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        • KCI등재

          Human papillomavirus (HPV) DNA detection in uterine cervix cancer after radiation indicating recurrence: a systematic review and meta-analysis

          Sasidharanpillai Sabeena,Santhosh Kuriakose,Binesh Damodaran,Nagaraja Ravishankar,Govindakarnavar Arunkumar 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.2

          Objective: The causal association of human papillomavirus (HPV) in uterine cervical cancer was well established and this oncogenic virus was reported to be a biomarker for overall recurrence and central pelvic recurrence. The objective of the present systematic review and meta-analysis was to assess the role of HPV DNA testing in early detection of recurrence among cervical cancer survivors after radiotherapy. Methods: We performed a systematic review and meta-analysis by means of searching electronic databases for published articles between January 1984 and June 2018, on the basis of standard systematic review guidelines prescribed by major agencies namely Cochrane Collaboration (https://www.cochrane.org) and Campbell Collaboration (https://www.campbellcollaboration.org). The meta-analysis component was further modified appropriately for the synthesis of sensitivity and specificity results. Results: A total of 1,055 cervical cancer cases who had received pelvic radiation with or without chemotherapy from ten cohort studies were evaluated. The overall pooled sensitivity and specificity of HPV DNA testing was 0.84 (95% confidence interval [CI]= 0.66–0.94) and 0.35 (95% CI=0.20–0.54) respectively. The positive likelihood ratio was 1.3 (95% CI=1.0–1.7) and the negative likelihood ratio was 0.45 (95% CI=0.18–1.10) with an estimated diagnostic odds ratio of 3 (95% CI=1–9). Conclusion: The screening for HPV DNA testing during follow-up facilitates early detection of recurrence after radiotherapy.

        • KCI등재

          Nutritional evaluation of processing discards from tiger tooth croaker, Otolithes ruber

          Vijayakumar Renuka,Abubacker Aliyamveetil Zynudheen,Satyen Kumar Panda,Chandragiri Nagaraja Rao Ravishankar 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.5

          Processing discards from tiger tooth croaker, such as head, viscera, and swim bladder, were analyzed for proximate, biochemical, fatty acid, and mineral composition. The proximate analysis showed high protein content (21.04%) in the swim bladder and high fat content (4.10%) and ash content (2.26%) in the head. The biochemical quality indices such as non-protein nitrogen, total volatile base, trimethylamine, free fatty acids, peroxide value, and thiobarbituric acid reactive substances in the viscera were higher than those in the head and swim bladder. Gas chromatographymass spectrometry analysis of fatty acids composition showed high polyunsaturated fatty acids in the head (58.82%), followed by the viscera (45.80%) and the swim bladder (35.57%). The major available saturated fatty acid, i.e., palmitic acid, was higher in the swim bladder (30.49%). Mineral and heavy metals analyzed via inductively coupled plasma-optical emission spectrometer showed high calcium, sodium, and magnesium contents in the head region (346.80, 62.55, and 14.89 mg/kg respectively). Heavy metal levels were within the permissible limit.

        • SCIESCOPUSKCI등재

          Nutritional evaluation of processing discards from tiger tooth croaker, Otolithes ruber

          Renuka, Vijayakumar,Zynudheen, Abubacker Aliyamveetil,Panda, Satyen Kumar,Ravishankar, Chandragiri Nagaraja Rao 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.5

          Processing discards from tiger tooth croaker, such as head, viscera, and swim bladder, were analyzed for proximate, biochemical, fatty acid, and mineral composition. The proximate analysis showed high protein content (21.04%) in the swim bladder and high fat content (4.10%) and ash content (2.26%) in the head. The biochemical quality indices such as non-protein nitrogen, total volatile base, trimethylamine, free fatty acids, peroxide value, and thiobarbituric acid reactive substances in the viscera were higher than those in the head and swim bladder. Gas chromatographymass spectrometry analysis of fatty acids composition showed high polyunsaturated fatty acids in the head (58.82%), followed by the viscera (45.80%) and the swim bladder (35.57%). The major available saturated fatty acid, i.e., palmitic acid, was higher in the swim bladder (30.49%). Mineral and heavy metals analyzed via inductively coupled plasma-optical emission spectrometer showed high calcium, sodium, and magnesium contents in the head region (346.80, 62.55, and 14.89 mg/kg respectively). Heavy metal levels were within the permissible limit.

        • KCI등재

          Effectiveness of Inspiratory Muscle Training on Respiratory Muscle Strength in Patients Undergoing Cardiac Surgeries: A Systematic Review With Meta-Analysis

          Fiona Verdine Dsouza,Sampath Kumar Amaravadi,Stephen Rajan Samuel,Harish Raghavan,Nagaraja Ravishankar 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.4

          To determine the effect of inspiratory muscle training (IMT) on pulmonary function, respiratory muscle strength (RMS), and functional capacity in patients undergoing cardiac surgery. The PubMed, PEDro, CINAHL, Web of Science, CENTRAL, and EMBASE databases were searched from inception to June 2020. Randomized controlled trials (RCTs) that evaluated patients who underwent cardiac surgery were included in this review. Meta-analysis performed using a random-effects model showed that the mean difference in forced vital capacity, forced expiratory volume in 1 second, 6-minute walk distance, and RMS was 3.47% (95% confidence interval [CI], 0.57 to 6.36), 5.80% (95% CI, 2.03 to 9.56), 78.05 m (95% CI, 60.92 to 95.18), and 4.8 cmH2O (95% CI, -4.00 to 13.4), respectively. There is strong evidence that IMT improves inspiratory muscle strength, pulmonary function, and functional capacity, and reduces the length of hospital stay in patients undergoing cardiac surgery.

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