불안장애의 위험주제

제영묘,김명정 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

In order to investigate the presence and the contents of the ideational components of the patients with the anxiety disorders, the authors studied 44 out-and inpatients of anxiety disorders diagnosed by the DSM-Ⅲ criteria at the neuropsychiatric department of Pusan National University Hospital. The results obtained were as follows. Forty three subjects out of 44 patients with anxiety disorders reported to recognize the ideational components of the themes of danger associated with anxiety experiences. 79.5 percent of the subjects had fears of physical disasters; 70.5 percent had psychological and 25 percent, social disasters. Twenty five of them reported two or three themes of danger simultaneously and 18 had themes of either physical or psychological disasters. Particularly there were many who had fear of death and fear of insanity simultaneously. A tendency of more prominent themes of physical disasters was noted in males, cases of acuteonset, cases with panic attacks and those with agoraphobia, and that of psychological disasters in females, cases of insidious onset and generalized anxiety disorder. But statistics failed to show significant difference probably due to insufficient numbers of the subjects. Surveying the contents of each theme, physical disasters were represented by fear of dying or death, psychological disasters by fear of insanity and social disasters by interpersonal rejection or social failure. From these results, the authors suggest that 1) themes of danger are consistently recognied by those with anxiety disorders during experiences of anxiety 2) the content and the intensity of the themes of danger have certain relationship with the intensity of anxiety 3) and the content of the themes of danger can be interpreted as the fear of annihilation.

都市 下水슬러지의 堆肥化에 關한 硏究

宋濟天,柳明辰,金東玟 동아대학교 환경문제연구소 1986 硏究報告 Vol.9 No.3

Composting may be defined as a biochemical process in which microorganisms break down and convert solid organic matters into stable, humus like end products. The composting of municipal wastewater sludge has become an accepted technology as a means of sludge stabilization and resource recovery in recent years. Investigated in this study were the compostability of municipal sludge without the use of bulking agents, e.g., wood chips, tree barks, sow-dusts and rice-hulls ; relevant, influencing factors such as moisture contents, pH values, aeration rates, and volatile solid contents ; and process reaction rates. The sample sludges, obtained from Seoul Cheongye Sewage Treatment plant, were those digested and dewatered by mechanical means with the aid of lime and ferric chloride. The pH values, moisture contents, voltile solid contents and C/N ratios of the sample sludge ranged 10 to 12, 60 to 70%, 55 to 55% and 8 to 12, respectively. In this study, three, 35-liter reactors were used; the reactors were operated on batch basis for the duration of 8 to 12days. In order to maintain aerobic conditions and expect air drying effects, air was supplied to each reactor in the rates of 50-300 ℓ/㎥, main in the first half of experiments and fixed to 120ℓ/㎥. min in the second half. The mixture was mixed completely once a day by mechanical agitator. The results of this study follow; 1. The municipal sludge can be composted without the use of bulking agents. 2. The composting of the sole sludge without any additives can be carried out in reduced reaction periods 1 to 2 weeks. 3. The compost sludge can be used as both, the soil conditioner and low-nutrient fertilizer. It contained 35 to 40% moisture, 35 to 45% valatile solids, 1.9 to 2.2% nitrogen, 2.1 to 2.5% phosphorus and 0.18 to 0.22% potassium, and was 7.5 to 8.0 in pH values and 8 to 10 in C/N ratios. 4. The optimum pH values, aeration rates, and moisture contents were 7.5 to 8, approximately 120ℓ/㎥.min and 55 to 60%, respectively.

발생 및 재생중인 흰쥐 간세포에 Actinomycin-D가 미치는 영향

조명제 대구산업정보대학 1989 논문집 Vol.3 No.-

This experiment observed ultrastructural exchange of developing and regenerating rat hepatocyte injected Actinomycin-D. The result are as fllowed. 1) After inject Actinomycin-D protein synthesis needing hepatocyte differation inhibited, mitochondra damage, RER nomber decrease, nucleous type was irregular and chromatin in nuclear becames dense. 2) After inject Actinomycin-D microorganelles damaged but amount of glycogen did'nt reduce. 3) After inject Actinomycin-D hepatocytes differation inhibited.

주정중독 환자에서 Fluoxetine이 혈중 알콜 농도와 음주효과에 미치는 영향

김명정,박제민,정봉주 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.1

The effect of chronic administration of fluoxetine on blood alcohol concentration and on a number of alcohol induced physical and psychological effects was studied. The subjects were 14 hospitalized alcoholics without significant depression. After 21 days of 60mg daily fluoxetine and placebo administration. 2.5ml/kg body weight of 40% alcohol was administrated in a single dose and blood alcohol concentrations were measured 10, 20, 40, 60, 120, and 240min, after the alcohol intake. Mania Rating Scale score(MRS), pulse rate, respiratory rate and subjective physical condition were measured before and 30min, after alcohol intake. The results were as follows: 1) Blood alcohol concentrations were significantly higher after fluoxetine administration than placebo administration at 40min, and 60min, after alcohol intake. 2) Fluoxetine suppressed the increase of pluse rate induced by alcohol intake. However, no significant difference was noted in the alcohol induced changes in the scores of MRS, respiratory rate, and subjective physical condition between the drug and placebo administrations. 3) After fluoxetine administration, a significant negative correlation was shown between blood alcohol concentration, 10min after alcohol intake and MRS. In contrast, however, a significant positive correlation was seen between the two variable after placebo administration. From these results, it is suggested that fluoxetine increases blood alcohol concentration only during higher alcohol concentration and that the reduction of alcohol intake after chronic administration of fluoxetine may be due, at least in part, to an attenuation of positie reinforcement of alcohol effect, rather than to an enhancement of the aversion reaction to alcohol.

Niwaella multifasciata Wakiya et Mori (Cobitidae)의 附屬骨格

成娟濟,楊洪準,南明模,蔡秉洙 경북대학교 과학교육연구소 1988 科學敎育硏究誌 Vol.12 No.-

The appendicular skeleton of Niwaella multifasciata was described as a part of systematic study of Cobitidae. In the pectoral girdle, posttemporal was sigmoid form, and upper and lower arms of cleithrum had an angle of 105°, the length of lower arm was one-third of upper one. The scapular had a foramen in the center, and actionst was consisted in three pairs of bone. Postcleithrum was absent. Pelvic girdle was consisted in a pair of innominatium and three pairs of basiost. In the pterygiophore, dorsal fin was supported by three interneural spine and thirteen basiost, and interneural spine was located between the neura니 spin of the 27-31th vertebrae. Anal fin was supported by five interhemal spine and nine basiost, interneural spine was located between the hemal spine of the 42-45th vertebras.

차체용 드로우 다이의 블랭크 홀더 굽힘 변형 해석

인정제,신용승,김헌영,김재우,송명환,박진수 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-

The contact forces between die components for the drawing of large size automotive panels introduce elastic deflections of the die components. Due to the deflections, the gap between blank holder and die varies locally resulting in nonuniform material flow. Such a nonuniform die gap usually requires correcting operation, so called die spotting, which is time consuming trial and error process. To reduce the die spotting time, the optimization of the blank holder bending deflection is needed. In this paper, we implemented an analysis procedure to predict the blank holder deflection. The analysis procedure and design of experiments techniques are applied to the optimization of balance block heights. The optimization results can be used as guidelines in actual die spotting process.

高麗末 士大夫의 儒佛一致論과 그 意義

趙明濟 영남대학교 2003 민족문화논총 Vol.27 No.-

The adoption of Sung-Confucianism brought about a huge ideological change at the end Koryo Dynasty, which is believed to be no less significant change than the replacement of dynastyideological, social transition from the Buddhism-centered society to confucianism-centered one. However, the understandings about this ideological change had been limited to the scope of confrontation between Confucianism and Buddhism. Therefore, it seems within the realm of idea that promoted such an ideological change. So, this dissertation has focused on approaching what the mutual relation between Confucianism and Buddhism was like through the Sa-Dae-Boo(士大夫)'s view on Buddhism. Especially, more focus has gone to the way the idea of harmony was realized. Because Buddhism had totally different values and outlook on the world from the traditional Chinese ideas in the process of its introduction into China, inevitable confronfation and conflict were generated. These confrontation and conflict emerged though the problem regarding such a problem as "Filial Piety" which had been placed ahead of any other value in Chinese society. Buddhism often insisted on its ideological superiority to other religions in dealing with actual challenge from Confucianism and Taoism. As Buddhism started moving forward under the banner of "harmony", and groped its way for "co-existence", however, the idea of harmony of three ideas-Confucianism, Buddhism, Taoism-was spreading widely. This trend was prevalent distinctively when the formation of Sung-Confucianism was underway during Song Dynasty. Especially, the relationship between Buddhism and Confucianism was groping its way for a compromise and harmony based on the idea of Confucian-Buddhist harmony. Such a trend is attributed to the historical background that Buddhism was absolutely subordinate to the nation at the time that Buddhists had no choice but to represent the interests of Sa-Dae-Boo(士大夫) group which took the lion's share of the society both politically and culturally. However, the idea of Confucian-Buddhist harmony had such limitations like failing to get out of the conventional scope, taking passive measure toward the actual interests. In contrast, the idea of Confucian-Buddhist harmony at the end of Koryo came across more active and practical in the matter. In the realm of idea during the end of Koryo, Sung-Confucianism was taking root gradually through the contact with Yuan(元), and criticism on Buddhism was drawn along with social reform policy. In some other sense, Koryo's realm of idea was being largely influenced from liberal and open-minded intellectual atmosphere of Yuan(元) during the early 14th century. So, Sa-Dae-boo group, sharing such intellectual, cultural experiences, fundamentally had positive views on Buddhism and was groping its way for the harmony of Confucianism and Buddhism. Even in the late 14th century, when Sung-Confucianism was being pervasive in the society and the critical voice toward Buddhism was mounting, the idea of Confucian-Buddhist harmony was consistently taking its place. The reason is traced to the fact that the understandings and practice about Buddhism, especially Zen(禪), were shared inside the group of Sa-dae-boo as a ideological basis in understanding a new idea-Sung-Confucianism.

알코올 의존 환자에서 갈근이 혈중 알코올 농도와 음주 효과에 미치는 영향

김명정,정영인,박제민,김성곤,최영길 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

갈근의 장기 투여가 혈중 알코올 농도와 음주 효과에 미치는 영향을 알아 보기 위하여 알코올 의존으로 입원하여 급성 알코올 중독과 금단 증상에서 회복된 남자 환자를 대상으로 갈근 투여군과 대조약 투여군으로 나누어 갈근과 대조약을 4주간 투여하였다. 갈근 혹은 대조약 투여 전후에 우울과 불안을 측정하고, 알코올 함량이 25%인 소주를 체중 kg당 ml를 음주하게 한 후 음주 전, 음주 후 10, 30, 60, 90, 120분에 각각 혈중 알코올 농도와 음주 효과를 측정하고 4주 동안의 일일 음식 섭취량을 측정하여 다음과 같은 결과를 얻었다. 1) 갈근 투여 전후 사이 그리고 실험군과 대조군 사이에 음주 후 혈중 알코올 농도에 유의한 차이가 없었다. 2) 갈근 투여 전에 비하여 투여 후에 음주 후 수축기 혈압은 음주 후 10, 30, 60, 90분에 그리고 이완기 혈압은 음주 후 10, 30, 60, 90, 120분에서 유의하게 낮았다. 갈근 투여 전의 수축기 혈압은 음주 후 10분에서 그리고 이완기 혈압은 음주 후 10, 30, 60분에서 음주 전에 비해 유의하게 상승하였으나 갈근 투여 후에는 알코올에 의한 위의 혈압 상승 효과가 차단되었다. 3) 갈근 투여 전에 비하여 투여 후에 운동량은 음주 60, 90분에서 유의하게 낮았고 목소리는 음주 후 10, 30, 60, 90분에서 유의하게 작았다. 갈근 투여 전의 운동량은 음주 후 10분부터 음주 전에 비하여 유의하게 상승하였으나 갈근 투여 후의 운동량은 음주 후 60분부터 유의하게 상승하여 알코올에 의한 상승 효과가 지연되었다. 4) 우울과 불안은 갈근 투여 전과 위약 투여 전 그리고 갈근 투여 후와 대조약 투여 후 간에는 유의한 차이가 없었다. 5) 음식 섭취량은 갈근 투여군과 대조약 투여군 모두에서 실험 기간 동안 유의한 변화가 없었다. Effect of radix puerariae on blood alcohol concentration and on alcohol effect in alcoholic patients was studied. The subjects were 57 hospitalized male alcoholics recovered from acute intoxication and withdrawal symptoms. They were divided into two groups of 29 subjects of experimental group and 28 control group. The experimental group was adminitrered with 10g/day of powder of radix puerarize and the control group with mixture of 4g/day of radix glycyrrhizae and 6g/day of flour for 4 weeks, respectively. Before and after treatment of the drugs, blood alcohol concentration, vital signs, and mania rating scale were measured at -5, 10, 30, 60, 90 and 120 minutes after administration of 25% alcohol at a dose of 6ml/kg b.w.p.o. The results were as follows: 1) Blood alcohol concentration was not changed by four weeks of radix puerariae treatment and no difference in the blood alcohol concentration was noted between the radix puerariae and the control groups. 2) Radix puerariae significantly lowered systolic blood pressures at 10, 30, 60 and 90 minutes after alcohol intake and diastolic blood pressures at 10, 30, 60, 90 and 120 minutes after alcohol intake as compared to the corresponding pre-treatment levels. Moreover, before radix puerariae treatment, alcohol-induced elevation of systolic blood pressure was significant at 10 minutes after alcohol intake and that of diastolic blood pressure was significant at 10, 30 and 60 minutes after alcohol intake. But after radix puerariae treatment, such elevation was abolished. 3) Radix puerariae reduced significantly levels of motor activity at 60 and 90 minutes after alcochol intake and levels of voice at 10, 30, 60 and 90 minutes after alcohol intake as compared to the respective pre-treatment levels. Alcohol-induced enhancement of motor activity was significantly increased from 10 minutes after alcohol intake before radix puerariae treatment. But after the drug treatment, it was significantly increased from 60 minutes after alcohol intake. Thus radix puerariae delayed the development of alcohol-induced enhancement of motor activity. 4) No significant differences were noted in the levels of anxiety and depression between the index group and the control, either before or after respective drug treatment. 5) Food intake was not changed during the experimental period in both groups.

高麗後期 戒環解 楞嚴經의 盛行과 思想史的 意義 : 麗末 性理學의 수용기반과 관련하여

趙明濟 부산대사학회 1988 역사와 세계 Vol.- No.12

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.