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Mohammad‑Taher Moradi,Kheirollah Yari,Zohreh Rahimi 한국유전학회 2017 Genes & Genomics Vol.39 No.11
Helicobacter pylori infection could induce oxidative stress. Oxidative stress is involved in the pathogenesis of gastric diseases. Glutathione peroxidase 1 (GPX1), is part of the enzymatic antioxidant defense, preventing oxidative damage. The aim of the present study was to assess the association of GPX1 Pro198Leu genotypes with gastric cancer in patients with and without H. pylori infection in a population of Northern Iran. The present case-control study consisted of 50 patients with gastric cancer and 78 cancer-free subjects as controls. Extraction of DNA was performed on bioptic samples and the GPX1 genotypes were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The frequencies of GPX1 Pro/Pro, Pro/Leu and Leu/Leu genotypes in controls were 21.8, 71.8 and 6.4%, respectively. However, in gastric cancer patients, the frequencies of 34, 56 and 10% were observed for Pro/Pro, Pro/Leu and Leu/Leu genotypes, respectively (p = 0.185). In 38 (76%) patients infected with H. pylori, the frequencies of Pro and Leu alleles were 94.7 and 3.3%, respectively. There was a higher frequency of combined genotype of Pro/Leu + Leu/ Leu (94.7%) in H. pylori positive patients than that in patients without H. pylori infection (75%, p = 0.047). The presence of this genotype tended to increase the risk of H. pylori related gastric cancer by 5.88–fold (p = 0.069) in our population. Our findings indicated the absence of association between the GPX1 Pro198Leu polymorphism and the risk of gastric cancer in an Iranian population. However, we detected an association between H. pylori related gastric cancer with GPX1 Pro/Leu + Leu/Leu genotype.
Mohammad Ali Ebrahimzadeh,Mohammad Mohammad Taheri,Ehsan Ahmadpour,Mahbobeh Montazeri,Shahabeddin Sarvi,Mohammad Akbari,Ahmad Daryani 대한약침학회 2017 Journal of pharmacopuncture Vol.20 No.3
Objectives: The currently available agents for use against toxoplasmosis have serious limitations. Thus, the aim of the present study was to investigate the anti-Toxoplasma gondii (T. gondii) activities of methanol extracts of Feijoa sellowiana (F. sellowiana) (leaves and fruits), Quercus castaneifolia (Q. castaneifolia) (fruits), and Allium paradoxum (A. paradoxum) (leaves) in vitro and in vivo. Methods: Vero cells were treated with different concentrations (from 0 to 400 μg/mL) of the above extracts or with pyrimethamine at a dose of 50 mg/mL (positive control). Then, the viabilities of the T. gondii-infected cells were measured by using colorimetric MTT (3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyltetrazolium bromide) assays. In addition, the survival rates of mice acutely infected with 2 × 104 RH strain tachyzoites of T. gondii were examined in vivo after intraperitoneal injection of the extracts at doses of 100 and 200 mg/kg/day for 5 days. Results: In the in vitro anti- T. gondii assay, the IC50 values were 12.77, 180.2, 74.73, 213.2 and 163.8 μg/mL, and the selectivity indices were 6.05, 1.31, 0.35, 0.69 and 1.30 for the F. sellowiana (leaves and fruits), Q. castaneifolia, and A. paradoxum extracts and pyrimethamine, respectively. Moreover, the mice treated with F. sellowiana (leaves and fruits) achieved better results in terms of survival than the others (P < 0.05). Conclusion: The results of the current study indicate that methanol extract of F. sellowiana has significant anti-Toxoplasma activity. Further study should be conducted to investigate the potential bioactivity of this extract through bioactivity-guided fractionation.
Building structural health monitoring using dense and sparse topology wireless sensor network
Mohammad E. Haque,Mohammad F.M. Zain,Mohammad A. Hannan,Mohammad H. Rahman 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.16 No.4
Wireless sensor technology has been opened up numerous opportunities to advanced health and maintenance monitoring of civil infrastructure. Compare to the traditional tactics, it offers a better way of providing relevant information regarding the condition of building structure health at a lower price. Numerous domestic buildings, especially longer-span buildings have a low frequency response and challenging to measure using deployed numbers of sensors. The way the sensor nodes are connected plays an important role in providing the signals with required strengths. Out of many topologies, the dense and sparse topologies wireless sensor network were extensively used in sensor network applications for collecting health information. However, it is still unclear which topology is better for obtaining health information in terms of greatest components, node\'s size and degree. Theoretical and computational issues arising in the selection of the optimum topology sensor network for estimating coverage area with sensor placement in building structural monitoring are addressed. This work is an attempt to fill this gap in high-rise building structural health monitoring application. The result shows that, the sparse topology sensor network provides better performance compared with the dense topology network and would be a good choice for monitoring high-rise building structural health damage.
Improvement in DRX Power Saving for Non-real-time Traffic in LTE
Mohammad Tawhid Kawser,Mohammad Rakibul Islam,Khondoker Ziaul Islam,Mohammad Atiqul Islam,Mohammad Mehadi Hassan,Zobayer Ahmed,Rafid Hasan 한국전자통신연구원 2016 ETRI Journal Vol.38 No.4
A discontinuous reception (DRX) operation is included in the Long Term Evolution (LTE) system to achieve power saving and prolonged battery life of the user equipment. An improvement in DRX power saving usually leads to a potential increase in the packet delay. An optimum DRX configuration depends on the current traffic, which is not easy to estimate accurately, particularly for non-real-time applications. In this paper, we propose a novel way to vary the DRX cycle length, avoiding a continuous estimation of the data traffic when only non-real-time applications are running with no active real-time applications. Because a small delay in non-real-time traffic does not essentially impact the user’s experience adversely, we deliberately allow a limited amount of delay in our proposal to attain a significant improvement in power saving. Our proposal also improves the delay in service resumption after a long period of inactivity. We use a stochastic analysis assuming an M/G/1 queue to validate this improvement.
Mohammad Zabetian,Mohammad Hassan Saidi,Mohammad Said Saidi,Mohammad Behshad Shafii 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.3
Particle manipulation using laser beam is almost a new and contactless technique in particulate sciences. The method is based on theradiation pressure of light photons on the particles suspended in a semi-transparent fluid. Applications of the technique mainly covermicroscopic separation and detection of biological objects. In this work, a theoretical study is conducted to investigate the hydrodynamicand thermal effects on a particulate flow in a mini-channel. Laser thermal effects are studied as a result of light absorption either in fluidor dispersed phase. An analytical model is developed to be the real simulator of a test bed developed by the authors. The main objectiveof performed simulation is to determine the conditions of hydrodynamic laser-particle interaction and the contribution of thermal effects. More specifically, the criteria for size of particles and beam parameters to meet the mentioned conditions are presented. The model resultsare used for design and selection of elements in a particle manipulation system.