechanical properties of 2D woven AF are compared with conventional non-auxetic fabric (NAF). AF was developed by orienting yarns in auxetic honey-comb (AHC) geometry and auxeticity is induced due to such orientation of yarns. AF was developed using conventional (non-auxetic) materials; cotton yarn and elastane cotton yarn in warp and weft dimension respectively, using air jet loom. Structure and auxeticity of AF were analyzed using a digital microscope and its different mechanical properties (tensile strength, tear strength, bursting strength, cut resistance, and puncture resistance) were studied. AF showed superior mechanical properties with a lower initial modulus, which is beneficial for different protective textiles applications like cut resistance gloves, blast resistant curtains, and puncture tolerant elastomeric composites.
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Effect of Pile Height on the Mechanical Properties of 3D Woven Spacer Composites
Muhammad Umair,Syed Talha Ali Hamdani,Yasir Nawab,Muhammad Ayub Asghar,Tanveer Hussain,Abdelghani Saouab 한국섬유공학회 2019 Fibers and polymers Vol.20 No.6
Three-dimensional (3D) woven spacer fabric is produced by connecting two woven fabric layers with the verticalpile yarns in the center part. Their composites have great potential for use in construction, automotive, marine, and aerospaceapplications due to outstanding mechanical properties. In this paper, 3D woven spacer fabrics with three thickness levels(4 mm, 10 mm and 20 mm) made of E-glass fibre, were used. Then 3D woven spacer fabrics were fabricated into theircorresponding composites by hand lay-up technique using green epoxy resin. Characterization was done at both stages i.e. fabric and composite. Bending length and modulus of 3D woven spacer fabrics were decreased while the stiffness of thefabric was increased with increase in sample thickness. While in 3D woven spacer composites, 20 mm thick composite wasmore needle penetration resistant as compared to the 10 mm and 4 mm thick composites. Flexural and slow velocity impactperformance of the 3D woven spacer composites was reduced with the increase of sample thickness. Flexural behaviour wasbetter in weft direction as compared to the warp direction in all samples. Furthermore, 4 mm thick composite showed thehighest value of energy absorbed and least deformation during the drop weight impact test.
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Saamia Zahid,Muhammad Ali Nasir,Saad Nauman,Mehmet Karahan,Yasir Nawab,H. M. Ali,Yasir Khalid,Muhammad Nabeel,Mudaser Ullah 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.1
In this study experimental investigation of interlaminar shear strength of glass fibre reinforced thermoplastic polyurethane (TPU) and epoxy based thermosets composites enhanced with multi walled carbon nanotubes (MWCNTs) is presented, and comparison is made between thermoplastic and thermosets composites. Suspension of MWCNTs in TPU and epoxy matrix was prepared using magnetic stirring and sonication technique. Both thermoplastic reinforced glass fibre and thermosets reinforced glass fibre composites were manufactured using hand layup technique. Carbon nanotubes were added in the concentrations of 0.1 %weight, 0.3 %weight and 0.5 %weight in both types of composites. Results showed that as the concentration of CNTs increases, the ILSS of the nanocomposites was also improved. With an addition of 0.5 % weight CNTs, there was improvement of 24.37 % in ILSS in epoxy based composites and 10.05 % enhancement in thermoplastic polyurethane reinforced glass fibre composites. The average ILSS obtained for thermoplastic polyurethane composites was less than that of epoxy composites. The TPU based composites also demonstrated inelastic deformations without any trace of brittle fracture. The pristine epoxy based composites on the other hand did show inelastic deformations followed by brittle fracture. Higher concentrations of MWCNTs led to an absence of brittle fracture during the tests, owing to the crack bridging effect of the CNTs.
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Effect of Fabric Structure on the Performance of 3D Woven Pressure Sensor
Khubab Shaker,Muhammad Umair,Syed Talha Ali Hamdani,Yasir Nawab 한국섬유공학회 2021 Fibers and polymers Vol.22 No.3
The textile-based pressure sensors are an integral part of the wearable electronic textiles, that helps to measure thepressure/load applied to the sensor. These sensors are used predominantly for health and sports application, especially tomonitor the blood pressure, heart rate or performance of muscles during exercise. The work done in this research is about theinvestigation of the response of a 3D woven fabric-based pressure sensor by varying the yarn interlacement pattern in 3layered fabric. Four samples were produced using a 3D weaving technique, with two types of yarns i.e. polyester/cotton (59tex) and multifilament steel (55.5 tex). The weave design of face and back layer of the three-layered structure was kept 1/1plain (P), while the weave design of middle layer was changed to plain (P), matt (M), twill (T) or satin (S), resulting instructures PPP, PMP, PTP, and PSP respectively. Working of pressure sensor was evaluated in terms of resistance offered bystructure, both under static and dynamic loading. The dynamic load was applied by the compression and subsequentrelaxation, i.e. under incremental loading followed by decremental unloading. All the structures showed variation inresistance in response to applied load showing potential being used as a pressure sensor. The structures PPP, PMP, and PSPbehaved as a pressure sensor up to 500 grams while the efficient sensor was PTP (plain/twill/plain) with activity up to a loadof 5500 grams. A statistical model was developed for the structure PTP, correlating the resistance with the applied load. Thedeveloped sensors can also be produced inside the fabrics or can be embedded inside garments.
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Personality Characteristic-based Enhanced Software Testing Levels for Crowd Outsourcing Environment
( Zainab U ),( Kamangar ),( Isma Farah Siddiqui ),( Qasim Ali Arain ),( Umair A ),( Kamangar ),( Nawab Muhammad Faseeh Qureshi ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.8
Crowd-based outsourcing is an emerging trend in testing, which integrates advantages of crowd-based outsourcing in software testing. Open call format is used to accomplish various network tasks involving different types of testing levels and techniques at various places by software testers. Crowd-sourced software testing can lead to an improper testing process as if it does not allocate the right task to the right crowd with required skills and not choose the right crowd; it can lead to huge results, which become time-consuming and challenging crowd-source manager for the identification of improper one. The primary purpose of this research is to make crowd-based outsourced software testing more effective and reliable by relating association between the software tester, personality characteristic, and different levels of software testing, i.e., unit, integration, and system, in order to find appropriate personality characteristic for required testing level. This research has shown an observed experiment to determine which software testing level suits which personality characteristic tester in a crowd-based software testing environment. A total of 1000 software testers from different software houses and firms in Pakistan were registered to perform tasks at different software testing levels. The Myers-Briggs Type Indicator (MBTI) test is used to identify each tester's personality characteristic involved in this research study.
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Wazir Muhammad,Asad Ullah,Amjad Hussain,Nawab Ali,Khan Alam,Gulzar Khan,Matiullah,뱅수진,이상훈 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.3
A medical linear accelerator (LINAC) room must be properly shielded to limit the outside radiation exposure to an acceptable safe level defined by individual state and international regulations. However, along with this prime objective, some additional issues are also important. The current case-study was designed to unfold the issues related to over-shielded and unplanned treatment rooms for LINACs. In this connection, an apparently unplanned and over-shielded treatment room of 610 × 610 cm2 in size was compared with a properly designed treatment room of 762 × 762 cm2 in size (i.e., by following the procedures and recommendations of the IAEA Safety Reports Series No. 47 and NCRP 151). Evaluation of the unplanned room indicated that it was over-shielded and that its size was not suitable for total body irradiation (TBI), although the license for such a treatment facility had been acquired for the installed machine. An overall 14.96% reduction in the total shielding volume (i.e., concrete) for an optimally planned room as compared to a non-planned room was estimated. Furthermore, the inner room’s dimensions were increased by 25%, in order to accommodate TBI patients. These results show that planning and design of the treatment rooms are imperative to avoid extra financial burden to the hospitals and to provide enough space for easy and safe handling of the patients. A spacious room is ideal for storing treatment accessories and facilitates TBI treatment.
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