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강나루,우영아,김효진 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-
The purpose of this study is to develop a noninvasive blood glucose measurement method by using near infrared spectroscopy (NIRS). Reflectance NIR spectra of different parts of human body (finger tip, earlobe, and inner lip) were Recoreded by using a fiber optic probe. The spectra were collected over the spectral range 1100-1700nm. Partial least squares regression (PLS) was applied for the calibration and validation for the determination of blood glucose. The calibration with the use of PLS model predicted for validation set glucose concentration with a standard error of prediction (SEP) of 33㎎/㎗.
강나루(Na Roo Kang),우영아(Young Ah Woo),차봉수(Bong Soo Cha),이현철(Hyun Chul Lee),김효진(Hyo Jin Kim) 대한약학회 2002 약학회지 Vol.46 No.5
The purpose of this study is to develop a non-invasive blood glucose measurement method by a portable near infrared (NIR) system which was newly integrated by our lab. The portable NIR system includes a tungsten halogen lamp, a specialized reflectance fiber optic probe and a photo diode array type InGaAs detector, which was developed by a microchip technology based on the lithography: Reflectance NIR spectra of different parts of human body (finger tip, earlobe, and inner lip) were recorded by using a fiber optic probe. The spectra were collected over the spectral range 1100~1740 nm. Partial least squares regression (PLSR) was applied for the calibration and validation for the determination of blood glucose. The calibration model from earlobe spectra presented better results, showing good correlation with a glucose oxidase method which is a mostly used standard method. This model predicted the glucose concentration for validation set with a SEP of 33 mg/Dl. This study indicated the feasibility for non-invasive monitoring of blood glucose by a portable near ifrared system.
샤임플러그 전안부사진기를 이용한 눈물막의 두께 측정 및 건성안 지표와의 관계 분석
강나희(Na Hee Kang)박연꽃(Yeon Ggoch Park),전루민(Roo Min Jun) 대한안과학회 2015 대한안과학회지 Vol.56 No.11
목적: 정상안과 건성안 두 군에서 Pentacam Ⓡ (Oculus, Wetzlar, Germany)을 이용하여 측정한 각막 앞 눈물막 두께(precorneal tear film thickness, PTFT)를 포함한 전안부 계측값을 비교해 보고, 건성안 군에서 PTFT와 건성안 지표들과의 관련성을 알아보고자 하였다. 대상과 방법: 정상안 31안(23명), 건성안 31안(25명)을 대상으로 Pentacam Ⓡ을 이용하여 측정한 PTFT, 각막두께 및 난시 값을 비교하 였다. 건성안 군에서 PTFT와 플루오레신 눈물막 파괴 시간(fluorescein tear break-up time, FBUT), 쉬르머 I 검사 및 안구표면질환지 수(ocular surface disease index, OSDI)와의 관련성을 알아보았다. 결과: 평균 PTFT는 정상안에서 37.6 ± 2.0 μm, 건성안에서 21.1 ± 2.0 μm로 건성안 군의 PTFT가 정상안에 비해 유의하게 얇았다 ( p <0.01). 건성안 군에서 각막두께는 더 두꺼웠으나 임상적으로 의미 있는 차이는 없었고, 각막난시의 빈도 및 정도가 높은 경향을 보였지만 통계적으로 유의하지 않았다. 건성안 군에서 OSDI는 FBUT 및 쉬르머 I 검사와 약한 음의 상관관계를 보였으나 유의하지 않았고, PTFT와는 통계적으로 유의한 음의 상관관계를 보였다(r=-0.46, p <0.01). PTFT는 FBUT와 쉬르머 I 검사와 약한 양의 상관관 계를 보였으나 통계적으로 유의하지 않았다. 결론: 건성안에서 Pentacam Ⓡ 으로 측정한 PTFT는 정상군에 비해 유의하게 얇았으며 주관적인 증상과 연관성을 보여 건성안 환자의 진단 및 치료에 유용하게 활용될 수 있을 것으로 생각된다. Purpose: To compare the anterior segment parameters including precorneal tear film thickness (PTFT) using Pentacam ??(Oculus, Wetzlar, Germany) between normal control and dry eye groups and to examine the relationships between the PTFT and other parameters for dry eye. Methods: The present study included 23 normal controls (31 eyes) and 25 patients with dry eyes (31 eyes). We compared meas-urements including PTFT, corneal thickness and astigmatism using Pentacam ?? and analyzed the correlations among the PTFT and fluorescein tear break-up time (FBUT), Schirmer I test (without anesthesia), and ocular surface disease index (OSDI). Results: The mean PTFT in dry eyes (21.1 ± 2.0 μm) was significantly thinner than in normal eyes (37.6 ± 2.0 μm; p < 0.01). In the dry eye group, the corneal thickness was thicker than in the normal eye group but there were no clinically significant differences. The dry eye group experienced more frequent and severe corneal astigmatism compared with the normal group. OSDI scores showed a weak negative correlation with objective clinical measures of dry eye (FBUT, Schirmer I test) but was not statistically significant. However, OSDI was statistically significantly negatively correlated with PTFT (r = -0.46, p < 0.01). The PTFT showed a weak positive correlation with FBUT and Schirmer I test without statistical significance. Conclusions: The mean PTFT using Pentacam ?? in the dry eye group was thinner than in the normal group. Additionally, the PTFT was correlated with subjective symptoms. Therefore, the PTFT measurement using Pentacam ?? could be considered a useful method for diagnosis and treatment of dry eye.
모 조선업체 아크 용접 작업자의 공기중 6가 크롬 및 니켈 노출에 관한 연구
신용철,강성규,오세민,이나루,문영한,이광용,이기라 한국산업위생학회 1998 한국산업보건학회지 Vol.8 No.2
The aim of this study was to evaluate welders' exposure to hexavalent chromium (Cr(VI)) and nickel (Ni) during welding operations in a Korean shipyard. The airborne Cr(VI) and Ni concentrations were measured during metal inert gas (MIG) welding on mild and stainless steel, and manual metal arc (MMA) welding on mild steel. The geometric mean (GM) of Cr(VI) concentrations inside the welding helmet during MIG welding on mild steel were 0.0018 ㎎/㎥ inside a ship section, and 0.0015-0.0026 ㎎/㎥ at the welding shops. All of the personal breathing zone air samples were below the American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV^ⓡ) of 0.01 ㎎/㎥. Conversely, eighty-eight percent(21 of 24) of the personal breathing zone air samples exceeded the National Institute for Occupational Safety and Health (NIOSH) recommended exposure limit of 0.001 ㎎/㎥. Ni was not detected on 20 of 23 air samples collected during MIG welding on mild steel. The three Ni samples above the limit of detection ranged from 0.015 to 0.044 ㎎/㎥. The GM of Cr(VI) concentrations during MMA welding on mild steel were 0.0013 ㎎/㎥, but Ni was not detected in the air samples during this operation. It is assumed that the airborne Cr(VI) and Ni during mild steel welding were derived from the base metals which contained about 0.03% Cr and 0.03% Ni. The GM of airborne total Cr, Cr(V1) and Ni concentrations during MIG welding on stainless steel were 4.02, 0.13 and 0.86 ㎎/㎥, respectively, and the levels of Cr(VI) and Ni were above the ACGIH-TLV^ⓡ Cr(VI) comprised about 35.5% of the total chromium(Cr) from MIG welding on mild steel, and about 8.4% of total Cr from MIG welding on stainless steel. The ratios of Cr(VI) to total Cr were significantly different among welding shops. It was concluded that welders were exposed to high levels of Cr(VI) and Ni during welding on stainless steel, and were exposed to low levels of Cr(VI) even during welding on mild steel.