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Cucurbituril complexes cross the cell membrane
Montes-Navajas, Pedro,Gonzalez-Bejar, Maria,Scaiano, J.C.,Garcia, Hermenegildo Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.12
Cucurbiturils (CBs) of the appropriate size (CB[7] and CB[8]) form strong guest-host complexes in phosphate buffer solution (PBS) with acridine orange (AO) and pyronine Y (PYY) with 1 : 1 and 2 : 1 stoichiometries for CB[7] and CB[8] complexes, respectively. Binding constants in the range $0.87-1.60{\times}10^6M^{-1}$ and $5.2-6.3{\times}10^{13}M^{-2}$ were determined by titration with fluorescence spectroscopy for 1 : 1 and 2 : 1 complexes, respectively. These binding constants in PBS and the eight-fold excess of CBs minimize the presence of free dye in solution and also stabilize the host-guest complex in the culture medium. Images showing that the CB complexes can cross the cell membrane of 3T3 cells have been acquired using fluorescence microscopy. Given the current importance of supramolecular CB complexes and the search for new drug delivery systems, the present findings open avenues for the use of CBs as nanocapsules to transport drugs into the cells.
Detecting Malware in Cyberphysical Systems Using Machine Learning: a Survey
( Montes F. ),( Bermejo J. ),( Sánchez L. E. ),( Bermejo J. R. ),( Sicilia J. A. ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.3
Among the scientific literature, it has not been possible to find a consensus on the definition of the limits or properties that allow differentiating or grouping the cyber-physical systems (CPS) and the Internet of Things (IoT). Despite this controversy the papers reviewed agree that both have become crucial elements not only for industry but also for society in general. The impact of a malware attack affecting one of these systems may suppose a risk for the industrial processes involved and perhaps also for society in general if the system affected is a critical infrastructure. This article reviews the state of the art of the application of machine learning in the automation of malware detection in cyberphysical systems, evaluating the most representative articles in this field and summarizing the results obtained, the most common malware attacks in this type of systems, the most promising algorithms for malware detection in cyberphysical systems and the future lines of research in this field with the greatest potential for the coming years.
Antonio Montes,Chandrasekar Chinnarasu,Clara Pereyra,Lourdes Casas,María Teresa Fernández-Ponce,Casimiro Mantell,Sangma Pattabhi,Enrique Martínez de la Ossa 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.2
Various extracts from olive leaves have been precipitated by a supercritical antisolvent (SAS) process to evaluate the possibility of producing polyphenol fine particles with controlled size and size distribution. Olive leaves were initially extracted with subcritical fluids using mixtures of CO2+ethanol at 10% and 50%, by pressurized liquid extraction (PLE) with water, ethanol and a hydroalcoholic mixture (50 : 50) (v/v), and also by conventional ethanol extraction (CE). PLE gave the extract with the highest yield and the best antioxidant activity. SAS precipitation was unsuccessful for the extracts obtained with pressurized water and with the hydroalcoholic mixture (50 : 50) (v/v). The SAS precipitates with the smallest particle sizes were produced from extracts obtained with subcritical fluids. The SAS precipitates obtained after the conventional ethanol extraction of olive leaves showed the best antioxidant activity.
An Estimate of the Yield Displacement of Coupled Walls for Seismic Design
Hernandez-Montes, Enrique,Aschheim, Mark Korea Concrete Institute 2017 International Journal of Concrete Structures and M Vol.11 No.2
A formula to estimate the yield displacement observed in the pushover analysis of coupled wall lateral force-resisting systems is presented. The estimate is based on the results of an analytical study of coupled walls ranging from 8 to 20 stories in height, with varied amounts of reinforcement in the reinforced concrete coupling beams and walls, subjected to first-mode pushover analysis. An example illustrates the application of these estimates to the performance-based seismic design of coupled walls.
Comparative study of the radiopacity of resin cements used in aesthetic dentistry
quel Montes-Fariza,Manuel Monterde-Hernández,Cristina Cabanillas-Casabella,Antonio Pallares-Sabater 대한치과보철학회 2016 The Journal of Advanced Prosthodontics Vol.8 No.3
PURPOSE The aim of this study was to compare the radiopacity of 6 modern resin cements with that of human enamel and dentine using the Digora digital radiography system, to verify whether they meet the requirements of ANSI/ADA specification no. 27/1993 and the ISO 4049/2000 standard and assess whether their radiopacity is influenced by the thickness of the cement employed. MATERIALS AND METHODS Three 3-thickness samples (0.5, 1 and 1.5 mm) were fabricated for each material. The individual cement samples were radiographed on the CCD sensor next to the aluminium wedge and the tooth samples. Five radiographs were made of each sample and therefore five readings of radiographic density were taken for each thickness of the materials. The radiopacity was measured in pixels using Digora 2.6 software. The calibration curve obtained from the mean values of each step of the wedge made it possible to obtain the equivalent in mm of aluminium for each mm of the luting material. RESULTS With the exception of Variolink Veneer Medium Value 0, all the cements studied were more radiopaque than enamel and dentin (P<.05) and complied with the ISO and ANSI/ADA requirements (P<.001). The radiopacity of all the cements examined depended on their thickness: the thicker the material, the greater its radiopacity. CONCLUSION All materials except Variolink Veneer Medium Value 0 yielded radiopacity values that complied with the recommendations of the ISO and ANSI/ADA. Variolink Veneer Medium Value 0 showed less radiopacity than enamel and dentin.
The buried arch structural system for underground structures
Hernandez-Montes, Enrique,Aschheim, Mark,Gil-Martin, Luisa Maria Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.20 No.1
In many cases, underground structures are built using conventional above-grade structural systems to carry gravity load. This paper proposes the use of underground arches, termed "buried arches", to support gravity loads, wherein the horizontal thrust of the arch is equilibrated by soil pressure. Because the horizontal soil pressure increases with depth, the depth of the arch may be reduced as the depth below grade increases. Critical to the success of such an approach is a proper accounting of creep and shrinkage for arches made of reinforced concrete. This paper addresses the influence of equilibrium, creep, and shrinkage as they affect the design of the arch from a theoretical perspective. Several examples illustrate the use of buried arches for the design of underground parking structures.
Modelling and Simulation of the Electrical Resistance Sintering Process of Iron Powders
J. M. Montes,F. G. Cuevas,F. J. V. Reina,F. Ternero,R. Astacio,E. S. Caballero,J. Cintas 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.7
In this paper, the process known as Electrical Resistance Sintering under Pressure is modelled, simulated and validated. Thisconsolidation technique consists of applying a high-intensity electrical current to a metallic powder mass under compression. The Joule effect acts heating and softening the powders at the time that pressure deforms and makes the powder mass todensify. The proposed model is numerically solved by the finite elements method, taking into account the electrical–thermal–mechanical coupling present in the process. The theoretical predictions are validated with data recorded by sensorsinstalled in the electrical resistance sintering equipment during experiments with iron powders. The reasonable agreementbetween the theoretical and experimental curves regarding the overall porosity and electrical resistance suggests that themodel reproduces the main characteristics of the process. Also, metallographic studies on porosity distribution confirm themodel theoretical predictions. Once confirmed the model and simulator efficiency, the evolution of the temperature and theporosity fields in the powder mass and in the rest of elements of the system can be predicted. The influences of the processingparameters (intensity, time and pressure) as well as the die material are also analyzed and discussed.
Carlos Eduardo Montes Cardona,Herney Andrés García-Perdomo 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.2
Purpose: To determine the efficacy of phosphodiesterase type 5 inhibitors (PDE5i) as medical expulsive therapy (MET) for the treatment of distal ureteral calculi. Materials and Methods: A search strategy was conducted in the MEDLINE, CENTRAL, and Embase databases. Searches were also conducted in other databases and unpublished literature. Clinical trials were included without language restrictions. The risk of bias was evaluated with the Cochrane Collaboration's tool. An analysis of random effects due to statistical heterogeneity was conducted. The primary outcome was the expulsion rate of the distal ureteral calculus in 28 days. The secondary outcomes were the time to expulsion, side effects of treatment, and amount (mg) of nonopioid analgesia. The measure of the effect was the risk difference (RD) with a 95% confidence interval (CI). The planned interventions were PDE5i vs. placebo, tadalafil vs. placebo, and tadalafil vs. tamsulosin. Results: Four articles were included in the qualitative and quantitative analysis. Records of 580 patients were found among the four studies. A low risk of bias was shown for the majority of the study items. The calculi expulsion rate had an RD of 0.26 (95% CI, 0.15–0.37) and a less prolonged expulsion as a secondary outcome with a mean difference of -4.39 days (95% CI, -6.69 to -2.09) in favor of PDE5i compared with the placebo. No significant difference was found for these outcomes when comparing tadalafil with tamsulosin. Conclusions: Compared with a placebo, PDE5i could be effective as MET for the treatment of distal ureter calculi.