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- 저자 : Na-Ra Han (검색결과 189 건)
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Han, Na-Ra,Nam, Sun-Young,Hong, Sungwei,Kim, Hee-Yun,Moon, Phil-Dong,Kim, Hyeong-Jin,Cho, Hosong,Lee, Boyoung,Kim, Hyung-Min,Jeong, Hyun-Ja Elsevier 2018 BIOMEDICINE AND PHARMACOTHERAPY Vol.103 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Menopausal hot flushes occur frequently in postmenopausal women. In the present study, we investigated a regulatory effect of a mixed extract of flowers of <I>Pueraria thomsonii</I> Benth. and peels of <I>Citrus unshiu</I> Markovich (PCE17), an extract of flowers of <I>Pueraria thomsonii</I> Benth. (PE), an extract of peels of <I>Citrus unshiu</I> Markovich (CE), a mixture of tectorigenin 7-<I>O</I>-xylosylglucoside, tectoridin, and tectorigenin (Tec, the active compounds of PE), and hesperidin (Hes, an active compound of CE) on menopausal hot flushes.</P> <P><B>Methods</B></P> <P>We examined the anti-hot flushes properties of PCE17, PE, CE, Tec, or Hes using a mouse model of ovariectomy-induced hot flushes.</P> <P><B>Results</B></P> <P>The ovariectomy-induced rise in the tail skin temperature was significantly prevented by PCE17, PE, CE, Tec, or Hes. PCE17, PE, CE, Tec, or Hes significantly enhanced 5-HT levels and attenuated RANKL levels in the hypothalamus of ovariectomized (OVX) mice. Treatment with PCE17, PE, CE, Tec, or Hes significantly enhanced the levels of estrogen receptor (ER)-β, 5-HT1A, 5-HT2A, and tryptophan hydroxylase mRNA expression in the hypothalamus of OVX mice. PCE17, PE, or CE decreased follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, but did not increase estrogen levels in the serum of OVX mice. Tec or Hes decreased FSH or LH levels and increased estrogen levels. Treatment with PCE17, PE, CE, or Tec ameliorated vaginal atrophy in OVX mice. Finally, PCE17, PE, CE, Tec, or Hes significantly increased norepinephrine and dopamine levels in the hypothalamus of OVX mice.</P> <P><B>Conclusion</B></P> <P>Thus, these results imply that PCE17 has protective effects against hot flushes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PCE17 prevented a rise in the tail skin temperature of OVX mice. </LI> <LI> PCE17 regulated the levels of 5-HT, RANKL, 5-HT1A, 5-HT2A, TPH, and MAO in OVX mice. </LI> <LI> PCE17 ameliorated vaginal atrophy in OVX mice. </LI> <LI> PCE17 has protective effects against hot flushes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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The Present and Future of the Food Market in Northeast Asia: Confectionery Markets
Han-Na-Ra Jeong,Junghoon Moon 한국농식품정보과학회 2012 Agribusiness and Information Management Vol.4 No.1
The Asian food market has been growing recently, due to the role played by major Asian countries, which include Korea, China, and Japan. This study is purposed to investigate the potential of the food market in these Northeast Asian countries and to suggest future direction for global food companies. For in-depth analysis, this study is limited in scope to the confectionery market and analyzes that market within two frameworks: first, the ‘Market Attractiveness Matrix’ which transforms the ‘BCG Matrix’ to fit into the food market in order to analyze the flow in the Asian confectionery market; and second, analysis of the potential growth of the market using a Category Development Index (CDI), which aids in understanding the growth potential of a market. The European food market has recently reached its capacity and is now experiencing a low growth rate (Data Monitor, 2011). It is time for food companies to find a new ‘blue ocean’ to avoid fierce competition in the mature markets of Europe. Therefore, this analysis of the confectionery market, using the Market Attractiveness Matrix and CDI will suggest opportune directions for global food companies.
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Han, Na-Ra,Moon, Phil-Dong,Kim, Na-Rae,Kim, Hee-Yun,Jeong, Hyun-Ja,Kim, Hyung-Min Institute for Advanced Research in Asian Science a 2017 The American journal of Chinese medicine Vol. No.
<P><I>Schisandra chinensis</I> (SC) and its main constituent, schizandrin (SCH) exhibit anti-inflammatory and anti-allergic activities. Allergic and inflammatory reactions are aggravated via caspase-1 signaling pathway. However, the regulatory effects of SC and SCH on caspase-1 activation have not been clarified yet. In this study, we aimed to clarify the anti-allergic effects of SC and SCH using an ovalbumin (OVA)-sensitized mice and anti-CD3 and anti-CD28 antibodies-stimulated splenocytes. SC or SCH significantly inhibited the levels of immunoglobulin (Ig)E, IgG1, or interleukin (IL)-4 in serum of OVA-sensitized mice. SC or SCH significantly inhibited the levels of IL-6, tumor necrosis factor (TNF)-<TEX>$ \alpha $</TEX>, and IL-1<TEX>$ \beta $</TEX> in spleen of the OVA-sensitized mice. SC or SCH significantly suppressed the expression of caspase-1 and receptor-interacting protein (RIP)-2 in spleen of the OVA-sensitized mice. In activated splenocytes, SC or SCH significantly decreased the expression of caspase-1 and RIP-2 as well as the production of IL-6 and TNF-<TEX>$ \alpha $</TEX>. We suggest that SC and SCH exert an anti-allergic effect by down-regulating caspase-1 signaling.</P>
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Han, Na-Ra,Moon, Phil-Dong,Yoo, Min-Sun,Ryu, Ka-Jung,Kim, Hyung-Min,Jeong, Hyun-Ja Elsevier 2018 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.62 No.-
<P><B>Abstract</B></P> <P>The aim of this study is to determine whether AST2017-01 which consists of <I>Rumex crispus</I> and <I>Cordyceps militaris</I> would improve atopic dermatitis (AD). We analyzed anti-AD effects of AST2017-01 and chrysophanol, a bioactive compound of AST2017-01, using a 2,4-dinitrofluorobenzene-induced AD murine model. AST2017-01 and chrysophanol relieved clinical severity in AD-like skin lesions and significantly decreased scratching behavior. The thickness of epidermis and infiltration of inflammatory cells in AD-like skin lesions were reduced by AST2017-01 or chrysophanol. AST2017-01 and chrysophanol significantly suppressed the levels of histamine, immunoglobulin E, thymic stromal lymphopoietin (TSLP), interleukin (IL)-4, IL-6, and tumor necrosis factor-α in serum of AD mice. The protein levels of TSLP, intercellular adhesion molecule-1, and macrophage inflammatory protein 2 were significantly inhibited in the skin lesions. The mRNA expressions of TSLP, thymus and activation-regulated chemokine/CCL17, and C-C chemokine receptor 3 were inhibited in the skin lesions by AST2017-01 or chrysophanol. In addition, AST2017-01 and chrysophanol significantly suppressed the expressions and activities of caspase-1 in the skin lesions. Taken together, these results suggest that AST2017-01 has beneficial effects on AD and may be used as a health functional food in AD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> AST2017-01 and chrysophanol relieve clinical symptoms of AD mice. </LI> <LI> AST2017-01 and chrysophanol reduce the number of inflammatory cells in lesions. </LI> <LI> AST2017-01 and chrysophanol lower histamine, IgE, cytokines, and chemokines levels. </LI> <LI> AST2017-01 and chrysophanol reduce caspase-1 levels in lesions. </LI> <LI> AST2017-01 and chrysophanol has beneficial effects on AD. </LI> </UL> </P>
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The regulatory effect of AST cream on atopic dermatitis-like skin disease.
Han, Na-Ra,Kim, Hyung-Min,Jeong, Hyun-Ja Cellmed Orthocellular Medicine and Pharmaceutical 2019 셀메드 (CellMed) Vol.9 No.3
In this study, we investigated an inhibitory effect of AST cream on atopic dermatitis (AD) using a 2,4-dinitrochlorobenzene-induced AD murine model. Topical treatment with AST cream ameliorated the severity of AD-like lesional skin through decreases in infiltration of inflammatory cells and time of scratching behaviors. Also, AST cream reduced histamine and IgE levels in serum. The protein levels of IL-4 and IL-6 in AD-like lesional skin were suppressed by AST cream. These findings suggest that AST cream would be an alternative therapeutic agent for AD-like skin diseases.
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The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP.
Han, Na-Ra,Kim, Hyung-Min,Jeong, Hyun-Ja The Society 2014 Experimental biology and medicine Vol.239 No.4
<P>The compound β-sitosterol (BS) is one of the most common forms of phytosterols and has anti-cancer, anti-oxidant, anti-bacterial, and anti-inflammatory effects. However, the effect of BS on atopic dermatitis (AD) has not been elucidated. Therefore, we investigated whether BS would be an effective treatment against AD. We treated BS on 2,4-dinitrofluorobenzene (DNFB)-induced AD-like skin lesions in NC/Nga mice, anti-CD3/anti-CD28-stimulated splenocytes, and phorbol myristate acetate/calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. Histological analysis, ELISA, PCR, caspase-1 assay, and Western blot analysis were performed. BS reduced the total clinical severity in DNFB-treated NC/Nga mice. Infiltration of inflammatory cells and number of scratching were clearly reduced in the BS-treated group compared with the DNFB-treated group. BS significantly reduced the levels of inflammation-related mRNA and protein in the AD skin lesions. BS significantly reduced the levels of histamine, IgE, and interleukin-4 in the serum of DNFB-treated NC/Nga mice. The activation of mast cell-derived caspase-1 was decreased by treatment with BS in the AD skin lesions. BS also significantly decreased the production of tumor necrosis factor-α from the stimulated splenocytes. In the stimulated human mast cell line, HMC-1 cells, increased intracellular calcium levels were decreased by treatment with BS. Further, BS inhibited the production and mRNA expression of TSLP through blocking of caspase-1 and nuclear factor-κB signal pathways in the stimulated HMC-1 cells. These results provide additional evidence that BS may be considered an effective therapeutic drug for the treatment of AD.</P>
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Protective effect of porcine placenta in a menopausal ovariectomized mouse
Han, Na-Ra,Park, Chan-Lee,Kim, Na-Rae,Kim, Hee-Yun,Yoou, Myoung-Schook,Nam, Sun-Young,Moon, Phil-Dong,Jeong, Hyun-Ja,Kim, Hyung-Min BioScientifica 2015 Reproduction Vol.150 No.3
<P>Menopause is a significant physiological phase that occurs as women's ovaries stop producing ovum and the production of estrogen declines. Human placenta and some amino acids are known to improve menopausal symptoms. In this study, we investigated that porcine placenta extract (PPE) and arginine (Arg), a main amino acid of PPE, would have estrogenic activities in ovariectomized (OVX) mice as a menopause mouse model, human breast cancer cell line (MCF-7) cells, and human osteoblast cell line (MG-63) cells. PPE or Arg significantly inhibited the body weight and increased the vagina weight compared to the OVX mice. PPE or Arg ameliorated the vaginal atrophy in the OVX mice. The levels of 17β-estradiol and the activities of alkaline phosphatase (ALP) were significantly increased by PPE or Arg in the serum of OVX mice. Trabecular bone parameters such as bone mineral density and porosity were also improved by PPE or Arg in the OVX mice. In the MCF-7 and MG-63 cells, PPE or Arg significantly increased the cell proliferation, estrogen receptor β mRNA expression, and estrogen-response elements luciferase activity. Finally, PPE or Arg increased the activations of ALP and extracellular signal-regulated kinase 1/2 in the MG-63 cells. These results indicate that PPE or Arg would have estrogenic and osteoblastic activity. Therefore, PPE or Arg may be useful as new pharmacological tools for treating menopausal symptoms including osteoporosis.</P><P><B>Free Korean abstract</B>: A Korean translation of this abstract is freely available at http://www.reproduction-online.org/content/150/3/173/suppl/DC1.</P>
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