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Minsoo Kim,Sun Kyung Park,Woong Mo Kim,Eunsoo Kim,Hyuckgoo Kim,Jun-Mo Park,Seong-Soo Choi,Eun Joo Choi 대한통증학회 2024 The Korean Journal of Pain Vol.37 No.2
There are growing concerns regarding the safety of long-term treatment with opioids of patients with chronic noncancer pain. In 2017, the Korean Pain Society (KPS) developed guidelines for opioid prescriptions for chronic non-cancer pain to guide physicians to prescribe opioids effectively and safely. Since then, investigations have provided updated data regarding opioid therapy for chronic non-cancer pain and have focused on initial dosing schedules, reassessment follow-ups, recommended dosage thresholds considering the risk-benefit ratio, dosereducing schedules for tapering and discontinuation, adverse effects, and inadvertent problems resulting from inappropriate application of the previous guidelines. Herein, we have updated the previous KPS guidelines based on a comprehensive literature review and consensus development following discussions among experts affiliated with the Committee on Hospice and Palliative Care in the KPS. These guidelines may assist physicians in prescribing opioids for chronic non-cancer pain in adult outpatient settings, but should not to be regarded as an inflexible standard. Clinical judgements by the attending physician and patient-centered decisions should always be prioritized.
A Feasibility Evaluation on the Outsourcing of Quality Testing and Inspection
Choi, Minsoo,Kim, Moohan Architectural Institute of Korea 2007 Architectural research Vol.9 No.1
The purpose of this research is to evaluate the feasibility of outsourcing test/inspection activity in construction work. This research conducted a questionnaire of interested parties as well as a survey by Analytic Hierarchy Process (AHP) with experts on quality control. For the evaluation by AHP, five criteria were adopted and a number of pair-wise comparisons were conducted through two stages. Finally, the weighting coefficient to approve the outsourcing was calculated at 0.606 and it therefore appeared more reasonable to permit rather than prohibit outsourcing. According to the AHP result, it was found that outsourcing would be necessary to enhance the objectivity and specialties of quality testing and inspection, even though somewhat undesirable in terms of enhancing a sense of responsibility and systemically conducting the testing and inspection.
A Feasibility Evaluation on the Outsourcing of Quality Testing and Inspection
Minsoo Choi,Moohan Kim 대한건축학회 2007 Architectural research Vol.9 No.1
The purpose of this research is to evaluate the feasibility of outsourcing test/inspection activity in construction work. This research conducted a questionnaire of interested parties as well as a survey by Analytic Hierarchy Process (AHP) with experts on quality control. For the evaluation by AHP, five criteria were adopted and a number of pair-wise comparisons were conducted through two stages. Finally, the weighting coefficient to approve the outsourcing was calculated at 0.606 and it therefore appeared more reasonable to permit rather than prohibit outsourcing. According to the AHP result, it was found that outsourcing would be necessary to enhance the objectivity and specialties of quality testing and inspection, even though somewhat undesirable in terms of enhancing a sense of responsibility and systemically conducting the testing and inspection.
A Channel Model of Scaled RC-dominant Wires for High-Speed Wireline Transceiver Design
Minsoo Choi,Jae-Yoon Sim,Hong-June Park,Byungsub Kim 대한전자공학회 2013 Journal of semiconductor technology and science Vol.13 No.5
This paper explains modeling and analysis of RC-dominant wires for high-speed wireline transceiver design. A closed form formula derived from telegrapher’s equation accurately describes a frequency response of an RC-dominant wire, yet it is simple and intuitive for designers to easily understand design trade-offs without a complex numerical equation solver. This paper explains how the model is derived and how it can help designers in example transceiver designs.
IL-4 Inhibits the Melanogenesis of Normal Human Melanocytes through the JAK2–STAT6 Signaling Pathway
Choi, Hyun,Choi, Hyunjung,Han, Jiyeon,Jin, Sun Hee,Park, Ju-Yearl,Shin, Dong Wook,Lee, Tae Ryong,Kim, Kwangmi,Lee, Ai-Young,Noh, Minsoo The Society for Investigative Dermatology, Inc 2013 The Journal of investigative dermatology Vol.133 No.2
Skin diseases can be characterized by their predominant CD4-positive T-helper (Th) cell profiles. Chronic dermatological conditions often give rise to abnormal skin pigmentation. To understand the role of Th cells in pigmentation, the effects of the major Th cell cytokines, IFNγ, IL-4, and IL-17A, on melanogenesis were evaluated using cultured normal human melanocytes (NHMs) instead of relying on transformed melanoma cell lines. IL-4 directly inhibited melanogenesis in NHMs and downregulated both transcription and translation of melanogenesis-associated genes, such as microphthalmia-associated transcription factor (MITF) and dopachrome tautomerase. Despite the lack of a direct inhibition of melanin pigment synthesis, IFNγ and IL-17A increased the synthesis of an antimelanogenic cytokine IL-6 in NHMs. IFNγ activated signal transducers and activators of transcription 1 (STAT1) and STAT3 phosphorylation in NHMs, and IL-4 increased the STAT3 and STAT6 phosphorylation. The differential phosphorylation profile of STAT proteins between IFNγ and IL-4 may explain the difference in their effect on melanogenesis in NHMs. The IL-4-induced downregulation of melanogenesis was inhibited by treating NHMs with a JAK2 inhibitor AG490 or STAT6 siRNA. In conclusion, the involvement of the IL-4-induced JAK2–STAT6 signaling and the IFNγ- or IL-17A-dependent antimelanogenic IL-6 production should be considered as one of the mechanisms explaining the association with hypopigmention in skin diseases.
An Approximate Closed-Form Channel Model for Diverse Interconnect Applications
Minsoo Choi,Jae-Yoon Sim,Hong-June Park,Byungsub Kim IEEE 2014 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS PART 1 R Vol.61 No.10
<P>This paper presents an approximate closed-form channel model for a wide range of high-speed interconnect designs. Closed-form formulas derived from telegrapher's equation can accurately describe frequency responses of various interconnects, which have hardly been described by simple closed-form formulas, as long as the channels meet clear validity conditions. The formulas also provide a simple and intuitive equivalent circuit representation which allows designers to separately consider the effects of transmitter impedance, receiver termination, and wire attenuation. For a wide range of applications, the relative error of our model is theoretically bounded by the validity conditions. The model's accuracy is verified by comparing the calculated transfer functions against simulation results using the previous method built in SPICE for various interconnect examples from LC-dominant printed-circuit-board interconnects to RC-dominant silicon-interposer interconnects. In addition, the simplicity of our model improves computation time by about 162 times compared to the previous numerical computation method. With this channel model, designers can intuitively and accurately analyze the behavior of interconnects and design trade-offs of a wide range of interconnects without complex numerical simulation.</P>
A Channel Model of Scaled RC-dominant Wires for High-Speed Wireline Transceiver Design
Choi, Minsoo,Sim, Jae-Yoon,Park, Hong-June,Kim, Byungsub The Institute of Electronics and Information Engin 2013 Journal of semiconductor technology and science Vol.13 No.5
This paper explains modeling and analysis of RC-dominant wires for high-speed wireline transceiver design. A closed form formula derived from telegrapher's equation accurately describes a frequency response of an RC-dominant wire, yet it is simple and intuitive for designers to easily understand design trade-offs without a complex numerical equation solver. This paper explains how the model is derived and how it can help designers in example transceiver designs.
A Study on the Price Escalation System in a Construction Contract
Minsoo Choi,Jinu Kim,Moohan Kim 대한토목학회 2006 KSCE journal of civil engineering Vol.10 No.4
The purpose of this study is to suggest policies to improve the price escalation system in a construction contract through a Policy Delphi technique. The Delphi, including two times questionnaires and a group discussion, was conducted by joining 14 experts. We also examined the escalation provisions of various countries. Results of the Delphi showed that the minimum fluctuation rate for price escalation was desirable at a level of3%. To compute the fluctuation rate, calculating the price fluctuation of overall articles was more desirable than using price indices. A bidding date was more reasonable as the initial date of change in price. Losses caused by price change should be shared between contractor and owner; therefore a deduction rate should be introduced in contract price escalation. Meanwhile, overhead and profit should be adjusted in proportion to the fluctuation rate; but advance payment or the delayed construction amount should be deducted from the adjusted amount.
MinSoo Byun,Dahyun Yi,JunHo Lee,YoungMin Choe,BoKyung Sohn,JunYoung Lee,HyoJung Choi,Hyewon Baek,YuKyeong Kim,YunSang Lee,ChulHo Sohn,Inhee MookJung,Murim Choi,YuJin Lee,DongWoo Lee,SeungHo Ryu,ShinGy 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective-The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer’s disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process. Methods-All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [11C]Pittsburgh compound B-positron emission tomography (PET), and [18F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests. Results-As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants-291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)-were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring. Conclusion-The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.