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우묵사스레피(Eurya emarginata)의 플라보노이드 화합물의 분리 및 동정
양홍철,박수영,강희경,이남호 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-
The extracts of Eurya emarginata showed inhibitory effect on the growth of HL-60 leukemia cells. So, 80% methanol(MeOH) extract of its leaves was partitioned to hexane, ethyl acetate, n-butanol and residual water fractions. The ethyl acetate fraction, which showed desirable activities, was further purified using SiO2 column chromatography(CC) followed by reverse phase silica gel CC, then another normal CC to give fraction 4-1-8 as a pure compound. The compound 4-1-8 was analyzed by NMR spectrometry using 1H, 13C, DEPT, HMQC and HMBC spectra, and finally proved to be well-known flavono glycoside, Quercitrin.
양재헌,김동수,류희두,이남희 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-
Precipitation was formed during the preparation of decoction from mixure of Scutellariae Radix and Coptidis Rhizoma or Phellodendri Cortex according to the prescription of Hwang-ryean-hae-dog-tang. Baicalin and berberine, the active ingredients of the two herbal medicine were identified in coprecipitated product. Pills were prepared using the coprecipitated product and various binders. The dissolution rate of baicalin and berberine from pills was increased in at pH1.2 when acacia or tragacanth was used. The absorption rate of baicalin from the coprecipitated product was raster than the from Scutellaria extract, but the absorption of berberine from CPP was slower in stomach, duodenum and jejunum of rats compared with Coptis expract. The time equired for the maximum serum concentration (Cmax) of baicalin and berberine from CPP in mice were 150 and 200 min after oral administration. respectively. The maximum serum concentration of baicalin from CPP in mice was higher than Scutellaria extract, but the concentration of berberine was lower compared with Coptis extract. The minimum inhibitory concentration of CPP was below 50 ug/ml against gram positive bacteria, and was higher than that against gram negative bacteria. The antibacterial activity of CPP was lower than the of berberine.but was more potent than Scutellaria extract. It was found that the ingibition rates of growth by CPP against S. cpidermidis, K. pneumoniae, B cereus and S. aureus were 60.1, 5.11, 45.4, and 39.9%. respectively.
양남희,홍은실 한국 가정과 교육 학회 1998 한국가정과교육학회지 Vol.10 No.2
The purpose of this study is to investigate the video game behaviors in middle and high school boys. The date were collected using questionnaires from 342 boys. The major results of this study were summarized as follows; Most of the middle and high school boys attempted video game and have been done more than one year. The half of them spent one hour or more on video game once.
치자엑스 가수분해물 제제의 피부투과 및 생체 피부조직과의 교차결합에 관한 연구
양재헌,이남희 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1
Gardeniae Fructus is consisted of geniposide and its derivatives. For the purpose of treatment of skin disease, geniposide and hydrolyzed products (HP) of Gardeniae Fructus were studied on skin permeation and crosslinking with biological tissue. The hydrolyzed products (HP) and active ingredients of Gardeniae Fructus were identified and investigated about skin permeability. Genipin has provided low cytotoxic crosslinking reagents and formed stable and biocompatible crosslinked products. The permeation enhancing effects of geniposide and genipin under the hydrolyzed products of cream and hydrogel preparations were tested using Franz type diffusion cell and the skin of hairless mouse. The remaining pro-portions of geniposide and genipin were measured in the hydrolyzed products of cream and hydrogel preparations. The crosslinking of epidermic and endodermic tissue with genipin under the hydrolyzed prodcuts of cream and hydrogel preparation was observed using light microscopy. Increased absorption ratio of the skin of hairless mouse about genipin was higher than that of geniposide. Loads at break, tensile strengths and skin permeation rate of the hydrolyzed products (HP) of cream and hydrogel preparations were higher than the nonhydrolyzed products (NHP). The hydrolyzed products (HP) of cream and hydrogel of Gardeniae Fructus Extracts were proper preparations and crosslinking agents to increase the trans-dermal absorption with epidermic and endodermic tissue.
양재헌,이남희 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2
Geniposide and its related iridoid compounds have been used in traditional herbal medicine for the treatment of Jaundice hepatic diseases and various inflammatorys. For the purpose to increase trandsdermal absorption, the hydrolyzed products of Gardeniae Furcuts were identified and assayed of active ingredients and investigated trandsdermal absorption and anti-inflammatory effects. Geniposide was hydrolyzed to genipin by β-glucosidase and it was suggested that genipin was more suitableform than geniposide for transdermal absorption by its lipophilic property. Using Franz type diffusion cell and the skin of hairless mouse, the permeation rate of hydrolyzed products and their emulsion preparation were determined. Genipin have more increased absorption ratio through the skin hairless mouse than geniposide. Also, the emulsion of hydrolyzed products of extracts showed higher permeability than that of nonhydrolyzed preparations. After 9 hours 280.85 ㎍/㎠ of genipin was absorbed and 193.52 ㎍/㎠ in case of geniposide. The Js of geniposide and genipin were 26.27±4.11 ㎍/㎠/hr and 40.35±5.04 ㎍/㎠/hr respectively. After carrageenan injection, the swelling was increased rapidly to 24 hr and maintained as a plateau. But emulsion group were reached about 2.5 mL and the swelling decreased successively from 24 hr to 72 hr. The anti-inflammation effects of extracts and hydrolyzed products emulsion were increased with significant difference with control group after 24 hr, 48 hr and 72 hr. In carrageenan induced edema, inhibition of swelling was increased in case of hydrolyzed product emulsion compare with nonhydrolyzed group at 24 hr, 48 hr and 72 hr after swelling. In histological study, the anti-inflammatory effects of hydrolyzed products were remarkable at 48 hr and 72 hr compare with nonhydrolyzed. Hydrolyzed products of Gardeniae Frucuts extract containing genipin would be a suitable preparation to increase the transdermal absorption and anti-inflammatory effects.
Hypophosphatemia rickets 환아의 증례보고 : A CASE REPORT
양규호,최남기,김선미,정희경 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1
Hypophosphatemia rickets는 비타민 D의 치료량에 내성을 갖기 때문에 Vitamin D-resistant rickets(VDRR)라고도 명명되며, 이는 요세관으로부터 무기질 인산의 재흡수가 감소됨으로써 혈청 칼슘농도는 정상이나 인산농도가 낮고 alkaline phosphatase가 약간 증가되기 때문에 쉽게 진단되는 구루병의 한 형태이다. 이러한 Hypophosphatemia rickets의 임상적인 소견으로 양 다리가 휘는 것, 작은 키, 척추측만, 손목과 발목부위의 팽대가 나타나며 구강내 소견으로는 자발적인 치성농양의 높은 발생률, 맹출 지연, 근단공의 폐쇄지연, 얇고 저형성된 법랑질, 명확히 인지하기 힘든 치조백선, 확대된 치수강, 법랑상아경계까지 연장된 치수각 등이 있다. 본 증례는 유치의 상실과 그에 따른 치료를 위해 본원 소아과에서 의뢰된 비타민 D 저항성 구루병 환아의 임상소견과 그 치과적 치료에 대해 보고하는 바이다. Hypophosphatemia rickets, also known as Vitamin D-resistant rickets(VDRR) and refractory rickets, is a form of rickets which is resistant to the usual doses of vitamin D. VDRR is characterized by decreased renal tubular reabsorption of inorganic phosphate and is easily diagnosed by a normal blood calcium, hypophosphatemia, and slightly elevated alkaline phosphatase. Clinical features of Hypophosphatemia rickets included lateral bowing deformities of the legs, short stature, scoliosis, and enlargement of wrist and ankles. Dental finding in patient with VDRR were spontaneous dental abscesses in caries free teeth and other dental findings included delayed eruption, delayed apical closure, thin and hypoplastic enamel, absent or poorly defined lamina dura, enlarged pulp chambers, and numerous accessory canals and pulp horns that extend up and into the dentinoenamel junction. we reported the clinical feature and treatment of VDRR child who was referred from the department of pediatrics for early loss of primary teeth and its treatment.
양남희,홍은실 한국 가정과 교육 학회 2000 한국가정과교육학회지 Vol.12 No.1
The purpose of this study was to analyse the relationship between behaviors of the video game(frequency, thime, career) and lelated variables in middle and high school boys. The data were collected using questionnaries from 342 boys. The major results of this study are summarized as follows ; (1) A correlation between the frequency and the time of video game was significant, but correlations between the career and the frequency, the time of video game were not significant. (2) The frequency of video game showed significant relationships with palce, preference formation, relative preference, and parents involvement. The time of video game showed significant relationships with place, preference formation, relative preference, and cost. The career showed significant relationship with palce and cost.
가정환경 변인에 따른 청소년의 생활의 질 만족에 관한 연구
양남희,한경순 조선대학교 기초과학연구소 1994 自然科學硏究 Vol.17 No.1
This study seeks to investigate the juveniles' satisfaction on the quality of life in 1he education environment and review wheir position and structure variables in the home surroundings. This findings will propose how much their satisfaction degree is and what effects work in the home environment variables. The purpose of this study is to offer the basic materials about their satisfaction and quality of life in jubeniles. The investigative objectives of this study are the seniors and juniors in S and C high schools and girls' high schools. The way of investigation is through the questionnaire of the Personal Administration, and the period is Dec. l0th - 2Oth in 199e. The 458 in 600 sheets presented was utilized in the resoureces of study. The analysis proposes the frequency number, percentages and averages by way of SAS computer program, examines Oneway ANOVA and Duncan's Multiple Range Test, and practices Person's Appropriate Rate Correlation and Stepwise Multiple Regression Analysis. The Summary of findings follows up: 1) The general inclination in juveniles' life shows the high degree of satisfaction, respectively, of 42.4% in the family life, 54.6% in ghe relation between friends, 41.9% in health, 44.8% in ghe family environment, 37.3% in the religion, and does the middle degree of satisfaction of 43.2% in kin-relation, 43.2% in education, 46.1% in leisure, 55.2% in mass media and 58.7% in the neighborhood and community. They show the unsatisfaction of 34.5% in the finanacial safety. 2)* The variables in the family life and the juveniles satisfaction are their school grade, the existence or nonexistence in parents, cultural understandings, nutrition health, life space, value orientation, learning system and group property. * The variables in friend satisfaction are the school grade, the existence or nonexistence in parents, mother employment, house size, father occupation, family members, cultural understanding, value orientation, group property. * The variables in education are ages, father schooling, cultural understanding, nutrition health, life space, value orientation, learning system and group property. * The variables in education are ages, father schooling, cultural understanding, nutrition health, life space, value orientation and group property. * The variables in health are school grade, father occupation, house size, cultural understanding, life spare, learning system, value orientation and group property. * The variables in family environment are school grade, the existence or nonexistence in parents, mother employment house environment, cultural understanding, nutrition health, life space, value orientation, learning system and group property. * The variables in leisure life are ages, school grade, father schooling, mother employment, value orientation and group property. * The variables in religion are father schooling, mother employment, belifef pattern, nutrition health, life space, value orientation, learning and group property. * The variables in mass media are value orientation and group property. * The variable in financial safety are mother schooling, mother employment, house size, father occupation, cultural understanding, nutrition health, life space, value orientation, learning system and group property. The variable in the neighborhood and community are the existence or nonexistence in parents, mother schooling, house size, value orientation, learning system and group property. 3) The correlation areas in the life satisfaction and variables are the value direction, learning system, group property in family life, value orientation, group property in family environment and the group property in the financial safety. 4) The independent variables in family life make much effect on family life, health, religion, mass media and financial safety, and show relatively the group property in the high dgree. The value direction shows the high degree in friend relation, education, family environment, neighbor and community, and learning system does in kin-jrelation. The leisure satisfaction shows the negative correlation according to the school grade.