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Anti-oxidant and Hepatoprotective Activities ofAlcoholic Extract of Terminalia arjuna
N. Anbalagan,Mallika M,Sara Kuruvilla,M.V.V. Prasad,A. Patra,K. Balakrishna 한국생약학회 2007 Natural Product Sciences Vol.13 No.2
extract of Terminalia arjuna [TA] was evaluated for its hepatoprotective activity againstcarbon tetrachloride (CCl4)-induced hepatic damage in rats. The hepatoprotective activity of TA was evaluated byglutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP). The serum levels of total proteins(TP), total albumins (TAL) and bilirubin (BILN) were also estimated. The histological studies were also carriedout to support the above parameters. Silymarin (SM) was used as standard drug. Administration of TA (250 and500 mg/kg/po) markedly prevented CCl4-induced elevation of levels of SGOT, SGPT, SALP, TP, TAL and BILN.These biochemical observations were supplemented by histopathological examination of liver sections. Alcoholicextract of TA also shown significant in-vitro free radical scavenging activity against 1, 1-diphenyl-2-picryltraditional use of this plant in the management of liver diseases.KeywordsTerminalia arjuna, In-vitro anti-oxidant, hepatoprotective, Liv 52, CCl4.
K. Balakrishna,N. Anbalagan,A. Patra,G. Veluchamy,M.V.V. Prasad 한국생약학회 2004 Natural Product Sciences Vol.10 No.5
In the present study, the alcoholic extract of Terminalia arjuna (TA) and Arjunolic acid (AA) were studied for its anti-asthmatic and anaphylactic activity. Treatment with TA (250 & 500 mg/kg) and AA (50&100 mg/kg) has shown significant protection against mast cell disruption in rats induced by compound 48/80. TA and AA also protected the guinea pig against histamine as well as acetylcholine induced bronchospasm. Both TA & AA exhibited better protection against histamine release than against acetylcholine release. Anti-asthmatic and anaphylactic activity may be possibly due to membrane stabilizing potential and inhibition of antigen induced histamine and acetylcholine release.