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( Pil Soo Sung ),( Dong Jin Yoon ),( Do Seon Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Jeong Won Jang ),( Jong Young Choi ),( Seung Kew Yoon ),( Seok Whan Moon ),( Hong Seok Jang ),( Si Hyun Bae ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: We performed a retrospective study to identify prognostic factors and determine outcomes for patients with brain metastases from hepatocellular carcinoma (HCC). Methods: A total of 72 patients with brain metastases from HCC were identified from two institutions; 26 of 72 patients received tumor-removing surgery or stereotactic radiosurgery with or without whole-brain radiotherapy (WBRT), 23 of 72 received WBRT only, and 23 of 72 received conservative treatment. Estimates for overall survival (OS) after brain metastases were determined and clinical prognostic factors were identified by Cox proportional hazards modeling. Results: Median OS after development of brain metastases was 48 days (one day to 536 days). The median age at the time patients were diagnosed with brain metastasis was 54 years. Fifty-one patients (71%) were male, and 62 patients (86%) were infected with hepatitis B virus. Median time from diagnosis of HCC to brain metastasis was 17.2 months, and 4 patients had brain metastases at the time diagnosis. Intracranial hemorrhage was frequently associated (42%) with brain metastasis. The most common presenting symptoms were motor weakness, mental change, and headache. Sixty-three patients (88%) had lung metastases, 25 patients (35%) had bone metastases, 18 patients (25%) had metastatic lymphadenopathy, and 7 (10%) patients had peritoneal seeding when diagnosed with brain involvement, and there was only one patient without metastasis to other organs. Univariate analyses showed that treatment with curative intent (surgery or SRS) and serum AFP levels were associated with improved survival (P<0.001, and 0.045, respectively), whereas a single brain metastasis, size of metastatic tumor, or intracranial hemorrhage were not. We further divided patients with three groups by the treatment modality; surgery or radiosurgery (group1), WBRT (group 2), or conservative treatment (group 3). Group 1 showed best survival, followed by group 2 and group 3, sequentially (P<0.001). Subgroup analysis with patients with single brain metastasis showed similar results. Multivariate analysis showed that treatment modality was the only factor that is associated with improved OS (P=0.001) Conclusions: When patients with lung metastases from HCC present neurologic symptoms, brain imaging is required to confirm intracranial metastases. Although the overall prognosis of patients with brain metastases from HCC is extremely poor, patients actively treated with surgery or radiosurgery have prolonged survival, suggesting that interventions to control intracranial disease are important treatment modalities.
Sang Il Park,Tae Won Moon,Pil Hwa Yoo 한국무역연구원 2014 貿易 硏究 Vol.10 No.6
This paper clarified the ambiguity in the literature regarding psychic distance by refining its conceptualization, operationalization, and measurement. It empirically investigated psychic distance in a more inclusive manner that involves its antecedents (i.e. psychic distance stimuli), marketing program adaptation, and performance outcomes. The results of the study revealed that psychic distance stimuli are positively associated with psychic distance. Furthermore, psychic distance positively influences marketing program adaptation. The results also demonstrated that psychic distance mediates the relationship between psychic distance stimuli and marketing program adaptation, and that marketing program adaptation is positively associated with export performance. Future research agenda were suggested.
Effect of the Axial Heat Flux on the Critical Heat Flux in Low Flow Conditions with Vertical Annuli
MOON, Sang-Ki,CHUN, Se-Young,PARK, Jong-Kuk,BAEK, Won-Pil Atomic Energy Society of Japan 2006 Journal of nuclear science and technology Vol.43 No.11
<P>An experimental study on the critical heat flux (CHF) has been performed for a water flow in vertical annuli with uniform and chopped cosine axial heat flux distributions under low flow and a wide range of pressure conditions. The effect of an axial heat flux distribution on the critical power is large at low-pressure conditions, but the effect decreases rapidly as the pressure increases. The ‘overall power’ hypothesis becomes more accurate as the pressure and critical quality increase, and the ‘local conditions’ hypothesis is not valid at high quality conditions. For a fixed mass flux and pressure, the relationship between the critical quality and the boiling length is represented by a single curve for the whole range of the present experimental conditions, regardless of the axial heat flux distributions. Smolin <I>et al.</I>’s <I>F</I>-factor and Bowring’s <I>Y</I> parameter show good prediction results for the present CHF data.</P>
Current-carrying capacity of double-wall carbon nanotubes
Moon, Sunkyung,Song, Woon,Kim, Nam,Sung Lee, Joon,Na, Pil Sun,Lee, Soon-Gul,Park, Jongwan,Jung, Myung-Hwa,Lee, Hyun-Woo,Kang, Kicheon,Lee, Cheol Jin,Kim, Jinhee IOP Pub 2007 Nanotechnology Vol.18 No.23
<P>We have studied electrical transport characteristics of individual double-wall carbon nanotubes (DWNT) under high bias voltages. As the bias voltage applied to the carbon nanotubes increases, the outermost shell of the DWNTs broke down sequentially, which enabled us to determine the current-carrying capacity of each shell. The maximum current-carrying capacity per shell was about 150 µA, which is well above that of any other previous reports. </P>
Moon, Sang-Ki,Chun, Se-Young,Cho, Seok,Baek, Won-Pil Elsevier 2005 Nuclear engineering and design Vol.235 No.21
<P><B>Abstract</B></P><P>An experimental study of the critical heat flux (CHF) has been performed for a water flow in a non-uniformly heated vertical 3×3 rod bundle under low flow and a wide range of pressure conditions. The experiment was especially focused on the parametric trends of the CHF and the applicability of the conventional CHF correlations to a return-to-power conditions of a main steam line break accident whose conditions might be a low mass flux, intermediate pressure, and a high inlet subcooling. The effects of the mass flux and pressure on the CHF are relatively large and complicated in the low pressure conditions. At a high mass flux or a low critical quality, the local heat flux at the CHF location sharply decreases with an increasing local critical quality. However, at a low mass flux or a high critical quality, the local heat flux at the CHF location shows a nearly constant value regardless of the increase of the critical quality. The CHF data at the very low mass flux conditions are correlated well by the churn-to-annular flow transition criterion or the flow reversal phenomena. Several conventional CHF correlations predict the present return-to-power CHF data with reasonable accuracies. However, the prediction capabilities become worse in a very low mass flux of below about 100kg/(m<SUP>2</SUP>s).</P>
Distribution of Certain Chlorobenzenes in Seawater from Youngil Bay, Korea
Moon, Hyo-Bang,Park, Hee-Gu,Kim, Sang-Soo,Jeong, Seung-Ryul,Lee, Pil-Yong The Korean Environmental Sciences Society 2001 Environmental sciences Vol.10 No.3
Surface seawater was sampled from 20 stations in Youngil Bay, Korea in November 2000. The samples were analyzed for eight chlorobenzenes(CBs) out of a total of 12 in the congener series using a gas chromatography coupled to a mass spectrometer detector(GC/MSD). The total CB levels varied from 1.3 to 6.1 ng/L with a mean of 4.0 ng/L. Trichlorobenzene groups (sum of 1,3,5-, 1,2,4-, and 1,2,3-trichlorobenzene) were the predominant class among the four congener groups, while tetrachlorobenzenes(sum of 1,2,3,5-, 1,2,4,5-, and 1,2,3,4- tetrachlorobenzene) and pentachlorobenzene showed a low presence. The total CB levels exhibited similar patterns for all the stations. A significant positive correlation was observed between the individual CB compounds in the particulate samples, while the dissolved samples revealed a strong correlation between the heavier molecular weight CBs.