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      • KCI등재SCIE

        The Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses

        Murat,Topdag,Ahmet,Kara,Esma,Konuk,Necdet,Demir,Murat,Ozturk,Sebla,Calıskan,Deniz,Ozlem,Topdag,Arif,Ulubil,Ibrahim,Gurkan,Keskin,Mete,Iseri 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.1

        Objectives. Healing processes of the nose and paranasal sinuses are quite complex, and poorly understood. In this study, we aimed to compare the effect of mucosal autologous grafts on the degenerated rabbit maxillary sinus mucosa with spontaneous wound healing. It is hypothesized that mucosal grafts will enhance ciliogenesis and improve the morphology of regenerated cilia. Methods. Ten female New Zealand rabbits were included in the study. They underwent external maxillary sinus surgery through a transcutaneous approach. A total of 20 maxillary sinuses were randomly divided into 2 groups: ‘spontaneous healing group' and ‘autologous graft group.' The animals were sacrificed at the 14th day after the surgery. Scanning electron microscope (SEM), and light microscope were used for the evaluation. Results. Cellular composition of the graft group is better than the spontaneous healing group. The graft group had larger areas covered with ciliary epithelium than the spontaneous healing group, and the mean length of the cilias were also longer. Additionally, there were wider cilia with abnormal morphology areas in the spontaneous healing group. Conclusion. In our opinion, covering of the denuded areas with a graft improves re-epithelization, and may prevent the early complications after sinus surgeries.

      • KCI등재

        Antithrombotic effect of epigallocatechin gallate on the patency of arterial microvascular anastomoses

        Murat,İğde,Mehmet,Onur,Öztürk,Burak,Yaşar,Mehmet,Hakan,Bulam,Hasan,Murat,Ergani,Ramazan,Erkin,Ünlü 대한성형외과학회 2019 Archives of Plastic Surgery Vol.46 No.3

        Background Microvascular anastomosis patency is adversely affected by local and systemic factors. Impaired intimal recovery and endothelial mechanisms promoting thrombus formation at the anastomotic site are common etiological factors of reduced anastomosis patency. Epigallocatechin gallate (EGCG) is a catechin derivative belonging to the flavonoid subgroup and is present in green tea (Camellia sinensis). This study investigated the effects of EGCG on the structure of vessel tips used in microvascular anastomoses and evaluated its effects on thrombus formation at an anastomotic site. Methods Thirty-six adult male Wistar albino rats were used in the study. The right femoral artery was cut and reanastomosed. The rats were divided into two groups (18 per group) and were systemically administered either EGCG or saline. Each group were then subdivided into three groups, each with six rats. Axial histological sections were taken from segments 1 cm proximal and 1 cm distal to the microvascular anastomosis site on days 5, 10, and 14. Results Thrombus formation was significantly different between the EGCG and control groups on day 5 (P=0.015) but not on days 10 or 14. The mean luminal diameter was significantly greater in the EGCG group on days 5 (P=0.002), 10 (P=0.026), and 14 (P=0.002). Intimal thickening was significantly higher on days 5 (P=0.041) and 10 (P=0.02). Conclusions EGCG showed vasodilatory effects and led to reduced early thrombus formation after microvascular repair. Similar studies on venous anastomoses and random or axial pedunculated skin flaps would also contribute valuable findings relevant to this topic.

      • KCI등재후보
      • KCI등재

        Management of Sacral Tumors Requiring Spino-Pelvic Reconstruction with Different Histopathologic Diagnosis: Evaluation with Four Cases

        Murat,Arıkan,Guray,Togral,Askin,Esen,Hasturk,Fevzi,Kekec,Murat,Parpucu,Safak,Gungor 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.6

        In this retrospective study, surgical results of four patients with sacral tumors having disparate pathologic diagnoses, who were treated with partial or total sacrectomy and lumbopelvic stabilization were abstracted. Two patients were treated with partial sacral resection and two patients were treated with total sacrectomy and spinopelvic fixation. Fixation methods included spinopelvic fixation with rods and screws in two cases, reconstruction plate in one case, and fresh frozen allografts in two cases. Fibular allografts used for reconstruction accelerated bony union and enhanced the stability in two cases. Addition of polymethyl methacrylate in the cavity in the case of a giant cell tumor had a positive stabilizing effect on fixation. As a result, we can conclude that mechanical instability after sacral resection can be stabilized securely with lumbopelvic fixation and polymethyl methacrylate application or addition of fresh frozen allografts between the rods can augment the stability of the reconstruction.

      • The Historical Development of Turkish Law

        Murat,Ş,EN 한국외국어대학교 법학연구소 2014 HUFS GLOBAL LAW REVIEW Vol.6 No.2

        Throughout history there have been different legal systems, states and nations had their own separate legal structures. Turks founded a state in 220 BC and developed the structure of a unique and independent legal system. The turning point in the Turkish Legal System was the time when the Turkish nation accepted Islam as its religion, which pave the way for the incorporation of Islamic values and norms in the legal system. The Islamization of Turkish law continued even after the establishment of the Ottoman Empire. The Turkish law at the time of Ottoman Empire was a combination of the rules of customary law and Islamic Law. When the Ottoman Empire started declining and later collapsed, the Turkish nation began adopting European legal norms and rules and consequently developed a modern legal system suitable to it. In this study, first time the Turks appeared on the scene in time to the present day legal structures, together with the Republic of radical changes that occurred before and after taking into consideration the Republic shall be dealt with in the form a separation.

      • SCOPUSKCI등재

        Antithrombotic effect of epigallocatechin gallate on the patency of arterial microvascular anastomoses

        Igde,,Murat,Ozturk,,Mehmet,Onur,Yasar,,Burak,Bulam,,Mehmet,Hakan,Ergani,,Hasan,Murat,Unlu,,Ramazan,Erkin Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.3

        Background Microvascular anastomosis patency is adversely affected by local and systemic factors. Impaired intimal recovery and endothelial mechanisms promoting thrombus formation at the anastomotic site are common etiological factors of reduced anastomosis patency. Epigallocatechin gallate (EGCG) is a catechin derivative belonging to the flavonoid subgroup and is present in green tea (Camellia sinensis). This study investigated the effects of EGCG on the structure of vessel tips used in microvascular anastomoses and evaluated its effects on thrombus formation at an anastomotic site. Methods Thirty-six adult male Wistar albino rats were used in the study. The right femoral artery was cut and reanastomosed. The rats were divided into two groups (18 per group) and were systemically administered either EGCG or saline. Each group were then subdivided into three groups, each with six rats. Axial histological sections were taken from segments 1 cm proximal and 1 cm distal to the microvascular anastomosis site on days 5, 10, and 14. Results Thrombus formation was significantly different between the EGCG and control groups on day 5 (P=0.015) but not on days 10 or 14. The mean luminal diameter was significantly greater in the EGCG group on days 5 (P=0.002), 10 (P=0.026), and 14 (P=0.002). Intimal thickening was significantly higher on days 5 (P=0.041) and 10 (P=0.02). Conclusions EGCG showed vasodilatory effects and led to reduced early thrombus formation after microvascular repair. Similar studies on venous anastomoses and random or axial pedunculated skin flaps would also contribute valuable findings relevant to this topic.

      • SCOPUSSCIEKCI등재

        Remote Cerebellar Hemorrhage Presenting with Cerebellar Mutism after Spinal Surgery : An Unusual Case Report

        Sen,,Halil,Murat,Guven,,Mustafa,Aras,,Adem,Bozkurt,Cosar,,Murat The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.3

        Dural injury during spinal surgery can subsequently give rise to a remote cerebellar hemorrhage (RCH). Although the incidence of such injury is low, the resulting hemorrhage can be life threatening. The mechanism underlying the formation of the hemorrhage is not known, but it is mostly thought to develop after venous infarction. Cerebellar mutism (CM) is a frequent complication of posterior fossa operations in children, but it is rarely seen in adults. The development of CM after an RCH has not been described. We describe the case of a 65-year old female who lost cerebrospinal fluid after inadvertent opening of the dura during surgery. Computerized tomography performed when the patient became unable to speak revealed a bilateral cerebellar hemorrhage.

      • SCOPUSKCI등재

        Original Articles : Intussusception: As the Cause of Mechanical Bowel Obstruction in Adults

        ( Murat Cakir ), ( Ahmet Tekin ), ( Tevfik Kucukkartallar ), ( Metin Belviranli ), ( Ebubekir Gundes ), ( Yahya Paksoy ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.1

        Background/Aims: Intussusception in adults is rarely seen and causes misdiagnosis due to its appearance with various clinical findings. The cause of intussusception in adults is frequently organic lesions. In this study, the underlying etiologic factors, diagnostic methods and alternative methods of treatment are discussed in the light of the literature. Methods: In this study, a retrospective evaluation was performed on 47 cases with the diagnoses of intussusception, who were operated on for bowel obstruction between 1990-2011 in Department of Surgery of Necmettin Erbakan University Meram Medical Faculty. Data related to presentation, diagnosis, treatment and pathology were analyzed. Results: Twenty-four of the patients (51%) were female, and 23 were male (49%). Mean age (year) was 49 (range: 23-78) in female group, and 50 (range: 17-72) in male group. All patients presented mechanical bowel obstruction findings and underwent operation. Intussusception was caused by benign and malignant tumors in 38 patients, and other reasons in 3 cases. No reason could be determined in the other 6 cases. Only small intestine resection was applied in 29 cases, and large intestine resection was also applied in 17 cases. Reduction and fixation surgery was performed in one patient. No postoperative mortality was observed. Conclusions: Adult intussusception remains a rare cause of abdominal pain. Diagnosis of intussusception in adults is still difficult. Main treatment was surgical in most cases. (Korean J Gastroenterol 2013;61:17-21)

      • KCI등재SCOPUS

        MSCT: AN EFFICIENT DATA COLLECTION HEURISTIC FOR WIRELESS SENSOR NETWORKS WITH LIMITED SENSOR MEMORY CAPACITY

        ( Murat Karakaya ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.9

        Sensors used in Wireless Sensor Networks (WSN) have mostly limited capacity which affects the performance of their applications. One of the data-gathering methods is to use mobile sinks to visit these sensors so that they can save their limited battery energies from forwarding data packages to static sinks. The main disadvantage of employing mobile sinks is the delay of data collection due to relative low speed of mobile sinks. Since sensors have very limited memory capacities, whenever a mobile sink is too late to visit a sensor, that sensor`s memory would be full, which is called a `memory overflow`, and thus, needs to be purged, which causes loss of collected data. In this work, a method is proposed to generate mobile sink tours, such that the number of overflows and the amount of lost data are minimized. Moreover, the proposed method does not need either the sensor locations or sensor memory status in advance. Hence, the overhead stemmed from the information exchange of these requirements are avoided. The proposed method is compared with a previously published heuristic. The simulation experiment results show the success of the proposed method over the rival heuristic with respect to the considered metrics under various parameters.

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