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- 저자 : Muhammad Z. Ahmad (검색결과 2 건)
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Hafi z Muhammad Ahmad Javaid,Hwayeon Lim,Sooim Shin,Joo Young Huh 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.10
Autophagy is a complex degradation pathwaythrough which damaged or dysfunctional proteins and organellesare removed. Its pharmacological modulators havebeen extensively used in a wide range of basic research andpreclinical studies. However, the eff ects of these inhibitorson metabolism, in addition to autophagy inhibition, are notfully elucidated. Chloroquine is a clinically relevant compoundthat inhibits autophagy by preventing the fusion ofautophagosomes with lysosomes. In this study, we aimed toexamine the eff ect of chloroquine on mitochondrial qualitycontrol and respiratory function by utilizing 3T3-L1 mouseadipocytes treated with chloroquine at various time points. We found that chloroquine could disturb genes related tomitochondrial fi ssion, biogenesis, and mitophagy, leadingto mitochondrial DNA damage. Although the inhibition of autophagy by chloroquine resulted in an increased prohibitinexpression, respiratory function was downregulated in atime-dependent manner. Moreover, chloroquine treatmentinduced oxidative stress, apoptosis, and metabolic dysregulation. These data demonstrated that chloroquine significantly aff ected mitochondrial respiratory function andmetabolism, which was consistent with impaired mitochondrialquality associated with autophagy inhibition.
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Fabrication of Gas-sensing Semiconductor Oxide Thin Films by Using a Short-wavelength Excimer Laser
강준희,박정현,Muhammad Z. Ahmad,Wojtek Wlodarski 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.9
Semiconducting metal oxides are widely used in chemical, electronic devices and in gas sensing applications. Among the many different deposition techniques, ablating the target materials with a high power laser is one of the most effective techniques in fabricating high quality gassensitive thin films. In this work, we used a 193-nm-wavelength ArF excimer laser, the shortest wavelength used in the fabrication of semiconductor oxides, to deposit high quality transition-metaloxide thin films. We used X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman spectroscopy, optical transmission spectroscopy, and conductivity measurements to characterize the films. The fabricated MoO<sub>3</sub> thin films were observed to show a good nanoplate structure in the orthorhombic α-MoO<sub>3</sub> phase. Depending on the deposition temperatures, MoO3 showed significantly different surface structures. Good gas sensitivity of a MoO<sub>3</sub> thin-film-based sensor exposed to low concentrations ethanol vapor was found by using resistance measurements.
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